• Korean Journal of Oriental Medicine
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• v.5 no.1
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• pp.1-15
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• 1999

Chronic asthma is considered as an incurable disease in modern society. This study focused on development of an animal model for the chronic asthma to investigate new drugs from traditional herbal medicine. And we tested the animal model with a typical prescription, Chungsangboha-tang and tried to find biochemical markers such as catecholamines and cAMP in serum, and as densities of beta-receptor in lung tissues. SD rats were actively sensitized by exposure to ovalbumine (OA). Ten days after sensitization, rats were challenged with OA aerosol by nebulizer six times every three days. Mucin was increased in bronchoalveolar lavages (BALs) after antigen (OA) challenge. Serum concentration of epinephrine was decreased significantly although there were not changed much in serum concentration of cAMP and the densities of beta-receptor in lung tissues. Chungsangboha-tang (5 g/kg/day) was given orally to ovalbumin-sensitized rats (n=8) for 15 days. Mucin in bronchoalveolar lavages (BALs) was increased significantly after treatment of Chungsangboha-tang although concentrations of epinephrine and cAMP were not changed significantly. The densities of beta-receptor in lung tissues were not different from those of controls. These results suggest that the ovalbumin-sensitized rats can be a good animal model of chronic asthma and Chungsangboha-tang is a possible drug in the treatment of chronic asthma.

• 보건세계
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• v.43 no.12 s.484
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• pp.4-9
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• 1996

기도가 협착되어서 증상을 일으키는 질환으로 만성기관지염, 폐기종, 만성폐쇄성질환, 기관지천식 등이 있으며, 기침, 가래, 호흡곤란(숨참)등이 주요 증상인데 비의료인에게는 해소천식으로 더 잘 알려져 있다. 일반적으로 기침 가래가 나오고 숨이차면 해소천식이라고 하는데 실제로 이 만큼 오용되고 남용되는 단어는 드물 것이다. 동의보감에 의하면 해수(해소의 원명)는 기침을 말하는데 해는 가래가 없이 소리가 심한 경우이고 수는 가래를 주로하는 기침을 말하며 16가지 종류로 구분된다. 천식은 숨이 찬 증상을 말하는 것으로 8가지 종류로 구분되어 있다. 따라서 해소천식은 기침가래가 나오고 숨이 찬 증상을 말하는 것으로 특정질환을 말하는 병명이 아니다. 비의료인이 말하는 천식의 경우에는 숨이 찬 증상을 말하는 것이고 의료인이 천식이라고 할 경우에는 특정 기도질환인 기관지 천식을 말하는 것이므로 서로 오해하기가 쉽다. 실제로 일간지 건강상식란에 천식을 소개하였는데 의사는 병명으로서의 기관지천식을 설명하였고 동참한 한의사는 증상으로서의 천식을 설명하여 혼란을 일으켰던 예가 있었다. 한의학에서는 예전에 기관지천식은 효천(孝喘)이라고 부르고 천식의 증상이 심하고 위중한 상황일 때에는 천급(喘急)이라고 하여 한의학에서도 구별하였는데 도리어 현대에 와서 정확성이 없어지고 모호해진 이유는 무엇일지 궁금하다. 폐쇄성기도질환은 기도가 좁아지는 기전과 기도폐쇄의 가역성(기도가 정상으로 회복되는지)여부에 다라서 가역성폐쇄질환인 기관지천식과 비가역적인 만성폐쇄성기도질환으로 구분하고 있다.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2019.05a
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• pp.174-175
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• 2019

우리나라 연안해역의 해양자원과 관광자원을 연계한 해양치유산업 기반구축 모델이 2017년부터 해양수산부 R&D 사업의 일환으로 '추진되고 있다. 동 R&D 사업을 통해 울진, 태안, 고성, 완도 등 4개 지역이 시범사업 대상지로 선정되었으며, 각 지역의 특성화된 해양치유 자원을 바탕으로 의학적 임상연구와 사회경제 현황과 연계한 비즈니스모델 수립 등이 추진되고 있다. 비즈니스모델 수립의 경우 지역 특성화 해양치유자원을 활용한 세부 프로그램 도출, 수요 추정, 도입시설의 규모 및 형태 등에 대한 사항을 도출함으로써 해양치유 활동이 이루어질 지역 해양치유센터(가칭)의 설립 기본계획 기초자료를 제공하게 된다. 본 연구에서는 4개 시범지역 중 울진해양치유센터를 대상으로 지역 특성화 해양치유자원으로 설정된 해양대기, 심층안반해수, 해사 등과 연계된 아토피 등 피부질환, 만성폐쇄성폐질환 등 호흡기계통질환 치유 프로그램을 제시하고 있다. 또한 해당 특성화 프로그램의 지속가능한 수요 창출을 위해 기본적 도입시설과 함께 요구되는 연계 인프라를 제시하였으며, 동 프로그램을 통해 예상되는 사회경제적 파급효과를 정량적으로 분석하여 제시하였다.

• Korean Journal of Ichthyology
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• v.29 no.1
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• pp.75-79
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• 2017

About 10% mortality occurred in cultured rainbow trout Oncorhynchus mykiss at a marine farm in Jeju in 2014. Diseased fish showed markedly abdominal distension and distended stomach. Although parasites, bacteria or viruses were not isolated from diseased fish, numerous Candida sp. were isolated from distended stomach. In experimental infection with Candida sp., mortality was not observed in most fish and clinical sign of distended stomach was not observed in the fish. These results suggest that Candida sp. may not be the etiologic agent of stomach distension syndrome. This is the first report of stomach distension syndrome in seawater farmed rainbow trout in Korea.

• Journal of Acupuncture Research
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• v.20 no.5
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• pp.236-243
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• 2003

Objective: This study is performed for the purpose of observing the effect of JSD on the cough Methods: 35 patients with the cough treated with JSD herbal acupuncture at 肺兪穴(BL13) and 平喘穴, then self-conscious complain rates were studied. Results: The result as follows. 1. There are remarkable improvement in self-conscious complain rate about chronic cough, sputum, sneezing, runny nose, sore throat, shortness of breath which chronic cough patients complained. 2. There is no significance in self-conscious complain rate according to suffering and treatment period. 3. These result indicates that the effect of JSD herbal acupuncture on chronic cough si exellent.

• Journal of Sasang Constitutional Medicine
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• v.16 no.3
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• pp.139-142
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• 2004

1. Objectives In this study, it is experienced that the process of sweating is important in chronic cough of Taeumin. In this case report, the patient has been simproved throuth reaction of sweating improvement. In "Dongyi Soose Bowon", The process of sweating change is described in detail. "Hamkeylhae" is similar to chronic cough in "Dongyi Soose Bowon", it is cough that is hard to spit. The chronic cough of Taeumin is related to the pathology of Liver and Lung, sweating condition is also related to condition of Lung in Sasang constitutional medicine. So the study for the process of sweating is needed. 2. Methods One patient diagnosed as chronic cough was practiced with Sasang constitutional medicine. And We observed sweating change process during treatment. 3. Results As sweating condition improved, chronic cough also decreased, but not improved, not decreased. 4. Conclusions So treating of Taeumin's chronic cough is closely connected with sweating change process.

• Journal of Acupuncture Research
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• v.30 no.5
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• pp.253-262
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• 2013

Objectives : The purpose of this study is to observe the effect of Cervi Pantotrichum Cornu Pharmacopuncture at Pyesu($BL_{13}$) on Chronic Cough. Methods : 6 patients with the cough treated with Cervi Pantotrichum Cornu Pharmacopuncture at Pyesu($BL_{13}$), then self-conscious complain rates were studied. Results : There are remarkable improvement in self-conscious complain rate about cough, sputum, sore throat, runny nose, chest pain, fatigue which chronic cough patients complained. Conclusions : Cervi Pantotrichum Cornu Pharmacopuncture is effective to chronic cough.

• Microbiology and Biotechnology Letters
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• v.16 no.4
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• pp.270-274
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• 1988

Samples used for the enrichment culture were collected from the sea water of suspected chronic petroleum contamination in the vicinity of Pusan, Chungmu and Ulsan ports, Korea. Alkaline Iysis and agarose gel electrophoresis techniques were employed to screen these isolates for the presence of plasmid DNA. There were n little differences in the percentage of isolates containing plasmids between sampling sites of unpolluted sen water (22％) and polluted son water (25％). Bacterial isolates taken from the Bunker-C oil enriched culture showed significantly more plasmid incidence (29％). About two thirds of strains grown on a variety of hydrocarbons were Gram negative strains of which 33％ contained one or more plasmids. Multiple plasmids were observed in 23％ of the plasmid-carrying strains. Forty one percent of the plasmids detected were estimated to have a mass of 20 kb or more.

• Journal of the Korean Electrochemical Society
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• v.21 no.4
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• pp.61-67
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• 2018

As emerging the new electric devices, the commercial lithium ion batteries have faced with various challenges. In this regard, many efforts to solve challenges have been tried. In order to solve the above problems in terms of development of a new secondary battery, we successfully demonstrated the two electrocatalysts, such as MCWB and PPY hydrogel, PPY hydrogel and MCWB showed typical H3-type BET isotherm, indicating that micro- and mesopores existed. Especially, in terms of voltage efficiency at the first cycle, PPY hydrogel was higher than that of MCWB, but lower than that of PtC. More interestingly, the PPY hygrogel based seawater battery exhibited charge-discharge reversibility during 20 cycles, and the voltage efficiencies ranged from 70.32 % to 77.35 % in cyclic performance test.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.35 no.5
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• pp.534-541
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• 2002

The use of triorganotins as insecticides, bacteriocides, and antifouling agents has increased dramatically over the past 30 years, In this paper, to evaluate the acute and chronic toxicity effects of various triorganotins (TBTO, TBTE, CTPT, TBTCI) on the growth of microalgae, Skeletonema costatum, we carried out the short term and long term experiments, respectively. In the short-term experiments, the growth of S. costatum was inhibited by the various triorganotins in the dose dependent manners, but recovered by the time laps. The growth inhibition of triorganotins were decreased in the groups with higher initial cell density. These data were resulted from the dilution effect and the biodegradation of triorganotins by the microalgae. In the long-term experiments, S. costatum died completely at the 1 $\mu$g/L of TBTP and CTPT, but didn't in short-term experiments. The facts suggest that the toxicity of the chronic exposure of triorganotins should be increased in the natural sea water with low phytoplankton density.