• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.72-72
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• 1993

Among the various diagnostic methods for the voice disorders, video laryngo-stroboscopy is one of the most practical techniques for clinical examination of the vocal fold vibration. It provides valuable informations about the nature of vocal folds' vibration, the extent of pathologic change and data recording for analysis. To obtain the stroboscopic characteristics of several voice disorders, and apply those informations to the diagnosis and management of disorders, we reviewed the stroboscopic findings obtained from the patients with voice disorders at Voice laboratory, the Institute of Logopedics and Phoniatrics form April 1992 to March 1993.

• Phonetics and Speech Sciences
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• v.7 no.3
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• pp.37-44
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• 2015

This study investigated the effects of the age of Korean speakers, place of articulation, and phonation types on voice onset time (VOT) of stops. Twenty-five preschoolers, 25 schoolers, and 25 adults who had no history of speech and language impairment produced plosives in /VCV/ words in isolation. A three-way ($3{\times}3{\times}3$) mixed design was used with the age of speakers (preschoolers, schoolers, adults) as a between-subject factor, the place of articulation (bilabials, alveolars, velars) and phonation types (plain, tense, aspirated consonants) as a within-subject factor. The dependent measure was the VOT values. Results revealed that three main effects were statistically significant. Preschoolers exhibited longer VOTs than adults (p<.05). There were significant differences in VOTs among the place of articulation, showing that speakers had the longest VOTs for velars (velars > alvelars > bilabials) (all p<.05). In addition, the VOTs for aspirated consonants were longer than those for plain and tense consonants, and the differences were significant among three phonation types (aspirated > tense > plain) (all p<.05). The current results suggested that VOTs would be linked to age and development, and schoolers over the age of 11 years had achieved adult-like VOTs. Moreover, the place of articulation and phonation types in Korean stops showed marked factors in normal speakers' VOT patterns.

• Proceedings of the KAIS Fall Conference
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• 2011.12a
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• pp.295-298
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• 2011

인간의 능력 중 가장 주목할 만한 것은 언어를 습득하고 그것을 이용하여 서로 의사소통을 할 수 있다는 것이다. 모든 언어에는 그 언어만이 가지는 특수성뿐만 아니라 공통적으로 존재하는 보편적인 특성이 있다. 이것 외에도 언어 위에 입혀지는 사람의 목소리는 의사소통을 하는데 있어 상대의 심리를 파악하는 중요한 단서가 된다. 특히, 언어는 습득되어져야 활용되고 그 습득되어지는 환경에 영향을 받으며 이러한 환경에 따라 사람의 목소리, 억양 등이 변화하게 되는 것이다. 따라서 본 논문에서는 음성신호 분석 기법을 적용하여 장르별 영화시청에 따른 시각적, 청각적 요인이 목소리에 미치는 영향을 분석하는 연구를 수행하였다. 이를 위해 장르별 영화를 시청한 후 성대 진동 및 음성에너지의 크기 변화를 측정하여 감정변화를 분석하는 실험을 수행하였다.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.1
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• pp.1-8
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• 2019

The optimal design parameters of a dynamic absorber (DA) in a machine body (that is considered as a rigid body) are discussed in this paper. The bounce and rotation motions of the rigid body have been controlled passively by a DA, which consists of a mass and a spring. The rigid body is subjected to a harmonically excited force and supported by linear springs at both ends. To define the motion of a rigid body with a DA, the equation of motion was expressed in the third-order matrix form. To define the optimal design conditions of a DA, the reduction of dynamic characteristics, represented by the amplitudes of bounce and rotation, and the transmitted powers, were evaluated and discussed. The level of reduction was found to be highly dependent on the location and spring stiffness of the DA.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.04a
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• pp.494-497
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• 2010

본 논문에서는 $C_2H_5OH$를 주성분으로 하고 있는 알코올량에 따른 음성학적 분석 요소값의 변화를 측정하였다. 이를 위해 알코올 섭취량의 변화를 측정하고 다양한 음성 분석기법을 적용한 실험 과정을 수행하였다. 따라서 본 연구의 결과를 토대로 다양한 환경에 용이하게 쓰일 수 있도록 알코올 섭취와 관련된 분야에 적용 가능한 실험 절차를 수행하였다. 따라서 본 논문에서는 음성 분석 요소의 Pitch값과 Shimmer 및 Jitter에 대해 분석을 수행하였으며 실험 결과를 통해 알코올 섭취량이 음성에 미치는 영향을 분석하였다. 최종적으로 실험에 의해 제안한 방법의 유용성을 입증하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.1043-1046
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• 2011

건강에 대한 예방과 관리를 반영한 것이 대체의학이다. 대체의학 중에 이침(耳針)요법은 부작용이 적은 방법으로 널리 사용되고 있다. 이침요법은 간단한 교육과정을 거친 후 자가 진단을 통해 응급처치가 가능한 것으로 실생활에서 손쉽게 이용되고 있다. 따라서 본 논문에서는 심장에 해당하는 이(耳)혈 상응점을 자극하여 심장과 관련된 음성 요소의 변화를 측정하였다. 이를 위해 심장에 해당하는 이(耳)혈 상응점을 자극하기 전과 후의 음성을 수집하여 음성 분석 요소 중 Jitter와 2Formant Frequency Bandswidth을 적용하여 단위 시간안의 발음에서 성대 진동의 변화율과 공명강의 변화를 통해 심장과 음성의 상관성을 분석하는 연구를 수행하였다.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.69-76
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• 2017

Citrin deficiency is an autosomal recessive disorder caused by mutations in the SLC25A13 gene on chromosome 7q21.3, and a type of urea cycle disorder that causes hyperammonemia. Although neonatal intrahepatic cholestasis and adult-onset type II citrullinemia, a type of citrin deficiency, have been described well in many articles for several decades, failure to thrive and dyslipidemia caused by citrin deficiency (FTTDCD), the other type of citrin deficiency, has been only identified recently. There was previously no case report about FTTDCD in Korea. Patients with FTTDCD could present with loss of appetite, fatigue, failure to thrive, hypoglycemia, hypercitrullinemia, dyslipidemia, and an increased lactate/pyruvate ratio. Routine evaluation may not reveal the cause of hypoglycemia caused by citrin deficiency. We recently had a case that presented with recurrent hypoglycemia in a 30-month-old boy. Chemistry profiling, urine organic acid analysis, plasma acylcarnitine analysis, and hormone studies indicated values within the normal range or non-specific findings. Mutation analysis to identify the cause of hypoglycemia identified the subject as a compound heterozygote carrying each of the c.852_855del ($p.Met285Profs^*2$), and c.1177+1G>A mutant alleles. We report here on this unusual case of citrin deficiency presenting with FTTDCD for the first time in Korea.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.55-62
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• 2017

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by beta-glucosidase deficiency. An 18 month-old male with hepatosplenomegaly, anemia, thrombocytopenia, and growth retardation referred to our hospital. The patient showed neurological symptoms, such as supranuclear gaze palsy and developmental delay. Bone marrow biopsy performed to rule out malignancy and the results revealed no malignant cell; however, abnormal histiocytes suggesting storage disease was noted. Based on hepatosplenomegaly, bicytopenia and unexplained neurologic manifestations, enzyme activity and genetic analysis were conducted emergently with a strong suspicion of GD. Beta-glucosidase activity in leukocyte was decreased. GBA sequencing to confirm the diagnosis revealed compound heterozygous pathogenic variants (i.e., c.754T>A, c.887G>A), both previously reported as the cause of neuronopathic GD. Under the diagnosis of type 3 GD, the patient immediately received enzyme replacement therapy (ERT). After 17 months of ERT, the size of spleen decreased, and hemoglobin and platelet count returned to normal. In addition, the activity of chitotriosidase and angiotensin converting enzyme decreased. However, myoclonic movement and generalized seizure occurred at the age of 19 months and antiepileptic drug was started. Other neurological deterioration including supranuclear gaze palsy and developmental delay also persisted. A new therapy to overcome neurologic problems should be developed for patients with type 3 GD.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.16 no.1
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• pp.52-56
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• 2016

Propionic acidemia (PA) is a rare autosomal recessive metabolic disease caused by the deficiency of propionyl-CoA carboxylase (PCC). PA affects the catabolism of branched chain amino acid and oddchain fatty acid then results in accumulation of propionic acid and other metabolites in plasma and urine. Catabolic stress such as infection, illness or any stress can precipitate cause acute metabolic decompensation, especially in the first years of life. Acute metabolic decompensation commonly calls for emergency treatment or admission and if the patient is in a serious condition, it can lead to coma or death. But frequent admissions or visiting the emergency room are much burden to the patients and their kins. And we experienced the propionic academia with a confirmed novel mutation and the patient suffered from frequent admission and visiting the emergency room. So, we tried the regular home carebased fluid therapy after securing a central venous line. Finally, we succeeded in preventing frequent admissions resulted from acute metabolic decompensation and could contribute to relieving the burden to the patient and their family.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.2
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• pp.87-92
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• 2015

Mucopolysaccharidosis (MPS) is an inherited disease entity associated with lysosomal enzyme deficiencies. MPS type 2, also known as Hunter syndrome, has a characteristic morphology primarily involving x-l inked recessive defects and iduronate-2-sulfatase gene mutation. The purpose of this case report is to provide important clues to help pediatricians identify Hunter syndrome patients earlier (i.e., before the disease progresses). A 30-month-old boy showed developmental delay and decreased speech ability. Physical examinations revealed a flat nose and extensive Mongolian spots. Brain magnetic resonance images (MRIs) showed bilateral multiple patchy T2 hyperintense lesions in the periventricular and deep white matter, several cyst-like lesions in the body of the corpus callosum, and diffuse brain atrophy, which were in keeping with the diagnosis. Based on these findings, the patient was suspected of having MPS. In the laboratory findings, although the genetic analysis of IDS (Iduronate-2-sulfatase) did not show any pathogenic variant, the enzymatic activity of IDS was not detected. We could confirm the diagnosis of MPS, because other sulfatases, such as ${\alpha}$-L-iduronidase, were detected in the normal range. Early enzymatic replacement therapy is essential and has a relatively good prognosis. Therefore, early diagnosis should be made before organ damage becomes irreversible, and brain MRIs can provide additional diagnostic clues to help distinguish the disorder.