• The Journal of the Korean dental association
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• v.23 no.1 s.188
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• pp.73-81
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• 1985

In the assessment of patency of a small vessel anastomosis, micro-arteriography using dental X-ray and film was used as a method of testing the patency of arterial anastomoses in the rat. Micro-arteriography could lead to an objective evaluation of the patency in End-to-End and End-to Side anastomoses. The method used in this study is easily accessible for Oral and Maxillo-facial surgeon to practice the microvascular anastomosis, and requires materials available in every dental clinic.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.3
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• pp.257-265
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• 1999

To investigate the sequential changes in microvascular architecture and osseous regeneration during the bony healing after an application of the guided tissue regeneration method, we made artificial defects measuring $0.7cm{\times}0.3cm$ in size on femoral bones of rats measuring about 200gm and applied non-absorbable TEFE membrane at experimental sites but not at control sites. Then we observed the sequential changes and correlations between new vacuolation and bony regeneration using microvascular corrosion cast method and routine light microscopic observation at 1, 2 and 3 weeks after operation, respectively. The results showed that there were close relationships between regeneration of microvasculature and bone. In early phase, the invasion of granulation tissue at control sites delayed bony regeneration, however, in later phase, there was no remarkable differences in bony regeneration between control and experimental sites. The placement of barrier also affected in revascularization of regenerating bony defects. This is, the experimental sites showed parallel arranged nutritional vessels along long axis with well developed retiform plexus whereas the control revealed vertical invasion of microvasculature from outside of marrow space through bony defects which was also rearrange with time into parallel pattern with a vertical plexus but lesser organized than that of experimental sites. These findings suggest that the reconstruction of regenerating vasculature within the marrow cavity only may be sufficient and/or more be efficient in regeneration of bony defects.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.229-230
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• 2015

신생혈관 형성은 기존에 존재하는 혈관으로부터 새로운 혈관을 형성하는 기작으로 정상 세포에서 상처 치유, 세포의 발생 및 성장에 관여한다고 알려져 있다. 더 중요한 것은 이 기작이 암의 성장 및 전이에서도 매우 중요한 역할을 하고 있다는 사실이다. 특히, 엔지오제닌(Angiogenin)이 신생혈관형성을 촉진하는 것으로 알려져있다. 이러한 주요 물질을 최신 바이오칩 기술 중 하나인 액적 기반 미세유체 시스템을 활용하여 1 나노리터 수준의 시료 내에 존재하는 엔지오제닌을 정량하는 기술을 개발함으로써 현재 일반적으로 사용되고 있는 정량 기술에 비해 시간뿐만 아니라 비용을 절감할 수 있음을 보여주었다. 이외에도 본 연구에서 개발한 액적 기반 미세유체 시스템 기술은 수은과 같은 중금속의 검출도 가능하기 때문에 환경 센서로의 활용 가능성을 보여준다.

• Journal of Life Science
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• v.26 no.1
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• pp.91-100
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• 2016

Angiogenesis is essential for the pathophysiological processes of embryogenesis, tissue growth, diabetic retinopathy, psoriasis, wound healing, rheumatoid arthritis, cardiovascular diseases, and tumor growth. Inhibition of angiogenesis represents an attractive therapeutic approach for the treatment of angiogenic diseases such as cancer. However, uncontrolled angiogenesis is also necessary for tumor development and metastasis. Inhibition of vascular endothelial growth factor (VEGF) signaling, a critical factor in the induction of angiogenesis, cause robust and rapid changes in blood vessels of tumors and therefore VEGF constitutes a target for such anti-angiogenic therapy. Recently, since natural compounds pose significantly less risk of deleterious side effects than synthetic compounds, a great many natural resources have been assessed for useful substance for anti-angiogenic treatment. Here we evaluated the anti-angiogenic effects of a hot water extract of Scutellaria baicalensis (SBHWE) using in vitro assays and ex vivo animal experiments. Our results show that SBHWE dose-dependently abrogated vascular endothelial responses by inhibiting VEGF-stimulated migration and invasion as well as tube formation in a human umbilical vein endothelial cell (HUVEC) model, without cytotoxicity, as determined by a cell viability assay. Further study revealed that SBHWE prevented VEGF-induced neo-vascularization in a rat aortic ring sprouting model. Taken together, our findings reveal an anti-angiogenic activity of Scutellaria baicalensis and suggest that SBHWE is a novel candidate inhibitor of VEGF-induced angiogenesis.

• 대한미세수술학회:학술대회논문집
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• 1992.11a
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• pp.59-59
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• 1992

• 대한미세수술학회:학술대회논문집
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• 1996.10a
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• pp.167-167
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• 1996

• 대한미세수술학회:학술대회논문집
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• 1999.11a
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• pp.210-210
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• 1999

• The Monthly Diabetes
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• s.151
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• pp.50-51
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• 2002

당뇨병성 막망증은 지속적인 고혈당과 이에 따른 대사이상으로 망막의 미세혈관이 점차 변형, 폐쇄되어 망막으로의 원활한 혈액공급이 되지 못하고 혈관투과성이 증가하여 망막에서 신생혈관이 생성되는 질환이다. 진행된 후에 치료를 통한 시력호전이 불가능하므로 조기진단 및 적절한 관리가 중요하나, 치료가 가능한 초기질환 외에 당뇨병성 망막증이 상당히 진행된 경우에도 주관적 증상이 없는 경우가 많다. 따라서 시력장애 등의 증상이 나타난 후에는 이러한 예방적인 조치를 취할 수 있는 시기를 지나치는 수가 많다.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.6
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• pp.91-96
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• 2010

A laser speckle is a random pattern that has a granular appearance produced by reflected light when a coherent laser illuminates an irregular course surface. Laser speckle system has many advantages. It can detect some animals functional parts. Moreover, it relatively consists of simple and in-expensive system. It is very important that detecting micro-vessels through image processed image. Current study is to improve image quality through variable image processing method. But this paper made laser speckle endoscope for miniaturization and commercialization laser speckle system. We had endoscope test through goldfish's tail. We will compare the processed speckle image and halogen image.

• Childhood Kidney Diseases
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• v.17 no.2
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• pp.149-153
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• 2013

We report the case of a 14-year-old girl, diagnosed with atypical thrombotic microangiopathy (TMA). The patient presented with persistent fever, nausea, and newly developed peripheral edema. Her laboratory findings indicated chronic anemia with no evidence of hemolysis, thrombocytopenia, or elevated serum creatinine level. A few days after hospitalization, acute renal failure and fever worsened, and proteinuria developed. On day 40 of hospitalization, she experienced a generalized tonic seizure for 5 min, accompanied by renal hypertension. Brain magnetic resonance imaging revealed posterior reversible leukoencephalopathy syndrome. After steroid pulse therapy, a renal biopsy was performed because of delayed recovery from thrombocytopenia. The biopsy findings showed features of thrombotic microangiopathic hemolysis with fibrinoid change restricted. Current diagnostic criteria for TMA have focused on thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, and diagnosis is based on the clinical presentation and etiology, with the consequence that idiopathic and atypical forms of TMA can be overlooked. Developing effective tools to diagnose TMA, such as studying levels of ADAMTS13 or testing for abnormalities in the complement system, will be the first step to improving patient outcomes.