• Development and Reproduction
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• v.6 no.1
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• pp.31-35
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• 2002

The major urinary proteins(MUPs) of mice that bind hydrophobic molecules known as pheromones are regulated in part by the actions of growth hormone. The expression of the MUPs was therefore investigated in transgenic mice that express a human growth hormone-releasing factor gene from a metallothionein gene promoter(MT-GRF) and as a result have elevated growth hormone levels. MUPs were severely down-regulated in the urine of these animals compared to normal mice or to control transgenic mice expressing another gene(the inhibin a subunit) from the same metallothionein promoter(MT-Inh) and more MUPs disappeared in male mice than female ones. MUPs were also down-regulated in the urine of the UT-GRF-injected mice. In addition, it was observed that the urine of the MT-GRF mice included a high molecular weight protein that co-migrates with the major serum protein albumin, indicating an impairment in glomerular filtration within the kidney. The urinary loss of serum proteins was more severe in male MT-GRF mice than female ones. Thus the overexpression of human GRF mimics changes observed in MUP protein expression and glomerular function in other models of growth hormone hypersecretion with sex-dependent differential effects.

• Journal of the Korean earth science society
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• v.32 no.3
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• pp.265-275
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• 2011

The Hamo and Hyeopjae beaches in the western part of Jeju Island were studied in terms of seasonal variations of surface sediment and beach profile. Seasonal drift direction of the beach sands also was investigated. The Hamo beach of $7.3^{\circ}-10.8^{\circ}$ steep is composed of medium sand containing volcanic clasts and shell fragments. The Hyeopjae beach of $2.8^{\circ}-6.5^{\circ}$ steep is composed of coarse shelly sand. Hamo beach deformation is probably caused by the jetties constructed in the western part of the beach. In the Hyeopjae beach, surface sands were drifted into the dune side by the northwestern stormy wind during winter season.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.12 no.1
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• pp.19-26
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• 2000

A numerical model is applied for predicting two-dimensional beach and dune erosion during severe storms. The model uses equation of sediment continuity and dynamic equation, governing the on-offshore sediment transport due to a disequilibrium of wave energy dissipation. And the model also uses sediment transport rate parameter K from dimensional analysis instead of that recommended by Kriebel. During a storm, a beach profile evolves to a form where the depth at the surf zone is related to the distance seaward of the waterline. In general, the erosion in the beach profile is found to be sensitive to equilibrium profile parameter, sediment transport rate parameter, storm surge level and breaking wave height.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.245-251
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• 2020

From the perspectives of grammaticalization and corpus, the purpose of this study is to examine the motivation of the emergence of the split infinitives in American English and to discuss the justification of the split infinitives based on the corpus empirical data such as COHA and COCA. The formerly ungrammatical split infinitives in the form of [to + adverb + verb] are now definitely grammatical forms in Present Day English (PDE). The corpus-based data confirms the legitimacy of the split infinitives with the empirical reasons like clarifying sentences (i.e., disambiguation) or strongly focused readings. In addition, the split infinitives are natural consequences caused by the grammaticalization of an infinitival particle to and most crucially by the loss of verb movement. When verb movement to T position does not occur in infinitival clauses, the word order results in [to + AdvP + V], thus forming the split infinitives. The split infinitives are no longer a matter of discussion and will continue to increase in both formal and informal contexts as being definitely grammatical forms.

• Journal of the Korean Geographical Society
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• v.46 no.6
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• pp.693-706
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• 2011

The Geomorphological properties and ages of river-mouth bar at Song-cheon River in the East Coast of Korea, Yeongdeok-gun, Gyeongbuk Province are estimated, and the long-term and short-term changing processes and causes are analyzed. Sand grains of the bar near the coastline show the finer trends from south to north and these can be attributed to the northward movement of waves and long-shore currents. The absolute ages of bar and nearby coastal sand dune are less than approximately 100 years ago, indicating that the bar has experienced the active geomorphological changes. While the inlet located at south part of the bar between 1971 and 1995, the inlet has located at north or middle part since 1995. These may caused by the changes of movement directions of waves and long-shore currents due to the apparent northward movements of winds and currents. In short-term, the higher elevation, larger area, simpler landform relief and more variable location of inlet and morphology of bar can be observed between September and March due to the dominance of sedimentary processes by wave and wind processes.

• Childhood Kidney Diseases
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• v.14 no.2
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• pp.132-142
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• 2010

Hypokalemia usually reflects total body potassium deficiency, but less commonly results from transcellular potassium redistribution with normal body potassium stores. The differential diagnosis of hypokalemia includes pseudohypokalemia, cellular potassium redistribution, inadequate potassium intake, excessive cutaneous or gastrointestinal potassium loss, and renal potassium wasting. To discriminate excessive renal from extrarenal potassium losses as a cause for hypokalemia, urine potassium concentration or TTKG should be measured. Decreased values are indicative of extrarenal losses or inadequate intake. In contrast, excessive renal potassium losses are expected with increased values. Renal potassium wasting with normal or low blood pressure suggests hypokalemia associated with acidosis, vomiting, tubular disorders or increased renal potassium secretion. In hypokalemia associated with hypertension, plasam renin and aldosterone should be measured to differentiated among hyperreninemic hyperaldosteronism, primary hyperaldosteronism, and mineralocorticoid excess other than aldosterone or target organ activation. Hypokalemia may manifest as weakness, seizure, myalgia, rhabdomyolysis, constipation, ileus, arrhythmia, paresthesias, etc. Therapy for hypokalemia consists of treatment of underlying disease and potassium supplementation. The evaluation of hyperkalemia is also a multistep process. The differential diagnosis of hyperkalemia includes pseudohypokalemia, redistribution, and true hyperkalemia. True hyperkalemia associated with decreased glomerular filtration rate is associated with renal failure or increased body potassium contents. When glomerular filtration rate is above 15 mL/min/$1.73m^2$, plasma renin and aldosterone must be measured to differentiate hyporeninemic hypoaldosteronism, primary aldosteronism, disturbance of aldosterone action or target organ dysfunction. Hyperkalemia can cause arrhythmia, paresthesias, fatigue, etc. Therapy for hyperkalemia consists of administration of calcium gluconate, insulin, beta2 agonist, bicarbonate, furosemide, resin and dialysis. Potassium intake must be restricted and associated drugs should be withdrawn.

• Analytical Science and Technology
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• v.18 no.4
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• pp.271-277
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• 2005

Urea in blood has been measured as an effective marker for diagnosis of renal function. Urea which is e end-product of nitrogen containing metabolites such as proteins is filtered through glomeruli of kidneys and then excreted as urine. If the renal function is deteriorated, the urea concentration in blood will be increased, from which the healthiness of renal function is judged. In order to improve the confidence of diagnosis results, the results must keep traceability chain to certified reference materials, which was certified by primary reference method. In this study, we proposed isotope dilution-liquid chromatography/mass spectrometry (ID-LC/MS) as a candidate primary method, in which $15^N_2$-urea is used as an internal reference material. The developed method is highly accurate in principle and is convenient as it does not require cumbersome derivatization. 0.1 mmol/L ammonium chloride was selected as a mobile phase for HPLC because it provided low interference in MS analysis of relatively low molecular weighted urea. HPLC and MS were connected with an electrospray ionization (ESI) interface of positive mode, which provided high sensitivity and reproducibility. The developed method was validated with internationally recognized reference materials, and we have obtained satisfactory results in an international ring trial. The expanded uncertainty calculated according to ISO guide was 1.8% at 95% confidence interval. The developed method is being used as a primary reference measurement method such as for certification of serum certified reference materials (CRMs).

• Journal of Korea Foresty Energy
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• v.23 no.2
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• pp.1-8
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• 2004

This study looked into the change of tree growth of seven forest growth monitoring plots which were set up at the Undulyeong Hongchungun Kangwondo, and was accomplished to offer the basic data for the forest administration calculating carbon storage and removal in the Undulyeong area. Annual height and DBH growth were slowly progressed in the Pinus koraiensis and Larix kaempferi stand which was young stand, but the growth rate of the other stands was lower than those young stand. The diameter class of the mixed forest and Qurcus mongilica stand was predicted to be similar to the now and Pinus koraiensis and Larix kaempferi stand was predicted to move now diameter class to the high diameter class because thickening growth speed of the those stands were rapid. Now the end of 2003, total carbon storage of the Undulyeong model forest increased 149,000TC$(2.7\%)$ compared with the previous year. Seeing by forest types, occupied broad-leaved forest$(50\%)$, mixed forest$(34\%)$ and coniferous forest. During in 2003, total carbon which was removed and stored according to growth of the forest was 156,813TC and net carbon removal(148,664TC) increased into 2,613TC$(1.8\%)$ compared with the previous year. Seeing by forest types, occupied coniferous forest$(3.3\%)$, mixed forest$(3.1\%)$, broad-leaved forest$(2.8\%)$. Resultingly, the Undulyeong model forest is acting to net removal resource when see as green-gas side and net carbon removal are showing the tendency to increase recently little by little.

• Journal of The Geomorphological Association of Korea
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• v.19 no.2
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• pp.123-132
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• 2012

In this study, we analyzed sedimentation and erosion environment around Halmiseom on Anmyeon Island using wind direction and wind speed data, gain size analysis data and datum-point measured values. To observe changes in sedimentation and erosion environment around Halmiseon, we installed datum points at 12 locations around Halmiseom and carried out at total of 32 field measurements from May 16th, 2010 to May 8th, 2012. The field measurement results showed that H-3, H-4, H-5 and H-9 points are dominated by sedimentation environment, and H-7, H-8, H-10, H-11 and H-12 points are dominated by erosion environment. Meanwhile, sedimentation and erosion appeared alternately at H-2 and H-6 points. These results indicate that a bank installed in the southwest side of Halmiseom prevented sand of the beach from moving to the northeast side, leaving the sand of the beach being deposited at the sites, and the northeast side, where sand was not provided from beach ridge of Halmiseon was dominated by sedimentation. That is, the southwest side of Halmiseom was dominated by sedimentation, but the northeast side was dominated by erosion in general. However, the opposite trends were observed at H-9 point of the northeast side and H-12 point of the southwest side. According to analysis, since H-9 point is located at the end of sand spit connected to Halmiseom, the supply of sediments by a tidal current is possible. On the other hand, it was difficult to analyze the cause of erosion in case of H-12 point located at the sand dune due to the short measurement period.

• Economic and Environmental Geology
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• v.41 no.2
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• pp.243-252
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• 2008

The Iho and Hamdeok beaches, the major coastal beaches in Jeju Island, have been studied through size analysis and using an experimental extension pole and sediment trap in beach profile, in order to understand their textural characteristics, migration patterns, and seasonal change in beach geometry. The Iho beach is composed of coarse and medium sands, 590 m in total length. The foreshore slope is 12.3$^{\circ}$ in summer and 10.8$^{\circ}$ in winter, which shows more steeper in summer. The Hamdeok beach consisting mostly of shell fragments is 950 m long, $5.7{\sim}7.4^{\circ}$ steep and 97.4${\sim}$114.5 m wide, respectively. The suspended load drift concentrations in the studied beaches showed 4.5 mg/l during the period of summer and 33.2 mg/l in winter, and those of fine-grained sediments are derived mostly from the marine of northeastward direction. The typical beach transformation of the Iho beach is resulting from the construction of jetties in the west side that built up the sand inside the jetties, whereas the erosion is occurring on the east side of beach. The center and berm sides of the sand in the Hamdeok beach drift into the dune side during the period of the stormy winter season.