• KSBB Journal
• /
• v.19 no.1
• /
• pp.88-92
• /
• 2004

The immunogenicity of investigational combined vaccine, composed of the Japanese encephalis virus(JEV) and the polysaccharide capsule(Vi) of Salmonella typhi covalently bound to tetanus toxoid(TT) was evaluated in mice. The mice immunized with combined vaccine elicited higher anti-Vi Immunoglobulin G(IgG) as well as anti-JEV IgG levels than the mice immunized with Vi-TT or JEV alone. The combined vaccine produced four-fold increase in anti-Vi IgG level than Vi-TT alone. In JEV the combined vaccine was significantly more immunogenic than JEV alone and induced six-fold increase in IgG level. Adsorption of combined vaccine onto aluminium hydroxide gel also enhanced IgG level for both Vi and JEV.

• Pediatric Infection and Vaccine
• /
• v.18 no.2
• /
• pp.124-134
• /
• 2011

Purpose : We have tried to search all concerning data on the policies of hepatitis B vaccination or surveillance of medical equipments that can transmit blood mediated diseases, including disposable syringe, in Republic of Korea, to propose references to other medical professionals. Methods : Data from domestic journals, government websites, computerized newspapers, etc. were reviewed. The data were arranged into four categories (governmental policies on hepatitis B control, hepatitis B mass immunization program in school, using process of hepatitis B vaccine, and policies on medical equipments surveillance, including disposable syringes, which is considered as source of blood mediated infection), and the periodic changes on each subjects in policies were reviewed. Results : Due to growing social concerns on hepatitis B in early 1980s, swift introduction and production of hepatitis B vaccine was made. After establishment of "5 year project for eradication of hepatitis B" in late 1983, number of vaccinated population jumped up to 6 million within 2 years (1984-85). However, since the immunization targets were mainly adult, not infant, this project was annulled in late 1985. Following this project, hepatitis B mass immunization program in school was carried out. In year 1995, hepatitis B vaccine was included in national immunization program. The use of disposable syringe was recommended from year 1980 but legislated in year 1985, finally. Conclusion : The mainstay in controlling hepatitis B in Republic of Korea was coordination of prompt introduction of vaccine, mass immunization, high vaccination coverage rate, or use of disposable syringes. However, since there is lack of official data available, it is urgent to arrange and computerize all government data related to infectious diseases.

• Pediatric Infection and Vaccine
• /
• v.29 no.1
• /
• pp.28-36
• /
• 2022

Purpose: To evaluate the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccines in children aged 5-11 years, a rapid systematic review was conducted on published clinical trials of COVID-19 vaccines and studies that analyzed real-world data on adverse events after COVID-19 vaccination. Methods: A systematic search was conducted on medical literature in international (Ovid-MEDLINE) and pre-published literature databases (medRxiv), followed by handsearching up to January 4, 2022. We used terms including COVID-19, severe acute respiratory syndrome coronavirus 2, and vaccines, and the certainty of evidence was graded using the GRADE approach. Results: A total of 1,675 studies were identified, of which five were finally selected. Among the five studies, four consisted of data from clinical trials of each of the four types of COVID-19 vaccines (BNT162b2, mRNA-1273, CoronaVac, and BBIBP-CorV). The remaining study consisted of real-world data on the safety of the BNT162b2 vaccine in children aged 5-11 years. This systematic review identified that COVID-19 vaccines in recipients aged 5-11 years produced a favorable immune response, and were vaccines were effective against COVID-19. The safety findings for the BNT162b2 vaccine in children and early adolescents aged 5-11 years were similar to those data noted in the clinical trial. Conclusions: There is limited data on COVID-19 vaccines in children aged 5-11 years. Consequently continuous and comprehensive monitoring is necessary for the evaluation of the safety and effectiveness of the COVID-19 vaccines.

• Journal of the korean veterinary medical association
• /
• v.49 no.3
• /
• pp.181-185
• /
• 2013

세계동물보건기구 (OIE)에서는 광견병을 매월 의무적으로 보고해야하는 질병 (reportable animal disease)으로 분류하고 있으며, 수의분야에서는 2종 법정전염병으로, 보건분야에서는 3종 감염병으로 규정하고 있다. 국내에서 광견병은 1907년에 최초로 확인된 이후로 2012년까지 16,140건이 보고되었다. 국내에서 광견병은 개를 포함한 여러 동물에서 1940년대까지 매년 400-700건이 발생하여 광견병 유행기로 분류된다. 1970년대에 광견병 불활화백신을 개발하고 가축과 개에 적용하여 광견병 발생건수가 줄어들면서 광견병의 제거기에 들어섰다. 광견병 생백신을 바탕으로 대량의 광견병 백신 접종정책을 실시하고, 유기견 (배회하는 개)의 제거 및 광견병 예방 홍보로 인하여 1984년부터 1992년까지 광견병 발생보고가 없었다. 그러나 1993년 철원에서 광견병이 다시 발생한 이후로 야생동물 즉 너구리에 의해 광견병이 전파되고 지속적으로 발생하고 있어 재발생기로 분류된다. 2012년에는 수원과 화성을 포함하여 7건의 광견병이 발생하여 방역당국은 물론 일반 국민들까지 긴장시키고 있다. 따라서, 여기에서는 야생 너구리에 의해 전파되는 최근 국내 광견병의 특성을 파악하고 이에 적절한 예방 및 방역 대책 관련 정보를 제공하고자 한다.

• The Journal of the Korea Contents Association
• /
• v.15 no.3
• /
• pp.265-271
• /
• 2015

This study is the analysis about materials (from 2012 to 2014) which was stored in the data made from the 397 infants subjects who were born in 2012, with the basis of the preventive injection management, public health care information system by using SPSS win 18.0 program. After we analyzed the present non-injection state and the non-injection reasons with the basis of each birth month, each vaccine, each injection period, we found out that 89 infants(22.4%) were the ones who were not computerized. Except the 20 infants-the ones having uncertain phone numbers and addresses, and computerization errors, 69 infants (17.4%) were the ones that didn't get injection. We guided protective injection to them by sending SMS text message and we could inject 39 infants (9.8%) of them. We could achieve the high 92.4% injection rate. we want this research to be used to try wipe out the infectious diseases in this district and be utilized as the basic materials of protective injection cost support and health care policies, etc.

• Pediatric Infection and Vaccine
• /
• v.20 no.3
• /
• pp.139-146
• /
• 2013

Objective: As per the requirement of Korean Food and Drug Administration, this post-marketing surveillance was conducted in Korea to evaluate the safety and reactogenicity of Poliorix$^{TM}$ following its introduction in 2006. Methods: In this open, multicenter study, the vaccine was administered as per the current practice of Korean doctors and in reference to the guidebook by the Korean Pediatric Society and as indicated in the Korean label which was as follows - for primary vaccination three doses were given to infants at ages 2, 4 and 6 months whereas, for the booster dose a single dose was given to children aged 4-6 years. Safety data during this six year surveillance was collected using diary cards which were distributed to the parents to record adverse events. Results: A total of 639 subjects were enrolled into the study. Of these, 617 subjects and 22 subjects received the vaccine as a primary and booster dose, respectively. At least one unsolicited symptom was reported in 11.4% (73/639) of the subjects during the 7-day follow-up period; upper respiratory tract infection (2.5%;16/639) was the most frequently reported unsolicited symptom. One subject reported at least one unsolicited symptom (gastroenteritis) of grade 3 intensity within the 31-day post-vaccination period. Approximately 1.7% (11/639) of subjects reported 13 serious adverse events (SAEs). All SAEs were resolved by the end of the study. Conclusion: In Korea, primary and booster vaccination with Poliorix$^{TM}$ was well-tolerated in healthy subjects when administered according to the prescribing information as part of routine clinical practice.

• Korean Journal of Clinical Laboratory Science
• /
• v.47 no.2
• /
• pp.78-82
• /
• 2015

The purpose of this study was to survey the anti-HBs positivity and titers of antibody in current students who received nationwide vaccination against Hepatitis B virus which targeted infants in 1995. The subjects were 262 students in Gyeongnam province from April 2014 to October 2014. The positive rate of anti-HBs was 55.3% (145 people) and the negative rate of anti-HBs was 44.7% (117 people). Positivity was shown to be higher in women than men. However, there was no statistically significant difference. Of the HBV-vaccinated subjects, 117 (44.7%) had anti-HBs titer <10, which is judged to be negative, 126 (47.8%) had anti-HBs titer 10-499.9 mIU/mL, which is judged to be positive, and 22 (7.3%) had anti-HBs titer more than 500 mIU/mL. The rate of anti-HBs with lower titer (10-99.9 mIU/mL) was 62% in the positive group. Classifying the antibody titer according to age, the rate of anti-HBs positivity in titer with less than 100 mIU/mL was indicated to be 78.3% in cases of 19-20 year old and 46.7% in 21-22 year old, 52.3% in 23-24 year old. A case of the lower titer with 10-99.9 mIU/mL, showed significant difference according to age. As a result of research, the antibody titers is decreased depending on the passage of time. Hence, the checking of anti-HBs titer is needed after Hepatitis B vaccination and many healthy adults will need periodic boosters of hepatitis B vaccine to maintain production of antibody to hepatitis B surface antigen.

• Journal of the korean veterinary medical association
• /
• v.49 no.3
• /
• pp.142-145
• /
• 2013

대만은 현재 구제역 발생국이다. 1997년 구제역의 발생 때문에 엄청난 경제적인 피해를 받았고, 그 이후 백신접종 정책으로 바꾸어 구제역 청정국을 이루어낸 바 있다. 그러나 2009년 들어 구제역이 다시 발생되어 현재까지도 지속적으로 발생되고 있다. 현재 대만의 방역정책은 무엇이며, 지금 처해 있는 방역적 상황과 대만에 구제역이 발생함으로써 우리나라에 미치는 영향에 대해서 고찰해 보고자 하였다.

• 보건세계
• /
• v.63 no.1
• /
• pp.30-32
• /
• 2014

협회는 국민보건 사업의 일환으로 결핵 및 호흡기질환의 예방과 퇴치를 위해 홍보, 교육 사업은 물론 결핵예방접종 백신 및 감염진단 시약의 생산과 연구 등과 같은 다양한 사업을 수행해오고 있다. 그 가운데에서도 이번 호에서는 결핵 발견의 최전방에 선 검진팀의 일과를 소개하고자 한다.

• 건강소식
• /
• v.35 no.1
• /
• pp.14-15
• /
• 2011

눈에 넣어도 아프지 않을 우리 아이. 출생률이 급감한 오늘날, 부모들에겐 자식 사랑이 더욱 더 각별할 수밖에 없다. 하지만 10개월 간 '엄마의 바다'에서 유유자적하던 아이는 세상에 나옴과 동시에 수많은 적들로부터 공격 대상이 된다. 여기 아이들을 적들로부터 지키는 방법이 있다. 바로 든든한 '백신 군단'이 그들이다.