• Journal of Nutrition and Health
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• v.23 no.6
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• pp.443-450
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• 1990

Pregnant rats were fed liquid diet to determine the influence of maternal ethanol intake on maternal and pup liver copper when dietary copper was low. The diets, which contained either 0.75(low) or 3.75(control)mg copper/1 with or without 30% of kcal from ethanol, were fed throughout gestation and the first 15 days of lactation. maternal calorie intake and body weight were unaffected by dietary treatment. Ethanol intake depressed maternal liver copper concentration only when diet copper was low(interactive effect P<0.05). Although ethanol intake depressed total pup liver copper concentration regardless of dietary copper level, the interactive effect observed in maternal liver was reflected incopper content of the pup liver metallothionein fraction eluted from a Sephadex G-75 column. The zinc content of metallothionein was inversely related to copper content of metallothionein. Results suggest that pregnancy and lactation is a special period to develop a copper deficiency when low copper intake and ethanol ingestion are combined not only in mothers but also in their offspring.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.274-279
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• 2000

Effect of potato polyphenolic compound on the concentrations of serum and liver lipids, serum glucose, and urine protein was investigated in Sprague Dawley rats by feeding a diet containing 0.5% of cholesterol for 2 weeks. Polyphenolic compound extracted from potato (Solanum tuberosum variety Dejima) was supplemented at a 0.5% level in the basal diet or the cholesterol diet. The supplementation of potato polyphenolic compounds decreased slightly the concentrations of total cholesterol and VLDL+LDL-cholesterol in serum, and atherosclerotic index in rats fed the cholesterol diet, while those measurements were not altered by the supplementation of potato polyphenolic compounds in rats fed the basal diet. In the rats fed the basal diet or the cholesterol diet containing potato polyphenolic compounds, urine protein increased by 12% and 27% at 1st week, respectively, but this change was not seen at 2nd week. The concentration of serum glucose, however, was not significantly different in the dietary groups.

• Journal of Food Hygiene and Safety
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• v.27 no.2
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• pp.133-140
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• 2012

Movement and accumulation of cadmium in male Sprague-Dawley rats, fed with brown rice from nearby Janghang smeltery area were investigated. The rat fed with five different cadmium level diets made with Cd-polluted during 12 weeks. The brown rice-polluted with 0.87 ppm Cd (PBR) was sampled from products in the Janghang smeltery area. Diets of brown rice group were brown rice (BR, 0.002 ppm Cd), each 50% of BR and PBR (BR+PBR 50%, 0.44 ppm Cd) and PBR (PBR 100%, 0.87 ppm Cd). To compare with BR+PBR 50%, the another group diet composed the feed (FE, 0.002 Cd ppm) and each 50% of FE and PBR (FE+PBR 50%, 0.44 ppm Cd). Accumulation of Cd, Zn and Cu in blood, liver and kidney rats was measured by GF-AAS. The weight gain in BR groups and FE groups were different 0.22-0.26 and 1.08-1.26 g/day, respectively. Daily intake cadmium was 10.77 and 22.36 ${\mu}g/rat$ in BR+PBR 50% and PBR 100%, and 8.83 ${\mu}g/rat$ in FE+PBR 50%. Cadmium contents in diets were higher, and total intake of the heavy metals was more increased on the whole. Weights of liver and kidney in FE+PBR 50% group was 2.64 and 2.27 folds higher than those in BR+PBR 50% group. Cadmium contents in blood were increased with intake of BR diet, but Zn and Cu were decreased with them. In the diet groups with the same Cd concentration, Cd content of FE+PBR 50% was higher 1.27 times than that of BR+PBR 50%. In the diet group of BR, BR+PBR 50%, and PBR 100%, the increase of Cd concentration was significantly different to the increase of Cd content in the livers. In the same condition of Cd concentration, Cd contents were higher in the BR+PBR 50% group. In the diet groups of BR, BR+PBR 50%, and PBR 100%, the increase of Cd content in the kidneys led to the increase of Zn and Cu contents. In the same condition of Cd concentration, the diet group with the addition of BR was shown to be 3.11 times higher than with the addition of FE. In view of the results so far achieved, It was closely related with Cd, Zn, and Cu content.

• Journal of Life Science
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• v.19 no.8
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• pp.1104-1111
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• 2009

This study was conducted to evaluate the effect of Sikhe made by medicinal herb on the functional level of liver. Water extract I (12.9% W/W) and II (25.8% W/W) were obtained from medicinal materials: Caragana Sinica, Glycyrrhiza uralensis, Atractylodes rhizoma alba, Atractylodes rhizoma alba, Crataegus pinnatifida, Paeonia lactiflora Pasll., Hordeum vulgare Linne, Oryza sativa Linne, ginger, peer and jujube. Experimental groups were divided into the control diet group (C), high fat diet group (HF), high fat diet treated with 5% extract I group (HFE I ) and high fat diet treated with 5% extract II group (HFE II). In sensory evaluation, overall quality scores associated with color, aroma, flavor and taste were significantly higher in water extract II than in water extract 1. After investigating functional and lipid levels of livers in rats, we found that the administration of water extract I or water extract II to the high fat diet group (HF) did not affect the gain of body weight but mildly reduced GOT or GPT activity in the high diet group. Moreover, administration of these medicinal herbal extracts significantly decreased the levels of total lipid, triglyceride and total cholesterol in the high fat diet group (HF). However, administration of these medicinal herbal extracts did not affect the level of phospholipid. In conclusion, as Sikhe made by medicinal herb slightly decreased the activity of GOT or GPT and amount of lipid in liver, prevention against high fat diet is thought to be important for liver protection.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.1
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• pp.40-45
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• 2013

This study was designed to examine the effect of sea buckthorn (SBT) leaves on hepatic antioxidative enzyme levels in diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats by an injection of streptozotocin (STZ). Sprague-Dawley rats were then fed for four weeks, with experimental groups receiving a modified diet containing 10% or 20% powder derived from SBT leaves. The experimental groups were divided into six groups: a normal (N)-control group, N-SBT 10% and N-SBT 20% treated groups, STZ-control, STZ-SBT 10% and STZ-SBT 20% treated groups. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione-S-transferase (GST) and xanthine oxidase (XOD) levels were measured in liver cytosol. The results showed that the level of SOD was significantly increased in the N-SBT 20% group but not statistically different in the diabetic group. The level of CAT was significantly higher in the N-SBT 20% group compared to the control group. The level of GPX was significantly increased in the N-SBT 20% group and the diabetic supplementary group. In contrast, the level of XOD was significantly decreased in the diabetic group supplemented with SBT leaves.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.4
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• pp.402-409
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• 2006

This study was performed to investigate the effects of Capsosiphon fulvescens (CF) extract on serum and liver lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia and were divided into six groups. Experimental groups were administered with following diets; normal diet group (NC), high cholesterol diet group (HC), normal diet and CF extract (200 mg/kg) administered group (NC-CFL), normal diet and CF extract (400 mg/kg) administered group (NC-CFH), high cholesterol diet and CF extract (200 mg/kg) adwlinistered group (HC-CFL), and high cholesterol diet and CF extract (400 mg/kg) administered group (HC-CFH). The body weight gain and feed efficiency ratio were increased by high cholesterol diet, but gradually decreased to the corresponding level of the normal diet group by administered CF extract. The serum total cholesterol concentration of normal diet group was significantly higher than those of NC-CFL group and NC-CFH group. The concentrations of serum total cholesterol LDL-cholesterol and triglyceride and the atherogenic index .were tended to decrease in the CF extract administered groups compared with the high cholesterol diet group. However, HDL-cholesterol and phospholipid concentrations in serum decreased in the high cholesterol diet group and markedly increased by the CF extract administered groups. There were no differences in the concentrations of serum triglyceride, phopholipid, LDL-cholesterol, HDL-cholesterol and free cholesterol in normal diet groups. Concentrations of total cholesterol and triglyceride in liver and kidney were also markedly decreased in the CF administered groups. Total cholesterol and triglyceride concentrations of adipose tissue in the CF administered groups were also decreased compared with the high cholesterol diet group. In addition, there were no differences in the concentrations of liver, kidney and adipose tissue total lipid, triglyceride and total cholesterol in normal diet groups. The activities of heparin-releasable lipoprotein lipase (LPL) and total-extractable LPL in adipose tissue were increased in the high cholesterol diet group compared with the CF extract administered groups, but those of the NC -CFL group and NC-CFH group were similar to the normal diet group. Taken together, it is suggested that the extract of CF have an antiatherosclerotic effect by reducing cholesterol level of serum and liver. Furthermore, the extract of CF decreased LPL activity and triglyceride concentration, resulting in less lipid storage.

• Journal of the Korean Society of Food Science and Nutrition
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• v.25 no.2
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• pp.205-213
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• 1996

본 연구에서는 남자대학생 80명을 대상으로 총 식이섬유 및 조섬유와 영양소 섭취상태를 비교 분석하였다. 남자대학생들의 평균 총 식이섬유 섭취량은 $20.54\pm5.82g으로$ 외국의 잠정적 권장량의 범위(20~30g)에는 들었으나 권장량의 하한치를 약간 상회하는데 그쳤다. 조섬유의 1일 평균 섭취량은 $8.43\pm5.56g으로$ 1일 식이섬유 섭취량의 약 41%에 해당하였으며 그 외 열량 및 다른 영양소의 평균 섭취량은 한국인 영양권장량과 비슷하거나 다소 더 높은 것으로 나타났다. 총 식이섬유 섭취량과 에너지 및 단백질, 당질, 그리고 조섬유의 섭취량 간에는 유의적인 상관관계를 보였으며, 당질이 가장 높은 상관계수(r=0.7232, p<0.001)를 보였다. 또한 조사 대학생들의 총 식이섬유 섭취량과 식품군별 섭취량과의 상관관계수를 보인 것은 채소류 (r=0.6548, p<0.001)였으며 그 다음은 곡류(0.5913, p<0.001)였으며 그 다음은 곡류(0.5913, p<0.001), 해조류(0.3300, p<0.01)였다. 조사 대학생들의 식이섬유 섭취량 중 총식이섬유 급원으로 가장 많이 섭취한 식품은 쌀과 김치였으며, 각각 총 식이섬유 섭취량의 11.98%와 7.64%에 기여하였다. 그 외 학생들이 많이 섭취한 라면, 고춧가루, 냉면, 빵, 콩나물, 밀가루, 깍두기, 무 등이 주요한 식이섬유 급원으로 나타났다. 본 연구의 남자대학생들의 식이섬유 섭취량은 외국의 잠정적 권장량의 범위(20~30g)에 속하였으나 충분한 양을 섭취하고 있는 것은 아니었으며, 오히려 경제수준의 향상으로 인한 식습관의 변화에 민감하게 반응하는 젊은 세대들인 조사대학생들의 장래 식이섬유 소비량은 더욱 감소할 것으로 추정된다. 그러므로 식이섬유 급원식품의 섭취를 증가시키는 방안이 모색될 필요가 있다. 따라서 성인기에 식이섬유 부족으로 나타나는 각종 질병의 위험을 예방하기 위해 정백비 위주의 식사를 지양하고 총 식이섬유 함량이 높은 해조류의 섭취를 널리 교육시키는 것이 바람직할 것으로 사료된다. 또한 보다 광범위하고 체계적인 대상자 선정을 통하여 식이섭취조사가 이루어져 식이섬유 섭취패턴을 연구할 필요가 있다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.7
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• pp.1054-1064
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• 2013

The purpose of this study was to examine the question of whether there is any difference in dietary habits, climacteric symptoms, and general health characteristics of middle-aged women according to food supplements (FS) use. A total of 745 midlife females participated in a face-to-face interview conducted by qualified interviewers, which guaranteed a higher quality of data collection. Three levels of FS use were defined: None, Single, and Multi for 0, 1, and 2 or more types of FS use, respectively. None, Single, and Multi accounted for 33.56%, 33.29%, and 33.15% of total subjects, respectively. FS users (Single and Multi) exerted more interest in FS and were more likely to believe that FS is helpful for health promotion and amelioration of climacteric symptoms than None (P<0.0001). Self-perceived health status of Multi was lower than that of None, but not different from Single (P<0.05). Factor analysis extracted three factors for dietary habits: regularity, variety and moderation, and four factors for climacteric symptoms: emotional, physical, psycho-somatic, and hot flash. The factor scores for dietary variety as well as emotional, psycho-somatic, and hot flash symptoms were higher for FS user than for None (P<0.01). Single reported more frequent family meals compared to None. Findings of the present study elucidated potential links between the level of FS use, dietary habits, and climacteric symptoms of middle-aged women, suggesting a possible scenario: the greater the climacteric symptoms a woman perceives, the more likely the woman will adopt FS use, the greater the efforts toward dietary improvement, such as dietary variety. Based on that, in this study, more peri-menopausal women belonged to Single and Multi; further investigation on the association between FS use, dietary quality, and climacteric symptoms in conjunction with menopausal status may be needed.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.12
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• pp.1560-1567
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• 2008

This study was designed to evaluate the effect of green tea products (GTP) on bone metabolism marker in ovariectomized (OVX) rats fed high cholesterol diet. Forty Sprague-Dawley female rats, 10 weeks of age ($279{\pm}2g$), were divided into 4 groups and fed on the experimental diets for 6 weeks: sham operated control (Sham-C) and OVX-control (OVX-C) groups treated high cholesterol diet. OVX-GTP 5% (OVX-G5) and OVX-GTP 20% (OVX-G20) groups were treated with high cholesterol diet containing 5% GTP and 20% GTP, respectively. Food efficient ratio was significantly (p<0.05) lower in OVX-G20 than in the other OVX groups. Bone mineral density of femur was not significantly different among the experimental groups in the order of Sham-C>OVX-G5 and OVX-G20>OVX-C. Alkaline phosphatase activities on serum was lower in the GTP supplement groups than in the OVX-C. Estradiol levels of serum were higher in the GTP supplement groups than in the OVX-C. Osteocalcin levels of serum was the lowest in the OVX-G20. Deoxypyridinoline crosslink values of urine, indicator of bone absorption, was the lowest in the OVX-G20 group. The GTP supplemented groups had a lower bone resorption ratio than in the OVX-C group. From the above results, these findings suggest the possibility of using GTP as a functional food materials related to bone metabolism in menopause.

• Journal of Nutrition and Health
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• v.24 no.4
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• pp.299-307
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• 1991

The present study was designed to evaluate the effects of dietary coenzyme $Q_{10}$ on mitochondrial coenzyme $Q_{10}$ and fatty acid composition in adriamycin (ADR)-treated rats. Two experiments were conducted in rats. Experiment 1 was undertaken under the condition of simultaneous administration of ADR and coenzyme $Q_{10}$ for 4 weeks. Experiment 2 was undertaken under the same condition as experiment 1 after feeding the experimental diets alone without administration of ADR for 4 weeks. Heart mitochondrial coenzyme $Q_{10}$ level of rats was greatly decreased by ADR treatment. but higher level of dietary coenzyme $Q_{10}$ elevated this decrease to control ranges. Pretreatment with dietary supplementation of coenzyme $Q_{10}$ showed a significant increase in myocardial coenzyme $Q_{10}$ level. With ADR treatment. polyunsaturated fatty acids such as arachidonic acid (20 : 4) and docosahexaenoic acid (22 : 6) were decreased. However, dietary supplementation of coenzyme $Q_{10}$ modified this decrement to some extent. In both experiment 1 and 2. the polyunsaturated fatty acids/saturated and polyunsaturated fatty acids (P/S+ M) ratio of ADR-treated rats tended to be lower than that of control rats.