• 동위원소뉴스
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• no.1 s.121
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• pp.7-9
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• 2007

• Food Industry And Nutrition
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• v.10 no.1
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• pp.42-47
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• 2005

• Proceedings of the Korean Nutrition Society Conference
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• 2001.05a
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• pp.135.1-135
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• 2001

• Korean Journal of Psychosomatic Medicine
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• v.24 no.2
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• pp.227-235
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• 2016

Objectives : The aims of this study were to know the frequency of cognitive dysfunction among patients with autoimmune thyroid disorders, and to reveal influencing factors on it, especially to clarify association with autoimmune thyroid antibodies. Methods : From sixty-five female patients with autoimmune thyroid disorders, demographic data were obtained by structured interview. Their cognitive funtions were measured using the MMSE-K and the MoCA-K tests. Depression was evaluated by the K-HDRS. Results : 1) Among patients with autoimmune thyroid disorders, 7.69% of them were below 24 on the MMSE-K, while 10.77% were below 22 on the MoCA-K. The frequency of cognitive deficit was not significantly different according to having positivity to antimicrosomal antibodies or not. 2) The antimicrosomal antibody-positive patients had significantly higher antithyroglobulin antibody titers, antimicrosomal antibody titers, and TSH concentration, while had significantly lower free T4 levels(p<0.05, respectively). 3) The total scores of the MMSE-K and the MoCA-K had significant correlation with age, marital status, antithyroglobulin antibody titers and K-HDRS(p<0.05, respectively). 4) The regression analysis revealed that variables such as age, education, autoimmune thyroid antibodies, thyroid function and depression did not influence on cognitive function of patients with autoimmune thyroid disorders. Conclusions : Our results could not support that cognitive function of patients with autoimmune thyroid disorders had correlation with autoimmune thyroid antibodies.

• Food Industry And Nutrition
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• v.7 no.3
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• pp.27-34
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• 2002

해바라기를 주원료로 한 복합조성물인 해바톤(HYE-BATON, (주) 새벽을여는사람들)의 면역활성 증진효과와 당뇨 및 지질대사에 미치는 영향을 분석하였다. 시험관 내에서 HYEBATON을 첨가하여 먼역세포를 배양한 결과 면역세포가 현저하게 활성화되었다. 생쥐에 HYEBATON을 투여한 결과 세포 매개성 면역반응이 증진되었으며, 암세포 이식 생쥐에서 종양의 생장을 억제시켜 생존기간을 연장시키는 경향을 보였다. 또한, HYEBATON이 혈당과 지질 대사에 미치는 영향을 흰쥐에서 살펴보았다. 쥐를 정상식이군, streptozotocin (STZ) 투여에 의한 당뇨군, 고지방식이군으로 나누어 HYEBATON을 7주간 투여하였다. 경구포도당 내성 검사에서 HYEBATON은 당뇨군의 증가된 공복시 혈당을 감소시켰으며, 경구로 포도당을 투여 시에도 당뇨군의 혈당을 계속 낮게 유지시켰다. HYE-BATON 이 지질대사에 미치는 영향을 살펴본 결과, HYE-BATON은 정상식이군, 당뇨군, 고지방 식이군의 혈중 및 간의 콜레스테롤과 지질의 양을 유의성 있게 감소시키거나 혹은 감소시키는 영향으 ?보였다. 한편, 시험관내 유전독성시험 및 생지의 급성독성시험에서 HYE-BATON은 안전한 것으로 평가되었다. 이러한 결과로 보아 HYEBATON은 면역활성 증진효과 뿐만아니라 당뇨 쥐의 혈당 및 지질대사 개선효과를 보였으므로, 면역증징 및 당뇨와 지질대사 개선을 위한 기능성 식품으로서 활용이 기대된다.

• Journal of Haehwa Medicine
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• v.1 no.1
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• pp.319-328
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• 1992

산한지통(散寒止痛)의 효능(效能)이 있는 고량강(高良薑)이 체내 면역활성에 미치는 영향을 검토하기 위하여 인삼과 함께 실험을 행하여 아래와 같은 결과를 얻었다. 고량강(高良薑) 및 인삼 수침액을 Sarcoma-180 고형 종양 세포를 이식한 생쥐에 투여하여 생존기간을 연장시켰다. 이를 바탕으로 면역에 대한 효과를 검토한 결과, 정상 ICR 생쥐에서 고량강(高良薑) 수침액은 백혈구수, 체중에 대한 상대적 비장의 무게를 약간 감소시켰으나 통계적으로는 유의성이 없었고, 간에는 영향을 주지 않았다. in vitro 실험에서, splenic IgM PFCs을 유의성있게 증가시켰으며, BSA를 주사한 생쥐에서의 Arthus반응도 증가시켰다. 그러나, 지연형 과민반응에는 영향을 주지 않았으며, 비특이성 면역에 관여하는 Macrophage 등의 탐식 세포의 기능에도 영향을 주지 않았다. 이상의 결과, 고양강은 체액성 면역을 강화할 것으로 보여진다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2002.12a
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• pp.478-481
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• 2002

본 논문에서는 생명체의 면역계에서 중요한 역할을 하는 세포독성 T세포의 생성과정의 하나인 긍정선택(positive selection)과 부정 선택(negative selection)을 모델링하여 침입에 의한 데이터 변경과 바이러스에 의한 데이터 감염 등을 탐지할 때 가장 중요한 요소인 변경 검사 알고리즘을 개발하였다. 제안한 알고리즘은 면역세포의 생성시 MHC 인식부를 형성해 주는 긍정 선택을 자기 인식 알고리즘으로 구현하여 컴퓨터에서 자기로 인식해야하는 파일이나 기능에 대해 MHC 인식부를 형성하고, 또한 항원 인식부를 형성하는 부정 선택을 이용해 변형 검지기(anomaly detector)를 구성한다. 따라서 제안한 알고리즘은 실제 면역세포와 마찬가지로 자신과 침입자 모두에 대한 인식기를 가지고 변경을 탐지하게 된다. 시뮬레이션을 통하여 자기파일의 일부가 변경되었을 때와 블록이 변경되었을 때에 대하여 두 가지 방법을 이용한 변경 검사 알고리즘의 특성과 유효성을 밝힌다.

• The Journal of Dong Guk Oriental Medicine
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• v.8 no.1
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• pp.1-33
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• 1999

This study was done in order investigate the object and the method of animal experimental paper on immunity The results were obtained as follows: 1. Rat, mouse, kk mouse and rabbit were used for experimental paper singe or combine. 2. It was examined a way of bringing about a lowering of immunity used as MTX and other reagent, and it has caused many cases which lead to bring about a lowering of immunity by causing specified disease. 3. It was examined, according to items of my observation. there are mainly hemagglutinin titer, hemolysin titer, phagocytic activity, Rosette forming cells, delayed type hypersensitivity, IL-2 productivity and NK cell activity in survey. 4. Most used drugs and 경혈(aqupuncture paint) have the characters reinforcing a fair spirit and reinforcing an unfair spirit(a miasma or poisonous air). 5. It is necessary to a deep study of an experimental way about aqua-acupuncture on immunity in the future.

• Journal of Life Science
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• v.29 no.7
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• pp.817-823
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• 2019

Immune system provides defense integrity of body against external invaders. In order to accomplish the important defending role immune system is composed of many different components which are regenerated continuously during lifespan. The key components are professional killing cells such as macrophage, neutrophil, natural killer cell, and cytotoxic T cell and professional blocking molecule, antibody, which is produced by plasma cell, the terminal differentiated B cell. Immune response is orchestrated harmoniously by all these components mediated through antigen presenting cells such as dendritic cells. Immune responses can be divided into two ways: innate immune response and adaptive immune response depending on induction mechanism. Aging is a broad spectrum of physiological changes. Likewise other physiological changes, the immune components and responses are wane as aging is progressing. Immune responses become decline and dysregulating, which is called immunosenescense. Immune components of both innate and adaptive immune response are affected as aging progresses leading to increased vulnerability to infectious diseases. Numbers of immune cells and amounts of soluble immune factors were decreased in aged animal models and human and also functional and structural alterations in immune system were reduced and declined. Cellular intrinsic changes were discovered as well. Recent researches focusing on aging have been enormously growing. Many advanced tools were developed to bisect aging process in multi-directions including immune system area. This review will provide a broad overview of aging-associated changes of key components of immunity.

• Clinical and Experimental Pediatrics
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• v.48 no.3
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• pp.292-297
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• 2005

Purpose : It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean. Methods : The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004, were analyzed retrospectively. Results : Forty-four males and 95 females were enrolled. At least one of the autoantibodies for thyroid was positive in 54 cases. The detection rate for AITD was not correlated with sex ratio, control of T1DM, body mass index, age at diagnosis of T1DM, and familial history of thyroid disease, between two groups. In the male group, AITD was more frequently found at a younger age than in the female group. The frequency of AITD was significantly higher in the goiter group without sex differences. In the thyroid disease group, 40 patients(74.0 percent) were euthyroid, seven patients(12.9 percent) were hypothyroid, and seven patients(12.9 percent) were hyperthyroid. Conclusion : We should monitor thyroid function and autoantibodies routinely in T1DM patients who develop goiters, or young boys with T1DM.