• The Korean Journal of Pharmacology
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• v.24 no.2
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• pp.189-195
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• 1988

This study aimed to investigate the autonomic innervations of human vas deferens and the effect of diazepam, a benzodiazepine sedative antianxiety drug, on the smooth muscle contractility of vas deferens. The specimens were obtained from healthy volunteers undergoing elective vasectomy with local anesthesia. The muscle preparation did not show any spontaneous contraction, but showed a good contraction induced by norepinephrine exerting the strongest response at $33^{\circ}C$. Phentolamine inhibited the norepinephrine-induced contraction concentration-dependently. Isoproterenol, a beta-adrenergic agonist evoked a considerable extent of contraction, and this contractile activity was antagonized by propranolol, a beta-adrenergic blocking agent. Acetylcholine induced a dashing contraction of the human vas deferens, and atropine, a muscarinic receptor blocking agent abolished the acetylcholine-induced contraction. Diazepam inhibited the norepinephrine-induced contraction in a concentration dependent manner. These results suggest that the smooth muscle of human vas deferens has cholinergic muscarinic and beta adrenergic receptors as well as the predominant alpha adrepergic receptor. Diazepam inhibits the motility, especially norepinephrine-induced contraction of human vas deferens.

• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.261-276
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• 2001

본 연구는 구강안면동통 중에서 빈번히 나타나는 근육성 동통의 주 원인인 저작근의 과활성으로 유발된 근육의 피로 시에 운동단위전위, 압력통각역치, 근전도 power spectrum의 변화 양상과 이들 척도간의 연관성을 조사하기 위해 시행되었다. 두개하악장애의 병력 및 현증이 없고 정상적인 구치부 교합관계를 가진 평균연령 25.8세인 36명의 정상 성인(남자 26명, 여자 10명)을 대상으로 교근과 전측두근의 지속적인 등길이 수축 전후의 압력통각역치 및 운동단위전위를 측정하였고 인내시간까지의 근수축 동안 근전도 power spectrum을 분석하여 다음과 같은 결론을 얻었다. 1. 지속적인 등길이 수축 후 교근과 전측두근의 압력통각역치는 수축 전에 비해 유의하게 감소하였다. 2. 압력통각역치는 수축 전과 수축 후 모두에서 전측두근이 교근보다 유의하게 높게 나타났으며, 전체적으로 남성이 여성보다 높게 나타나는 양상을 보였으나 성별간의 차이는 전측두근의 수축 후 압력통각역치에서만 통계적으로 유의하게 나타났다. 3. 지속적인 등길이 수축말기의 중간주파수는 수축초기에 비하여 유의하게 감소하였고, 전측두근의 수축초기 중간주파수와 수축말기 중간주파수 모두 교근보다 유의하게 높게 나타났다. 4. 교근은 지속적인 등길이 수축 전에 비하여 수축 후의 운동단위전위의 지속시간,진폭, 면적, 상의 4가지 척도에서 유의한 증가를 보였고 전측두근은 진폭을 제외한 나머지 3가지 척도, 즉 지속시간, 면적, 상의 유의한 증가를 보였다. 5. 교근과 전측두근의 지속적인 등길이 수축 전의 압력통각역치와 운동단위전위 척도 사이에는 통계적으로 유의한 상관관계가 없었고 교근에서는 수축 후의 압력통각역치와 운동단위전위의 지속시간, 진폭, 면적, 상 사이에 유의한 상관관계가 존재하였다. 위의 실험결과를 통해 근육피로 검사에 압력통각역치, 근전도 power spectrum 검사 외에 근육수축의 기능적 최소 단위인 운동단위전위의 분석 또한 유용할 수 있고 추후 만성으로 진행된 근막동통환자와 정상 대조군간의 운동단위 수준에서의 비교연구와 근피로에 더욱 민감한 운동단위전위의 다른 척도에 대한 개발과 연구가 필요하다고 사료된다.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.5
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• pp.104-110
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• 2019

Shrinkage is one of typical characteristics of concrete with cement paste and aggregates. A lot of studies on this has been conducted with an assumption that the concrete is a homogeneous material. However, as shrinkage acts on only one of the components that consist of concrete, it is hard to be characterized only by the average effective properties. Therefore, in this paper, the concrete shrinkage, which is one of the typical characteristics and still has a lot of uncertainty, is simulated considering its heterogeneous properties. Using a meso model, concrete is modeled with the combination of mortar and aggregates, and the shrinkage is simulated by applying the shrinkage strain on the mortar only. According to the results, it is shown that the cracking of shrinking concrete is largely influenced by the types of aggregates and the degree of restraint. Also, the shrinkage cracking cannot be represented only by the single values such as tensile strength since the stiffness of aggregates and the degree of restraint influence the cracking.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.296-302
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• 2016

Studies aimed at reducing the occurrence of cracks by the shrinkage of concrete are in demand because the repair and reinforcement for cracks caused by declining concrete durability costs the user to maintain the concrete structure. In particular, in underground power facilities for power transmission, the cost is a heavy burden to repair and reinforce. For this reason, underground power facilities demanded effective methods for crack reduction at the engineering design step. This study, as a part of the development of shrinkage reducing agent for low shrinkage concrete on underground power facilities, investigated TEA to complement the shrinkage reducing agent to improve the early strength of concrete. In the case of TEA 3% as a shrinkage reducing agent, the early strength was improved significantly, and the shrinkage reducing effect was excellent. In addition, TEA 3.0 % and the shrinkage reducing agent 2.0 % showed excellent shrinkage property and compressive strength. On the other hand, more study of shrinkage reducing materials, including performance reviews on the shrinkage reducing materials with variable factors and type of materials, will be needed to generalize these results.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1996.04a
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• pp.82-82
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• 1996

후두전적출술은 상부 소화관의 연속성을 변형시킴으로써, 식도운동의 장애를 가져올 수 있으며, 술 후에 연하곤란을 호소하는 경우는 10% 가량 된다. 본 연구의 목적은 식도내압검사를 통하여, 후두전적출술이 상부식도괄약근의 휴지기와 최대 압력에 어떠한 변화를 주는가 및 술 후 인두와 상부식도괄약근의 조화성 여부와, 만일 상부식도괄약근의 기능에 변화가 생긴다면, 그 영향이 식도체부 및 하부식도괄약근의 운동성에 어떠한 영향을 주는지를 알아보기 위함이다. 식도내압검사는 8개의 내관을 가진 폴리에틸렌 도관으로, 후두전적출술을 받은 환자군 14명과 정상인 12명을 대상으로, stational pull-through 방법으로 시행하였다. 환자군에서 상부 식도괄약근은, 휴지기 압력, 최대 수축압력, 이완정도, 괄략운동의 조화성 및 괄약근의 길이 등이, 정상 대조군 보다 의미있게 감소되었다. 환자군에 있어서 식도체부의 운동성은 주로 근위부 식도체부에서, 수축력, 수축기간 및 연동파의 전파시간이 대조군에 비하여 의미있게 감소되었고, 연동운동시 동시 수축도 3례에서 관찰되었다. 하부 식도괄약근의 기능은 환자군과 대조군이 의미있는 차이를 보이지 않았다.

• The Korean Journal of Pharmacology
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• v.26 no.1
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• pp.13-23
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• 1990

Methylene Blue (MeB) and gentian violet $(10^{-6}{\sim}10^{-4}\;M)$ produced contractions in isolated thoracic aortic preparations of rabbits in a dose-dependent fashion, while other dyes, evans blue and eosine yellowish, did not affect the basal tension in the same range of doses. Porcine mesenteric arterial rings also responded to MeB with dose-dependent contractions. Single dose of $10^{-4}$ M MeB produced a biphasic response: contraction followed by relaxation. The contraction developed slowly within $2{\sim}4$ min and peaked in about 20 minutes and then slowly relaxed to the basal level. Tyramine $(10^{-4}\;M)$ also induced contraction but it developed faster and was more persistent than that of MeB. While the tyramine-induced tension was reproducible, the MeB-induced one wat not reiterable until 3 to 5 hours after washing out the MeB. Adding $10^{-4}$ M MeB further potentiated the contraction induced by $10^{-4}$ M tyramine. However, the MeB contraction was not affected by further addition or tyramine. Both tyramine- and MeB-induced tensions were abolished or significantly inhibited by pretreatment with various drugs acting on the sympathetic nervous system. The tyramine-induced tension was more sensitive to guanethidine and 6-hydroxydopamine than the MeB-induced tension, while the latter was more sensitive to $Ca^{2+}-free$ PSS and reserpine. But they have similar sensitivity to prazosin. The MeB-induced tension was significantly inhibited but not abolished by 6-hydroxydopamine pretreatment. However, either tyramine or 6-hydroxydopamine could not affect the basal tension of the ring that MeB once had been tested. These results suggest that MeB-induced contractions of rabbit thoracic aorta and porcine mesenteric artery result from a release of endogenous norepinephrine from adrenergic nerve endings and are dependent in part on extracellular calcium, and that the potency of MeB to release or to deplete norepinephrine is greater than that of either tyramine or 6-hydroxydopamine.

• Journal of Yeungnam Medical Science
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• v.12 no.2
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• pp.246-259
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• 1995

This study aimed to investigate the mechanism of action of baclofen on the detrusor muscle isolated from rat. Rats (Sprague-Dawley) were sacrificed by decapitation and exsanguination. Horizontal muscle strips of $2mm{\times}15mm$ were prepared for isometric myography in isolated muscle chamber bubbled with 95% / 5%-$O_2$ / $CO_2$ at $37^{\circ}C$, and the pH was maintained at 7.4. Detrusor strips contracted responding to the electrical field stimulation (EFS) by 2 Hz, 20 msec, monophasic square wave of 60 VDC. The initial peak of EFS-Induced contraction was tended to be suppresed by ${\alpha},{\beta}$-methylene-adenosine 5'-triphosphate (mATP), a partial agonist of purinergic receptor, and baclofen, a $GABA_B$ receptor agonist (statistically nonsignificant). The late sustained contraction by EFS was suppressed significantly (p < 0.05) by additions of atropione, a cholinergic muscarinic receptor antagonist and baclofen. The adenosine 5'-triphosphate-induced contraction was completely abolished by mA TP but not by baclofen. In the presence of atropine, the subsequent addition of acetylcholine could not contract the muscle strips: but the addition of acetylcholine in the presence of baclofen evoked a contraction to a remarkable extent. These results suggest that in the condition of present study, the cholinergic innervation may play a more important role than the purinergic one, and baclofen suppresses the contractility of rat detrusor by the stimulation of the $GABA_B$ receptors to inhibit the release of neurotransmitter from the cholinergic nerve ending.

• Journal of the Korea institute for structural maintenance and inspection
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• v.10 no.3
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• pp.97-105
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• 2006

The autogenous shrinkage of high-performance concrete is important in that it can lead the early cracks in concrete structures. The purpose of the present study is to explore the autogenous shrinkage of high-performance concrete with admixture and to derive a realistic equation to estimate the autogenous shrinkage model of that. For this purpose, comprehensive experimental program has been set up to observe the autogenous shrinkage for various test series. Major test variables were the type and contents of admixture and water-cement ratio is fixed with 30%. The autogenous shrinkage of HPC with fly ash slightly decreased than that of OPC concrete, but the use of blast furnace slag increased the autogenous shrinkage. Also, the autogenous shrinkage of HPC is found to decrease with increasing shrinkage reduction agent and expansive additive. A prediction equation to estimate the autogenous shrinkage of HPC with admixture was derived and proposed in this study. The proposed equation show reasonably good correlation with test data on autogenous shrinkage of HPC with mineral and chemical admixture.

• Polymer(Korea)
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• v.37 no.2
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• pp.249-253
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• 2013

From poly(lactic acid) (PLA) and poly(propylene carbonate) (PPC) synthesized using $CO_2$, a PLA/PPC/PLA layered film is prepared by coextrusion and then stretched to uniaxial orientation. The mechanical, optical, and barrier properties and shrinkage of the prepared film were investigated in detail. The maximum shrinkage of PLA/PPC/PLA film reached to 60% at $75^{\circ}C$. With increasing PPC content, the ratio of shrinkage of the film was increased and its shrinkagerate was increased. The ratio of shrinkage of the film decreased with increasing stretching temperature. The prepared film has oxygen and vapor transmission barrier properties. In this study, the PLA/PPC/PLA film is expected to be commercialized as a environmentally friendly shrinkable film.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.6
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• pp.4298-4307
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• 2015

The expenses of maintenance and reinforcement for aged concrete structures are significantly on the increase as their durability and general performance has been naturally degraded. Due to this reason, interests on concrete crack reduction technology are growing but more researches are required to fulfill such fast growing demands. Particularly in the underground power facilities, it is difficult to maintain the quality of aging concrete spheres for underground power as their deterioration caused by long-term operation is on-going. In recent years, many studies have been made to overcome the issues and now it is determined that the shrinkage reducing technology which can dramatically reduce the crack at the design stage is one of the most effective solutions. In this study, the test investigated fundamental propertiesof concrete using various shrinkage reducing materials to develop low shrinkage mortar. According to results of experimental study, for mortar and concrete, glycol based material showed excellent shrinkage property and compressive strength. For the later study to generic application of the shrinkage reducing materials, performance reviews on the shrinkage reducing materials with variable factors and various materials such as changes in the amount and type of materials should be followed.