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주충노;곽한식
- Journal of Ginseng Research
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- v.7 no.2
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- pp.108-114
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- 1983
1. To know the site of saponin synthesis in this plant, 4-years old Panax ginseng C.A. Meyer was administered with 1, 2-l4C-acetate (Na salt, 10 ucilplant) by stem injection and was continued to grow for 3 weeks and the distribution of the radioactivity in leaf, stem and root part was identified. The percentage of radioactivity recovered was about 3.99%. 2. The sliced roots or leaf discs (2g) were bathed in the reaction mixture containing sugar, ATP, NADPH, and the distribution of the radioactivity of the fractions (sugar, saponin, sapogenin) was identified. 3. It seemed that major synthesized saponins in roots and leaves are dial and triol-type, respectively. Although both types of saponins are synthesized in roots, the main saponins seemed to be dial saponins and a significant portion of triol saponins are supplied from leaves through stem.
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박창진;이동권
- Journal of Ginseng Research
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- v.5 no.1
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- pp.49-55
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- 1981
The effects of total, protopanaxadiol-and protopanaxatriol-saponins on the in vitro activities of several enzymes in rat serum were observed Alkaline phosphatase activity was increased 61 % by total saponin and 46% by protopanaxatriol-saponin, compared to control group. While SCOT activity was slightly decreased by total saponin and protopanaxatriol- saponin, it was slightly increased by Protopanaxadiol-saponin And while SCPT activity was slightly decreased by total saponin, it was increased by protopanaxadiol-saponin and protopanaxatriol-saponin. Creatine phosphokinase activity had a tendency to be increased by protopanaxatriol-saponin. Lactate dehydrogenase activities were increased in three saponin treated groups, but those were nonignificant. Compared to the control group, lipase activity was increased by all saponin samples. It was increased 157% by total saponin The increase in lipase activity by total saponin corresponded with the decrease in serum t total lipid by total saponin .
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Kwak, Hahn-Shik
- The Journal of Natural Sciences
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- v.4
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- pp.29-58
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- 1991
Ethanol은 섭취량에 따라 간 대사에 여러가지 영향을 미치는 것으로 알려져 있다. 과량의 ethanol 섭취가 유해한 것은 ethanol 그 자체보다는 산화과정에서 생성된 acetaldehyde와 과량의 수소(NADH)에 기인한다. 과량의 NADH는 간 세포의 화학적 평형을 저해하고 대사이상을 초래한다. 본 연구에서는 in vitro 뿐만 아니라 in vivo에서 alcohol dehydrogenase(ADH), aldehyde dehydroge-nase(ALDH), microsomal ethanol oxidizing system(MEOS)에 미치는 인삼 사포닌의 영향을 조사하고, 간에서의 수소 평형, 간에서의 $[1^(-14)C]$-ethanol의 분포, ethanol의 acetaldehyde와 lipid로의 전환 등을 관찰하였다. 인삼 사포닌은 상기 효소외에도 ethanol 대상에 관련된 다른 효소들의 활성을 증가시키는 것으로 관찰되었으며 이는 동물 체내로부터 acetaldehyde와 과량의 수소를 신속히 제거하는 것으로 사료된다.
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