• Title/Summary/Keyword: 방사화학

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Quality Control of Radiopharmaceutical (진단용 방사성 의약품의 정도관리)

  • An, Sung-Min;Hong, Tae-Kee;Ham, Jun-Cheol;Kim, Sung-Chul
    • The Journal of the Korea Contents Association
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    • v.9 no.11
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    • pp.240-246
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    • 2009

  • Quality control test in this field of study were carried out in 3 categories, radionuclidic purity, chemical purity and radiochemical purity. Also, indication efficiency was tested every 3 hours changed after binding the radiopharmaceutical to see how long the medicine is available for usage after indicating. The result showed that currently used radiopharmaceutical have good radionuclidic purity and chemical purity. However, radiochemical purity indication showed small differences depending on indication method and indication period. Radiopharmaceutical are indicated by treatment providers, so they need to pay more attention to the indication process and quality control to provide more efficient treatment.

  • https://doi.org/10.5392/JKCA.2009.9.11.240 인용 PDF

Quality Control Tests and Acceptance Criteria of Diagnostic Radiopharmaceuticals (진단용 방사성의약품의 품질관리시험 및 기준)

  • Park, Jun Young
    • Korean Journal of Clinical Laboratory Science
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    • v.53 no.1
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    • pp.1-10
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    • 2021

  • Radiopharmaceuticals are drugs that contain radioisotopes and are used in the diagnosis, treatment, or investigation of diseases. Radiopharmaceuticals must be manufactured in compliance with good manufacturing practice regulations and subjected to quality control before they are administered to patients to ensure the safety of the drug. Radiopharmaceuticals for administration to humans need to be sterile and pyrogen-free. Hence, sterility tests and membrane filter integrity tests are carried out to confirm the asepticity of the finished drug product, and a bacterial endotoxin test conducted to assess contamination, if any, by pyrogens. The physical appearance and the absence of foreign insoluble substances should be confirmed by a visual inspection. The chemical purity, residual solvents, and pH should be evaluated because residual by-products and impurities in the finished product can be harmful to patients. The half-life, radiochemical purity, radionuclidic purity, and strength need to be assessed by analyzing the radiation emitted from radiopharmaceuticals to verify that the radioisotope contents are properly labeled on pharmaceuticals. Radiopharmaceuticals always carry the risk of radiation exposure. Therefore, the time taken for quality control tests should be minimized and care should be taken to prevent radiation exposure during handling. This review discusses the quality control procedures and acceptance criteria for a diagnostic radiopharmaceutical.

  • https://doi.org/10.15324/kjcls.2021.53.1.1 인용 PDF KSCI

A Study on the Recycling of Radioactively Contaminated Metal Waste (방사성오염 금속폐기물의 재활용 연구)

  • 문제권;박상윤;정종헌;이정원;오원진
    • Resources Recycling
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    • v.6 no.3
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    • pp.22-27
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    • 1997

  • Recycling of radioactively contaminated metal wasles is very attractive to reduce thc final disposal volumc of the radioactive wastes, thereby maximizing the usage of nahrral rzsuunts and minimizmg the detrimental effects of thz rzdioaclive wastes on the environment. In the recycling process, many complicated processes arc involved. Among those processes the 'surface contamination removal techniques such as physical, chemical and electrochern~calm ethods are the most critical and Ircquently applied in accordance with the contamination characteristics and the chemical compositions of the metal wastes. In this sludy, the sulfuric acid-cerium method and electmchemical methods were applied lu removc the conatiminated suhce. The results showed the surface contaminalion could he lowered to the background levcl by lhasc mclhods.

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Radiochemical cis-trans Isomerization of ${\beta}$-Styrylnaphthalene (${\beta}$-스티릴나프탈렌의 방사화학적 시스-트란스 이성질화 반응)

  • Sang Chul Shim;George S. Hammond
    • Journal of the Korean Chemical Society
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    • v.20 no.4
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    • pp.290-294
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    • 1976

  • Radiation-induced cis-trans isomerization of ${\beta}$-styrylnaphthalene is studied by determination of G values and the radiostationary states. The results are compared with data obtained in direct and sensitized photoisomerization of the compound. Both the excited singlet and triplet states are involved in the isomerization of ${\beta}$-styrylnaphthalene in the radiolysis of benzene solution.

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