• Journal of Veterinary Clinics
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• v.30 no.5
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• pp.399-402
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• 2013

An 8-year-old, female, mixed Thoroughbred horse was presented for the evaluation of the left upper eyelid mass with ocular discharge during 4 months. After unilateral surgery, excised eyelid mass and left eye were submitted for diagnosis. Grossly, the removed mass was $6{\times}7{\times}2$ cm in size and dome shape with rough irregular surface. On the cut surface, mass was firm and yellowish white in color. Histopathologically, severely proliferated stratified squamous epithelia were heavily invaginated into dermis, and then formed rete ridge or numerous squamous islands. These neoplastic islands were composed of multiple layers of prickle cells with intercellular bridge and central laminated keratin pearls or necrotic cellular debris. Based on the above results, this case was diagnosed as squamous cell carcinoma in upper eyelid of horse.

• Applied Microscopy
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• v.2 no.1
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• pp.17-31
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• 1972

Light and electron microscopic studies were made to investigate the morphological changes in growing galls on the leaf of Lycium chinense MILL caused by Eriophyes kuko Kishda. The results are summarized as follows: 1. Light microscopy At the early stage of the invasion of E. kuko on the back side of the young leaf of L. chinense, the.epidermal cells become hypertrophic and develope a gall. As the gall grows, the cells of both palisade and spongy-layers become hypertrophic and these tissues are hard to be distinguished because of their irregular outgrowth. As the gall grows, the nuclei of the gall also become hypertrophic and larger than these of normal cells. 2. Electron microscopy Under electron microscopy the mitochondria, the golgi apparatus and the plastids of the advanced galls are degenerated and disintergrated and the cell walls become thicker than normal ones. The characteristic star bodies and the ring-form structures are found in the mature gall cells.

• The Korean Journal of Malacology
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• v.29 no.1
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• pp.7-13
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• 2013

This study was conducted to find out biological response of Manila clam, Ruditapes philippinarum exposed to lead (Pb). Experimental period was four weeks. Experimental groups were composed of one control condition and three lead exposure conditions (0.25, 0.50 and 1.00 mg/l). The results of the study confirmed that lead induces reduction of survival rate and oxygen consumption rate and histopathology of organ structure of the bivalve. Oxygen consumption rate was observed exposure groups lower than control decline by 25%-72%. Histological analysis of organ system illustrated expansion of hemolymph sinus, disappearance of epidermal layer and degeneration of connective tissue layer of the mantle. Also, histological degenerations as epithelial necrosis and hyperplasia of mucous cells are recognized in the gill and it was observed expansion of hemolymph sinus, disruption of epithelial layer, decrease of mucous cell and degeneration of connective tissue layer in the foot. In the digestive diverticulum, it was showed atrophy of basophilic cell and degeneration of epithelial cell in the digestive tubules, and as the concentration of lead increased the accumulation of lipofuscin increased.

• Korean Journal of Veterinary Research
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• v.21 no.1
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• pp.11-23
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• 1981

서울 경마장(競馬場)의 경주마(競走馬) 517두를 대상으로 호흡기병상(呼吸器症狀)을 관찰하여 1978년 12월 중순(中旬)부터 1979년 1월 초순(初旬) 까지 42.9%의 호흡기병상발생률(呼吸器症狀發生率)을 보았고 1979년 1월 하순(下旬)부터 5월 중순(中旬)까지 임신마(姙娠馬)의 60%가 사산(死産)을 일으켰다. 사산(死産)된 태자(胎仔)는 육안적(肉眼的)으로 흉강수액(胸腔水液)의 저류, 각 장기(臟器)의 울혈성수종(鬱血性水種), 출혈성병변(出血性病變)과 간장(肝臟)의 소상괴사(巢狀壞死)를 나타내었고, 조직학적(組織學的)으로는 간장(肝臟)의 한국성괴사소(限局性壞死巢), 비장(脾臟), 임파절(淋巴節), 흉선(胸線)과 Peyer판(板)에서의 세강(細網) 세포(細胞)의 증식성(增殖性), 괴사성변화(壞死性變化)와 임파양세포(淋巴樣細胞)의 붕괴(崩壞)를 시현(示顯)하였다. 여기서 간세포(肝細胞), 담관상피세포(膽管上皮細胞), 소기관지상피세포(小氣管支上皮細胞) 및 비장(脾臟), 임파절(淋巴節), 흉선(胸線)의 세강(細網) 세포(細胞)에서 Cowdry type A 봉입체(封入體)를 확인하였다. 이상의 역학적(疫學的) 및 병리학적(病理學的) 소견(所見)에 의하여 본(本) 마유산증(馬流産症)을 말 바이러스성 비폐염(鼻肺炎)이라고 진단(診斷)할 수 있었으며 본(本) 발병예(發病例)가 한국(韓國)에서 초발생(初發生)인 것으로 추정(推定)되었다.

• The Korean Journal of Food And Nutrition
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• v.10 no.4
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• pp.462-467
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• 1997

The DIS process(dewatering and impregnation soaking process) are using for dewatering of food materials at room temperature. And the DIS process are resulted in diffusion process as well as dewatering phenomena. During the DIS process, plasmolysis or cytorrhysis was happened by according to solute size. A tissue state of food material was very important variables for movement of water or solute, and running conditions are important for dewatering and impregnation. And models for DIS process were fundamentally given by Fick's law at unsteady state or mass balance. For example, Bicompartmental Model was given for quantification of water loss and solid gain.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.110-110
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• 1993

Necrotizing lymphadenitis, or Kikuchi's disease, a newly recognized disease of unknown origin, occurred usually in young woman and mostly resolved spontaneously without treatment within a few months. Clinically, characteristic symptoms and sings were local lymph node enlargement, sometimes accompanied by tenderness, fever, weightless, leukopenia, and elevated erythrocyte sedimentation rate, and so necrotizing lymphadenitis can be confused with malignant lymphoma and tuberculosis. The histologic features of necrotizing lymphadenitis are distinctive. : lymph node biopsy reveals areas with frank cellular necrosis, karyorrhexis, and absence of plasma cell. We present nineteen cases of necrotizing lymphadenitis during from March 1990 to January 1993 and discuss their exact diagnosis and proper treatment.

• The Korean Journal of Malacology
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• v.27 no.3
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• pp.213-221
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• 2011

Equilateral venus, Gomphina veneriformis exposed to tribultyltin chloride (TBTCl) for 36 weeks was showed ultrastructural changes of the mantle. The fine mantle had 4-folds and its epidermal layer consisted of simple columnar epithelial cells and ciliated cells and secretory cells. Inner and outer epidermal layer covered connective tissue. The mantle exposed to TBTCl at 12 weeks was decreased cilia in the inner epidermal layer, and observed extension of the hemolymph sinus and destruction of the septum. At 20 weeks, it revealed vacuole formation and pycnosis in the cytoplasm, and scattered muscular fiber. After 28 weeks of exposure, the mantle revealed partially degenerative changes in the epidermal layer. In the ciliated cells, basal body was isolated from the cilia and rootlet complex and basal foot were scattered. The sarcolemma had debris fiber. At 36 weeks, it observed degenerative cells that it revealed disappearance of the cilia, atrophic nucleus, poorly membrane and destruction of the cresternae in the mitochondria, and increasing heterophagosome. The outer epithelial cell had necrotic nuclus, numeous lysosome and disappearance of the microvilli. Therefore, results of this study suggested that chronical TBTCl exposure in the Gomphina veneriformis induced the disorders of shell growth and physiological function with histopathological changes of the mantle.

• Journal of Life Science
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• v.30 no.4
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• pp.379-385
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• 2020

Phlojodicarpus sibiricus and Artemisia kruhsiana Besser are medicinal plants traditionally used in Russia. Phlojodicarpus sibiricus extracts (PSE) have been shown to have anti-obesity properties, and Artemisia kruhsiana Besser extracts (AKBE) contain terpenoid compounds that exert various medicinal effects. Here, we investigated the potential pro-apoptotic effects of PSE and AKBE in diffuse large B-cell lymphoma (DLBCL) and elucidated the underlying mechanism. PSE and AKBE treatment of six DLBCL cell lines with various genetic abnormalities effectively reduced cell viability in a dose-dependent manner, while having a minimal impact on the survival of normal murine bone marrow cells and splenocytes. This suggests that the cytotoxic effects of PSE and AKBE are specific to DLBCL cells. Therefore, we expect limited side effects when these plant extracts are administered to DLBCL patients. Our JC-1 assays demonstrate that the pro-apoptotic effects of these plant extracts are produced by a reduction of anti-apoptotic Bcl-2 family members and, thereby, disruption of the mitochondrial membrane potential. Moreover, PSE and AKBE induce cell death independently of Myc, whose abnormalities are frequently observed in patients with DLBCL and are associated with poor prognosis. Our findings reveal hitherto uncharacterized pro-apoptotic effects of PSE and AKBE in DLBCL. Isolation of single compounds with anti-lymphoma activities should be pursued further.

• The Korean Journal of Malacology
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• v.24 no.3
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• pp.229-241
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• 2008

Changes of growth and histopathological feature in the mantle structure of the equilateral venus, Gomphina veneriformis exposed to tribultyltin chloride (TBTCl) for 36 weeks were observed. Concentrations of TBTCl were 0, 0.4, 0.6, and $0.8{\mu}g/L$. A regression analysis by power function of SPSS was shown that the growth of experimental groups was significantly decreased after 12 weeks of exposure. For histological analysis, mantle tissues were characterized using H-E stain, AB-PAS (pH 2.5) reaction and Masson's trichrome stain, and epidermal layer thickness and mucous cell distribution were analysed using the image analyser. The mantle had 4-folds (inner-inner, inner-outer, middle, and outer) and its epidermal layer consisted of simple epithlia. A periostracum was observed in the periostracal groove between middle and outer fold. Inner epidermal layer consisted of simple ciliated columnar epithelia, but the outer epidermal layer consisted of simple non-ciliated columnar epithelia. Alcian blue positive mucous cells showed blue color (7462c, 653c) in the inner fold, violet color (2583c) in the middle fold, and blue color (647c, 7455c) in inner epidermal layer (numbers in the parenthesis are codes of Pantone process coated color). Hemolymph sinus in the mantle was extended, and mucous cells in inner plica of the middle fold were stained as blue (7455c) and violet (2587c), after 12 weeks of TBTCI exposure. Cilia and striated border were disappeared, and number of mucous cells in the inner epidermal layer was reduced. Serious histopathological changes in middle and outer fold near the periostracum were observed after 36 weeks. Moreover, epidermal layer thickness and mucous cell distribution were showed decreasing tendency as exposure time to TBTCI was increased. Results of this study suggested that TBTCl induced growth disorder with histopathological changes.

• Journal of Bio-Environment Control
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• v.22 no.2
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• pp.87-90
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• 2013

The average annual and winter ambient air temperatures in Korea have risen by $0.7^{\circ}C$ and $1.4^{\circ}C$, respectively, during the last 30 years. Due to climate change, the occurrence of abnormal weather conditions has become more frequent, causing damage to vegetable crops grown in Korea. Hot pepper, chinese cabbage and radish, the three most popular vegetables in Korea, are produced more in the field than in the greenhouse. It has been a trend that the time for field transplanting of seedlings is getting earlier and earlier as the spring temperatures keep rising. Seedlings transplanted too early in the spring take a longer time to resume the normal growth, because they are exposed to suboptimal temperature conditions. This experiment was carried out to figure out the change of cellular tissue of chinese cabbage under the condition of low temperature to provide the information regarding the coming climatic change, on the performance of 'Chunkwang' chinese cabbage during the spring growing season. In our study, plant height, number of leaf, chlorophyll and leaf area was lower at the open field cultivation than heating house treatment after transplanting 50 days. Especially in fresh weight, compared with heating treatment, open field and not heated treatment were notably low with the 1/3 level. Of damage symptoms due to low temperature cabbage leaves about 10 sheets when $-3.0^{\circ}C$ conditions in chinese cabbage was a little bit of water soaking symptoms on the leaves. $-7.4^{\circ}C$ under increasingly severe water soaking symptoms of leaf turns yellow was dry. Microscopy results showed symptoms of $-3.0^{\circ}C$ when the mesophyll cell of palisade tissue and spongy tissue collapse, $-7.4^{\circ}C$ palisade tissue and spongy tissue was completely collapsed. The result of this study suggests that the growers should be cautioned not to transplant their chinese cabbage seedlings too early into the field, and should be re-transplanting or transplanting other plants if chinese cabbage are exposed to suboptimal temperature conditions ($-3.0^{\circ}C$ or $-7.4^{\circ}C$).