• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.1
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• pp.124-143
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• 2000

Objectives：The primary purpose of this study is to understand the psychopathology of the victims of school violence in terms of early psychosis. By doing this, the early detection of psychosis among the victims is possible, and early detection may lead to early intervention. Methods：Two-thousand and nine-hundred seventy two students from 16 middle schools in Seoul were asked to fill out questionnaire comprised of popularity and intellectual and school status of Piers-Harris Children's Self Concept Inventory, Symptom Check List-90-Revised, and Ostracism Scale. The subjects whose scores upon Ostracism Scale were higher than average by two standard deviation were labeled as ‘Repelled and Isolated group', and subjects whose scores on popularity were significantly lower than average and whose scores on psychoticism of SCL-90-R were higher than average were defined as 'tentative early psychosis group'. Odds ratios were calculated from the numbers of subjects with and without high psychoticism scores and high ostracism scores. On the subjects of 'tentative early psychotic group', we examined every clinical characteristic and conducted correlation analysis and regression analysis in order to find out the risk factors and to construct theoretical model that explains the psychoticism scores. Results：The results were as follows：1) Total 157(5.3%) subjects were rated significantly higher on ostracism scale, and among them, 47 subjects(29.9%) were rated significantly higher than average on psychoticism scale, while only 50 subjects among 2,135 students who were rated within normal range showed significantly higher score on psychoticism scale. Odds ratio for psychotic group of isolated group were 17.82 and it was statistically significant. 2) Forty-seven subjects(31 boys, 16 girls) who were rated as they were unpopular and rejected from peers had significantly higher psychoticism scores. They were not significantly different from simply high psychoticism subjects in anxiety, social anhedonia scale, magical thinking, obsessivecompulsive symptoms, phobic anxiety, psychoticism, somatization, but showed higher ostracism scores and paranoid tendencies. Among school violence victims, who rated themselves unpopular and showed higher psychoticism scores, the psychoticism scores were mainly explained by anxiety, depression, hostility, interpersonal sensitivity, obsessive-compulsive symptoms, paranoid tendency, somatization scales($r^2=0.93$). Conclusion：Thus, it can be concluded that the subjects with higher ostracism score have the substantially high risk for psychosis development. By these results, we propose that school violence victims with anxiety, depression, hostility, interpersonal sensitivity, obsessive-compulsive symptoms, paranoid tendency, somatization should be tested individually considering school adjustment, attentional deficit, concept formation problems.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.8 no.2
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• pp.143-149
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• 2005

Purpose: The aim of this study was to evaluate the significance of pH monitoring at two levels, hypopharynx and esophagus in gastroesophageal reflux. Methods: 29 patients with pathological gastroesophageal reflux were classified into two groups: Group I had recurrent respiratory symptoms and Group II had not recurrent respiratory symptoms. The ambulatory pH monitoring was performed at the hypopharynx and the esophagus simultaneously with two channel catheter for 18~24 hr. The pathological reflux was defined when the percent of time that pH was below 4.0 exceeding the 95th percentile of normal value. Hypopharyngeal reflux was defined as the pharyngeal pH drops below 4. Results: 39 patients were performed pH monitoring at the level of hypopharynx and esophagus for 24 hours. Among 7 patients with chronic respiratory symptom, 6 patients (85.7%) have pathological esophageal reflux. Among 32 patients without chronic respiratory symptom, 23 patients (71.8%) have pathological esophageal reflux. Thus 29 out of 39 patients (74%) have pathological esophageal reflux. In the Group I, all parameters except the longest episode showed significant differences between hypopharyngeal and esophageal pH monitoring. None of parameters showed significant differences between group I and II in the pharyngeal pH monitoring. Conclusion: Regardless of presence of respiratory symptoms, the pH monitoring at the pharyngeal level in patients with gastroesophageal reflux did not showed any differences compared with the esophageal pH monitoring. Therefore we may reconsider the usefulness of hypopharyngeal pH monitoring in patients with chronic respiratory symptoms.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.1
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• pp.17-23
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• 2003

Purpose: The aim of this study was to determine clinical significance of dual-probe esophageal pH monitoring and to compare four pH monitoring parameters between proximal and distal esophagus in pathological gastroesophageal reflux disease with recurrent respiratory symptoms. Methods: Among the thirty-four patients who were performed 24 hr pH monitoring, seventeen patients with pathological distal reflux were classified into two groups: Group I (n:12) had recurrent respiratory symptoms and Group II (n:5) hadn't recurrent respiratory symptoms. The ambulatory dual-probe esophageal pH monitoring was performed for 18~24 hr. A pathologic GER was defined when reflux index (percent of the investigation time a pH<4) exceeded the 95th percentile of normal value. Results: Among the sixteen patients with recurrent respiratory symptoms, twelve patients (75%) have pathological distal reflux. Whereas among the eighteen patients without recurrent respiratory symptom, five patients (28%) have pathological distal reflux. In the Group I, the significant differences between proximal and distal esophageal pH recordings persisted for all parameters, but didn't persist in group II except for longest episode. Comparing esophageal pH four parameters between group I and group II at the proximal esophageal site, all parameters didn't show statistically significant differences. Conclusion: Regardless of respiratory symptoms, patients with pathological distal reflux didn't show statistically significant differences in the all parameters at the proximal esophageal site. Therefore we may reconsider usefulness of dual probe pH meter in patients with recurrent respiratory symptoms.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.2
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• pp.209-220
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• 2000

The purpose of this study is to find out the characteristics of depressive episode about major depression and bipolar disorder in child and adolescent. The subjects of this study were 34 major depression patients and 17 bipolar disorder patients hospitalized at child and adolescent psychiatry in OO university children's hospital from 1st March 1993 to 31st October 1999. The method of this study is to review socio-demographic characteristics, diagnostic classification, chief problems and symptoms at admission, frequency of symptoms, maternal pregnancy problem history, childhood developmental history, coexisting psychiatric disorders, family psychopathology and family history and therapeutic response through their chart. 1) The ratio of male was higher than that of female in major depressive disorder while they are similar in manic episode, bipolar disorder. 2) Average onset age of bipolar disorder was 14 years 1 month and it was 12 years 8 months in the case of major depression As a result, average onset age of major depression is lower than that of bipolar disorder. 3) The patients complained of vegetative symptoms than somatic symptoms in both bipolar disorder and depressive disorder. Also, the cases of major depression developed more suicide idea symptom while the case of bipolar disorder developed more aggressive symptoms. In the respect of psychotic symptoms, delusion was more frequently shown in major depression, but halucination was more often shown in bipolar disorder. 4) Anxiety disorder coexisted most frequently in two groups. And there coexisted symptoms such as somartoform disorder, mental retardation and personality disorder in both cases. 5) The influence of family loading was remarkable in both cases. Above all, the development of major depression had to do with child abuse history and inappropriate care of family. It is apparent that there are distinctive differences between major depression and bipolar disorder in child and adolescent through the study, just as in adult cases. Therefore the differences of clinical characteristics between two disorders is founded in coexisting disorders and clinical symptoms including onset age, somatic symptoms and vegetative symptoms.

• Sleep Medicine and Psychophysiology
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• v.24 no.2
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• pp.97-105
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• 2017

Objectives: To evaluate sleep characteristics and factors associated with sleep disturbance in schizophrenia patients with concurrent active psychotic symptoms and insomnia. Methods: Schizophrenia patients with insomnia and active psychotic symptoms (n = 63) were recruited from community-based mental rehabilitative facilities. Sleep scales such as the Korean version of the Insomnia Severity Index (ISI-K) and the Korean Version of the Pittsburgh Sleep Quality Index (PSQI-K) were evaluated and those with ISI-K >15 were included in the study. Psychotic, anxiety and depressive symptoms were rated with the Brief Psychotic Rating Scale (BPRS), the Korean Version of the Anxiety Sensitivity Index (K-ASI), and the Korean Version of the Beck Depression Inventory-I (K-BDI), respectively. Pearson correlation analyses were performed between the sociodemographic data, ISI-K and PSQI-K. Multiple linear regression analysis was conducted to investigate the factors which affected the ISI-K and PSQI-K. Results: The mean ISI-K and PSQI-K scores were $18.1{\pm}2.6$ and $12.0{\pm}2.2$, respectively. Pearson correlation analysis showed a negative correlation between age of onset and ISI-K score and positive correlations between BRPS and PSQI-K scores and between K-ASI and both ISI-K and PSQI-K scores. Multiple regression analyses for both ISI-K and PSQI-K with K-ASI, age of onset, and BPRS as covariates revealed K-ASI as the only significant remaining factor. Conclusion: Our study suggests that anxiety symptoms are associated with insomnia symptoms in schizophrenia patients regardless of depressive or psychotic symptoms.

• Korean Journal of Biological Psychiatry
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• v.13 no.4
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• pp.234-243
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• 2006

Objectives : Several factors, such as biological markers, clinical correlates, and course of the depressive disorders with psychotic symptoms differ from those without psychotic symptoms. Therefore, specification of a treatment algorithm for depressive disorder with psychotic symptoms is legitimated. This article provides a systematic review of somatic treatments for depressive disorder with psychotic symptoms. Methods : According to the search strategy of the Clinical Research Center for Depression of Korean Health 21 R & D Project, first, PubMed and EMBASE were searched using terms with regard to the treatment of depressive disorders with psychotic symptoms(until July 2006). Reference lists of related reviews and studies were searched. In addition, relevant practice guidelines were searched using PubMed. All identified clinical literatures were reviewed and summarized in a narrative manner. Results : Treatment options, such as a combination of an antidepressant and an antipsychotic versus an antidepressant or an antipsychotic alone are summarized. In addition, issues regarding the electroconvulsive therapy( ECT), combination therapy, and maintenance treatment are discussed. Conclusion : In former times, the combination of an antidepressant and an antipsychotic or ECT were recommended as the first line treatment for depressive disorder with psychotic symptoms. Recently, however, there was a suggestion that there was no conclusive evidence that the combination of an antidepressant and an antipsychotic drug is more effective than an antidepressant alone. More evidence regarding the pharmacological treatment for depressive disorder with psychotic symptoms is needed.

• Korean Journal of Psychosomatic Medicine
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• v.5 no.1
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• pp.118-122
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• 1997

We experienced a case of 51-year-old female patient who showed symptoms of persecutory delusion, auditory hallucination and hallucinatory behavior, severe insomnia, psychomotor retardation and social withdrawal, along with some clinical signs of the deficiency of various hormones those gradually progressed after massive postpartum vaginal bleeding 13 years ago. She was admitted to a psychiatric ward under the impression of psychotic depression. However careful history taking and evaluation of clinical feature gave rise to the possibility of underlying medical condition. Laboratory work-up revealed panhypopituitarism, hypoglycemia and hyponatremia. After replacement of thyroid hormone and cortisol for 1 week, her clinical symptoms including psychiatric symptoms were improved. Taken together, these findings were compatible with the diagnosis of Sheehan's syndrome. On reporting this case, we would like to emphasize again the importance of differential diagnosis of medical problems causing psychiatric symptoms those are easily neglected in the clinical approach toward psychiatric patients.

• The Journal of the Korean dental association
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• v.21 no.7 s.170
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• pp.525-528
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• 1983

치수가 어떤 병적상태에 있는지 정확히 구분해 내는 것은 매우 어려운 일이다. 한 병적상태에서 다른 질환으로 쉽게 이행되고 염증상태에 있는 치수는 위촉되어 질환을 분류하는데 중첩되고 또한 병리조직학적 관점에서 진단해 내야 하기 때문에 임상에서 정확한 진단을 내리는데는 난점이 많다. 그러나 환자가 호소하는 주증상과 기왕증은 진단에 매우 중용한 부분을 찾이 하고 술자가 관찰하는 여러 가지 시험들을 토대로 하여 종합관찰한 후에 진단을 내려야 할 것이다.

• Korean Journal of Health Education and Promotion
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• v.5 no.1
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• pp.17-20
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• 1988

$\ulcorner$20세기의 페스트$\lrcorner$로 불리우는 후천성 면역결핍증(AIDS)이 지난 81년 처음보고된 이후 세계곳곳에서 무서운 속도로 퍼져 인류생존 자체를 위협하고 있다. 세계보건기구(WHO)의 집계에 따르면 올 3월말 현재 AIDS환자는 전세계적으로 8만5천여 명에 이르렀고 항체양성자는 수백만명선으로 잡고 있어 이들중 상당수에서 병적증상이 나타날 경우 이 전염병은 걷잡을 수 없이 확산될 전망이다. 한편 우리나라에도 지난 85년 주한미국인에서 첫 AIDS환자가 발견된 후 내국인에서도 항체양성자들이 잇달아 발견 모두 18명에 이르고 있다.

• Journal of Korean Medical classics
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• v.18 no.1 s.28
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• pp.67-72
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• 2005

통과분석(通過分析)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$양명형증용약여포괄중경적(陽明形證用藥？包括仲景的)${\ulcorner}$상한론(傷寒論)${\lrcorner}$재내적주요의학가대양명병적개념(在內的主要醫學家對陽明病的槪念), 득출여하결론(得出如下結論): 1.${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$적양명형증용약당중이대편비결위중심, 미사용가이낭괄양명병증재내적위가실저개개념, 상세나열출양명병적구체증상 내급양명병하료정의(來給陽明病下了定義). 병미장대편비결작위대표성증상(幷未將大便秘結作爲代表性症狀), 이시근거표본관계분성경병여부병진행설명. 이기육작위표(以肌肉作爲表), 위작위리적표리개염분석기증상(胃作爲裏的表裏槪念分析其症狀). 2. 기찰급양명병하정의적의서(畿察給陽明病下定義的醫書), 발현제료중경적(發現除了仲景的)${\ulcorner}$상한론(傷寒論)${\lrcorner}$여기주석본성무이적${\ulcorner}$주해상한론(注解傷寒論)${\lrcorner}$이외(以外), 도장목동(都將目疼), 비건(鼻乾), 불득면부간주양명병대표증상(不得眠部看做陽明病代表症狀). 저충정의방식시종송도명대적보편관점 3. 재(在)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$당중작위인용서목적${\lrcorner}$의학입문(醫學入門)${\ulcorner}$, 근거표본(根据標本), 표리개염대증상진행료분류(表裏槪念對症狀進行了分類). 비기지전단순적대증상적서술갱구유조리성. 저가이간주시집당시제다견해지대성(這可以看做是集當時諸多見解之大成), 대병정적분석변적갱가구체. 선택(選擇)${\lrcorner}$의학입문(醫學入門)${\ulcorner}$작위인체서목(作爲引滯書目), 가이인위시채납료당시적최신견해, 병차흡수료용역장악병정적이증상위주적기술방식(幷且吸收了容易掌握病情的以症狀爲主的記述方式). ${\lrcorner}$의학입문(醫學入門)${\ulcorner}$취시집이상관점위일체적대성(就是集以上觀点爲一體的大成). 4. 여태양병당중양형증용약진행비교, 관찰병정적주요관점(觀察病情的主要觀点), 양자도추종료(兩者都追從了)${\lrcorner}$의학입문(醫學入門)${\ulcorner}$적견해(的見解). 단시태양형증용약몰유대몰위초출중경태양병적제망(但是太陽形證用藥沒有大沒圍超出仲景太陽病的提網), 상비지하양명형증용약기몰유인용(相比之下陽明形證用藥旣沒有引用) 중경적(仲景的)${\ulcorner}$상한론(傷寒論)${\lrcorner}$, 대증상적설명야대상경정(對症狀的設明也大相徑庭). 5. 양명형증용약당중몰유인용중경적위가실관점, 이시리용미악한(而是利用微惡寒), 발열(發熱), 갈(渴), 유한(有汗), 목동(目疼), 비건(鼻乾), 조한(潮汗), 폐삽(閉澁), 만갈(滿渴), 광섬, 불면등증상진행설명(不眠等症狀進行說明), 비기장악륭명병작위장부질병(比其掌握隆明病作爲臟腑疾病), 이해위이열위주적상당우양명속성적질병.