• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.7-13
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• 2020

This paper focuses on detecting abnormal patterns of respiration of humans. In this study, a contact-based device was used to acquire both normal and abnormal respiration signals. To this end, this paper reports the development of a monitoring system to investigate the respiratory status of humans in a normal environment. This work aims to classify the respiratory status, i.e., normal and abnormal status, quantitatively. The respiration signal is acquired using a contact-based medical device (BIOBPAC), and noise reduction is carried out before classifying the respiratory status. To reduce noise, a mixed filter that combines the Savitzky-Golay filter and Median filter is applied to the acquired respiration signals. The inter-class distance is maximized, and the intra-class distance is minimized. The proposed algorithm is straightforward and can be applied to a practical environment. In addition, the experimental results are provided to substantiate the proposed approach.

• Journal of Korean Medical classics
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• v.18 no.1 s.28
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• pp.121-136
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• 2005

통적연구진사탁적장부오행병리급잡병오행병리적운용연구(通適硏究陳士鐸的臟腑五行病理及雜病五行病理的運用硏究), 득출이하결론(得出以下結論) : 진사탁인위진관폐금극간목(陳士鐸認爲盡管肺金克肝木), 단시약간중지화왕성(但是若肝中之火旺盛), 칙폐무법극간차치간화극토사장토수손(則肺無法克肝且致肝火克土使將土受損), 종이사비위무법생금이치폐금갱가쇠약(從而使脾胃無法生金而致肺金更加衰弱), 폐불능생수이수무법극화(肺不能生水而水無法克火), 도치상중하삼초지화균과왕(導致上中下三焦之火均過旺). 타인위간희소설(他認爲肝喜疏泄), 당약울체회사기극비위(?若鬱滯會使其克脾胃), 비위수극칙토극수(脾胃受克則土克水), 이신수손무법생목(而腎受損無法生木), 사간울갱심심화무법화생(使肝鬱更甚心火無法化生), 차폐역무법극목(且肺亦無法克木). 차시(此時), 응이해울법내치료(應以解鬱法來治療). 타인위수연토극수(他認爲雖然土克水), 단시토생수여금생수적관계갱위밀절(但是土生水與金生水的關係更爲密切), 이폐여신우위밀절차유상생적관계(而肺與腎尤爲密切且有相生的關係), 고지유신중지수충족(故只有腎中之水充足), 방가수화기제(方可水火旣濟). 타인위심위군화시유형지화(他認爲心爲君火是有形之火), 가용수극지(可用水克之), 이신중지화위무형지화(而腎中之火爲無形之火), 차가양수(且可養水). 타인위명문지화가생비토(他認爲命門之火可生脾土), 단약과왕칙무법생비토반이극토(但若過旺則無法生脾土反而克土). 차시(此時), 여기직접보신수(與其直接補腎水), 불여보폐금사금생수(不如補肺金使金生水), 차위보수적근본지법(此爲補水的根本之法). 진사탁재설명오장적병리기제시인위(陳士鐸在說明五臟的病理機制時認爲), 오장지화과왕칙회사상생관계변성상극관계(五臟之火過旺則會使相生關係變成相克關係), 이적의적화칙능유지정상적상생관계(而適宜的火則能維持正常的相生關係), 차즉사화불족역가유지상생(且卽使火不足亦可維持相生). 진사탁인위제료외감(陳士鐸認爲除了外感), 기호소유적잡병도이장부오행적상생(幾乎所有的雜病都以臟腑五行的相生), 상극(相克), 이급상관적관계위중심내설명료기병리(以及相關的關係爲中心來說明了其病理), 저일점성위료기학술사상적중요특점(這一點成爲了其學術思想的重要特點).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.6
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• pp.2859-2865
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• 2011

The welded connection is known as an essential factor for establishing qualified construction and/or maintenance of wrapped steel pipe. In this study, welded connection conditions in the coated pipes with large diameter (over 700 mm) in Korea water distribution systems were estimated for suggesting technically and economically available welded connection method. For the study analysis, current steel pipe usage and accident cases were investigated. In addition, the characteristics of each welded connection method and automatic or manual connection techniques were also compared and estimated. As results, automatic welded connection method is superior than manual welded connection method in aspect of pure construction cost (average 9%) or pure welded connection cost (average 13.5%). When the poor welding-working situations in Korea are considered such as high tolerance of out-of-roundness in KS regulation, a number of lap joint welded connections, the real cost benefits of automatic welded connection should be much higher than those of manual welded connections.

• The Journal of Korean Medicine
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• v.29 no.4
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• pp.146-160
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• 2008

Objectives: The present study was designated to evaluate the direct effects of Fructus Liquidambaris on suppression of eosinophil activity and on suppression of chemokines such as eotaxin, IL-8, ICAM-1, and VCAM-1, in vitro. Methods: A549 cells were stimulated with TNF-$\alpha$ (100 ng/ml), IL-4 (100 ng/ml) or IL-$1{\beta}$(10 ng/ml) to induce chemokines and adhesion molecules involved in eosinophil chemotaxis. Then after treatment of Fructus Liquidambaris, inhibition effect assay such as ELISA, real-time RT-PCR, and chemotaxis assay was performed. Results: Eotaxin level was suppressed in both protein secretion and mRNA expression. Eosinophil recruitment to lung epithelial cells was also reduced by Fructus Liquidambaris, implying the role of eotaxin in eosinophil recruitment. In addition, expression of IL-8 was also suppressed by Fructus Liquidambaris (p<0.05). However, expression of adhesion molecules (ICAM-1, VCAM-1) related to eosinophil was not affected. The eosinophil migration was inhibited at high concentration of Fructus Liquidambaris (p<0.05). Conclusion: These results suggest that Fructus Liquidambaris may regulate a common signaling pathway of eotaxin and IL-8. FS might be of therapeutic value in diseases such as asthma.

• Journal of Acupuncture Research
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• v.20 no.4
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• pp.93-101
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• 2003

Objective: The purpose of this study is to find out the effect of acupuncture at HT7 (Shinmun) on the feeding behavior and hypothalamic neuropeptide Y(NPY) expression in the maternally separated rat pups. Methods: To show the effect of acupuncture, we performed maternal separation(MS) for 7 days beginning on postnatal day 14, and observed body weight, food intake, and NPY immunoreactivity in the paraventricular nucleus (PVN) of hypothalamus after acupuncturing at HT7, the end of the transverse crease of the ulnar wrist of the forepaw. Results: MS induced a significant decreases in body weight and food intake, while acupuncture treatment at acupoint HT7 showed much more improvement in those evaluations. NPY-immunoreactivity in area PVN were decreased in the MS group, but significantly increased in the HT7 group. Conclusions: These findings suggest that acupuncture has an effect on the feeding disorders caused by MS, possibly by modulating NPY expression in the PVN.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.211-219
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• 2008

목적 : 전통적으로 태충($LR_3$)과 양릉천($GB_{34}$)은 운동기능과 관련된 질환에 사용되어 왔다. 우리는 두뇌에 신경독을 주입하여 파킨슨병 쥐모델을 제작하였고, 쥐는 운동기능이 손상되고 도파민성 신경세포가 선택적으로 소멸하였다. 병증 모델 쥐에게 태충과 양릉천에 자침한 결과 운동기능이 개선되고 신경세포보호효과가 나타남을 관찰한 바 있다. 이에 실제로 태충과 양릉천에 자침하여 운동기능과 관련된 추체외로 영역에서 신경의 활성화가 나타나는지를 fMRI를 통하여 관찰하였다. 방법 : 자침은 수기침을 선택하였으며, 혈위는 (1) 태충, (2) 양릉천, (3) 태충+양릉천의 세군데를 설정하였고, 자침에 대한 대조자극으로 피부자극을 채택하였다. fMRI 스캐너는 3T를 사용하였고 뇌신경 활성화의 신호는 BOLD(blood-oxygen-level dependant)를 관찰하였다. 두뇌에서 관찰부위는 중뇌를 중심으로 추체외로로 한정하였다. 결과 : 태충에 자침하였을 때 두뇌의 substantia nigra, subthalamic nucleus, red nucleus, pons 등이 활성화 되었다. 양릉천에 자침하였을 때 substantia nigra, subthalamic nucleus, caudate nucleus, thalamus가 활성화 되었다. 태충과 양릉천에 동시에 자침하였을 때는 substantia nigra, subthalamic nucleus, red nucleus, globus pallidus가 활성화되었다. 대조자극에 의해서는 위의 영역들이 활성화되지 않았다. 결론 : 태충, 양릉천, 태충+양릉천 자극은 대뇌에서 추체외로 영역을 활성화시키며 특히 substantia nigra의 활성화는 파킨슨병과 같은 질환의 조절가능성을 시사한다.

• Journal of Acupuncture Research
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• v.24 no.6
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• pp.195-206
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• 2007

Objectives : The aim of this study is to investigate the safety of Acupuncture needles made from duplex stainless steel. Methods : In order to check the safety concern of the DSS Acupuncture needle, we employed biochemical measures, DSS and SS304 Acupuncture needles were tested for pH level, heavy metals and UV absorbance spectrum along with cytotoxicity and hemolysis. As a guideline, we have referred to the 'standards for acupuncture needles', 'standards for disposable needles' and 'standards and experimental procedures for stents' for the Korean Food & Drug Administration(KFDA). Results & Conclusions : The DSS Acupuncture needle extract satisfied these requirements. There was no significant difference between the DSS and SS304 Acupuncture needle extract. In conclusion, the DSS Acupuncture needle displayed biochemical safety.

• Applied Chemistry for Engineering
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• v.8 no.3
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• pp.446-453
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• 1997

The initial product was prepared by heating for 3 hrs at $1000^{\circ}C$ using a mixture of the rutile sand and industral $K_2CO_3$ in the molar ratio 2.0. And the intermediate product, fibrous potassium tetratitanate of layer structure, was obtained by the boiling water treatment of 10hrs for initial product using the calcination method. Also $KHTi_4O_9{\cdot}1.1H_2O$ was synthesized by ion exchange reaction through the acid treatment for 30 min at 0.005M HCl solution and then $K_2Ti_8O_{17}$ whisker of $length=10{\mu}m$, $diameter=0.2{\mu}m$ was synthesized by heat treatment at temperature range of $400{\sim}600^{\circ}C$.

• The Journal of Korean Medicine
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• v.27 no.1 s.65
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• pp.57-77
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• 2006

Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that more experiments, especially on their sample sizes, are needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

• The Journal of Korean Medicine
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• v.22 no.2
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• pp.109-119
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• 2001

Objective : There are many reports that acupuncture has thermoregulatory effects on human and animals. To investigate the effect and mechanism of antipyretic action of acupuncture, we observed the body temperature and cytokine expressions in the hypothalamus of rats. Methods : Lipopolysaccharide (LPS, i.p., 2.5mg/kg) was injected to conscious rats (Sprague-Dawley, male, n=4l) to cause hyperthermia and simple needling (stainless steel, 0.25 mm o.d., 5 mm insertion for 10 sec with no manipulation) was performed bilaterally with the measurement of rectal temperature. Next, we sacrificed rats to remove brain and determined the level of mRNA for interleukin-6 (IL-6), $interleukin-1{\beta}{\;}(IL-1{\beta})$, interleukin-2 (IL-2) and $interferon-{\gamma}{\;}(IFN-{\gamma})$ in the hypothalamus by using reverse transcriptase-polymerase chain reaction (RT-PCR). Resul1s : Needling on forepaw (acupoint HT8) and needling on hindpaw (acupoint BL66 and acupoint LR2) significantly inhibited LPS-induced fever of rats (P<0.01, 10 min after treatment respectively), but same treatment on proximal tail (non-acupoint) did not cause any change on fever. The levels of IL-6 and $IL-1{\beta}$ mRNA in the hypothalamus was significantly enhanced by LPS-injection, while the level of IL-6 and $IL-1{\beta}$ mRNA was markedly reduced after treatment on BL66 (P<0.01). Treatment on forepaw reduced it slightly, but not significantly. Equivalent stimulation on proximal tail did not cause any changes. Conclusions : Our results indicate that acupuncture stimulation on various body parts has differential thermoregulatory effects on LPS-induced fever of rats with site-specificity. And, we suggest that its antipyretic action might be accompanied with the suppression of hypothalamic production of pro-inflammatory cytokine of immune system, IL-6 and $IL-1{\beta}$.