• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.159-160
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• 2019

2차 세계대전 당시 독일에 의한 유대인 학살은 인류 역사상 가장 참혹한 만행으로 알려져 있다. 이같은 비극적 과거를 되풀이 하지 않기 위해 세계 곳곳에 이와 관련된 박물관들이 건립되어 희생자를 추모하고, 잊지 않게 하고 있다. 대표적인 곳이 유대인의 본거지인 이스라엘의 예루살렘, 독일의 심장부인 베를린, 그리고 세계 정치의 중심인 미국 워싱턴 DC에 있는 홀로코스트 뮤지엄들이다. 이 발표에서는 각각의 박물관들의 입지가 갖는 메시지와 전시콘텐츠들이 갖는 특성들을 분석해 보고자 한다. 이를 통해 과거사에 대한 기억과 반성이라는 역사교육에 있어서 중요한 사안 해결방안의 일단을 찾아보고자 한다.을 통해 평화와 화해를 이루고자 하는 세계인들의 노력에 대해 이해를 하고자 한다.

• Journal of Korean Philosophical Society
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• v.145
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• pp.297-324
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• 2018

This paper aims to reconstruct the theme of the crisis of modernity and its overcoming possibility as one of the most intense implications of Nietzsche philosophy on the theme of "love". It analyses Nietzsche's statements about love, from the onset of physical desire for the opposite sex, through the forms of religiously distorted love, such as compassion and charity, to the amor fati as the positive affirmation of life. For Nietzsche, love is basically an urge to grow out of the possessive craving for power. The impulse of love is part of life, because it is willpower that makes man. Christianity, which linked sexual impulses to sin, made eros immoral. Nietzsche says we must overcome Christian love, which intends to deny human nature and reality and superimpose other ideals, and learn to love beyond itself. In the Nietzsche philosophy, it is the love of one's fate.

• The Korean Society of Law and Medicine
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• v.23 no.4
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• pp.3-28
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• 2022

Recently, the targets and clauses of negotiation between 'National Health Insurance Service (NHIS)' and Pharmaceutical companies has been expanded. Due to newly adopted 'Quality management clause', 'Compulsory supply maintenance clause' and 'Penalty for breach of contract clause', not only 'Ministry of Health and Wellfare (MOHW)'s 'drug listing' and 'Price cap' announcement, but also 'negotiation between NHIS and pharmaceutical companies' can be a legal sanction to the suppliers. Once secretary of MOHW order NHIS to negotiate with pharmaceutical company, NHIS notify this order to the company and enter into the negotiation. 'The order' exists in the public domain between the government (MOHW) and public institutions (NHIS) and does not constrain the legal rights of companies (Therefore companies cannot pile a lawsuit about the order). However, 'the notice' or 'negotiation' is an act which has a counterpart, can be a target of administrative litigation if the company get some disadvantages from the talks. Negotiations can be divided into four types according to "the target (whether it is listed on the insurance benefit list)" and "the purpose (whether the target is price or conditional)." In particular, negotiations on listed drugs, whose goal is to set unfavorable conditions for companies, can be illegal if there is no price. So we need to consider compensation for the company as an incentive to negotiate.

• The Journal of Korean Medical History
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• v.12 no.2
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• pp.147-167
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• 1999

1. 연구 목적 한국의학사(韓國醫學史)의 한 분야인 식품사(食品史) 및 약물사(藥物史)는 미개척분야라 해도 과언은 아닐 정도로 연구 업적이 부족하다. 특히 식물명칭에 대한 정리는 기초학문이지만 방치되어진 것도 부인할 수 없다. 따라서 본고는 식품문화사(食品文化史)를 정리하는 과정중의 일환으로 고추의 어원(語源)을 중심으로 살펴보고자 한다. 이는 식품사(食品史) 연구에 도움이 되는 동시에 체질식이요법을 강조하는 사상의학(四象醫學)의 식품 분류에 대한 학술적 근거를 제시하는 계기로 삼고자 한다. 1493년 콜럼버스에 의해 알려진 고추는 우리 나라에 들어와 천초(川椒)대신 사용됨으로서 현재 중요한 양념이 되었다. 이에 고추의 도입과정과 호칭변화를 살펴봄으로서 현재 사전류에서 잘못 서술되고 있는 것을 시정하고, 고추가 도입된 이래 우리가 어떻게 이해하고 응용하였는 지에 대하여 문헌고찰을 통하여 의학사적(醫學史的) 입장으로 정리하는 것이 본 연구의 목적이다. 2. 연구 방법 "산림경제(山林經濟)"(1715), "임원경제지(林園經濟志)"(1827)같은 농서(農書), "물명고(物名考)"(1830), "오주연문장전산고(五洲衍文長箋散稿)"(1850) 같은 유서(類書), "훈몽자회(訓蒙字會)"(1527), "신증유합(新增類合)"(1574)같은 사전류, "지봉유설(芝峰類說)"(1614), "성호사설(星湖僿說)"(1763)같은 문집류, "흠정수시통고(欽定授時通考)"(1737), "본초강목습유(本草綱目拾遺)"(1765)같은 중국본초서(中國本草書) 등과 국내의서 등 을 통하여 고추에 대한 문헌정리를 시도하였다. 3. 연구 결과 고추가 도입된 이래 남만초(南蠻椒), 남초(南椒), 번초(番椒), 왜초(倭椒), 왜고초(倭苦椒), 왜개자(倭芥子), 고초(苦椒), 랄가(辣茄), 고쵸, 등으로 표기되어 왔다. 하지만 고추가 도입되기 전에 출간된 "구급간이방(救急簡易方)"(1489)에 '초(椒) 고쵸, 죠피'라는 기록이 나온다. 이는 천초(川椒)(초피나무)를 의미하는 '고쵸'로 보아야 한다. 후에 고추가 도입됨에 따라 의미가 변하여 고추를 의미하게 되는데 이를 정리하면 다음과 같다. 첫째, 현존하는 문헌 중 고추에 대한 최고기록인 "지봉유설(芝峰類說)"(1614)에 근거하여 고추(남만초(南蠻椒))는 임진왜란때 일본에서 도입되었다는 것이 정설이었다. 하지만 임진왜란 이전에 일본을 통하여 고추가 도입되었고 이의 개량종을 오히려 임진왜란때 일본으로 전해주었을 가능성이 높다. 둘째, 현재 대부분의 사전류에서 "훈몽자회(訓蒙字會)"(1527)의 '고쵸 쵸(초(椒))'를 고추에 대한 최초의 어원으로 보고 있으나 이는 잘못된 것이다. "훈몽자회(訓蒙字會)"의 '고쵸(초(椒))'는 고추가 아닌 매운 열매의 총칭으로 호초(胡椒), 천초(川椒), 진초(秦椒)를 의미한다. 이는 "구급간이방(救急簡易方)"(1489)의 천초(川椒)를 의미하는 '초(椒) 고쵸'에서도 확인할 수 있다. 셋째, 현재 대부분의 사전류에서 고추의 한문표기가 고초(苦草)로 되어 있으나 고초(苦椒)로 정정되어져야 한다. 초(草)(상성(上聲))와 초(椒)(평성(平聲))는 발음은 같지만 성조(聲調)가 다르며, 또한 "본사(本史)"(1787)에 고초(苦椒)와 고초(苦草)는 서로 다른 식물로 기록되어 있다. 넷째, 고초(苦椒)는 '고쵸'라는 우리말에 맞추어 만든 국자(國字)로 고추가 천초(川椒)와 비슷하지만 맵고 쓰다라는 뜻으로 사용된 것이다. 다섯째, 맵고 뜨거운 성질이 있는 고추는 냉증(冷症)을 유발시킬 수 있는 냉성(冷性)야채를 중화(中和)시키는 작용을 한다. 여섯째, 고추는 소음인 식품의 경향성을 띈 훈채류에 속한다.

• The Magazine of the IEIE
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• v.39 no.7
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• pp.54-61
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• 2012

우리 몸에서 가장 중요한 것은 얼굴과 두 눈이고, 아름다움도 얼굴에서 나온다. 세상에서 가장 아름다운 여인으로 서양에서는 클레오파트라(Cleopatra)이고, 동양은 양귀비(楊貴妃, 719~756)를 대표적 예로 든다. 미국 캘리포니아 대학의 Zadeh 교수는 강의 시 휴식시간에 '어느 교수의 부인이 아름다운가?' 라는 농담을 하면서 제일 예쁜 여자는 A그룹, 그 다음은 B 그룹 등으로 구분하는데 착안하여 Fuzzy 개념을 발견(1965)하였고, 그 후 연구계 및 산업체에서 이 이론을 확장해 퍼지세탁기, 퍼지냉장고 등이 가전 시장을 석권한 바 있다. 한편, 2004년 미국 하버드대 기숙사에서 친구와 함께 재미삼아 페이스북을 만든 마크 저커버그(28). 여자친구의 사생활을 여기에 올려 이별의 아픔을 맛보기도 했던 그가 8년 만에 세계적 282억 달러의 부호가 됐다. 세계 인터넷업계가 가슴을 졸이며 기다려온 페이스북의 기업공개(IPO 주식상장)를 통해서다. 1783년 스위스 수학자인 오일러(Euler, 1707~1783) : 학문적으로 방대한 업적을 남긴 만큼 오일러의 인생도 파란만장했다. 그는 20대 초반의 젊은 나이에 병으로 한쪽 눈을 실명하는 불운을 겪기도 했다. 러시아로 돌아간 말년에는 수학문제를 풀기위해서 사흘 밤낮을 꼬박 몰두하다 다른 쪽 시력마저 잃게 된다. 당시 파리아카데미에서는 수여하는 권위 있는 상을 수상하고자 저명한 수학자들도 몇 개월 붙잡는 어려운 문제를 단 사흘 만에 풀었는데 너무나 집중한 나머지 실명한 것이었다. 양쪽 눈을 모두 잃었지만 오일러는 비서에게 자신의 생각들을 받아 적게 하는 방식으로 계속해서 훌륭한 업적을 남겼다. 양 눈(안(眼)) 사이 거리는 6.5cm, 이 시각차가 오늘 3D TV 시대를 열었다. 본고에서는 최근 관심이 고조된 저커버그의 페이스북과 오일러 e에 관해 요약했다.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.5
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• pp.983-991
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• 1992

This investigation is carried out numerically for the two dimensional natural convection and surface radiation heat transfer in a square enclosure. The bottom and top walls are isothermal at hot and cold temperatures respectively whereas the left and right side walls are adiabatic except a transparent window on the right side partially. The exchange of radiant energy is obtained by the net radiation method and the shape factor by the crossed string method. The changes in temperature and Nusselt number distributions of the walls due to the surface radiation and insolation are also investigated.

• Journal of Families and Better Life
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• v.22 no.5
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• pp.211-236
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• 2004

This study is designed to conducted group counseling programs applied to the wives of jobless families by Satir's growth model and to help them to recognize the value of themselves and families in their jobless situation and to possess desire and hope for the life of their families in the future. The researcher provided 7 wives of jobless families with group counseling at the family education room of a university from April to June, 2003. The group counseling program consisted of a total of 8 sessions, and each session lasted for three hours to four hours. The researcher came to have a in-depth understanding of the experiences of 5 subjects, who took part in more than 7 sessions in a total of 8 counseling sessions, in the group counseling to which Satir's growth model was applied and analyzed the effects of counseling changing the subjects. The researcher analyzed the following: viewing the subjects themselves and their spouses in a new way, rendezvous with the true self and its acceptance, objective insight into their families, learning how to communicate, and expecting hope through changes. All in all, the wives of jobless families were able to newly recognize the value of the existence of themselves and families and find desire and hope for the life of their families in the future through the group counseling program to which Satir's growth model was applied.

• Journal of Life Science
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• v.28 no.6
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• pp.718-725
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• 2018

Toll-like receptor 4 (TLR4) has been implicated in cell proliferation and apoptosis in several types of cancer. In this study, the impact of TLR4 activation on apoptotic cell death in gynecologic cancers induced by lipopolysaccharide (LPS) was investigated. Cervical cancer cell lines were produced from isolated surgical specimens supplied by Paik Hospital. The primary cultures of normal myometrium and gynecologic cancers, including cervical, endometrial, and ovarian cancers, were used to examine the differences in morphological characteristics between normal and cancerous cells. A reverse transcription polymerase chain reaction analysis was used to determine the relative expression levels of TLR4 gene involved in apoptosis-associated signaling in cervical cancer cells. The cancer cell colonies showed a tendency to reach high levels of confluency compared with normal cells. In addition, an enhanced growth rate and loss of contact inhibition were observed in gynecologic cancer cells compared with normal cells (doubling times of 16.6 hr vs. 26 hr, respectively). The expression level of ITGA5, an alpha-5 integrin marker, was upregulated in normal myometrial cells, but this tendency was not exhibited in cervical cancer cells. Furthermore, p53 tumor suppressor gene expression was upregulated, whereas TLR4 and caspase-3 gene expressions were downregulated in cervical cancer cells. Notably, the expression levels of TLR4 and caspase-3 were increased significantly in LPS-treated cancer cells compared with those in non-LPS-treated cells. These results suggest that the TLR4-mediated caspase-dependent apoptotic signaling pathway could be suggested as a therapeutic target for the treatment of gynecologic cancers, including cervical cancers.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.3
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• pp.1-13
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• 2011

Objectives: This study was designed to investigate the analysis of apoptosis by Scirpi Tuber in Hela cell and MCF-7 cell. Methods: For cytotoxic effect of Scirpi Tuber extract, Scirpi Tuber extract were cultured on NIH3T3 cell in vitro. After treatment with various concentration of Scirpi Tuber, cell growth was evaluated in Hela cell and MCF-7 cell. Hoechst 33342 staining was performed to estimate DNA fragment effect of Scirpi Tuber on the apoptosis in Hela cell and MCF-7 cell. Annexin V/PI apoptosis assay was used to estimate the effects of Scirpi Tuber on the early apoptosis in Hela cell MCF-7 cell. All the stained cells were analyzed by a FACS. RT-PCR was used to estimate the apoptosis gene expression effect of Scirpi Tuber extract on Hela cell and MCF-7 cell. Results: Cytotoxic effect of Scirpi Tuber extract was not found on per NIH3T3 cell. The viability of Hela cell was significantly decreased Scirpi Tuber (500, $1000{\mu}g/m\ell$) in Hela cell 1day, 3day and 5days after treatment (p<0.01). The viability of MCF-7 cell was significantly decresed Scirpi Tuber ($1000{\mu}g/m\ell$) in MCF-7 cell (p<0.01), Scirpi Tuber ($500{\mu}g/m\ell$) in MCF-7 cell only 3days after treatment (p<0.01). In RT-PCR analysis, after treatment of $100{\mu}g/m\ell$ of ACR extract, BCL-2 were decreased and BAX, caspase-3 were increased both in Hela cell and MCF-7 cell. DNA fragmentation was observed the Scirpi Tuber on Hela cell and MCF-7 cell. As time goes on DNA fragmentation incresed. In Annexin V/PI apoptosis assay, after treatment of $1mg/m\ell$ of Scirpi Tuber, the early apoptotic cell increased both in Hela cell and MCF-7 cell. As time goes on apoptotic cell increased. Conclusion: Scirpi Tuber appears to have considerable activity on the apoptosis in Hela cell and MCF-7 cell.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.1
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• pp.47-68
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• 2006

Purpose : This study was carried out to investigate the effects of Gagamdokhwalgisang-Tang on the morphometric changes of femur, and on the hormones and cytokines associated with bone metabolism in overiectomized rats. Methods : Twenty-four female Sprague-Dawley rats were divided into sham operated group(normal) ovariectomized group(control), and treated with extract of GD group(treated). Each group was evaluated the changes of body weight at 0, 3, 6, 8 weeks after ovariectomy. Morphometric analysis(femur weight, femur/body weight ratio, femur ash weight femur ash/body weight ratio cross sectional area of compact bone and concellous bone of femur) and histopathological examination were performed at 8 weeks after ovariectomy. Estrogen, Alkaline Phosphatase(ALP) and cytokine(Tumor necrosis $factor-{\alpha}$, $Interleukin-l{\beta}$, Inerleukin-6) assay were performed at 8 weeks after ovariectomy. Results : 1. The body weight of control and treated group was significantly increased(p<<0.001) compared with the normal group at 8 weeks. 2. The femur weight and femur/body weight ratio of treated group were significantly increased(p<<0.05, p<<0.01) compared with the control group at 8 weeks. 3. The femur ash weight showed no significantly different changes, but femur ash/body weight ratio of treated group was significantly increased(p<<0.05) compared with the control group at 8 weeks. 4. In the cross sectional area of cancellous bone of femoral body, the treated group was significantly increased(p<<0.001) compared with the control group at 8 weeks. 5. The serum estrogen level of treated group showed no significantly different changes compared with the control group at 8 weeks. 6. The serum ALP activity of treated group was significantly decreased(p<<0.01) compared with the control group at 8 weeks. 7. The serum Tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ level of treated group was significantly decreased(p<<0.05) compared with the control group at 8 weeks. 8. The serum $Interleukin-l{\beta}(IL-1{\beta})$ level of treated group was significantly decreased(n<<0.001) compared with the control group at 8 weeks. 9. The serum Interleukin-6(IL-6) level of treated group was significantly decreased(P<<0.01)compared with the control group at 8 weeks. Conclusion : These results indicate that GD inhibits bone resorption in ovariectomized rats. And the major inhibitory mechanism may be related to the inhibitory effects of GD on the secretion of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 in the pathogenesis of osteoporosis in estrogen deficient rats.