• Title/Summary/Keyword: 생체 내 미세단층촬영 시스템

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Detecting and Tracking Changes of Mechanical Characteristics of the Trabecular and Cortical Bone in the Lumbar Vertebrae of an OVX Rat - Use of In-Vivo Micro-CT and Micro-FE Analysis - (난소 절제술을 시행한 흰쥐 등뼈의 해면골과 피질골의 구조적 특성 추적관찰 및 기계적 특성 분석 - 생체 내 미세단층촬영 시스템과 미세 유한요소법 적용 -)

  • Ko, Chang-Yong;Woo, Dae-Gon;Lee, Tae-Woo;Lee, Beob-Yi;Tack, Gye-Rae;Kim, Han-Sung
    • Journal of the Korean Society for Precision Engineering
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    • v.24 no.1 s.190
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    • pp.110-117
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    • 2007
  • This study investigated changes of mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae of the ovariectomised (OVX) rat. In previous researches, there were many studies for morphology of osteoporotic bones based on Micro-Computed Tomography (Micro-CT). However, there were few studies for detecting and tracking changes of mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae of the OVX rat. For this study, the 4th lumbar of the OVX rat (female Sprague-Dawley) was utilized as a specimen. An OVX rat was scanned at week 0 (just before surgery), at week 4, and week 8 after surgery. Micro-finite element (${\mu}-FE$) analysis was used to investigate mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae for an OVX rat. When the OVX rat (at week 8) was compared with the OVX rat (at week 0), the structural modulus of cortical and trabecualr bone was decreased by 52% and 99%, respectively. This study showed the change of mechanical characteristics of cortical bone as well as trabecular bone of an OVX rat. Detecting and tracking changes of mechanical characteristics could greatly contribute to an experiment test for the trabecular and cortical bone in the lumbar vertebrae of an OVX rat by using In-vivo Micro-CT.

A Feature Extraction Method in Iris Image for Biometrics (생체인식을 위한 홍채영상의 특징 추출)

  • Kim Sin-Hong;Cho Yong-Hwan;Kim Tae-Hoon
    • The Journal of the Korea Contents Association
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    • v.5 no.5
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    • pp.59-64
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    • 2005
  • The biometrics of iris is a very accurate authentication method. The biometrics of iris can recognize and identify a person for shortly. But the image of iris is changed by transformation of body in the life. The existing iris authentication system has problem that can be mis-recognized. In this paper, we proposed and implemented Renewable Iris Authentication Algorithm(RIAA) for biometrics in authentication system. This algorithm tries to present a new way to people identification, we show contour line when shift take photograph in regular side. Namely, it generate iris code based on boundary of projection or submergence side and compared to original, so that it describes iris identification method to people identification.

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Development of a High-Speed Endoscopic OCT System and Its Application to Three-Dimensional Intravascular Imaging in Vivo (고속 내시경적 OFDI 시스템 개발과 이를 이용한 3차원 생체 혈관 내부 이미징)

  • Cho, Han Saem;Jang, Sun-Joo;Oh, Wang-Yuhl
    • Korean Journal of Optics and Photonics
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    • v.25 no.2
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    • pp.67-71
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    • 2014
  • Intravascular optical coherence tomography (OCT) enables imaging of the three-dimensional (3D) microstructure of a blood vessel wall. While 3D vascular visualization provides detailed information of the vessel wall and intraluminal structures, a longitudinal imaging pitch that is several times bigger than the imaging resolution of the system has limited true high-resolution 3D imaging. In this paper we demonstrate high-speed intravascular OCT in vivo, acquiring images at a rate of 350 frames per second. A 47-mm-long rabbit aorta was imaged in 3.7 seconds, after a short flush with contrast agent. The longitudinal imaging pitch was 34 micrometers, comparable to the transverse imaging resolution of the system. Three-dimensional volume rendering showed greatly enhanced visualization of tissue microstructure and stent struts, relative to what is provided by conventional intravascular imaging speeds.

Evaluation of Hormone Deficiency in Vertebral Body: Analysis of Bone Structure and Quality (호르몬 결핍이 척추체에 미치는 영향 평가: 골의 구조학적 및 질적 요소 분석)

  • Kim, Chi-Hoon;Woo, Dae-Gon;Park, Ji-Hyung;Lee, Beob-Yi;Kim, Chi-Hyun;Kim, Han-Sung
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.5
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    • pp.92-101
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    • 2010
  • This study evaluated the structure and quality of osteoporotic vertebral bone. To induce osteoporosis, eight rats were ovariectomized (OVX). All rats were divided into two groups (Normal group: 4, OVX group: 4). Total lumbar vertebrae for each rat were scanned by in-vivo ${\mu}CT$ at 0, 4 and 8 weeks. Morphological characteristics (BV/TV, Tb.Th, Tb.N, Tb.Sp and SMI) were calculated by in-vivo ${\mu}CT$ image analyzer. Three dimensional finite element models were analyzed to investigate bone strength of OVX and Normal groups. Moreover, the elastic modulus was quantitatively analyzed to evaluate the quality changes of osteoporotic bone. In the OVX group, BV/TV, Tb.Th and Tb.N were significantly decreased at all the lumbar over time (p<0.05). We also investigated a contrary tendency in Tb.Sp and SMI, compared to the above results in each group. A degree of alteration of mechanical characteristics in OVX group was decreased over measuring time (p<0.05). Bone quality presented by distribution of elastic modulus was improved in the Normal group more than OVX group. The findings of the present study indicated that both bone structure and quality of whole lumbar could be tracked and detected by analyzing the morphological and biomechanical characteristics of bones, based on a nondestructive method.

Longitudinal Alterations on Lumbar Vertebral Trabecular Bone Qualities during Pregnancy (임신기간 중 척추 해면골의 골질(bone qualities) 변화)

  • Ko, Chang-Yong;NamGung, Bum-Seok;Kim, Hyo-Seon;Kim, Hyun-Dong;Kim, Han-Sung
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.4
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    • pp.95-101
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    • 2010
  • The aim of this study was to detect longitudinal alterations on lumbar vertebral trabecular bone quality (microarchitecture and degree of mineralization) and bone mineral density (BMD) during pregnancy Virginal eighteen mice were used. Then, twelve mice were mated. Mice lumbar vertebrae were scanned before mate, at 7 days of pregnancy (early pregnancy, 6 mice) and immediately after delivery (late pregnancy, 6 mice) by using in-vivo micro-computed tomography Structural parameters, degree of mineralization and BMD were measured. During early pregnancy, there were no significant alterations on structural parameters, degree of mineralization and BMD. At late pregnancy, Tb.Th (11.8%) and BMD (12.7%) were significantly decreased and Tb.N (6.3%), Tb.Pf (43.0%) and BS/BV (15.1%) were significantly increased (p<0.05). Additionally, the lower degree of mineralization was increased, although, the higher degree of mineralization was decreased. These results indicated that the quality and BMD might be not affected during early pregnancy. At late pregnancy, however the bone quality and BMD were likely to be negatively affected.

Effects of Unloading induced Denervation on Trabecular Bone of Growing Mice; Gender-difference (궁둥신경절제술을 통한 무부하가 성별에 따른 성장기 쥐 해면골에 미치는 영향)

  • Seo, Dong-Hyun;Ko, Chang-Yong;Kang, Sun-Young;Lim, Do-Hyung;Kim, Han-Sung
    • Journal of the Korean Society for Precision Engineering
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    • v.26 no.10
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    • pp.122-128
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    • 2009
  • The aim of this study was to investigate, through a longitudinal tracking, whether gender influences morphological characteristics on trabeucular bone of tibia during unloading. 12 male and 15 female ICR mice at 6 week of age were used and randomly allocated into two groups in each gender; unloading and normal group, respectively Mice in unloading group were operated on denervation (sciatic neurectomy). The tibiae were scanned by using in vivo micro-computed tomography (micro-CT) at 0 day (before denervation) and after 14 days. Structural parameters and BMD on tibia were measured. In female, BV/TV (65%), Tb. Th (5%), Tb.N (61%) and BMD (62%) were significantly decreased and BS/BV (17%), Tb.Sp (54%), SMI (19%) and Tb.Pf (75%) were significantly increased after unloading (p<0.05). In male, BV/TV (1%) and Tb.N (10%) were significantly decreased and SMI (5%) was significantly increased after unloading (p<0.05). In addition, trabeuclar bone loss of female was significantly bigger than that of male (p<0.05). These results indicated that effects of unloading on trabecular bone in growing mice might have difference between female and male, although unloading result in loss of quantity and quality on trabecular bone both female and male.