• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.31-31
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• 2000

최근 원전주변지역을 중심으로 한 기형가축이 발생함에 따라 이의 원인을 규명하기 위하여 우선 역학적 조사와 혈청학적 검사 및 기형송아지 , 유산·사산 태아 등의 수집가 검물을 중심으로 하여 병리학적 검사를 실시하였다. 원전주변 기형우 발생농가의 역학적 조사와 모우의 임상적 소견에서는 하동의 이상을 관찰할 수 없었다 . 수집된 가검물 (울진원전주변지역 : 3두, 월성원전주변지역 : 3두, 고리원전주변지역 : 3두, 기타지역 2두) 총 11개 농가 11두에 대한 병리학적 검사와 모우 및 자우의 혈청학적 검사에서 9두가 Akabane 병으로 진단되었고, 나머지 2 두는 곰팡이감염증 1두 그리고 간경화 l 두로 판정되었다. Akabane virus에 감염된 9두는 기형송아지, 유·사산태아로서 사지기형, 척추만곡 및 중추신경계이상(대뇌결손, 뇌수두증)등이 관찰되었다. (중략)

• Pediatric Infection and Vaccine
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• v.23 no.1
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• pp.67-71
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• 2016

Erythema nodosum (EN) is a painful skin disease characterized by erythematous tender nodules located predominantly over the extensor aspects of the legs. Various etiological factors, including infection, drug administration, and systemic illness have been implicated as causes of EN. Mycoplasma pneumoniae is one of rare infectious agents to cause EN in children. We report a case of a 7-year-old boy with context of respiratory illness and skin lesions with arthralgia. From stepwise approaches, IgM antibody against M. pneumoniae was positive with titers of 12.18, consistent with respiratory infection of M. pneumoniae and histopathology showed findings of septal and lobular inflammation without vasculitis consistent with EN. In addition, we reviewed the pathogenesis of this disease based on our case and the previous reports.

• Journal of the korean veterinary medical association
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• v.32 no.4
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• pp.234-246
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• 1996

양의 스크래피(scrapie)는 우리나라에서의 발생보고가 없는 해외가축전염병의 일종이며, 동물의 전염성 해면형 뇌증(Transmissible Spomgifrom Encephalopathies; TSEs)중 역사가 가장 오랜 질병인데, 현재 영국에서 문제되고 있는 새로운 전염병인 소 해면형 뇌증(Bovine Spongiform Encephalopathy; BSE) 즉 일명 광우병(mad cow disease)과의 어떤 연관 가능성 때문에 수의학계의 관심의 대상이 되고 있는 질병이다. 일단 감염되어 발병되면 치료대책 없이 100$\%$ 폐사되는 세기의 불치병으로 알려진, 소 해면형 뇌증(BSE)은 영국에서 현재 사람의 크로이츠휄트-야콥병(Creutzfeldt-Jakob disease; CJD)과의 관련 가능성 여부를 놓고 독특한 문제가 되고 있는 세계적인 희귀질병이다. 이들 질병에 대하여는 아직까지 확실한 병인체가 밝혀져 있지도 않으며, 그렇기 때문에 면역 혈청학적 진단방법도 확립되어 있지 못할 뿐만아니라 예방백신의 개발 또한 불가능하다. 다만, 임상적인 병력과 임상소견, 뇌조직 표본에 대한 현미경 검사 또는 전자현미경 검사에 의한 특이소견 관찰 등 조직병리학적 진단만이 가능할 뿐이다. 본편에서는 소 해면형 뇌증(BSE)의 병리학적 감별진단과 관련, 지금까지 보고된 임상증상을 검토해보고, 우리나라에서 경험한 소의 광견병에 대한 조직병리학적 진단 재료를 근거로하여 감별진단을 위한 참고자료로 설명하고, 국제수역사무국(Office de International Epizooties; O.I.E.)에서 발생한 Manual of Standards for Diagnostic Tests and Vaccines for List A and B Diseases of Mammals, Birds and Bees(1992)(포유류, 조류, 꿀벌에 있어서의 A급 및 B급 질병에 대한 진단시약 및 예방백신에 대한 표준지침) 중에서 소 해면형 뇌증(B 83; p 742-747)과 스크래피(B 32; p 424-427)에 관한 내용 (Chapter 22, 205-215)을 기본자료로 제공하고자 한다.

• Korean Journal of Veterinary Research
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• v.9 no.1
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• pp.23-62
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• 1969

Throughout the studies the following experimental results were obtained and are summarized: 1. Multiplication of agents in primary cell cultures of both GF classical and CR-64 acute strain of Marek's disease infected chicken kidneys was accompanied by the formation of distinct transformed cell foci. This characteristic nature of cell transformation was passaged regularly by addition of dispersed cell from infected cultures to normal chicken kidney cell cultures, and also transferred was the nature of cell transformation to normal chick-embryo liver and neuroglial cell cultures. No cytopathic changes were noticed in inoculated chick-embryo fibroblast cultures. 2. The same cytopathic effects were noticed in normal kidney cell monolayers after the inoculation of whole blood and huffy coat cells derived from both forms of Marek's disease infected chickens. In these cases, however, the number of transformed cell foci appearing was far less than that of uninoculated monolayers prepared directly from the kidneys of Marek's disease infected chickens. 3. The change in cell culture IS regarded as a specific cell transformation focus induced by an oncogenic virus rather than it plaque in slowly progressing cytopathic effect by non-oncogenic viruses, and it is quite similar to RSV focus in chick-embryo fibroblasts in many respects. 4. The infective agent (cell transformable) were extremely cell-associated and could not be separated in an infective state from cells under the experimental conditions. 5. The focus assay of these agents was valid as shown by the high degree of linear correlation (r=0.97 and 0.99) between the relative infected cell concentration (in inoculum) and the transformed cell foci counted. 6. No differences were observed between the GF classical strain and the CR-64 acute strain of Marek's disease as far as cell culture behavior. 7. Characterization of the isolates by physical and chemical treatments, development of internuclear inclusions in Infected cells, and nucleic acid typing by differential stainings and cytochemical treatments indicated that the natures of these cell transformation agents closely resemble to those described fer the group B herpes viruses. 8. Susceptible chicks inoculated with infected kidney tissue culture cells developed specific lesions of Marek's disease, and in a case of prolonged observation after inoculation (5 weeks) the birds developed clinical symptoms and gross lesions of Marek's disease. Kidney cell cultures prepared from those inoculated birds and sacrificed showed a superior recovery of cell transformation property by formation of distinct foci. 9. Electron microscopic study of infected kidney culture cells (GF agent) by negative staining technique revealed virus particles furnishing the properties of herpes viruses. The particle was measured about $100m{\mu}$ and, so far, no herpes virus envelop has been seen from these preparations. 10. No relationship of both isolates to avian leukosis/sarcoma group viruses and PPLO was observed.

• Journal of Korean Medical classics
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• v.24 no.6
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• pp.131-133
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• 2011

비단은 비만을 기초로 한 당뇨병의 초기상태이며, 당내량 손상(IGT)은 당대사가 정상과 당뇨병 사이에 있는 아건강 상태를 말한다. 비단의 병인병기와 임상특징은 당내량 손상과 기본적으로 일치한다. 당내량 손상은 비만환자가 비단을 거쳐 당뇨병으로 발병되는 자연발전과정으로 비단과 당내량 손상의 공통적인 발병인소는 비만이며, 그 병리중심은 비위(脾胃)기능실조로 인한 당내량 이상으로 중의(中醫) 증형(證型)에 있어 허실(虛實)변화가 있다. 비단과 비만형 IGT 증후, 병리방면에서의 발생과 발전의 작용을 탐구하여 조기에 중약(中藥)을 사용하면 체중을 감소시키고 더 나아가 당뇨병을 예방하는데 중요한 임상의의가 있다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.19-19
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• 1982

Pathogenesis of otitis media was studied in an animal model of rats from a histopathological and biochemical point of view. Basic anatomical outline, and distribution and type of normal epithelial cells of the rat bulla were described as a background study. Pseudomonas otitis media was developed in rats by inoculating $10^{9}$ bacteria into the tympanic bulla. Histopathologic change of the mucoperiosteal layer showed acute stage of infection from 3 days to 3 weeks, and it became chronic after 4 weeks animals through 12 weeks. Enzyme profile in the extracts of the inflammatory middle ear tissue was studied. The levels of three enzymes, PZ-peptidase, LDH, and lysozyme were much higher in the middle ear tissue than in the corresponding sera as might be expected. Tissue/serum ratios of the enzyme activities were 13-38 for PZ-peptidase, 63-177 for LDH, and 18-94 for lysozyme. Possible role of the PZ-peptidase and possible origins of the three enzymes detected in the tissue were discussed.

• Herbal Formula Science
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• v.19 no.2
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• pp.161-178
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• 2011

Objectives : The aim of this study is to find the therapeutic meaning of Rhizoma Cyperi in herbal medication. Methodes : In this study, we investigate 85 prescriptions related to the use of Rhizoma Cyperi main blended from Dongeuibogam. we research about field of therapy, symtoms of a disease, the chief virtue of a medicine, the cause of a disease, the pathology of a disease, dosage, contents of composition. Results : The following conclusions were reached through investigations on the prescriptions that use Rhizoma Cyperi as the main ingredient. Prescriptions that Rhizoma Cyperi was taken as a monarch drug are utilized for 24 therapeutic purpose, for example, woman disease, uterine disease, vitality and abdominal mass. In particular, 16.4% of prescriptions appear in the chapter of woman, and 15.2% of those appear in the chapter of uterus. Prescriptions that utilize Rhizoma Cyperi as the main ingredient are used in the treatment of menstrual disorder, pain due to disorder of Gi, infertility, irregular menstruation and abdominal mass. Rhizoma Cyperi is used in pathogenic factors such as seven modes of emotions and used in pathology related to the stagnation of blood system. The dosage of Rhizoma Cyperi is 6li(about 0.23g) to 6don(about 22.5g), however 1don(about 3.75g) has been taken the most for clinical application. Gyogamdan and Yukmisamleunghwan are the most useful base prescriptions which use the Rhizoma Cyperi as the main component. Conclusions : This information provide the rationale for establishing Basic evidance in the oriental medical prescription.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.337-352
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• 2000

According to the literatual study on the Infantile Vomiting since the publication of ${\ll}Hwangjenaekung{\gg}$, the results were as follows. 1. The causes of vomiting are classified into the following kind: external cause are the cold and heat, not external and internal are disorder of food and mood, internal are the dysfuntion of spleen, stomach, liver, kidney. 2. The Oriental Medical cause of Infantile Vomiting is disorder of food, intusion of outside evil, heat accumulation in the stomach, deficiency of stomach liquid, reverse flowing of Qi resulted from fear and being frightened. There are so many causes of Infantile Vomiting, but they are all related to the stomach. 3. The Western Medical cause of Infantile Vomiting are classified with the situation of stimulation, age, accompanied symptom. The main cause related with the age is inhalation of amniotic fluid, maternal blood, infectious disease, wrong lactation method, functional and organic abnormality. 4. The Infantile Vomiting is similar with the adults, but the spleen and stomach of infants is so feeble that the vomiting happens very easily. The reverse flowing of Qi resulted from fear and being frightened and disorder of food are the main cause in infants. 5. The cause of Infantile Vomiting between Oriental Medicine and Western's is so similar and both emphasized the function of spleen and stomach. But the comment on the external cause(cold, heat) and not internal & external cause(mood disorder) is a creative view of Oriental Medicine.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1976.06a
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• pp.85.3-86
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• 1976

Sudden deafness requires immediate investigation and treat if there is to be any prospect of salvaging the hearing. It present an otological emergency and a diagnostic challenge. Sn Sudden sensorineural deafness can be caused by a wide variety of pathologies. A battery of tests and investigations must be performed forthwith if treatment is to be started without further delay. The concept that nothing can be done for the patient with sensori-neural deafness must be abandoned. Some pathologies causing sudden deafness are not amenable to therapy or can show only partial reversibility. But there are several causes, showing little or no spontaneous recovery, which do responed to appropriate treatment. It is important to identify them and concentrate on their management. The age and sex ratios and the unilaterral or bilateral nature of the lesion are related to the etiology and depend upon which type of case is included in the series. Though individually rare, collecting for about 2.5 per cent of new otoloical patients. Some 70 per cent of cases are unilateral. Viral, bacterial and treponemal infections accounted for about 30 per cent of the cases. Some 16 per cent were due to vascular lesions of the cochlea. In almost 22 per cent there was no obvious cause (idiopathic), they occurred in young adult and were either sensory or neural. About 12 per cent were traumatic and 9 per cent were ototoxic in origin. The remaining 11 per cent were due to a group of rarities. The two vital factors are the site of the lesion and the duration of the hearing loss. The earlier these are diagnosed and treated the better the response. The etiology, pathology and treatment are reviewed.

• The Journal of Dong Guk Oriental Medicine
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• v.8 no.1
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• pp.159-169
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• 1999

Osteomalacia is syndrome of diverse etiology. characterized pathophysiologically by a failure of normal mineralization of bone and epiphyseal cartilage. This study was performed to investigate causes of disease, pathogenic mechanisms, symptoms, therapies and precriptions through the successive medical literatures. recent chinese medical literatures and chinese medical journals. It is similar to atrophic debility of bones, bone leaning, bone exhaustion, rheumatism involving the bone, osteodynia and cold and heat of bone etc. of oriental medicine. The most principal cause of this is deficiency of kidney. similar to hypophosphatemia caused by increased renal clearance and deficiency of vitamin D, and the rest are senility, deficiency of spleen, deficiency of qi and deficiency of blood. There are nourishing the kidney and spleen, nourishing the qi and blood, warming and passing the muscle and mac, passing an articulation an invigorating the muscle and bone, in principal therapy. And in medical herbs are rehmanniae radix preparat, corni fructus, discoreae rhizoma, cuscutae semen, tigridis os, juglandis semen, hominis placenta, drynariae rhizoma, eucommiae cortex, cynomorii herba, cervi cornus colla, cervi pantotrichum cornu, moutan cortex, polygoni multiflori radix, angelicae gigantis radix, achyranthis bidentatae radix, cibotii rhizoma, hirudo, eupolyphaga, spatholobi caulis, salviae miltiorrhizae radix, draconis resina, curcumae longae rhizoma. In care there are a sun-bath, exercise, high protein diet and taking vitamin D. And they reduce smoking, coffee, drinking etc.