• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.345-353
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• 2002

Bone morphogenetic proteins(BMPs) are secretory signal molecules which have a variety of regulatory functions during morphogenesis and cell differentiation. To evaluate roles of BMPs and their receptors on mouse sagittal suture development, we have examined their expression patterns in serial sections of sagittal sutures by in situ hybridization during embryonic stages(E15-E18). BMP-2 and BMP-3 were expressed in the osteogenic front and parietal bone on embryonic 15day, from E16 in hair follicle. BMP-4 was strongly expressed in the osteogenic front and weakly expressed in the mesenchyme and parietal bone. BMP-S was expressed in the hair follicles. BMP-6 was not expressed in this study. BMP-7 was expressed in parietal bone during embryonic stage. BMPR-IB was expressed in the osteogenic front, but BMPR-IA was not. From these datas, we suggest that the BMP-4 regulates the early commitment of mesenchymal cells to the osteogenic lineages, the BMP-2 and BMP-3 may be involved in regulating the differentiation of osteoblast precursor cells. BMP-7 was involved in maintenance of differentiated osteoblasts. BMPs were key signaling molecules that regulate early calvarial bone morphogenesis, mediated by BMPR-IB.

• 재활복지
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• v.18 no.4
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• pp.237-255
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• 2014

Idiopathic Parkinson disease(IPD) is an neurodegenerative disease caused by the loss of dopamine cells in the substantia nigra, a region of midbrain. Its major symptoms are muscular rigidity, bradykinesia, resting tremor, and postural instability. An estimated 70~90% of patients with IPD also have hypokinetic dysarthria. Subthalamic nucleus deep brain stimulation (STN-DBS) has been reported to be successful in relieving the core motor symptoms of IPD in the advanced stages of the disease. However, data on the effects of STN-DBS on speech performance are inconsistent. A medline literature search was done to retrieve articles published from 1987 to 2012. The results were narrowed down to focus on speech performance under STN-DBS based perceptual, acoustic, and/or aerodynamic analyses. Among the 32 publications which dealt with speech performance after STN-DBS indicated improvement(42%), deterioration(29%), mixed results(26%), or no change(3%). The most favorite method was found to be based upon acoustic analysis by using a vowel prolongation and Unified Parkinson's Disease Rating Scale(UPDRS). For the purpose of verifying the effect of the STN-DBS, speech evaluation should be undertaken on all speech components such as articulation, resonance, phonation, respiration, and prosody by using a contextual speech task.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.50-59
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• 2016

Objective : The goal of this study was to investigate neurological mechanism of emotional regulation and to examine the relationship between the regulation and sensory processing. Subjective : Emotional regulations are mainly processed in limbic system, particularly the basal-lateral group of amygdala takes on a major role in the regulations. The basal-lateral group of amygdala links to thalamus directly and/or indirectly which processes sensory information together. This sensory information connects to orbital and medial prefrontal cortex. Inadequate sensory processing may cause difficulties in emotional regulations and behaviors because of a circuit linking the amygdala, the thalamus, and the orbital and medial prefrontal cortex. These difficulties and impairments has been reported in neurological studies for children with ASD and ADHD. Conclusion : Neurological states are different between the normal children and children with ASD and ADHD and these represent various aspects in sensory processing, emotional regulations and behaviors. Thus, therapists working with children with ASD and ADHD need to understand mechanisms of sensory processing and emotional regulations in order to provide adequate treatments.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.15 no.3
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• pp.229-237
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• 1993

This study was intended to evaluate a post-operative relapse tendency in mandibular prognathism patients with open-bite. 18 patients with or without open-bite have undergone sagittal split ramus osteotomy and were investigated radiologically with cephalogram. The results were as following 1. The preoperative anterior facial height, mandibular plane angle and mandibular gonial angle were larger in open-bite patients than in nonopen-bite patients.(p>0.05) 2. There was significant correlation between surgical change of SNA, mandibular plane length and long-term relapse.(p<0.01). 3. There was relatively stable postoperative anterior facial height in open bite patients. 4. There was no significant correlation between the surgical change of mandibular plane angle, amount of mandibular setback and long-term relapse.(p>0.01) 5. This study showed that horizontal relapse was more significant than vertical relapse.

• Journal of Digital Convergence
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• v.18 no.1
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• pp.241-247
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• 2020

The effect of radiofrequency radiation (RF) exposure on mouse associated with the exercise was investigated in the brain at the molecular level. The expression of tyrosine hydroxylase(TH), FoxO3a, AMPKα and mRNA was investigated by real-time RT-PCR in striatum and the hypothalamus. In the striatum, TH mRNA expression was decreased in the exercise and RF exposure group. FoxO3a mRNA expression was significantly increased in the spontaneous exercise group and a significant decrease was observed in the RF exposure and spontaneous exercise group. In the hypothalamus, TH mRNA expression was significantly decreased in the RF exposure and spontaneous exercise group. But, FoxO3a mRNA expression was significantly increased in the RF exposure and spontaneous exercise group. We will further investigate the expression of protein molecules in the hippocampus of the brain to reveal the effects of RF radiation on memory.

• Tribology and Lubricants
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• v.35 no.1
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• pp.77-86
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• 2019

The present study focuses on the effect of staggered integration factor (SIF) on Morton effect simulation results. The Morton effect is a synchronous rotordynamic instability problem caused by the temperature differential across the journal in fluid film bearings. Convection and conduction of heat in the thin film displaces the hot spot, which is the hottest circumferential position in the thin film, from -20 to 40 degrees ahead of the high spot, where the minimum film clearance is experienced. The temperature differential across the journal causes a bending moment and the corresponding thermal bow in the rotating frame acts like a distributed synchronous excitation in the fixed frame. This thermal bow may cause increased vibrations and continued growth of the synchronous orbit into a limit cycle. The SIF is developed assuming that the response of the rotor-lubricant-bearing dynamic system is much quicker than that of the bearing-journal thermal system, and it is defined as the ratio between the simulation time of the thermal system and the rotor-spinning period. The use of the SIF is unavoidable for efficient computing. The value of the SIF is chosen empirically by the software users as a value between 100 and 400. However, the effect of the SIF on Morton effect simulation results has not been investigated. This research produces simulation results with different values of SIF.

• Tuberculosis and Respiratory Diseases
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• v.52 no.5
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• pp.529-538
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• 2002

Background : Many clinicians are reluctant to prescribe systemic corticosteroids to manage an asthmatic attack because of many complications such as osteoporosis, cushing's syndrome, diabetes, hypertension and bleeding tendency. The use of nebulized budesonide may be of value in some infants, old men, and in particular adult asthmatic patients who complain of severe dyspnea. A clinical validation and steroid-sparing effect of nebulized budesonide in asthmatic adults and COPD were evaluated, and the short-term effects of budesonide use on the HPA axis were assessed. Materials and Methods : Study A was prospectively done with 41 patients diagnosed with pure asthma and 30 patients diagnosed with COPD (including asthmatic component) in Soonchunhyang Hospital, Chunan from June. 2000 to Sep. 2001. They were treated with nebulized budesonide including systemic steroids (Group 1), a budesonide tubuhaler including a systemic steroid (Group 2), or only the systemic steroid(Group 3). The peak flow rate, arterial blood gas in room air, pulmonary function test, symptom scoring, steroid amount and hospital stay were analyzed. Study B was conducted with 19 patients to evaluate the short-term effects on the HPA axis of treatment with nebulized budesonide 1mg twice daily and a budesonide turbuhaler 5 puffs twice daily. The adrenal function was assessed prior to budesonide inhalation and after 7 days of budesonide inhalation. Results : In the pure asthmatic patients, the mean value of the symptoms (dyspnea, wheezing, cough, night asthma) or the arterial BGAs, total amounts of steroid or hospital stay and the difference in the results of the pulmonary function tests or peak expiratory flow rate were similar in the three groups. In COPD with an asthmatic component, there were no significant differences among the three groups. Although nebulized budesonide suppressed HPA function,(p=0.006) the HPA responses from the nebulized budesonide and turbuhaler budesonide were similar (p=0.288) Conclusion : This result suggests that systemic steroid should only be made available for acute asthmatic patients irrespective of the inhaled budesonides. Nebulized budesonide at the therapeutic dose has similar effects on the HPA axis compared to that of turbuhaler budesonide.

• 대한위암학회:학술대회논문집
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• 2002.10a
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• pp.11-18
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• 2002

위암의 진단에서 CT스캔은 수술 전 병기결정이나 수술 후 추적검사에서 필수적인 검사방법으로 인정을 받고 있고, 보편적으로 가장 많이 유용되고 있다. 그러나 나선식 CT를 사용하고 여러 가지 스캔방법의 개선에도 불구하고, 인접장기로의 직접침윤, 작은 크기의 간전이의 발견, 정상 크기범위의 림프절에서 전이의 발견, 양성 림프절과 전이의 감별, 복막전이에 대한 평가에서 지금까지의 보고들은 만족스러운 결과를 얻지 못하고 있으며 CT의 한계점으로 남아 있다. 그러나 최근에는 나선식 CT보다 더 빠른 시간내 더 얇은 두께의 절편을 얻을 수 있고, 이를 이용하여 관상면 및 시상면으로 정밀하게 재구성하거나 3D영상을 얻을 수 있는 다검출식 나선식 CT가 개발되어 사용되고 있고, CT 진단의 정확도를 높일 것으로 기대한다.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.70.2-70.2
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• 2018

KMTNet에서는 프로젝트의 소개와 운영현황 등 파악하기 위해 웹서비스를 운영하고 있다. 홈페이지(http://kmtnet.kasi.re.kr; 국문, 영문)에는 최신 뉴스와 공지사항, 실시간 모니터링 영상 및 기상정보, 관측일정, 관측자료 공개, 활용성과 등을 게시 하였고, 관측 결과와 운영 정보 관리를 위해서 모니터링 홈페이지(kmtnet-monitor)를 제작하였다. KMTNet은 남반구 3개 관측소에 상주하는 현지 관측자에 의해 관측이 이루어지기 때문에, 국내 연구자가 남반구 관측소 현황을 파악할 수 있는 모니터링 시스템이 필수적이다. 웹서비스에 실시간 기상과 관측자료 전송속도를 함께 표시하여 관측 진행 여부를 확인할 수 있으며, 관측일지를 데이터베이스화하여 망원경/카메라/관측돔의 이상 유무, 관측 현황, 기상/시상 통계 등으로 활용하고 있다. 여기서는 지금까지 개발한 웹 서비스를 소개하고 앞으로 관측소 운영에 유용한 정보와 웹 서비스의 발전 방향에 대해 논의하고자 한다.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.119.2-119.2
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• 2011

대 소 마젤란은하는 항성진화 및 은하진화를 연구할 수 있는 가장 중요한 실험실이다. 두 은하는 우리은하에 매우 가깝고, 각크기가 매우 크기 때문에 이들 두 은하에 대한 측광학적 연구는 매우 지엽적이고 단편적으로 이루어졌다. 시상이 매우 좋은 KMTNet의 1호기 (칠레)를 사용하여 대마젤란은하 ($10^{\circ}{\times}10^{\circ}$)와 소마젤란은하 ($5^{\circ}{\times}5^{\circ}$) 영역에 대한 UBVI 및 협대역 $H{\alpha}$, [OIII] $5007{\AA}$ 측광 탐사관측을 통해 다음과 같은 연구를 제안한다. 1. $V{\approx}23$ 등급까지 대 소 마젤란은하 천체들의 측광 자료의 제공 2. 거리를 지시할 수 있는 천체들의 공간적 분포를 통해 3차원 구조 연구 3. 협대역 $H{\alpha}$ 측광을 통해 Herbig Ae/Be 천체들의 분포와 별 탄생 연구 4. 협대역 $H{\alpha}$ 및 O[III] 측광을 통해 행성상성운의 분포와 광도함수 연구 5. 색-등급도 연구를 통해 위치에 따른 별 탄생의 역사 연구 6. 어두운 별들의 공간적 분포를 통해 LMC-SMC, LMC-MWG, SMC-MWG의 상호작용 연구.