• Journal of Acupuncture Research
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• 제21권5호
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• pp.1-12
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• 2004

Objective : This study was to investigate the effect of acupuncture on NADPH-diaphorase and nNOS in the brain stem and cerebellum of spontaneously hypertensive rats. Methods : The experimental groups were divided into four groups : Normal, Choksamni(ST36), Kokchi(LI11), arbitrary group. Thereafter we evaluated changes in NADPH-diaphorase positive neurons histochemically and changes in nNOS neurons immunohistochemically. Results : 1. The optical densities of NADPH-diaphorase positive neurons of all the Choksamni & Kokchi groups were significantly different in SuG, DLPAG, IP, Pr, Gi areas of brain stem and cerebellum as compared to normal & arbitrary groups. In PPTg only Choksamni group was significantly different as compared to normal and arbitrary groups. 2. The optical densities of nNOS-positive neurons of Choksamni & Kokchi groups were significantly different in SuG, DLPAG areas of brain stem as compared to normal group. In IP, Pr only Kokchi group was significantly different as compared to normal group. The optical densities of nNOS-positive neurons of Choksamni & Kokchi groups were significantly different in SuG, DLPAG, PPTg, Pr, Gi areas of brain stem as compared to arbitrary group. In IP, Pr only Kokchi group was significantly different as compared to arbitrary group. 3. The optical densities of nNOS-positive neurons of all the Choksamni & Kokchi groups were not significantly different in cerebellum as compared to normal & arbitrary groups. Conclusions : We found out that acupuncture have effects on NADPH-diaphorase and nNOS in the brain stem and cerebellum of spontaneously hypertensive rats.

• 대한간호학회지
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• 제40권3호
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• pp.423-432
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• 2010

Purpose: This study was done to examine effects of Nei-Guan acupressure on nausea, vomiting and level of satisfaction for gynecological surgery patients who were using a patient-controlled analgesia (PCA). Methods: For this study, 51 patients were assigned to one of three groups, a control group (17 patients), experimental group 1 (finger acupressure group) (17 patients), and experimental group 2 (relief band group) (17 patients). The data were collected for 24 hr in the recovery room of a university hospital located in Seoul. The 6 hr-intervals including the time of leaving the recovery room were taken into consideration. Results: The occurrence of nausea between the experimental group with Nei-Guan acupressure treatment and the control group was different. However, there was no difference in nausea and vomiting control or level of patient satisfaction between the finger acupressure group and the relief band group. Conclusion: Nei-Guan acupressure is recommended for nursing practice as a way for alleviating the opioid-induced nausea and accelerating the recovery of patients who are using PCA after surgery.

• 한국지능시스템학회논문지
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• 제14권7호
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• pp.920-926
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• 2004

인간은 외부로부터 새로운 정보를 입력받고 나서 시간이 지남에 따라 그 정보가 점차 잊혀져 가지만 그 정보를 반복적으로 학습하면 오래도록 기억에 남고 잘 잊혀지지 않게 된다. 우리가 처음 듣는 전화번호를 기억할 때 한번 듣고 나서 다시 생각하지 않는다면 곧 잊혀지게 되지만 반복하여 말하고 기억해내면 좀 더 오래 기억할 수 있는 것도 그와 비슷한 현상이다. 또한 인간이 강한 자극과 함께 새로운 정보를 입력받을 때에는 그것을 반복하여 학습하지 않는다 하더라도 기억에 오랫동안 남을 수 있다. 목숨을 잃을 뻔했던 사고를 당한 적이 있지나 뜻밖의 큰 행운을 얻은 경험이 있는 사람은 누구나 그 순간을 쉽게 잊을 수 없을 것이다. 인간은 기억력의 한계가 있음에도 불구하고 위와 같은 과정에 의해서 기억을 오래 유지할 수 있게 된다. 본 논문에서는 이러한 과정을 신경 회로망과 퍼지를 이용하여 구현하고자 한다.

• 대한임상전기생리학회지
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• 제9권2호
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• pp.19-24
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• 2011

Purpose : This study is to examine the effects of transcranial direct current stimulation on the excitability of the central neuron. Methods : This study selected 24 suitable women in their twenties. A positive electrode of transcranial direct current stimulation was placed on the primary motor area (M1) C4 and a negative electrode was placed on the left supraobital. A stimulation of 0.04mA/$cm^2$ was applied for 20 minutes. H-reflex and V wave used diagnostic electromyography. An active electrode was placed at the muscle belly of the medial gastrocnemius muscle at a prone posture. An electrical stimulation was given to the posterior tibial nerve. Measurements were made before and after the stimulation. All data were analyzed with SPSS 12.0 and between each measuring before and after the change of the H-reflex and V wave amplitude. Results : There were no significant differences in all H wave, M wave, and V wave amplitude before and after transcranial direct current stimulation. There were no significant differences in the change of H/M ratio and V/M ratio before and after transcranial direct current stimulation. Conclusion : We know that transcranial direct current stimulation cannot have an influence on a normal grown-up person's central neuron.

• 대한치과마취과학회지
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• 제9권1호
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• pp.17-23
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• 2009

배경: 보툴리눔 독소 A형은 강직성 질환을 비롯한 여러 질환의 치료제로 널리 사용되고 있다. 최근에 보툴리눔 독소 A형은 근육비대를 치료하기 위해 널리 이용되고 있다. 하지만 보툴리눔 독소의 근육비대의 치료효과에 대해서 알려진 바가 거의 없다. 본 연구는 토끼 정강뼈 근육에 보툴리눔 A, B형을 주입 후 시간경과에 따른 근육의 위축을 확인하여 근육비대의 치료에 보툴리눔 B형이 효과적인지 확인하고자 하였다. 방법: 36마리의 토끼를 4그룹으로 분류하였다(1 그룹: 생리식염수 주사: 2 그룹: 보툴리눔 독소 A, B - 2U, 3 그룹: 보툴리눔 독소 A, B - 5U, 4 그룹: 보툴리눔 독소 A, B - 10U). 정강뼈근육에 보툴리눔 독소 A, B형을 주입 후 1, 2, 4주에 정강뼈 근육의 부피를 측정하였다. 신경자극기를 이용하여 독소 주입 후 1, 2, 4주의 근육의 단일 수축을 확인하여 근육기능의 변화여부를 확인하였다. 결과: 보툴리눔 독소 B형을 주입시 통계적으로 유의하지 않지만 A형에 비해 근육 부피의 감소가 관찰되었다(P>0.05). 반면, 근육의 단일 수축은 보툴리눔의 용량에 관계없이 B형을 주입한 근육에서 더 높게 관찰 되었다. 결론: 보툴리눔 독소 B형을 주입한 경우 근육 기능의 회복속도는 빠른 반면 근육의 위축은 A형에 비해 더 오랫동안 지속되었다. 따라서 근육비대의 치료에 있어 보툴리눔 독소 B형이 A형보다 보다 더 효과적이라고 사료된다.

• 한국전문물리치료학회지
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• 제10권1호
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• pp.37-50
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• 2003

The purpose of this study was to compare visual analogue scale (VAS), pain threshold (PT), $%RMS_{RVC}$, and EMG gaps before and after applying transcutaneous electrical nerve stimulation (TENS) on the upper trapezius muscle at the patients with myofascial pain syndrome (MPS). The subjects were 4 men and 10 women composed of both the inpatients and outpatients who were diagnosed as MPS at Wonju Medical Center. VAS and PT measurements were performed to assess the subjective pain level. The reference voluntary contraction (RVC) test was performed for 15 seconds for normalization on the bilateral trapezius muscle using surface electromyography (sEMG). After 3-minute resting time, the EMG signal was recorded while performing a typing activity for 2 minutes and then TENS was applicated with a comfortable intensity for 10 minutes. The EMG activity of the upper trapezius muscle was recorded during typing for 2 minutes. The results of study were as follows: 1) VAS score was significantly decreased on the more painful side after treatment, however, it was not significantly different on the less painful side. 2) PT was increased after treatment on both sides, however, it was not significantly different between before and after the TENS application. 3) The EMG activity during typing was significantly decreased after treatment, and 4) The EMG gaps were significantly increased after TENS treatment compared to before it. Consequently, the study showed that TENS was effective in decreasing VAS, $%RMS_{RVC}$, and in increasing EMG gaps. The EMG gap analysis could be a useful method to measure pain in patients with MPS in the upper trapezius.

• Investigative Magnetic Resonance Imaging
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• 제10권1호
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• pp.26-31
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• 2006

목적 : 감각 및 운동기능에 대한 기능적 자기공명영상에서 데이터 분석 시 global scaling이 뇌 활성화 영상에 미치는 영향을 알아보고자 하였다. 대상 및 방법 : 신경학적 병력이 없는 정상 성인 피검자 4명을 대상으로 하였다. 운동기능은 오른쪽 상지를 구부렸다가 폈다가를 반복하는 운동을 시행하였고 청각기능은 1 KHz 순음자극을 시행하였다. 기능적 자기공명영상은 3.0T 자기공명영상기기(GE, Milwaukee, USA)에서 BOLD-EPI 기법을 사용하였고 데이터 분석은 SPM2를 사용하였다. 데이터 분석 시 움직임 보정, 통계적 유의 수준 등은 동일하게 한 상태에서 global scaling의 시행 전후의 뇌 활성화 영상을 획득하였다. 결과 : 오른쪽 상지운동에 대한 기능영상에서 global scaling 효과를 고려하지 않은 경우와 고려한 경우의 뇌 활성화 영상의 차이는 크지 않았다 (p<0.000001). 청각기능 검사에서는 global scaling 효과를 고려한 경우에서 고려하지 않은 경우에 비해 뇌 활성화 영상이 훨씬 크게 나타났다 (p<0.05). 결론 : 국소적 BOLD 신호의 변화가 작은 기능영상 검사에서는 데이터 분석 시 global scaling이 뇌 활성화 결과에 큰 영향을 미칠 수 있으므로 주의가 요구된다.

• 대한임상전기생리학회지
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• 제2권2호
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• pp.1-12
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• 2004

The purpose of this study was to determine the effect of muscle fatigue by neuromuscular electrical stimulation(NMES). Using Biodex System 3PRO(Biodex Medical Systems Inc, USA), experiment was conducted as to the normal group(I) composed of fifteen adults and the patient group(II) composed of fifteen patients with spastic hemiplegia. As to each group, maximal tolerated intensity(MTI) and maximal tolerated isometric contraction(MTIC) in electric currents yielded by low rate(20 pps) and high rate(100 pps) neuromuscular electrical stimulation and the aspects of decrease and restoration of the isometric contraction were examined, and their strength decrement index(SDI) and strength recovery index(SRI) were also calculated. 1. As for MTI in NMES, the MTI of the group II was higher than that of the group I in both low rate and high rate NMES. In comparison within group, MTI of group II was significantly higher in high rate NMES rather than in low rate NMES(p<0.05). 2. In comparison of MTIC between groups, the group I showed higher in both low rate and high rate NMES. In comparison within group, MTIC of group II was significantly higher in high rate NMES rather than in low rate NMES(p<0.01). 3. As for SDI, both groups showed highest SDI in high rate NMES, but no significant differences could be observed. 4. As for SRI, both groups showed significantly low SRI in low rate NMES(p<0.01, p<0.05), and comparison between groups showed no significant differences could be observed. These result lead us to the conclusion that muscle fatigue was influenced by frequency, high rate NMES was lower at SDI and higher at SRI on compare to low rate NMES, therefor, a further studies concerning electrical stimulation should consider differences each frequency in response to treatment.

• 대한한방내과학회지
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• 제29권3호
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• pp.621-628
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• 2008

Objectives : The aim of this study was to investigate changes of gastric vagal nerve activity and pyloric valve function after execution of combination treatments of both electroacupuncture at Zusanli(ST36) and manual acupuncture at other acupoints in patient with functional dyspepsia. Methods : Bowel sounds of 49 patients (18 male, 31 female) were recorded and their % of bowel sound (%BS) and ratio of dominant frequency (DF) were analyzed. Postprandial %BS was used to indicate the gastric vagal activity after eating. Ratio of postprandial/fasting dominant frequency was used to present the degree of pyloric valve function. According to values of %BS and DF ratio, each patient was classified into normal or abnormal (<6 %BS, hypoactivity: <1 DF ratio, dysfunction) group. For 2 weeks, patients received a treatment consisting of both electroacupuncture stimulation at Zusanli (ST36) and acupuncture at other meridian points. Variation of parameters shifting normal to abnormal or abnormal to normal was observed, and total cure rate was calculated. Results : Total cure rate of %BS was 16%, and that of DF was 37%. Patients who improved to normal value from abnormal or aggravated to abnormal level showed both significant difference in both vagal nerve hypoactivity and pyloric valve dysfunction, respectively. Conclusions : Analysis of bowel sound might be useful to evaluate both gastric vagal nerve activity and pyloric valve function. Combination effects of Zusanli (ST36) electroacupuncture and manual acupuncture of other acupoints showed a bidirectional effect in which their activity and function were in general improved. sometimes from aggravated to abnormal level.

• 인간행동과 음악연구
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• 제7권2호
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• pp.65-81
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• 2010

본 연구는 소뇌 별아교세포종 발병으로 인해 소뇌 수술을 받은 12세 환아의 보행 기능 개선을 위해 RAS 보행훈련을 실시하여 보행인자의 변화를 관찰한 사례연구이다. 객관적 분석을 위해 VICON 370 Motion Analysis System을 이용한 동작분석을 RAS 보행 훈련 사전 사후에 실시하였다. 매 회기 30분씩 총 9회의 훈련을 실시한 결과 시공간적 지표 중 분속수, 보행속도, 보행시간, 보장, 활보장의 증가와 운동형상학적 지표의 움직임이 정상범주의 형상과 근접해가는 경향성을 나타내었다. 이는 RAS 보행훈련 후 보행의 효율성이 증진되는 것으로 해석될 수 있다. 이는 신체적 재활이 요구되는 여러 대상군에게 적용 가능성을 보여주었으며 효율성 검증을 위한 후속 연구가 요구된다.