• 한국자원식물학회지
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• 제34권5호
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• pp.451-461
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• 2021

제주도에는 줄기, 열매, 꽃, 가시, 개화시기가 서로 다른 부채 선인장이 분포하고 있다. 아직 이 두 분류군에 대한 비교 연구가 없어 같은 종으로 취급하는 경우가 많다. 이에 본 연구는 제주도에 자생하고 있는 O. monacantha와 O. stricta두 분류군의 계통학적 유연관계를 밝히기 위하여 이루어졌다. 연구 결과, nrITS와 엽록체 유전자 matK, atpB-rbcL유전자 분석을 통해서 두 개체군이 전혀 다른 종이라는 것이 밝힐 수 있었다. 또한 두 분류군 중 O. monacantha는 Elatae series에 포함되어 있어 남아메리카가 원산지이며, O. stricta는 Scheerianae series에 포함되어 북아메리카가 원산지라는 것을 확인할 수 있었다. 그리고, 제주도에 분포하고 있는 O. monacantha에 대해서 지리적 입지조건과 상징적 특성을 고려해 국명을 '제주백년초'로 명명하였다.

• 생약학회지
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• 제32권4호통권127호
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• pp.330-337
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• 2001

Prickly pear(Opuntia ficus-indica var. saboten Makino, Cactaceae) is a tropical or subtropical plant, which is widely used as folk medicine for burned wound, edema and indigestion. Screening on the biological properties of the fruits(OFS-Fr) and stems(OFS-St) of the plant was carried out to prove the pharmacological significance. By hot plate and acetic acid-inducing writhing methods, significant analgesic effects of OFS-Fr and OFS-St were found in mice and anti-edemic effect was observed in carrageenin-induced inflammatory rats. However, the extracts showed no significant actions on central and autonomic nervous system and blood circulatory system, which imply no toxic effects to animal.

• 생명과학회지
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• 제10권4호
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• pp.362-364
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• 2000

Opuntia ficus-indca(Op) extract has been claimed to have several therapeutic properties in oriental medicine including anti-inflammatory and anti-rheumatoid arthritis effects. Little is known of its effect on the activation of immune cells such as T cells and macrophages. To evaluate the functional effect of Op extract on immune cells, we examined whether Op extract stimulates the proliferation of T cells and the secretion of cytokines including IL-1 beta, IL-6 and tumor necrosis factor-alpha in THP-1 cell lines by RT-PCR. Op extract significantly enhanced the proliferation of T cell clone(D10S). Transcription of cytokines including IL-1 beta, IL-6, and TNF-alpha peaked 6 hrs after exposure to Op extract(100g/ml) in the THP-1 cell line and declined and declined thereafter. In an experiment to test the dose dependency of transcription of cytokines, transcription increased at a dose of 10 g/ml and the maximum expression was obtained at 100 g/ml, 6 hrs after exposure to Op extract. These findings suggest that Op extract is a potent stimulant of immune cells including T cells and macrophages, which acts by stimulating T cell proliferation and upregulating cytokines. These phenomena imply that some edible plants may be beneficial to living animals through the activation of immune functions.

• 한국식품영양학회지
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• 제26권3호
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• pp.526-534
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• 2013

This study was conducted to examine the effects of Opuntia ficus-indica complex (OF) on the lipid metabolism, bile acid in feces, alanine aminotransferase (ALT) activity, aspatate aminotransferase (AST) activity, composition of urine and expression of cholesterol related mRNA in streptozotocin (STZ)-induced diabetic rats. Thirty two male Sprague-Dawley rats were randomly divided into non-diabetic control (NC), diabetic control (DC), diabetic OF of 2% (OF-2) and diabetic OF of 5% (OF-5), then each group was fed for 3 weeks. Plasma total cholesterol, non-esterified fatty acids (NEFA), total cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL) were decreased significantly (p<0.05) in OF-5 group compared to DC, but high density lipoprotein (HDL) was not changed. AST and ALT were also reduced and bile acid excretion was improved. Composition of urine in OF-5 was almost same in NC. The expression of cholesterol $7{\alpha}$-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA-R), Low density lipoprotein receptor (LDL-R) mRNA indicated that feeding OF have the effects of cholesterol decreation in plasma by synthesis of bile acid from cholesterol. These results provide experimental evidence about improved lipid metabolism of the OF feeding in the STZ-induced diabetic rats.

• 한국식품영양학회지
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• 제22권1호
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• pp.48-56
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• 2009

손바닥선인장 복합물(OCB)의 항당뇨 효과 및 기작을 알아보기 위한 연구의 일환으로, OCB의 급여가 STZ으로 당뇨가 유발된 8주령 수컷 흰쥐의 음수량, 식이 섭취량, 체중, 공복혈당, 당내성에 미치는 효과와 당뇨의 합병증인 고지혈증(중성지방, 유리 지방산, 총 콜레스테롤, LDL-콜레스테롤, VLDL-콜레스테롤, HDL-콜레스테롤)의 개선효과를 조사하였다. OCB는 손바닥선인장의 줄기, 여주, 천화분, 목단피, 산약, 강황과 호로파를 조합하여 제조하였고, 기본사료에 2%와 5%의 수준으로 첨가하여 8주령 rat 수컷에게 3주간 자유 채식시켰다. OCB의 수분함량 약 12%, 조회분 15.4%, 조지방 1.26%, 조단백질 4.9%, 조섬유량 6.3% 및 탄수화물 함량은 60% 이상으로 주성분은 탄수화물이었다. 체중은 NC에 비해 DC, OCB-2와 OCB-5에서 감소하였다. 음수량과 사료섭취량은 NC에 비해 DC가 각각 약 8배 및 1. 5배 이상 증가하였고, OCB-2와 OCB-5는 DC와 비교해 유의적 차이가 없었다. NC의 공복 혈당은 평균 100 $mg/d{\ell}$, DC는 416 $mg/d{\ell}$이었으며, OCB-2는 362 $mg/d{\ell}$, 그리고 OCB-5는 329 $mg/d{\ell}$로 혈당농도의 감소를 보였다. 당내성 실험에서 모든 실험군은 포도당을 급여한지 30분 후에 최고 혈당을 나타냈고, OCB-5는 유의적인 감소를 보였다(p<0.05). 혈장 인슐린 함량도 DC와 비교해 NC, OCB-2, 그리고 OCB-5에서 유의적인 증가를 보였다(p<0.05). 이상의 결과에서 OCB의 급여는 STZ으로 당뇨가 유발된 쥐에서 당뇨의 개선효과가 있는 것으로 판단된다. 또한, OCB의 급여는 당뇨의 합병증인 지질대사에서 혈장의 중성지방, 유리지방산, 총콜레스테롤, LDL-콜레스테롤 그리고 VLDL-콜레스테롤을 모두 DC와 비교해 유의적인 수준으로 감소시켰다(p<0.05). 이러한 결과에서 볼 때, OCB의 급여는 당뇨의 합병증인 지질대사의 이상도 개선하는 것으로 관찰되었다.

• 한국약용작물학회지
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• 제16권1호
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• pp.1-8
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• 2008

Immune activities of Opuntia ficus indica L. Miller were investigated through aqueous extracts associated with ultrasonification process at $60^{\circ}C$, and showed the highest promotion of human B and T cell growth, up to 52% and 41%, respectively, compared to the control. The secretion of TNF-${\alpha}$ and IL-60 was also enhanced by the addition $(0.5mg/m{\ell})$ of the extracts, up to 48%. NK cell activation was significantly improved up to 1.3 times higher than the case of adding other extracts. It was also found that extracts from O. ficus indica could yield higher nitric oxide production from macrophage than Lipopolysaccaharides (LPS). It can be concluded that, in general, the extracts treated with ultrasonification has higher Immune acitivities than others, possibly by higher yielding immune-modulatory than conventional extraction process. The optimum condition for the extraction of O. ficus-indicais water extraction associated with ultrasonification.

• 공업화학
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• 제28권2호
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• pp.252-256
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• 2017

백년초(Opuntia) 손바닥 선인장은 우리나라 남쪽 지방인 거제도, 제주도, 남해안 등지에서 자생하며 매년 4~5월경에 꽃이 피고 11~12월경에 자주색 열매가 익는다. 백년초는 예로부터 민간요법에 흔히 사용되었으며 혈액순환을 원활하게 하고 해독, 진통, 항산화 작용 등에 큰 효과가 있다. 본 연구에서는 서귀포 백년초의 항산화성 기능, 항당뇨, 항균활성 효능을 입증하여 기능성 원료로서의 가치를 파악하고자 하였다. 연구 결과 백년초 내 항산화성을 갖는 물질인 택시폴린을 추출하여 강력한 항산화 효과를 확인하였고 항당뇨성 기능 실험에서 시판되고 있는 당뇨치료제와 비교하였을 때 높은 수준의 항당뇨 기능을 확인하였다. 또한 항균 효과 측정 결과 대장균과 살모넬라균 등에서 강한 항균활성을 보여 서귀포 백년초의 기능성 원료로서의 우수한 가치를 입증하였다.

• 생약학회지
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• 제43권4호
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• pp.308-315
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• 2012

Opuntia humifusa known as the Eastern prickly pear have been used as a treatment of burns, diarrhea, asthma, rheumatism, gonorrhea, and diabetes in alternative medicine. O. humifusa is widely cultivated in the middle and southern provinces of Korea and distributed in North America. The aim of this study is to investigate anti-diabetic effect of O. humifusa stem (OHS) water or 80% MeOH extract using 3T3-L1 adipocytes and db/db mice animal models. OHS 80% MeOH extract at a dose of $250{\mu}g/ml$ significantly increased the glucose uptake and lipid accumulation compared with the control in 3T3-L1 adipocytes. Blood glucose, plasma total cholesterol and triglyceride levels were significantly reduced by oral treatment of OHS 80% MeOH extract (200 mg/kg BW) for 6 weeks in db/db mice. Also, the oral treatment of OHS 80% MeOH extract slightly changed the plasma insulin and insulin resistance levels in db/db mice, but were no significance in comparison to control. Glucose transporter(GLUT)4 expressions of adipose tissue and muscle were significantly increased more than that in the control. Therefore, these results suggest that OHS 80% MeOH extract inhibits the blood glucose level through regulation of lipid profile, insulin resistance, and GLUT4 expression in db/db mice and its diabetic effect is effective more than water extract.

• Journal of Nutrition and Health
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• 제45권5호
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• pp.462-469
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• 2012

We investigated dietary effects of prickly pear cactus (Opuntina ficus-indica) on plasma lipids, platelet aggregation (PA), hemolysis, plasma TBARS and liver enzymes. Twenty eight volunteer diving women in Jeju island had daily 20 g cactus tea containing 27% prickly pear cactus (PPC) powder for 4 weeks, and data for the study subjects were analyzed, on the basis of diagnostic criteria for blood pressure (BP)(${\geq}$ 140/90 mmHg), plasma cholesterol (${\geq}$ 200 mg/dL) and triglyceride (${\geq}$ 150 mg/dL). The subjects with higher BP had higher plasma total cholesterol (TC) and triglyceride (TG) concentrations than those with normal BP. Those with higher TC also had higher TG. Subjects with normal BP or normal TC had higher initial slope of PA than their higher counterpart in BP and TC. PPC intake decreased plasma TG in those with higher BP. PPC intake significantly decreased the elevated initial slope in groups with normal BP, TC, and TG. Hemolysis after PPC intake decreased significantly in all the subjects and plasma TBARS decreased in the subjects with higher plasma TC and higher TG. Glutamic-oxaloacetic transaminase (GOT) significantly increased and total bilirubin significantly decreased in all the subjects after PPC intake. The present study with diving women showed that beneficial effects of short term intake of prickly pear cactus might differ depending on the subject conditions in term of blood pressure, and plasma lipids. However, long term usage of prickly pear cactus may provide preventive effects of cardiovascular diseases to all the population, presumably by hypolipidemic, antithrombotic, and antioxidant actions of its bioactive flavonoids and soluble fiber.

• 한국수산과학회지
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• 제52권4호
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• pp.358-365
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• 2019

This study investigated the effects of dietary cactus Opuntia ficus-indica stem and fruit extract on the growth, flesh quality, lysozyme activity, and histological changes of growing Korean rockfish Sebastes schlegeli. Three replicates of fish (152 g/fish) were fed one of the following diets: containing 0 additions (control); 0.1, 0.5, or 1.0% cactus stem powder; or 1.0% fruit extract for 11 weeks. Growth performance did not differ significantly among treatments, including survival, final weight, feed efficiency, and daily feed intake. The experimental diets did not affect the proximate and fatty acid compositions, plasma biochemistry, or dorsal muscle texture of the fish. However, the plasma lysozyme activity of the fish fed the diet containing 0.1% cactus stem was significantly higher than that of the fish fed the control diet. These fish had variously sized lipid vacuoles in the liver tissue compared with the control. Distinct mucosal folds and mucus-secreting goblet cells developed in the fish fed the diet containing 1% cactus stem compared with the other dietary groups. These results suggest that feeding growing Korean rockfish cactus stem might increase the plasma lysozyme activity and induce histological changes in the gastrointestinal tract that might be related to digestion.