• Agrochemical news magazine
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• v.17 no.5 s.134
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• pp.68-75
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• 1996

''소비자는 통상 매스컴에서 많이 다루고 있는 식품중 잔류농약, 항생물질이나 방사선 조사식품에서 대한 우려를 많이 하고 있다. 그러나 식품과학적 측면에서 이와같은 오염물질에 의한 위해발생 가능성은 별로 높지않다. 오히려 우리가 별 문제가 없다고 생가가하고 있는 식품중 미생물의 증식이나 영양적 불균형이 더 큰 위해발생 요인이다.'' ''발생가능한 모든 위해를 완전히 차단하는 것은 현실적으로 불가능할 분만 아니라 국민건강상 더 큰 위해를 초래할 수 있다. 그러나 대부분의 국민들은 단순히 적은 가능성일 뿐인 위해발생에 더 관심이 많고, 그 실익에 대해서는 모르거나 현실상황을 외면하는 경우가 많아 식품위생행정에 대한 불신이 증폭되고 있다. '' 최근 산국식품연구원의 송인상 박사는 한국농촌의학회지를 통해 발표한 $\ulcorner$식품의 안전성 확보를 위한 과제들$\lrcorner$이란 주제에서 이같이 지적하고 식품위생에 대한 보다 정확하고 과학적인 지식을 소비자에게 제공하는 교육과 홍보의 기능이 매우 중요하다고 주장했다. 주요내용을 발췌 소개한다.

• Agrochemical news magazine
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• v.17 no.5 s.134
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• pp.76-76
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• 1996

''소비자는 통상 매스컴에서 많이 다루고 있는 식품중 잔류농약, 항생물질이나 방사선 조사식품에서 대한 우려를 많이 하고 있다. 그러나 식품과학적 측면에서 이와같은 오염물질에 의한 위해발생 가능성은 별로 높지않다. 오히려 우리가 별 문제가 없다고 생가가하고 있는 식품중 미생물의 증식이나 영양적 불균형이 더 큰 위해발생 요인이다.'' ''발생가능한 모든 위해를 완전히 차단하는 것은 현실적으로 불가능할 분만 아니라 국민건강상 더 큰 위해를 초래할 수 있다. 그러나 대부분의 국민들은 단순히 적은 가능성일 뿐인 위해발생에 더 관심이 많고, 그 실익에 대해서는 모르거나 현실상황을 외면하는 경우가 많아 식품위생행정에 대한 불신이 증폭되고 있다. '' 최근 산국식품연구원의 송인상 박사는 한국농촌의학회지를 통해 발표한 $\ulcorner$식품의 안전성 확보를 위한 과제들$\lrcorner$이란 주제에서 이같이 지적하고 식품위생에 대한 보다 정확하고 과학적인 지식을 소비자에게 제공하는 교육과 홍보의 기능이 매우 중요하다고 주장했다. 주요내용을 발췌 소개한다.

• Korean Journal of Food Science and Technology
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• v.30 no.3
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• pp.523-528
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• 1998

Response surface methodology (RSM) was used to monitor extraction characteristics of electron donating ability and organoleptic properties for ethanol extracts from Chrysanthemum petals, thereby determining optimum extraction conditions. A central composite design was applied to investigate effects of solvent per sample $(X_1)$, ethanol concentration $(X_2)$ and extraction time $(X_3)\;at\;60^{\circ}C$ on dependent variables such as electron donating ability $(Y_1)$, organoleptic color $(Y_2)$ and organoleptic aroma $(Y_3)$ of the extracts. Second-order models were employed to generate 4-dimensional response surfaces for qualitative and quantitative aspects of ethanol extracts. Coefficients of determination $(R_2)$ of the models for dependent variables were ranged from 0.8180 to 0.9696. Optimum extraction conditions for each variable were 50 mL/g, 61% and 16 hrs in electron donating ability, 88 mL/g, 21% and 16 hrs in organoleptic color, 55 mL/g, 73% and 19 hrs in organoleptic aroma, respectively. The optimum condition ranges for maximized characteristics of ethanol extracts were $65{\sim}78\;mL/g,\;90{\sim}100%\;and\;15{\sim}25\;hrs$. Predicted values at the optimum conditions were in good agreement with experimental values.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.1
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• pp.60-66
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• 2014

The aim of this study was to evaluate the antioxidant activity and protective effect of extracts from the stems and leaves of Chrysanthemum boreale (CBSL) on t-BHP induced oxidative stress in human liver cells (Chang cells). Antioxidant activities in the extracts were determined for various radical scavenging activities including ferric reducing antioxidant power, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity, and oxygen radical absorbance capacity (ORAC). CBSL showed a very good scavenging effect of DPPH radical ($IC_{50}$ $0.009{\pm}0.002$ mg/mL), alkyl radical ($IC_{50}$ $0.004{\pm}0.001$ mg/mL), and hydroxyl radical ($IC_{50}$ $6.742{\pm}0.152$ mg/mL). CBSL also showed a strong antioxidant effect in the ORAC assay. In the MTT assay on human liver cells (Chang cells), the extracts showed protective effects by increasing cell viability, decreasing ROS, and restoring mitochondria membrane potential upon t-BHP induced oxidative stress. Our findings suggest that CBSL extracts are a potential therapeutic with protective antioxidant effects upon oxidative stress.

• Korean Journal of Plant Resources
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• v.23 no.1
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• pp.47-53
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• 2010

Flowers and shoots of three species of Dendranthema boreale, Dendranthema indicum, Dendranthema zawdskii var. lucidum, were extracted with 80% ethanol by reflux, and polyphenol content, scavenging activity on DPPH and ABTS radicals, ferrous ion chelating effects and inhibition effects on lipid peroxidation were analyzed. Total polyphenol and flavonoid contents were highest in D. zawdskii var. lucidum, especially in the flower part. Scavenging activity on DPPH and ABTS was also highest in D. zawdskii var. lucidum flower with less activity in shoot. Ferrous ion chelating effects was highest with D. boreale flower and lowest in D. zawdskii var. lucidum flower. Inhibition activity on lipid peroxidation was highest in D. zawdskii var. lucidum shoot with 41.01% inhibition activity showing 32 days after reaction, which is higher than synthetic antioxidant BHT. Due to higher antioxidant level and activity of shoot and flower of D. zawdskii var. lucidum is promising material for natural plant antioxidant. It was also shown that antioxidant activity is different according to plant part ever in same plant, and proper plant species should be used for antioxidant after careful studies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.49-56
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• 2013

Chrysanthemum boreale(CB) is an oriental medicinal herb which has been used traditionally for the treatment of various brain disease including headache, dizziness and sedation. In order to examine the mechanism of anti-parkinsonism effect, water extract of CB(100 mg and 200 mg/kg of b.w.) were administered orally during 28 days in MPTP-induced parkisonism mice model. Water extract of CB increased the motor activities. CB did not affect total MAO and MAO-B activity in the brain of MPTP-induced mice. CB significantly increased the concentration of lipid peroxidation in the mid brain. Also, CB significantly increased antioxidant enzyme including were SOD, catalase and glutathione peroxidase in the mid brain activity. CB significantly increased the concentration of dopamine and homovanillic acid in the brain. These results suggest that the anti-parkinsonism effect of CB is possibly due to the antioxidative effects at mid brain in MPTP-induced animal model.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.1
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• pp.144-147
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• 1997

For the investigation of antitumor agents, two kinds of sesquiterpene lactones were isolated and purified from Chrysanthemum boreale M. and designated as Compound I and ]U . And then in vivo antitumor test of the sesquiterpene lactones was carried out against ICR mice. In vivo test against Sarcoma180 implanted ICR mice, life prolongation effects of Compound I and II were showed as 143% and 134% at the dose of 10mg/kg, respectively. Besides, at the tested group mixed Compound I and II each 1mg/kg was showed rather high life prolongation effect as 158%.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.10 no.4
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• pp.259-265
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• 1977

After a great mortality owing to abnormal oceanographical condition and fungal disease in 1973 hanging cultch lines per raft has been reduced to 450 from 558, and oyster production per raft has also been decreased. It seems to be result of dense culture of oysters and its resulting accumulation of waste materials on the sea bottom in the farm area. The present study was carried out to investigate the effect of rearing density and the degree of eutrophication in Geoje Bay for 6 months from June through November in 1977. Total area of this bay is about $48.9\;km^2$, and the area of registered oyster farms as of November in 1977 is around $10.9\;km^2$, which is about $22.3\%$ of this bay. Water Quality during summer season was shown as transparency 5.5 m, COD 1.5ppm, degree of oxygen saturation $90.6\%$ in upper and middle layers and $82.2\%$ near bottom, chlorophyll-a 3.0 mg/m^3, and phytoplankton $8.7\times10^4\;cells/l$. In superficial mud in August COD was 35.4 mg/g, total sulphide 0.24 mg/g, and phaeophytin $43.7\;{\mu}g/g$dry mud. These values indicate that water qualify in this bay is so far excellent but quantities of chemical oxygen demend and sulphide in bottom mud show maximum level or a little over eutrophication standard.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.31-37
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• 2011

Objectives : Chrysanthemum boreale flower is widely distributed in Korea, Japan, China, and Eastern countries. C. boreale flower is also one of the herbs used for the treatment of various inflammatory disease in Korean Medicine. So, this research was designed to study anti-inflammatory effect of C. boreale flower and its mechanism. Methods : We investigated nitro oxide (NO) and prostaglandin $E_2$ ($PGE_2$) production by ELISA. And expressions of inducible nitric oxide synthase (iNOS), Cyclooxygenase-2 (COX-2) and nuclear factor-${\kappa}B$ P50/65 (NF-${\kappa}B$ P50, NF-${\kappa}B$ P65) were measured in RAW 264.7 murine macrophage cells induced by LPS. Results : MeOH ex., EtOAc fr., $CHCl_3$ fr. and Water fr. of C. boreale flower showed anti-inflammatory effect through inhibition of NO and PGE expression respectively. Among them, EtOAc fr. and $CHCl_3$ fr. inhibited production of NO and $PGE_2$ through inhibition of iNOS and COX-2 expression. And MeOH ex., EtOAc fr. and $CHCl_3$ fr. inhibited translocation of NF-${\kappa}B$ P65, NF-${\kappa}B$ P50 by inhibiting phosphrylation of $I{\kappa}B$. Conclusions : MeOH ex. EtOAc fr, $CHCl_3$ fr., and Water fr. of the C. boreale flower have anti-inflammatory activity.

• Korean Journal of Medicinal Crop Science
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• v.8 no.4
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• pp.342-350
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• 2000

This study was carried out to screen antioxidative by in vitro bioassay method from 89 Korean natural sources extracted by 100% MeOH. Antioxidant activity test was used the DPPH method. MeOH extracts from Castanea crenata and Ulmus davidiana var. japonica showed high antioxidant activity by $5.8{\mu}g\;(RC_{50})$ and $12.2{\mu}g\;(RC_{50})$, respectively, among 13 plants exhibiting the activity. The extracts from Platycarya strobilacea, Lindera erythrocarpa, Chrysanthemum boreale, Rumex crispus and Viburnum awabuki also showed over 90% antimicrobial activity, according to in vivo bioassay method.