• Korean Journal of Cognitive Science
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• v.14 no.3
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• pp.1-11
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• 2003

Two experiments were conducted to investigate effects of target types and retinal eccentricity on the search of a target while both target and background stimuli were static or moving. A visual search task was used in both experiments. The retinal eccentricity was determined by five concentric circles increasing by the unit of 1.6 and the target was different from the background stimuli in either orientation(orientation target) or a distinctive feature(feature target). In Experiment 1 where both the target and background stimuli were presented statically, an interaction between retinal eccentricity arid target type was found. While search time of the orientation target was not affected by the retinal eccentricity, that of the feature target increased as the retinal eccentricity increased. In Experiment 2 where all stimuli were moving, the interaction effect was also found. But the reason was not the same as that in Experiment 1. In the moving condition, while the search time of the orientation target decreased consistently as the retinal eccentricity increased, that of the feature target was not affected by the retinal eccentricity. The implications and limitations of the present results were discussed with respects to the real world situations such as driving cars or flying airplanes.

• Journal of Life Science
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• v.33 no.3
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• pp.287-294
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• 2023

Healthy adipose tissue is critical for preventing obesity by maintaining metabolic homeostasis. Adipose tissue plays an important role in energy homeostasis through glucose and lipid metabolism. Depending on nutritional status, adipose tissue expands to store lipids or can be consumed by lipolysis. The role of adipose tissue as an endocrine organ is emerging, and many studies have reported that there are various adipose tissue hormones that communicate with other organs and tissues through metabolic signaling. For example, leptin, a representative peptide hormone secreted from adipose tissues (adipokine), circulates and targets the central nervous system of the brain for appetite regression. Furthermore, adipocytes secrete inflammatory cytokines to target immune cells in adipose tissues. Not surprisingly, adipocytes can secrete fatty acid-derived hormones (lipokine) that bind to their specific receptors for paracrine and endocrine action. To understand organ crosstalk by adipose tissue hor- mones, specific metabolic signaling in adipocytes and other communicating cells should be defined. The dysfunction of metabolic signaling in adipocytes occurs in unhealthy adipose tissue in overweight and obese conditions. Therapy targeting novel adipose metabolic signaling could potentially lead to the development of an effective anti-obesity drug. This review summarizes the latest updates on adipose tissue hormone and metabolic signaling in terms of obesity and metabolic diseases.

• 한국공간정보시스템학회:학술대회논문집
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• 2005.05a
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• pp.201-205
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• 2005

미국과 일본 등 많은 나라들이 연안역에 대한 오염총량관리제를 실시하고 있으며 우리나라 역시 90년도 초반부터 환경부와 국립환경연구원에 의하여 4대강을 대상으로 내륙에 대한 지자체 단위의 오염총량관리제가 추진되고 있다. 연안해역에서도 최근 해양오염방지법의 개정으로 특별관리해역 지정 등 특정 연안해역에 영향을 미치는 육역을 포함하는 연안역 통합관리제가 해양수산부에 의하여 추진되고 있다 또한 외국의 사례로서 미국 체사피크만에서는 오염총량관리제를 포함하는 연안역 통합관리제 수립 및 운용을 위하여 GIS 및 모델 package로 구성된 시스템을 구축 활용하고 있으며, 이런 GIS 및 모델 package로 구성된 시스템을 바탕으로 연안역 통합관리를 위한 기본적인 자료를 수집 분석하고 정책 수립의 방향을 제시하고 있다. 하지만 우리나라에서는 아직까지 연안역 통합관리를 위한 기초 자료도 많이 부족하고 이런 기초 자료를 토대로한 분석 도구인 GIS-modeling 시스템 개발도 매우 미미한 실정이다. 따라서 본 연구에서는 GIS를 이용하여 오염원의 발생 및 배출부하 산정 과정을 공간적으로 분석하여 환경관리에 응용할 수 있는 방안을 제시하고자 한다. 또한 효율적인 연안의 오염원 관리를 위하여 기존 환경부 및 관련 기환 자료를 활용하여 잠실 수중보에서 한강 하구의 세부 오염원자료를 수집하여 GIS 기반의 오염원데이터베이스를 구축하고, 오염부하산정모델을 개발한 후, 구축된 정보의 효율적인 관리와 분석을 위한 GIS 프로그램을 개발하였다. 아울러 육역에서의 오염물질 배출에 따른 연안역 수질의 모의를 통해 육역과 연안역에 대한 효율적인 통합관리방안을 제시하고자 한다.사용될 수 있는 블루투스 서비스와 서비스 속성을 기술한 XML 문서에서 블루투스 기기에 적합한 내부 정보를 생성하는 생성기를 설계하고 구현을 하였다.보다는 현저히 낮았다. 총 휘발성 유기화합물읜 농도는 실내가 실외 보다 높았다(I/O ratio 2.5). BTEX의 상대적 함량도 실내가 실외보다 높아 실내에도 발생원이 있음을 암시하고 있다. 자료 분석결과 유치원 실내의 벤젠은 실외로부터 유입되고 있었고, 톨루엔, 에틸벤젠, 크실렌은 실외뿐 아니라 실내에서도 발생하고 있었다. 정량한 8개 화합물 각각과 총 휘발성 유기화합물의 스피어만 상관계수는 벤젠을 제외하고는 모두 유의하였다. 이중 톨루엔과 크실렌은 총 휘발성 유기화합물과 좋은 상관성 (톨루엔 0.76, 크실렌, 0.87)을 나타내었다. 이 연구는 톨루엔과 크실렌이 총 휘발성 유기화합물의 좋은 지표를 사용될 있고, 톨루엔, 에틸벤젠, 크실렌 등 많은 휘발성 유기화합물의 발생원은 실외뿐 아니라 실내에도 있음을 나타내고 있다.>10)의 $[^{18}F]F_2$를 얻었다. 결론: $^{18}O(p,n)^{18}F$ 핵반응을 이용하여 친전자성 방사성동위원소 $[^{18}F]F_2$를 생산하였다. 표적 챔버는 알루미늄으로 제작하였으며 본 연구에서 연구된 $[^{18}F]F_2$가스는 친핵성 치환반응으로 방사성동위원소를 도입하기 어려운 다양한 방사성의 약품개발에 유용하게 이용될 수 있을 것이다.었으나 움직임 보정 후 영상을 이용하여 비교한 경우, 결합능 변화가 선조체 영역에서 국한되어 나타나며 그 유의성이 움직임 보정 전에 비하여 낮음을

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.78-85
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• 2019

Membrane proteins are involved in many common diseases, including heart disease and cancer. In various disease states, such as cancer, abnormal signaling pathways that are related to the membrane proteins cause the cells to divide out of control and the expression of membrane proteins can be altered. Membrane proteins have the hydrophobic environment of a lipid bilayer, which makes an analysis of the membrane proteins notoriously difficult. Therefore, this study evaluated the efficacy of two different methods for optimal membrane protein extraction. High-speed centrifuge and reagent-based method with a -/+ filter aided sample preparation (FASP) were compared. As a result, the high-speed centrifuge method is quite effective in analyzing the mitochondrial inner membranes, while the reagent-based method is useful for endoplasmic reticulum membrane analysis. In addition, the function of the membrane proteins extracted from the two methods were analyzed using GeneGo software. GO processes showed that the endoplasmic reticulum-related responses had higher significance in the reagent-based method. An analysis of the process networks showed that one cluster in the high-speed centrifuge method and four clusters in the reagent-based method were visualized. In conclusion, the two methods are useful for the analysis of different subcellular membrane proteins, and are expected to assist in selecting the membrane protein extraction method by considering the target subcellular membrane proteins for study.

• The Journal of the Acoustical Society of Korea
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• v.43 no.3
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• pp.293-304
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• 2024

In this paper, efficient and reliable methodologies for conducting sea trials to evaluate the performance of hull-mounted sonar systems is discussed. These systems undergo performance verification during ship construction via sea trials. However, the evaluation procedures often lack detailed consideration of variabilities in detection performance due to seabed topography, seasonal factors. To resolve this issue, temperature and salinity structure data were collected from 1967 to 2022 using ARGO floats and ocean observers data. The paper proposes an efficient and reliable sea trial method incorporating Bellhop modeling. Furthermore, a machine learning model applying a Physics-Informed Neural Networks was developed using the acquired data. This model predicts the sound speed profile at specific points within the sea trial area, reflecting seasonal elements of performance evaluation. In this study, we predicted the seasonal variations in sound speed structure during sea trial operations at a specific location within the trial area. We then proposed a strategy to account for the variability in detection performance caused by seasonal factors, using results from Bellhop modeling.