• Journal of Korean Society of Coastal and Ocean Engineers
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• v.14 no.2
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• pp.136-150
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• 2002

To improve the water quality of the recently constructed Siwhaho, sluice gates were operated to allow free exchange of water with the sea. This estuarine lake connected to the outer sea through narrow gates is affected mainly by flushing by gate operation and river flows and wind forcing sometimes. As a predicting tool far the water qualities, a three-dimensional finite volume model CE-QUAL-ICM is incorporated into a finite element hydrodynamic model, TIDE3D. In coupling these two different modules, a new error minimization technique is applied by considering conservation of mass. Model tests for one year after calibration and validation using field observation show that eutrophication and other biological changes reach quasi-steady state after initial 60 days of simulation, thus it would be necessary to consider moderate ramp up option to remove initial uncertainties due to cold start option. Sediment-water interaction might not be a concern in the long-term simulation, since its effect is negligible. Simulated results show the newly applied scheme can be applied with satisfaction not only fur lessening of eutrophic processes in an estuarine lake but also looking for some active circulation to improve water quality.

• Korean Journal of Clinical Pharmacy
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• v.20 no.1
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• pp.9-16
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• 2010

Purpose: 본 연구는 한국인 성인 조혈모세포이식환자를 대상으로 경구용 사이클로스포린의 집단약동학 분석을 통하여 사이클로스포린의 약동학적 파라미터에 영향을 미치는 요인 분석을 실시하고자 하였다. Methods: 2000년 12월부터 2006년 8월까지 서울대학교병원에서 동종조혈모세포이식을 받고 면역억제제로 사이클로스포린을 복용한 성인 백혈병환자를 대상으로 후향적으로 자료를 수집하였다. 사이클로스포린의 약동학에 영향을 미치는 인자로는 연령, 성별, 이식 후 날짜, 신기능, 공여자와의 관계, 질병의 종류, 혈중 빌리루빈 농도, 사이클로스포린의 대사를 유도하는 프레드니솔론의 투여량, 헤마토크리트, 사이클로스포린의 대사를 저해하는 약물의 병용여부 등을 검토하였다. 분석은 NONMEM$^{(R)}$ VI 프로그램을 이용하였으며, 변수를 추가하지 않은 기본 모형을 만든 후에 단계적인 요인의 추가와 제거를 통해 최종모형을 제작하였다. Results: 최종 상관 모형은 다음과 같다; CL/F (L/h) = $85.6{\times}e^{(0.646\;{\times}\;HCT/28.9\;+\;0.0464\;{\times}\;Gender)}$. 사이클로스포린의 겉보기 클리어런스는 환자의 성별이 남자일 때 또는 헤마토크릿이 감소할수록 증가하였다. 그 외 파라미터는 다음과 같이 계산되었다; $K_{\alpha}=0.0787\;(h^{-1})$; Q=57.1(L/kg/h); $V_{d-central\;compartment}$=1,100 (L); $V_{d-peripheral\;compartment}$ = 213,000(L). 개체간 편차는 40% 미만이었으며, 개체내 편차를 포함하는 잔차는 24.02%였다. Conclusions: 사이클로스포린의 약동학적 특징과 그 클리어런스에 영향을 끼칠 수 있는 임상적 요인을 이해하는 것은 환자 개개인의 용량과 용법의 결정 및 이상반응 발생의 예방에 유용할 수 있다. 한국인 조혈모세포이식환자에서 사이클로스포린의 약동학에 영향을 미치는 최종 파라미터를 구한 본 연구의 결과는 조혈모세포이식을 받은 한국인 성인환자에서 사이클로스포린의 모니터링 및 용량조절에 유용할 것으로 전망된다.

• The Journal of Engineering Geology
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• v.27 no.4
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• pp.429-438
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• 2017

Monte Carlo N-Particle (MCNP) modeling algorithm based on the Monte Carlo method was used to perform the simulation of neutron logging in order to increase the reliability and utilization of neutron logs applied in geological and resource engineering fields. To perform the simulation using MCNP, we used a realistic three-dimensional configuration of neutron sonde and formation. Validation of the modeling was confirmed by comparing the calibration curves of sonde manufacture with those calculated by MCNP modeling. After the validation, lithology effects, pore fluid effects, borehole diameter change, casing effect, and effects of borehole water level were investigated through modeling experiments. Numerical tests indicate that changes in neutron count ratio according to the lithology were quantitatively understood. In case of a borehole with a diameter of 3 inches, ratio of counting rates was higher than expected to be interpreted as borehole fluid has small effects on neutron logging. Effect of casing was also small in general, particular when porosity increases. Since modeling results above the groundwater level showed a tendency opposite to those below the groundwater level, neutron logs can be used to detect groundwater level. The modeling results simulated in this study for various borehole environments are expected to be used for data processing and interpretation of neutron log.

• Radiation Oncology Journal
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• v.20 no.2
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• pp.186-192
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• 2002

Purpose : Measurement of transmission dose is useful for in vivo dosimetry. In this study, previous algorithm for estimation of transmission dose was modified for use in cases with tissue deficit. Materials and Methods : The beam data was measured with flat solid phantom in various conditions of tissue deficit. New algorithm for correction of transmission dose for tissue deficit was developed by physical reasoning. The algorithm was tested in experimental settings with irregular contours mimicking breast cancer patients using multiple sheets of solid phantoms. Results : The correction algorithm for tissue deficit could accurately reflect the effect of tissue deficit with errors within ${\pm}1.0\%$ in most situations and within ${\pm}3.0\%$ in experimental settings with irregular contours mimicking breast cancer treatment set-up. Conclusion : Developed algorithm could accurately reflect the effect of tissue deficit and irregularly shaped body contour on transmission dosimetry.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.44-49
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• 2006

In this study, the resolution capabilities of electrical resistivity tomography (ERT) in the monitoring of $CO_2$ injection are investigated. The pole-pole and bipole-bipole electrode configuration types are used between two uncased boreholes straddling the $CO_2$ plume. Forward responses for an initial pre-injection model and three models for subsequent stages of $CO_2$ injection are calculated for the two different electrode configuration types, noise is added and the theoretical data are inverted with both L1- and L2-norm optimisation. The results show that $CO_2$ volumes over a certain threshold can be detected with confidence. The L1-norm proved superior to the L2-norm in most instances. Normalisation of the inverted models with the pre-injection inverse model gives good images of the regions of changing resistivity, and an integrated measure of the total change in resistivity proves to be a valid measure of the total injected volume.

• Korean Journal of Cognitive Science
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• v.10 no.3
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• pp.39-49
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• 1999

The space of IID([ndependently, Identically Distributed) textures was built with axes of mean luminance and contrast, and studied on what kind of mechanisms were required to mediate texture segregation in this space. The conjecture was tested that one of these mechanisms is sensitive to the differences between the means of textures to be discriminated, whereas the other is sensitive to the differences between variances. The probability of discrimination was measured for various pairs of textures in the lID space The data were well fit by a model in which discrimination depends on two mechanisms whose responses are combined by probability summation. The conjecture was rejected that two mechanisms respectively tuned to mean and variance of texture function in segregation. Discrimination within space is mediated by 2 independent channels however: the 2 independent channels are not exactly tuned to texture mean and variance. One m mechanism was primarily sensitive to texture mean, whereas the other was sensitive to b both texture mean and variance.

• Geophysics and Geophysical Exploration
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• v.10 no.4
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• pp.275-284
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• 2007

For precise interpretation of magnetotelluric (MT) data distorted by irregular surface terrain, topography effects are investigated by computing apparent resistivities, phases, tippers and induction vectors for a three-dimensional (3D) hill-and-valley model. To compute MT responses for the 3D surface topography model, we use a 3D MT modeling algorithm based on an edge finite-element method which is free from vector parasites. Distortions on the apparent resistivity and phase are mainly caused by distorted currents that flow along surface topography. The distribution of tipper amplitudes over both hill and valley are the same, while the tipper points toward the center of hill and the base of the valley. The real part of induction vector also points in the same direction as that of tipper, while the imaginary part in the opposite direction.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.462-462
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• 2021

최근 도시화 및 불투수면의 증가와 지하수의 과다한 사용으로 직접유출이 증가하고, 침투량이 감소하며, 하천의 건천화가 발생하고 있다. 이에 환경부에서는 이러한 물순환의 왜곡을 막기위해 물환경보전법상의 물순환율을 정의하고 물순환 관리목표를 설정하였다. 하지만 지역 별 물순환 특성을 반영한 관리계획이 부족하고, 현재 제한된 재원의 효율적 활용을 위해서는 물순환 관리지역에 대한 우선순위 결정도 필요하다. 본 연구에서는 PSR framework를 통해 유역 물순환 평가방법론을 만들고 이를 활용한 지역별 관리계획 및 우선순위를 결정하고자하였다. PSR framework는 지속가능성을 위해 OECD가 개발한 개념 모형이며, Pressure, State, Response 세 가지 요소로 구분해 평가하게된다. PSR framework의 기본 개념은 인간의 활동들이 환경에 압력 (P)를 주고, 이로 인해 자연의 질과 영향 (S)을 미치며, 이에대한 회복을 위해 인식과 행동을 통해 정책과 제도 등을 통해 반응 (R)한다는 것이다. 유역 물순환을 4가지 그룹 (기후, 수문학적, 사회경제학적, 환경적)으로 구분하고 각 그룹 별 평가요소에 대하여 도출하였다. 기후그룹은 강우, 수문학적 그룹은 증발산, 토지이용, 유출특성을, 사회경제학적 그룹은 재정, 사회구조, 기반시설, 정책을, 환경적 그룹은 수질, 수생태계를 선정하였다. 이후 각 요소 별 평가를 위해 다양한 지표를 고려하여 선정하였으며, 각 지표를 PSR framework에 맞춰 재분류하였다. 각 지표를 하나의 점수로 통합하기 위해 지표 별 가중치를 산정하였으며, 이때 연구자의 주관이 반영되지않는 엔트로피 기법을 이용하여 산정하였다. 구한 식을 통해 우리나라 소유역구분을 기준으로 모든 지표를 계산하였으며, 각 지표에 가중치를 적용해 유역 종합점수를 산정하고 유역 별 취약지역 및 취약요소를 평가하였다.

• Journal of Radiation Protection and Research
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• v.22 no.2
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• pp.119-125
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• 1997

PHWR achieves high neutron economy by adopting heavy water as its moderator and coolant. On the other hand it permits much tritium generation, compared to LWR, due to the neutron capture reaction of deuterium in heavy water. Meanwhile in the reactor core, $^3He formed as the result of-decay of tritium, captures a thermal neutron and transforms to tritium again. The existing calculation models on tritium generation in PHWR neglect the contribution of $^3He$ in both moderator and coolant due to its relatively low solubility. However the neutron capture cross-section of $^3He$ is almost $1.6{\times}10^7$ times as large as that of deuterium. That means that the dissolved amount of 0.03 ppm of $^3He$ in heavy water is enough to generate the same amount of tritium as that generated by the deuterium of total heavy water in the system. This study dealt with the contribution of $^3He$ to tritium generation. As a sample case, the contribution of $^3He$ to the tritium generation in Wolsong #1 was evaluated and compared to the measured values. According to the result of this study, it is concluded that $^3He$ in coolant contributes very much to the tritium generation but that in moderator shows negligible effects due to the low solubility and $^4He$ cover gas. At the beginning of the plant operation, the contribution of $^3He$ is slightly greater than the measured value but agrees well with the measured as the operating time increases.

• Geophysics and Geophysical Exploration
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• v.5 no.2
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• pp.84-92
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• 2002

In this study, the new modeling scheme has been developed for recently designed and tested electromagnetic survey, which adapts horizontal magnetic dipole with $1\;kHz\~1\;MHz$ frequency range as a source. The 2.5-D secondary field formulation in wavenumber domain was constructed using finite element method and verified through comparing results with layered-earth solutions calculated by integral equations. 2-D conductive- and resistive-block models were constructed for calculating electric field, magnetic field and impedance - the ratio of electric and magnetic fields which are orthogonal each other. This study showed that electric field and impedance are superior in identifying 2-D isolated-body model to magnetic field. In particular, impedance gives more stable results than electric field with similar spatial resolving power, because electric field is divided by magnetic field in impedance. Thus the impedance analysis which uses electric and magnetic fields together would give better result in imaging the shallow anomalies than conventional EM method.