• The Journal of the Convergence on Culture Technology
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• v.10 no.6
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• pp.73-79
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• 2024

Cyanoacrylate glue has the property of sticking to human tissue as it reacts with anions in human body fluids and hardens through a polymerization reaction. It was developed as an adhesive for epidermal bonding, but is also widely used in clinical practice for vascular embolization to occlude blood vessels that are bleeding or at risk of bleeding. In vascular embolization, it is necessary to control the curing speed according to the size of the blood vessel and the speed of blood flow, and to achieve this, the speed of the polymer reaction is adjusted by mixing with lipiodol. In this study, we prepared the mixed solutions of industrial ethylcyatoacrylate and medical n-butyl cyanoacrylate glues with Lipiodol and poppy seed oil, the raw material of Lipiodol. Video was filmed of the process in which each cyanoacrylate glue and lipiodol mixture hardened on the surface of the aqueous solution and turned into a solid. When the cyanoacrylate glue came into contact with the surface of the aqueous solution, polymerization occurred immediately at the interface, forming a disk-shaped solid. As the monomers inside the disk escaped and came into contact with the aqueous solution, the secondary polymerization reaction proceeded slowly. NBCA's polymerization reaction time was about 1 minute, increased to about 2 minutes when Lipiodol was 50%, and to about 4 minutes when it was 67%. These observation results are expected to be very useful in understanding vascular occlusion in clinical embolization.