• Journal of the Institute of Electronics Engineers of Korea TE
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• v.37 no.2
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• pp.41-53
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• 2000

In this paper, the Maekjin and the Yangdorak Diagnosis algorithm by using a neuro-fuzzy method is proposed and it is implemented on the DSP-based system. Maekjin is measured by 3-channels of the Maekjin board through Maekjin probe which is attached on Chon, Kwan and Chuk of patient's wrist. First, we experiment Chon, Kwan and Chuk, 3-parts simultaneously and second perform one part of Chon, Kwan and Chuk respectively, The experimental results show that the Maekjin signal is measured precisely with any Maekjin probe. In Yangdorak diagnosis, the pulse generated by electric stimulator stimulates a portion of body and the response signal is measured through electrodes which is attached on representative points of 12 kyungmaks. The experimental methods are (1) 1 channel-measure, (2) 2 channels-measure, (3) 6 channels-measure and (4) 24 channels-measure. A fuzzy diagnosis is performed and neural networks is learned using fuzzy values as inputs, and we show that neuro-fuzzy diagnosis method is performed well.

• Korean Journal of Adult Nursing
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• v.14 no.2
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• pp.222-232
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• 2002

Background and Purpose: After the coronary angiography procedure, patients are required to remain on bed rest to reduce the risk of bleeding and hematoma formation at the puncture site. This prolonged bed rest in the supine position is difficult for many patients, who frequently complain of low back pain. The purpose of the study was to determine whether a specially designed exercise therapy and transcutaneous electrical nerve stimulation (TENS) had an effect on the alleviation of low back pain. Method: Sixty-two patients were assigned to one of three groups : specially designed exercise therapy plus TENS plus general nursing care (exercise group N=21), general nursing care plus TENS (TENS group, N=23) or general nursing care (control group, N=18). The exercise therapy consisted of five movements including stretching, pelvic tilting, knee to chest, modified situps and trunk rotation with minimizing the motion of the puncture site. The severity of low back pain was assessed by a visual analogue scale(VAS) every two hours. The use of analgesic and any development of bleeding or other complications were monitored as well. The level of serum ${\beta}$-endorphin was determined before and after the three interventions. Result: The pain score of the exercise group was significantly lowered compared to that of the other groups. There was no difference in the serum ${\beta}$-endorphin level among three groups. Analgesic were less frequently taken by the exercise group. However the incidence of bleeding complications was not significantly different among the three groups. Conclusion: Exercise therapy is more effective than general care or TENS in alleviating low back pain of the patients with coronary angiography.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.8 no.1
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• pp.63-73
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• 2013

Objectives: The purpose of this case is to investigate and report the effectiveness of korean Medicine treatment and Harpagophytum radix. Pharmacopuncture for the type 1 complex regional pain syndrome. Methods: One patient is admitted at Bu-Chun Jaseng Hospital of Korean Medicine, diagnosed as type 1 complex regional pain syndrome and treated with korean Medicine treatment and Harpagophytum radix. pharmacopuncture. This case is measured and assessed by Neumerical Rating Scale(NRS), Oswestry Low-back Pain Disability Index(ODI) and Manual Muscle Test(MMT). Results: After treatment, the intensity and frequency of complex regional pain is gradually decreased and the result of NRS, ODI, MMT showed improvement. Conclusions: As seen in this cases of type 1 complex regional pain syndrome, korean Medicine treatment and Harpagophytum radix. pharmacopuncture appear to be effective for the pain relief and musculoskeletal function recovery.

• Korean Journal of Animal Reproduction
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• v.25 no.3
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• pp.277-286
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• 2001

Improvement and possible commercialization of a home-made electroporation apparatus(home-made) were further tried to establish a simple and effective introduction of foreign gene into sperm followed by in vitro fertilization. Expressions of introduced pJJ9 and pNT plasmids were shown in all fertilized eggs with electroporated spermatozoa. In particular, with this gene transfer system all the fry showed a consistently transient expression in the syncytium of the yolk sac. This fact is important since some required, minute quantity of human proteins can be produced from the established transient expression on the yolk sac of all fry derived from in vitro fertilization with electroporated spermatozoa. To explore tissue-specific expression in fish, which we will use a similar system later, we targeted the nerve tissue to see whether tissue-specific promoter is working in fish properly. pNT plasmid containing a nerve cell-specific tubulin promoter gene demonstrated consistently exact targeted expressions among the developing nerve cells in later stages of embryos and hatched fry. Finally, liver-specific genes are now being cloned by using already selected primers for useful human protein gene fusion.

• Journal of Oriental Neuropsychiatry
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• v.15 no.1
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• pp.197-209
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• 2004

Objectives : The purpose of this case-control research was to investigate the effects of acupuncture stimulation on autonomic nervous system for patients with HRV and to find out relationship with anti-stress effects. Methods : The study group consists of 24 patients with self-recognition of stress as the case group, and 20 normal person as the control group by similar age. We measured HRV of case and control groups before acupuncture stimulation, prick acupuncture in Hegu(LI4), Taichong(Liv3), Shenme(H7), Neiguan(P6), Zusanli(S36). After treating for 20 minutes, measurement values of HRV and PSV were compared for pre-acupuncture and post-acupuncture. Results : 1. LF norm, HF norm, LF/HF between the case and control groups were significant different in HRV before acupuncture stimulation in the 1st experiment. 2. HRT, SDNN, SDSD, LF norm, HF norm, and LF/HF of the case group were significant different in HRV after acupuncture stimulation in the 1st experiment. HRT of the case group was significantly different in HRV after acupuncture stimulation in the 1st experiment. 3. LF norm, HF norm, LF/HF of the case group were significant different between the 1st and 2nd experiment in HRV before acupuncture stimulation. 4. LF norm, HF norm, and LF/HF were significant different between the 1st and 2nd experiment in HRV of patients whose symptoms improved. But HRV of patients whose symptoms unimproved didn't show significant difference. Conclusion : The results suggest that acupuncture stimulation is associated with changed activity in the sympathetic and parasympathetic nervous system. Measurement values of HRV is suitable to estimate the activity of automatic nervous system.

• Journal of Oriental Neuropsychiatry
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• v.19 no.2
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• pp.223-230
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• 2008

소합향원 (蘇合香元) 가감방(加減方) 정유향기의 진통효과가 투여방법에 따라 어떤 차이가 있는지를 비교, 검토함으로서 본 약재의 새로운 적용방법을 탐색해 보고자 한다. 방법 : 가감소합향원에서 추출한 정유향기를 실험동물을 대상으로 7일간 경구 (50mg/kg, 100mg/kg), 흡입 (매일 3시간씩 1일 2회), 또는 피부도찰 (10mg) 방법으로 투여하여 페닐퀴논-유도 writhing test, 아세트산-유도 writhing test 및 hot-plate test를 실시하였다. 결과 : 가감소합향원 정유향기는 페닐퀴논-유도 writhing test에서는 피부도찰이 가장 효과적 이었으며 그 효과는 양성 대조약물인 아세트아미노펜 보다 약간 더 우수하였다 (p<0.05). 아세트산-유도 writhing test에서도 피부도찰법이 가장 좋은 효과를 나타내었으며 양성대조 약물인 아미노피린보다는 좀 더 좋은 효과를 보여주었다 (p<0.05). 그러나 hot-plate test에서는 경구투여가 가장 좋은 진통효과를 나타내었는데 고용량 (100mg/kg)에서는 양성 대조약물인 아세트아미노펜보다 유의적으로 더 효과적이었으나 저용량 (50mg/kg )에서는 이보다 다소 약하였다. 이상의 연구결과, 가감소합향원의 정유향기는 피부도찰시에는 비특이적 화학자극제인 페닐퀴논이나 아세트산에 의한 통증의 완화에 보다 효과적이며, 경구투여시에는 중추신경계에 영향을 미치는 hot plate에 의한 열자극성 통증에 더 유효함을 의미한다. 결론 : 가감소합향원의 정유향기액은 향기흡입보다는 피부흡수나 경구투여방법으로 진통의 목적으로 응용될 수 있을 것으로 사료된다.

• Journal of Oriental Neuropsychiatry
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• v.20 no.2
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• pp.101-110
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• 2009

Objectives : The purpose of this study was to investigate the effects of acupuncture on autonomic nervous system in anxiety patients and normal subjects by using SCR(Skin Conductance Response). Methods : The study group consists of 15 anxiety patients as the experimental group stimulated by verum acupuncture, 15 anxiety patients as the control group stimulated by sharm acupuncture, and 15 normal subjects stimulated by verum acupuncture. We measured GSR of experimental and control group, normal subjects during Working Memory Test and acupuncture stimulation. Results : 1. Measured value of SCR during Working Memory Test was significant different in control group, but it was not significant different in experimental group. 2. SCR value of three groups was significantly decreased during acupuncture stimulated. There was only significantly SCR value change during 0min.-5min, of first acupuncture. The section of the other groups was no significantly different. 3. STAI scores of experimental group and control group were significantly decreased. Conclusions : The study results suggest that acupuncture stimulation and sham acupuncture also effective on activity in the sympathetic nervous system and STAI scores.

• Journal of Oriental Neuropsychiatry
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• v.18 no.2
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• pp.25-34
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• 2007

Objective : This study was done to investigate the differences of HRV(Heart Rate Variability) change as the response to the emotional stimulus in each Sasang constitutions. Method : We investigated 44 healthy volunteers consisted of 10 Soyangin, 14 Soeumin and 20 Taeumin. After diagnosing the Sasang constitution by specialist of Sasang medicine, we measured the baseline emotional state(100 sec) before the stimulus, the changing emotional state(100 sec) while fearful film was being played. And we rechecked the emotional state(100 sec) while taking a rest. At last, volunteers checked the questionnaire for emotional response. We analysed ECG data with HRV-time domain and frequency domain analysis. Results : (1) There were no significant difference in Mean-RR , SDNN between each groups. (2) LF of Taeumin group significantly increased by the emotional stimulation compared with other groups. (3) There was no significant difference in TP, HF, normalized LF, normalized HF, but the variation of each period in Taeumin group was bigger than those of other groups. (4) Soeumin group reported that they felt significant disgust-emotion in the questionnaire compared with other groups. Conclusion : Taeumin group showed significant emotional changes on HRV by fear stimulus film.

• Annals of Clinical Neurophysiology
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• v.16 no.2
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• pp.62-69
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• 2014

Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in stroke patients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: Seventy Sprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successful stroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave on ipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the stroke rat was evaluated by the Rota rod and Garcia test. Results: Forty rats ($N_{rTMS}=20;\;N_{sham}=20$) completed all experimental course. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11 (p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group at day 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortex can help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneously associate with changes in neurophysiological activity in brain.

• Journal of Internet Computing and Services
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• v.15 no.4
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• pp.9-20
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• 2014

Making good predictions about the outcome of one's actions would seem to be essential in the context of social interaction and decision-making. This paper proposes a computational model for learning articulated motion patterns for action recognition, which mimics biological-inspired visual perception processing of human brain. Developed model of cortical architecture for the unsupervised learning of motion sequence, builds upon neurophysiological knowledge about the cortical sites such as IT, MT, STS and specific neuronal representation which contribute to articulated motion perception. Experiments show how the model automatically selects significant motion patterns as well as meaningful static snapshot categories from continuous video input. Such key poses correspond to articulated postures which are utilized in probing the trained network to impose implied motion perception from static views. We also present how sequence selective representations are learned in STS by fusing snapshot and motion input and how learned feedback connections enable making predictions about future input sequence. Network simulations demonstrate the computational capacity of the proposed model for motion recognition.