• Title/Summary/Keyword: 복령

Search Result 77, Processing Time 0.027 seconds

Effects of Poria cocos and Panax ginseng Extracts on Hemogram of Sarcoma-180 Mouse (복령 및 인삼추출물이 Sarcoma -180 Mouse의 혈액상(血液象)에 미치는 영향(影響))

  • Lee, Bok-Im;Hong, In-Pyo;Kim, Dong-Won;Lee, Min-Woong
    • The Korean Journal of Mycology
    • /
    • v.18 no.4
    • /
    • pp.218-224
    • /
    • 1990

  • This study was made to observe changes in hemograms of the Sarcoma-180 mouse treated with extracts of Poria cocos and Panax ginseng. The life span of the Sarcoma-180 mouse administered with the mixture of the extract of Panax ginseng with the extract of P. cocos and the extract of P. cocos was extended more than the non-treated group. In the body weight of the Sarcoma-180 mouse, the non-treated group was increased more than the normal group and the groups administered with the mixture of ginseng extract with hoelen extract and hoelen extract. In the numbers of white blood cell especially lymphocyte, the groups administered with the mixture of ginseng extract with hoelen extract and hoelen extract were similar to the normal group, but the non-treated group was decreased. The Hematocrit, mean corpuscular volume and mean corpuscular hemoglobin in the mice infected with Sarcoma-180 were not significantly different between the group treated with extracts of them and the non-treated group. In the distributions and sizes of white blood cell and platelet in the mice, the group administered with the Hoelen extract was similar to the normal group comparing to the non-treated group.

  • PDF

Pesticides, heavy metals, radioactive substances, and ash of Poria cocos distributed in Korea (국내 유통 복령(Poria cocos)의 농약, 중금속, 방사선물질 및 회분 함량 조사 연구)

  • Jang, Eun-Kyoung;Jang, Hye-Mi;Wi, Chang-Heun;Ban, Seung-Eon
    • Journal of Mushroom
    • /
    • v.19 no.4
    • /
    • pp.294-299
    • /
    • 2021

  • The purpose of this study is to provide basic data on the safety of Poria cocos, a major Korean herbal medicine, and to establish tolerance levels for hazardous substances. Residual pesticides (321 types), heavy metals (7 types), radioactivity (3 types), and ash content were analyzed in 10 Poria cocos products distributed in Korea (5 domestic and 5 in China). Of the residual pesticides, cypermethrin was detected at 0.03 mg/kg in one domestic sample and was below the standard value. Of the heavy metals, the levels of Zn, Pb, Ni, Cu, Hg, and Cr were below the standard values in all samples. Hg was not detected in any sample. Cd was detected at 0.011 mg/kg in one Chinese sample. The radioactivity concentration was also below the MDA value in all P. cocos samples. The ash content was less than the standard value of 1.0% in all P. cocos samples. The findings indicate that P. cocos distributed in Korea is safe. However, because P. cocos is always exposed to harmful substances because of the nature of its cultivation in the soil, it seems necessary to establish systematic management standards for the entire production stage, such as cultivation, storage, and distribution.

  • https://doi.org/10.14480/JM.2021.19.4.294 인용 PDF KSCI

Effects of Compounds Isolated from an Ethanol Extract of the Sclerotium of Wolfiporia hoelen on Osteoblast Differentiation and Osteoclast Formation (복령 균핵의 에탄올 추출물에서 분리한 화합물의 조골세포 분화 촉진 및 파골세포 생성 억제 효과)

  • Sora Lee;Seokju Kim;Bowook Moon;Sik-Won Choi;Rhim Ryoo;Hyung Won Lee
    • Journal of Korean Society of Forest Science
    • /
    • v.113 no.1
    • /
    • pp.73-87
    • /
    • 2024

  • Wolfiporia hoelen (Fr.) Y.C.Dai & V. Papp, commonly known as Poria cocos, is a significant traditional herb used for medicinal and culinary purposes Asian and European countries. Many studies have confirmed that the main components of W. hoelen have pharmacological activities and thatits extract has been shown to affect bone metabolism. This study aimed to the potential of a 50% ethanol extract of the sclerotium of W. hoelen for preventing and treating bone diseases. The ethanol extract was systematically fractionated using n-hexane, dichloromethane, and ethyl acetate. The dichloromethane fraction caused an approximately 29% increase in alkaline phosphatase (ALP) differentiation activity in C2C12 cells compared to the control. Four compounds isolated from this active dichloromethane fraction were identified through instrumental analysis and literature references as 3α-dehydrotrametenolic acid, ergosterol, pachymic acid, and dehydrotumulosic acid. All four compounds were evaluated at increasing concentrations (1, 3, 10, 30, and 100 μM) to determine their effects on ALP differentiation activity in C2C12 cells and RANKL-induced inhibition activity in bone marrow macrophages (BMMs), with a concurrent assessment of cytotoxicity at these concentrations. At a concentration of 3 μM, dehydrotumulosic acid caused a 160% increase in ALP activity, 24% higher than in the BMP-2 control. BMMs treated with dehydrotumulosic acid at concentrations between 10 and 100 μM showed a substantial 15-86% decrease in RANKL-induced inhibition activity compared to the control, with distinct patterns of RANKL inhibition and cytotoxicity observed at 10 μM. These findings suggest that the ethanol extract from the sclerotium of W. hoelen has potential to modulate bone-cell differentiation, while highlighting the possible benefits of dehydrotumulosic acid isolated from the dichloromethane fraction of W. hoelen for preventing and treating osteoporosis.

  • https://doi.org/10.14578/jkfs.2024.113.1.73 인용 PDF HTML