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Kim, Dong-Jin
- KOREAN POULTRY JOURNAL
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- v.50 no.5
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- pp.135-137
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- 2018
닭을 건강하게 키우고 싶은 것은 모든 양계인들의 바램일 것이다. 열악한 환경 속에서 발생하는 각종 질병으로부터 닭을 보호하고, 질병을 사전 차단해 최고의 성적을 낼 수 있는 면역증강제가 개발되어 전 세계에 큰 인기를 얻고 있다. 그 물질은 해조류에서 추출하여 특허를 획득한 차세대 베타글루칸인 알레타(Aleta)이다. 알레타는 케민코리아(주)를 통해 지난 2017년 11월 국내에 출시되었고 메이저급 사료회사들이 사용할 정도로 그 효과를 인정받고 있다. 본고는 이 제제를 직접 개발한 죠프 호스트(Geoff Horst) 박사(케민 미시건 R&D팀)를 만나 방한 목적과 면역증강제의 특징 및 개발에 대한 뒷얘기를 들어보았다.
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Son, Hyeog-Jin;Shim, Ji-Young;Ahn, Ji-Yeon;Yun, Yeon-Sook;Song, Jie-Young
- Journal of Radiation Protection and Research
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- v.33 no.3
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- pp.99-104
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- 2008
According to the increase in the use of radiotherapy to cancer patients, many approaches have been tried to develop new agents for the protection of surrounding normal tissues. However, it is still few applied in the clinic as a radioprotector. We aim to find a representative parameter for radioprotection to easily predict the activity of in vivo experiment from the results of in vitro screening. The polysaccharide extracted from Panax ginseng was used in this study because the immunostimulator has been regarded as one of the radioprotective agent category and was already reported having a promising radioprotective activity through the increase of hematopoietic cells and the production of several cytokines. Mitogenic activity, AK cells activity and nitric oxide production were monitored for the in vitro immunological assay, and endogenous colony-forming unit (e-CFU) was measured as in vivo radioprotective parameter. The immunological activity was increased by the galactose contents of ginseng polysaccharide dependently. The result of this study suggests that mitogenic activity of splenocytes demonstrated a good correlation with in vivo radioprotective effect, and may be used as a representative parameter to screen the candidates for radioprotector.
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Chung, Ha-Yull;Kim, Hyun-Bae
- Korean Journal of Food Science and Technology
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- v.32 no.3
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- pp.699-705
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- 2000
The superoxide scavenging activities of thirteen kinds of herbal extracts were examined together with their cytotoxic and immunomodulating effects. The extracts of 6 kinds of herbs such as eucalyptus, mate, peppermint, sage, thyme and yarrow, so called medicinal herbs, showed above 70% of the superoxide scavenging activities. They also showed cytotoxicities against the cancer cell lines of Hepa-1c1c7 and KB-3-1 as well as the normal fibroblast cell line of mouse. The $IC_{50}$ values of above 6 herb extracts on the cancer cell lines were above or similar to the $IC_{50}$ values on the normal cell line, so it was unable to observe the herb extract which showed cytotoxicity only to the cancer cell lines. Considering the results of nitric oxide test that the sage extract was the only one having the immunomodulating effect(37% of positive control), there was no significant relationship between the superoxide scavenging activities of herbs and their immunomodulating effects.
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Geon-Woo Kim;Yeong-Bin Yoon
- Advanced Industrial SCIence
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- v.2 no.1
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- pp.8-14
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- 2023
This study was performed as a preliminary experiment to develop functional feed additives using by-products generated during the production of black garlic. Therefore antioxidant and immune enhancing activity of black garlic pomace were measured. As a result of measuring the antioxidant activity of black garlic pomace, it was found antioxidant activity. Nitric oxide (NO) assay was performed to test the immune enhancing activity of vegetable samples including black garlic pomace among the samples used in the experiment. As a result of the NO assay experiment, highest concentrations of black garlic pomace, aster glehni, and MIX form produced NO, which Garlic pomace (69.4%), aster glehni (35.9%), and MIX (45.3%), respectively, compared to LPS (100%). In conclusion, it is considered that black garlic pomace contains an anti-inflammatory effect, and if the optimal mixing ratio of black garlic pomace and aster glehni is selected, it will be of sufficient value as a feed additive containing an anti-inflammatory effect.
https://doi.org/10.23153/AI-Science.2023.2.1.008 인용 PDF