• Proceedings of the Korean Information Science Society Conference
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• 2003.04a
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• pp.443-445
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• 2003

본 논문에서는 디지털 이미지를 대칭 및 비대칭 암호화와 워터마킹 기법을 사용하여 안전하게 전송하는 방법을 제안한다. 제안된 기법은 디지털 이미지의 안전한 전송을 위하여 필수적인 네가지 조건 즉. 비밀성, 인증, 무결성, 부인방지 기능을 제공한다. 비대칭 키 암호화 기법은 전자서명의 발행과 대칭키의 암호화를 위해 사용하고, 대칭키 암호화 기법은 워터마크가 삽입된 디지털 이미지를 암호화 하는데 사용하며, 워터마킹 기법은 전송하고자 하는 디지털 이미지에 전자서명을 삽입하기 위해 사용한다. 제안한 방법의 장정은 전자서명이 별도의 파일로 첨부되는 기존의 전송방식과는 달리 암호화된 디지털 데이터와 전자서명이 동일한 파일 내에 존재하게 되는 것이다.

• Journal of Life Science
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• v.28 no.6
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• pp.718-725
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• 2018

Toll-like receptor 4 (TLR4) has been implicated in cell proliferation and apoptosis in several types of cancer. In this study, the impact of TLR4 activation on apoptotic cell death in gynecologic cancers induced by lipopolysaccharide (LPS) was investigated. Cervical cancer cell lines were produced from isolated surgical specimens supplied by Paik Hospital. The primary cultures of normal myometrium and gynecologic cancers, including cervical, endometrial, and ovarian cancers, were used to examine the differences in morphological characteristics between normal and cancerous cells. A reverse transcription polymerase chain reaction analysis was used to determine the relative expression levels of TLR4 gene involved in apoptosis-associated signaling in cervical cancer cells. The cancer cell colonies showed a tendency to reach high levels of confluency compared with normal cells. In addition, an enhanced growth rate and loss of contact inhibition were observed in gynecologic cancer cells compared with normal cells (doubling times of 16.6 hr vs. 26 hr, respectively). The expression level of ITGA5, an alpha-5 integrin marker, was upregulated in normal myometrial cells, but this tendency was not exhibited in cervical cancer cells. Furthermore, p53 tumor suppressor gene expression was upregulated, whereas TLR4 and caspase-3 gene expressions were downregulated in cervical cancer cells. Notably, the expression levels of TLR4 and caspase-3 were increased significantly in LPS-treated cancer cells compared with those in non-LPS-treated cells. These results suggest that the TLR4-mediated caspase-dependent apoptotic signaling pathway could be suggested as a therapeutic target for the treatment of gynecologic cancers, including cervical cancers.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.2
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• pp.29-49
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• 2019

Objectives: This study was a methodological study to verify the reliability and validity and to make a diagnosis of a diagnostic tool for climacteric and postmenopausal syndrome pattern identification (CaPSPI). Methods: This study was conducted from June 1, 2018 to October 18, 2018 with ${{\bigcirc}{\bigcirc}}$ University Korean Medicine Hospital IRB's approval (2018-3). To make a diagnosis using CaPSPI, we decided the cut-points for the tool. Three professors of ${{\bigcirc}{\bigcirc}}$Korean Medical University conducted pattern identification diagnosis. The result is marked from 0 to 3, 0 is 'No', 1 is 'Slightly Yes', 2 is 'Yes' and 3 is 'Very Yes'. And if two or more professors' diagnoses are the same, we took the diagnoses as a diagnostic criteria. The decision of pattern by three experts converted to 0-1 scores in two ways. In "method 1", if the diagnosis was zero points, the score was 0 (have no such identification), and the rest was 1 (have such identification). In "method 2", if the diagnosis was zero or 1 point, the score was 0, and the rest was 1. After that, intraclass correlation was calculated for experts agreement. And logistic regression was conducted. A response variable was the results of the experts' diagnosis and an explanatory variable was the results of the pattern identification diagnostic tool. Results: The diagnosis of the three experts showed excellent concordance of more than 0.794 and showed a significant correlation with the diagnostic tool. Both 'Method 1' and 'Method 2' showed statistically significant effects with the diagnosis of 3 experts and the results of the diagnostic tool. The frequency of cumulative pattern identification diagnosis in 'Method 1' and 'Method 2' were found to be 578 occasions and 203 occasions, respectively. The average number of pattern held by participants in 'Method 1' and 'Method 2' were found to be 5.26 and 1.85, respectively. In both "Method 1" and "Method 2," the yield frequency of liver qi depression was the highest, and the frequency of kidney yin deficiency and liver-kidney yin deficiency was relatively high. Conclusions: Based on the above results, it is thought that, in diagnosis using CaPSPI of menopausal women, 'method 1' could be used for the health diagnosis and prevention, 'method 2' could be used for the pattern diagnosis. On the conclusion, CaPSPI is thought to be available for pattern diagnosis of menopause women.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.1
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• pp.1-14
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• 2021

Objectives: We studied for the adjustment of the patterns of 'The Diagnostic Tool for Climacteric and Postmenopausal Syndrome Pattern Identification (hereinafter CaPSPI)' (studyI) and the correlation between CaPSPI and Korean medicine doctors' diagnosis which was carried out without knowing the results of CaPSPI (studyII). Methods: The studyI followed the previous study method in 2018 (2018-3). The studyII was conducted from June 1, 2019 to July 10, 2020 with ◯◯ University Korean Medicine Hospital IRB's approval (2019-4). Doctors' diagnosis was conducted face-to-face with the subjects. Doctors' diagnosis was carried out based on the Kupperman's questionnaire, 'Diagnosis System of Oriental Medicine (hereinafter DSOM)' and four examinations (四診) records. The diagnosis was marked with 0 for 'no', 1 for 'somewhat', 2 for 'yes' and 3 for 'very yes'. The correlation between CaPSPI and the mean of doctors diagnostic scores were investigated statistically. Results: The studyI showed that heart-heat (心火) pattern was added. The Factor loading coefficient for heart-heat was 0.551 to 0.789, and the Cronbach's coefficient was 0.896. The studyII showed that the diagnosis (Kappa statistic) of two doctors showed statistically significant concordance (all eight patterns), with correlation of them were 0.3 or higher. And the correlation between the CaPSPI score and the mean of doctors' diagnostic score showed a statistically significant correlation, with liver qi depression (肝鬱) being the highest at 0.552 and dual deficiency of the heart-spleen (心脾兩虛) being the lowest at 0.301. Conclusions: Since the diagnosis results of CaPSPI showed a significant correlation with the diagnosis of Korean traditional medicine experts, it was believed that the CaPSPI results can be trusted and used for clinical purposes.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.3
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• pp.1-27
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• 2021

Objectives The purpose of this study is to investigate the effect of herbal medicine on bone growth and growth factors by collecting and analyzing domestic and foreign experimental research papers to establish a platform for future research. Methods Experimental studies published before March 2021 were searched using 7 Korean databases and 2 foreign databases. Among the numbers of studies searched, 48 experimental studies met the criteria and were selected. The results of those 48 studies upon herbal medicine administration were analyzed by bone growth, growth plate, weight. Results 23 studies mainly used monotherapy of either Astragali Radix and Cervi Parvum Cornu. 28 studies used combination of Poria Sclerotium, Dioscoreae Rhizoma, and Acanthopanacis Cortex. Among all studies selected, weight, bone growth, Insulin-like growth factor-1 (IGF-1) and Growth hormone (GH) were increased, but the increase was significant only in some of the studies. Conclusions The result of this study can be utilized as a background information for further studies and treatment in pediatric growth. Further randomized control studies are needed to underscore the finding.

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.22 no.8
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• pp.57-63
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• 2004

e-세상의 도래와 함께 기업경영 차원에서는 e-비즈니스가 기업경영 패러다임의 근본적인 재전환을 촉구해 왔으며, 기업교육 차원에서는 e-learning이 기업교육 패러다임의 전면적인 재고를 촉구해 왔다. 그 동안 디지털이 만들어 가는 e-세상은 이와 같이 기업경영, 기업교육은 물론 일상생활에까지 여러 가지 측면에서 가히 혁명적이라고 볼 수 있을 정도로 엄청난 변화의 물결을 몰고 온 점에 대해서는 누구도 부인할 수 없다.

• Journal of Preventive Medicine and Public Health
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• v.2 no.1
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• pp.23-59
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• 1969

• The Korean Publising Journal, Monthly
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• s.174
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• pp.14-17
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• 1995

해방 직후엔 우리글과 우리 책의 갈증으로 출간만 되면 곧 매진되는 폭발적 수요현상을 빚었다. "무정"이나 "상록수" "순애보" 등이 대표적인 목록이다. 50년대의 베스트셀러로는 우선 "자유부인"을 꼽을 수 있다. 이밖에도 "얄개전" "청춘극장" "슬픔은 강물처럼"등 일제와 전쟁의 아픔을 정신적으로 어루만져주는 책들이 베스트셀러로 꼽힌다.70년대는 그 무렵의 사회변화를 반영한 '호스티스 문학'과 사회적 운동적 주장과 이념과 사상을 담은 사회과학 논저 및 소설들이 대중적 베스트셀러의 자리를 얻는다. 80년대의 역시 사회비리를 고발하는 "어둠의 자식들" "인간시장" "객주" 등의 대하 역사소설들이 이어진다. 90년대 들어 이러한 이념성 도서는 종언을 맞게 된다.

• Review of KIISC
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• v.8 no.3
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• pp.71-82
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• 1998

공개키 기반구조에서는 인증서를 사용 함으로서 기본적으로 암호 및 인증기능을 제공한다. 이와 더불어 신뢰성 있는 부인방지기능을 제공하기 위하여 사위등급의 보안기능을 가진 인증기관 혹은 제3의 신뢰성 있는 공증기관을 별도로 둠으로서 타임스탬프 기능과 공증기능을 부가하여 전자공증 서비스를 제공할 수 있다. 사용자의 요구에 따라 데이타 혹은 인증서에 대하여 타임스탬프를 발행하는 타임스탬프 발행당국(TSA)과 공증을 행하는 공증당국(NA)을 살펴보고, 현재까지 제안된 타임스탬프 및 공증 프로토콜에 대한 분석과 더불어 전자공증 서비스에 대한 국제동향을 검토, 분석한다.

• The Science & Technology
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• no.1 s.404
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• pp.56-60
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• 2003

세계 최고의 극비기관인 미 국가안전보장국(NSA)이 운영하는 '에셜론(Echelon)' 시스템은 국경을 넘나드는 전화통화, 팩스, 텔렉스, 전자우편은 물론 단파, 항공 및 해상주파를 포함한 무선신호 등 세계 각국에서 벌어지는 전자통신을 대부분 감청할 수 있다. 하지만 1998년 이른바 '에셜론 국제통신 감청 시스템'에 관해 이런저런 보도가 나갔을 때 미국과 유럽 당국은 이 사실을 대부분 부인했다. '에셜론'은 어떤 조직이며 어떤 일을 하는 곳인지, 유럽의회의 2000년 도청능력보고서를 통해 알아보았다.