• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.1
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• pp.40-59
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• 2024

Objectives: Since infertility has been big social issue in Korea, this study aims to analyze the domestic study trends in Korean Medicine (KM) for female infertility treatment. Methods: Case studies applying KM treatment on female infertility were selected through 5 domestic journal databases. General characteristics, interventions, outcomes and results and the quality of the reports were analyzed. Especially, the quality assessments of studies were made using CAse REport (CARE) guideline and Joanna Briggs Institute (JBI) critical appraisal checklist. Results: 14 studies (22 cases) were finally selected for the analyzation. The mean age of the participants was 35.1 and the most common factor of female infertility in this study was Uterine factor. Herbal medicine was applied in all studies, and acupuncture was also used frequently. Most cases reported pregnancy of the participants. According to quality assessment, 'Diagnostic challenges', 'Intervention adherence and tolerability', 'Adverse and unanticipated events', 'Patient perspective' and 'Informed consent' were showed low reporting rates. Conclusions: Korean Medicine treatment for female infertility is expected to be effective. In quality evaluation, there were some items with low reporting rates. Further clinical studies have to be conducted to establish the evidence for the treatment.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.3
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• pp.333-340
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• 1999

이 논문에서는 송수신 부인봉쇄와 내용은닉 서명의 기본 개념과 공평한 비밀정보 교환을 위한 프로토콜인 불확정 전송 프로토콜에 대하여 소개하였다. Lein등이 제안한 검증 가능한 불확정 전송 프로토콜은 대화형 전송 방식을 사용하기 때문에 통신량이 많이 발생한다. 이러한 문제를 해결하기 위하여 M.Bellare & S. Micali가 제안한 비대화형 불확정 전송을 확장하여 믿을 수 없는 두 통신 주체간에 안전하게 비밀 정보를 전송할수 있고 , 송수신자간의 단 한번의 통신으로 이루어지는 검증 가능한 비대화형 불확정 전송 프로토콜을 제안하고, 추후 송수신 사실의 부인에 대한 문제가 발생할 경우 이를 중재할 수 있는 새로운 송수신 부인봉쇄 기능을 갖는 검증 가능한 비대화형 불확정 전송 프로토콜을 제안한고, 제안한 프로토콜에 대하여 안전성을 분석하였다.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.4
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• pp.87-101
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• 2019

Objectives: The purpose of this study is to investigate the effect of herbal medicine during the Western medicine therapy in adenomyosis. Methods: The author searched 5 electronic databases and search keywords were 'Adenomyosis' and 'Herbal Medicine'. We included randomized controlled clinical trials (RCTs) using herbal medicine therapy combined Western medicine for adenomyosis patients. Results: The author selected 12 studies. The systematic review of the 12 trials indicated that herbal medicine therapy integrated Western medicine therapy was more effective than Western medicine therapy alone. Conclusions: The herbal medicine therapy combined Western medicine for adenomyosis patients seems to improve pain relief and improvement of illness from this research. However, this result should be taken cautiously by unclear risk of bias. More clinical research will be needed to standardize the results of this study through herbal medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.218-227
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• 2008

Purpose: The purpose of this study is to report the TKM Management for the recovery after laparoscopic gynecological surgery. Methods: The basic informations about laparoscopy and report 3 laparoscopic postoperative patients were managed with TKM. Patients had taken the surgery for the different gynecologic diseases. Results: The 3 patients' symptoms were improved gradually. TKM management is good for the recovery of laparoscopic surgery. And the management need to reflect postoperative complications. the cause and part of operation. and postoperative common symptoms. Conclusion: The TKM managements are effective in the postoperative recovery after laparoscopic gynecological surgery. And more study is needed for developing the model.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.200-217
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• 2008

Purpose: The aim of this study is to review and analyze the status on the obstetric and gynecologic RCTs with acupuncture. Methods: Searching were performed in $7{\sim}14$ July, 2008. Search term used was "acupuncture" only. And we classified all the searched articles as diseases and related health problems. Then we also classified OBGY diseases and analyzed the trends of those parts. Results: We could search 666 articles, RCTs with acupuncture. Of them, we found 88 OBGY articles about nausea and vomiting in pregnancy, labor and postpartum. OBGY surgery, hot flashes and climacteric, ART, Disease with Pregnancy women and menstruation, fetal breech presentation, and breast disease etc. Conclusion: To improve traditional Korean OBGY research, it is needed activation of RCT research, study of meta analysis, development of clinical practice guidelines, variation of research subject, and co-works with conventional medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.1
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• pp.139-149
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• 2020

Objectives: This paper aims to report the effects of Korean medical treatment on three patients who operated laparoscopic gynecological surgery. Methods: Three patients operated laparoscopic gynecological surgery and got Korean medical treatment during 5 or 6 days hospitalization. The treatment included Ikgibohyeol-tang-gagambang, acupuncture, moxa and hot pack treatment. Numerical Rating Scale (NRS) of chief symptoms was measured every morning. Results: After the treatment, the pains following surgery decreased, and general conditions improved. Conclusions: These cases show that Korean medical treatment including Ikgibohyeol-tang-gagambang is effective for patients who operated laparoscopic gynecological surgery.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.3
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• pp.174-191
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• 2019

Objectives: This study was aimed to analyze clinical characteristics and menstrual pattern of female patients who have cold hypersensitivity on hands and feet. Methods: This study was performed from May, 2018 to April, 2019. We checked the patients' hand and feet's temperature and those who diagnosed with cold hypersensitivity filled in survey. Data were collected from 27 participants and we divided data into 2 group; Dysmenorrhea group and Non-dysmenorrhea group. Results: Throughout the study, we found out differences between 2 groups in age, height, weight, VAS score of cold hypersensitivity on hands and feet, menstrual pattern, upper and lower extremity temperature difference, pattern identification, VAS of menstrual pain, and pattern of leukorrhea. Conclusions: By analyzing of study, Dysmenorrhea group's VAS score of cold hypersensitivity on hands and feet was $6.67{\pm}1.73$, Non-dysmenorrhea group's VAS score of cold hypersensitivity on hands and feet was $7.78{\pm}1.72$ (p-value 0.015). This shows that the degree of hypersensitivity on hands and feet is not necessarily proportional to the degree of menstrual pain.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.2
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• pp.48-61
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• 2021

Objectives: This study was aimed to review the effect of acupuncture on endometriosis related pain in patients. Methods: Researchers searched data through 6 online databases up to November 2020. The data was limited to randomized controlled trial studies on endometriosis patients diagnosed with laparoscopy. Results: 7 Randomized controlled trials were included in this study. All of studies were published in Chinese, in China. Intervention of treatment group were composed of simple acupuncture and electroacupuncture. Intervention of control group were made up with mifepristone, herbal medicine and acupuncture. Outcome measurements were effective rate, serum Cancer antigen-125 (CA-125), Visual analogue scale (VAS)/pain score, and recurrence rate in 1 year. In all outcome measurements, treatment group were more effective than control group and it was statistically significant. Conclusions: Acupuncture therapy is effective in decreasing endometriosis related pain and preventing recurrence. However, because endometriosis is easy to recur, additional long-term research is needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.2
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• pp.43-59
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• 2009

Purpose: This study was performed to determine the inhibitory effect of Persimmon Leaves extract (PL) on melanin synthesis in B16F10 melanoma cells B16F10. Methods: The inhibitory effects of PL on melanin synthesis were determined by in vitro assay. To elucidate inhibitory effects of PL on melanin synthesis, we determined the melanin release and melanin production in B16F10. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, PKA, PKC${\beta}$, ERK-1, ERK-2, AKT-1, MITF in B16F10. Results: 1. PL inhibited melanin release, melanin production in B16F10. 2. PL inhibited tyrosinase activity in vitro and in B16F10. 3. PL suppressed the expression of tyrosinase, TRP-1, TRP-2 in B16F10. 4. PL suppressed the expression of PKA, PKC${\beta}$ in B16F10. 5. PL increased the expression of ERK-1, ERK-2, AKT-1 in B16F10. 6. PL suppressed the expression of MITF in B16F10. Conclusion: From these results, it may be concluded that PL is possesed of the antimelanogenetic effects.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.4
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• pp.1-18
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• 2009

Purpose: This study was performed to elucidate the inhibitory effect of Mibaeksan (MB) on melanin synthesis in B16F10 mouse melanoma cell. Methods: To demonstrate the inhibitory effects of MB on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma cell. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, MMP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma cells. Results: 1. MB decreased the release and production of melanin in B16F10 melanoma cells. 2. MB decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. MB decreased the expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$ and MMP-2 in B16F10 melanoma cells. 4. MB increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 5. MB decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that MB has the antimelanogenetic effects.