• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.55-55
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• 2003

본 연구에서는 최근 미래형 방사선치료 기술로서 관심이 집중되고 있는 자기장을 이용한 선량분포 변환 및 집중기술에 대하여 물리적 배경과 임상적 응용 가능성을 논의하였다. 먼저 물리적 이론으로부터 물질속 자기장에서 전자의 운동을 고찰하였으며 다음에는 몬테칼로 계산을 이용하여 임상에 이용되는 고에너지 광자와 전자선에 대하여 선량분포를 계산하였다. 물에 인가된 수 Tesla 자기장에 대하여 전자들의 기본 경로는 자기장과 수직방향으로 편향을 받으며 원궤도를 취하였으며 궤도반경은 에너지의 손실에 따라 점차 줄어드는 것으로 나타났다. 가로방향의 인가 자기장에 대한 몬테칼로 계산결과 광자 및 전자선에 대하여 자기장 인접영역에서 급격한 선량증가 현상이 발생하였는데 10 MV 광자선의 경우에 3T와 5T에서 각각 약 40%와 80%의 선량증가를 확인하였으며 전자선의 경우에도 유사한 결과가 나타남을 확인하였다. 또한 자기장 종단영역에서는 흡수선량의 급격한 감소가 발생하는 것으로 나타났는데, 본 연구에서는 이러한 특성들을 이용하여 종양에 방사선량을 집중시키고 주변 정상조직을 효과적으로 보호할 수 있는 미래형 최적화 방사선치료의 모델들을 제시하였다. 본 연구의 주요결과들은 최근 관련 실험들로부터 점차 명백해지고 있으며, 자기장을 병행한 방사선치료 기술의 국내 기반기술 확보에 기여할 것으로 기대한다.

• Journal of the Korean Society of Radiology
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• v.15 no.6
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• pp.813-819
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• 2021

In this study, the shielding rate of L-block-type shielding equipment used for radiation protection when radioactive fluorine is injected into the human body and the dose distribution of the space in the injection room were calculated using the Monte Carlo method. The shielding rate of the body and window parts of the L-block-type shielding equipment was 99.99%. The dose distribution calculated at a distance of 1 m was relatively high at 135°, 45°, 225°, 315°, and 180° of the XZ plane, and was calculated to be very low at 0°, 90°, and 270°. In the YZ plane, it was relatively high at 135°, 180°, and 225°, and was calculated very low at the remaining angles. The AZ and BZ planes also showed similar results to the YZ plane. In addition, it was confirmed that the shielding rate was the best in the range of 225° to 315° through the dose distribution in the horizontal direction of the source and the 45° direction above the source. These results can be used as basic data necessary for radiation protection of radiation workers.

• Journal of Radiation Protection and Research
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• v.29 no.2
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• pp.105-115
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• 2004

The Monte Carlo simulation requires very much time to obtain a result of acceptable accuracy. Therefore we should know the optimum number of history not to sacrifice time as well as the accuracy. In this study, we have investigated the effects of statistical uncertainties of the photon dose calculation. BEAMnrc and DOSXYZnrc systems were used for the Monte Carlo dose calculation and the case of mediastinum was simulated. The several dose calculation result from various number of histories had been obtained and analyzed using the criteria of isodose curve comparison, dose volume histogram comparison(DVH) and root mean-square differences(RMSD). Statistical uncertainties were observed most evidently in isodose curve comparison and RMSD while DVHs were less sensitive. The acceptable uncertainties $(\bar{{\Delta}D})$ of the Monte Carlo photon dose calculation for the radiation therapy were estimated within total 9% error or 1% error for over than $D_{max}/2$ voxels or voxels at maximum dose.

• Progress in Medical Physics
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• v.18 no.4
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• pp.221-225
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• 2007

Monte Carlo calculations were performed to demonstrate the dose modulation with dynamic magnetic fields in phantom. The goal of this study is to obtain the uniform dose distributions at a depth region as a target on the central axis of photon beam under moving transverse magnetic field. We have calculated the depth dose curves for two cases of moving magnetic field along a depth line, constant speed and optimal speed. We introduced step-by-step shift and time factor of the position of the electromagnet as an approximations of continuous moving. The optimal time factors as a function of magnetic field position were calculated by least square methods using depth dose data for static magnetic field. We have verified that the flat depth dose is produced by varying the speed of magnetic field as a function of position as a results of Monte Carlo calculations. For 3 T magnetic field, the dose enhancement was 10.1% in comparison to without magnetic field at the center of the target.

• Korean Journal of Environmental Biology
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• v.24 no.4
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• pp.387-391
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• 2006

Computational and experimental dosimetry of Henschke applicator with respect to high dose rate brachytherapy using the MIRD phantom and a remote control afterloader were performed. A comparison of computational dosimetry was made between the simulated Monte Carlo dosimetry and GAMMADOT brachytherapy Planning system's dosimetry. Dose measurements was performed using ion chamber in a water phantom. Dose rates are calculated using Monte Carlo code MCNP4B and the GAMMADOT. Thecomputational models include the detailed geometry of Ir-192 source, tandem tube, and shielded ovoids for accurate estimation. And transit dose delivered during source extension to and retraction from a given dwell position was estimated by Monte Carlo simulations. Point doses at ICRU bladder/rectal pointswhich have been recommened by ICRU 38 was assessed. Calculated and measured dose distribution data agreed within 4% each other. The shielding effect of ovoids leads to 19% and 20% dose reduction at bladder surface and rectal points.

• Progress in Medical Physics
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• v.10 no.1
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• pp.55-62
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• 1999

In an effort to study the characteristics of x-rays utilized in radiation therapy, we calculated the energy distribution and the mean energy of x-rays generated from a tungsten target bombarded by 6, 10, and 15 MeV electron beams, using a Monte Carlo technique. The average photon energies calculated as a function of the beam radius lied in 1.4 ∼ 1.6, 2.1 ∼ 2.5 and 2.8 ∼ 3.3 MeV ranges for 4, 10, and 15 MV electron beams, respectively, which turned out to have no strong dependence on the radius. Using the energy distributions of 6,10, and 15 MV x-rays obtained for the target distance of 100 cm, percentage depth doses were determined using Monte Carlo calculations. For the case 10 MV, a comparison was made between our calculation and measurement performed by others. The calculated percentage depth dose appeared somewhat smaller than the measured one except in the surface region. We conclude that this is due to the fact that the beam hardening effect resulting from the flattening filter was not properly allowed for in our Monte Carlo calculations.

• Progress in Medical Physics
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• v.13 no.4
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• pp.187-194
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• 2002

In this work we investigated through Monte Carlo calculations the physical characteristics of the absorbed dose from the Ir-192 source used in brachytherapy The Monte Carlo calculations were performed using the code EGS4, which was extensively modified in order to handle cylindrical sources, phantoms, and energy distributions to suit out own purpose. From the results of the calculations for the $\beta$ -rays, it was found that they contribute on the average 0.02% to The total absorbed dose in the distance range of 0.5-5.0 cm from the source. This is due to the face that, although most of the primary $\beta$ -rays are absorbed in the source and encapsulation material, the resulting low energy braking radiation from them contribute to such a distance. The absorbed dose in the encapsulation material varied on the average from 2.8% for platinum down to 1.1% for iron. The radial dose functions obtained by our Monte Carlo calculations were consistent within $\pm$3% with those of the TG-43 report for the radial distance interval 0.5-10.0 cm from the source. The user code we wrote in this work can be used for other sources of different sizes and so it can be very useful in designing and producing the sources for brachytherapy.

• Progress in Medical Physics
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• v.22 no.3
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• pp.124-130
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• 2011

In this study the dosimetric evaluation for a biological sample irradiated by gamma rays from Cs-137 irradiator (Gamma Irradiator, Chiyoda Technol Co., Japan) was performed for radiobiological experiment. A spherical water with a diameter of 3 cm was assumed as a biological sample. The absorbed dose were determined by the air kerma based dosimetric calculation system. The theoretical and Monte Carlo calculations (MCNPX) were performed and compared to evaluate measured air kerma and determined absorbed dose respectively. As a result of comparison with theoretical calculation, the measured air kerma was in good agreement within 3.1% at the distance of 100 and 200 cm from the source. In comparison with Monte Carlo results the determined absorbed dose along the central axis was in good agreement within 1.9% and 3.7% at 100 cm and 200 cm respectively. Although the preliminary results were obtained in this study these results were used as a basis of dosimetric evaluation for radiobiological experiment. Extended study will be performed to evaluate the dose in various conditions of biological samples.

• Progress in Medical Physics
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• v.22 no.4
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• pp.190-197
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• 2011

Currently, the dose distribution calculation used by commercial treatment planning systems (TPSs) for high-dose rate (HDR) brachytherapy is derived from point and line source approximation method recommended by AAPM Task Group 43 (TG-43). However, the study of Monte Carlo (MC) simulation is required in order to assess the accuracy of dose calculation around three-dimensional Ir-192 source. In this study, geometry factor was calculated using segmented sources integration method by dividing microSelectron HDR Ir-192 source into smaller parts. The Monte Carlo code (MCNPX 2.5.0) was used to calculate the dose rate $\dot{D}(r,\theta)$ at a point ($r,\theta$) away from a HDR Ir-192 source in spherical water phantom with 30 cm diameter. Finally, anisotropy function and radial dose function were calculated from obtained results. The obtained geometry factor was compared with that calculated from line source approximation. Similarly, obtained anisotropy function and radial dose function were compared with those derived from MCPT results by Williamson. The geometry factor calculated from segmented sources integration method and line source approximation was within 0.2% for $r{\geq}0.5$ cm and 1.33% for r=0.1 cm, respectively. The relative-root mean square error (R-RMSE) of anisotropy function obtained by this study and Williamson was 2.33% for r=0.25 cm and within 1% for r>0.5 cm, respectively. The R-RMSE of radial dose function was 0.46% at radial distance from 0.1 to 14.0 cm. The geometry factor acquired from segmented sources integration method and line source approximation was in good agreement for $r{\geq}0.1$ cm. However, application of segmented sources integration method seems to be valid, since this method using three-dimensional Ir-192 source provides more realistic geometry factor. The anisotropy function and radial dose function estimated from MCNPX in this study and MCPT by Williamson are in good agreement within uncertainty of Monte Carlo codes except at radial distance of r=0.25 cm. It is expected that Monte Carlo code used in this study could be applied to other sources utilized for brachytherapy.

• Radiation Oncology Journal
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• v.28 no.4
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• pp.238-248
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• 2010

Purpose: To compare the dose distributions between three-dimensional (3D) and four-dimensional (4D) radiation treatment plans calculated by Ray-tracing or the Monte Carlo algorithm, and to highlight the difference of dose calculation between two algorithms for lung heterogeneity correction in lung cancers. Materials and Methods: Prospectively gated 4D CTs in seven patients were obtained with a Brilliance CT64-Channel scanner along with a respiratory bellows gating device. After 4D treatment planning with the Ray Tracing algorithm in Multiplan 3.5.1, a CyberKnife stereotactic radiotherapy planning system, 3D Ray Tracing, 3D and 4D Monte Carlo dose calculations were performed under the same beam conditions (same number, directions, monitor units of beams). The 3D plan was performed in a primary CT image setting corresponding to middle phase expiration (50%). Relative dose coverage, D95 of gross tumor volume and planning target volume, maximum doses of tumor, and the spinal cord were compared for each plan, taking into consideration the tumor location. Results: According to the Monte Carlo calculations, mean tumor volume coverage of the 4D plans was 4.4% higher than the 3D plans when tumors were located in the lower lobes of the lung, but were 4.6% lower when tumors were located in the upper lobes of the lung. Similarly, the D95 of 4D plans was 4.8% higher than 3D plans when tumors were located in the lower lobes of lung, but was 1.7% lower when tumors were located in the upper lobes of lung. This tendency was also observed at the maximum dose of the spinal cord. Lastly, a 30% reduction in the PTV volume coverage was observed for the Monte Carlo calculation compared with the Ray-tracing calculation. Conclusion: 3D and 4D robotic radiotherapy treatment plans for lung cancers were compared according to a dosimetric viewpoint for a tumor and the spinal cord. The difference of tumor dose distributions between 3D and 4D treatment plans was only significant when large tumor movement and deformation was suspected. Therefore, 4D treatment planning is only necessary for large tumor motion and deformation. However, a Monte Carlo calculation is always necessary, independent of tumor motion in the lung.