• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.426-438
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• 2022

The current study explored the relative effects of reciprocal/empathic type on messages appealing to help patients with Lou Gehrig's disease and their family. By this, we attempted to examine the applicable scope of the reciprocal type, a way of appealing rationally in the delivery of helping messages. The focus was on the moderation of empathic concern trait, a representative altruistic personality. Conducted as the online experiment, empathic concern trait was measured in the first stage, and the helping messages presented each by reciprocal/empathic type were shown and evaluated in the second stage after about 7 days. The data of 134 people were finally analyzed, excluding insincere participants. As a result, the relative advantage of empathic type was shown, but it was only limited to the subject attitude. In the result of the interaction, the reciprocal type were as much or more influential as the empathic type for the individuals high in empathic concern trait.

• Analytical Science and Technology
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• v.28 no.5
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• pp.331-340
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• 2015

Mutations in Fused in Sarcoma (FUS) have been identified in patients with amyotrophic lateral sclerosis (ALS) or Frontotemporal Dementia (FTD). Pathological FUS is mis-localized to cytosol and forms aggregates associated with stress granules (SG), while FUS is normally localized to nucleus. However, it is largely unknown how pathological FUS forms SG-aggregates and which domains are responsible for this process. In this study, we examined cellular localization and aggregation of ALS-linked FUS missense mutants (P525L, R521C, R521H, R521G), analyzed the domains responsible for cytosolic FUS aggregation in HEK293T cells, and confirmed this in cultured mouse neurons. To do this, we firstly generated missense mutants of FUS and then examined their cellular localization. We found that P525L was mostly mis-localized to cytosol and formed FUS-positive SG aggregates while R521C, R521H, or R521G was localized to both nucleus and cytosol. To further characterize the domains required for aggregate formation of cytosolic FUS, we generated different domain-deletion mutants using FUS-∆17 which has a deletion of nuclear localization signal. Interestingly, cytosolic FUS without SYGQ and RGG1 domain or cytosolic FUS without RGG2-ZnF-RGG3 domain did not form FUS-positive SG aggregates, while cytosolic FUS without RRM domain generated more aggregates compared to FUS-∆17. Taken together, these data suggest that SYGQ-RGG1 or RGG2-ZnF-RGG3 domain contributes to formation of cytosolic aggregate, while RRM domain might interfere with FUS aggregation. Therefore, our studies will provide important insight for understanding cellular pathogenesis of neurodegeneration associated with FUS aggregate as well as finding therapeutic targets for ALS or FTD.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.06a
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• pp.289-292
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• 2007

우리가 다른 이들과 만나 대화하는 것은 극히 평범한 일이다. 하지만 대화뿐만이 아니라 의사소통마저도 힘들어하는 이들이 있다. 이들은 언어 장애를 가진 이들이다. 언어 장애에는 태어나면서부터 장애를 가지는 선천적 장애와 사고와 질병으로 인한 후천적 장애가 있다. 그 중 후천적 장애는 언어장애와 더불어 신체적 장애를 가진 이들이 있다. 이들을 본 논문에서는 중증 언어 장애인이라고 분류하였다. 중증 언어 장애인의 장애정도를 크게 글자 표현이 불가능한 상태로부터 4가지 단계로 나뉠 수 있다. 글자 표현이 불가능하지만 개체 선택이 가능한 1단계, 손 혹은 발을 이용하여 가부 결정만 가능한 2단계, 지체를 이용하여 표현이 불가능한 3단계, 그리고 마지막 4단계가 3단계의 표현마저도 불가능하여 의사소통이 전혀 불가능한 상태이다. 사고로 인한 후천적 장애인 경우 위의 4가지 단계중 하나의 단계에서 머물러 있지만, 루게릭병과 같은 병은 위의 4가지 단계를 몇 년에 걸쳐서 진행되기 때문에 일반적인 장비로써는 이 들과의 의사소통이 불가능하다. 본 논문에서는 위의 1,2,3단계의 중증 언어 장애인을 대상으로 그들이 의사소통을 정확하고 신속하게 전달하기 위해서 어떠한 인터페이스를 사용하는 것이 효과적인 방법에 대해 논해보고, 향후 발전될 방향에 대해서 그 방향을 제시하였다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.696-699
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• 2018

This paper introduces a system that enables pupillary tracing and communication with patients with amyotrophic lateral sclerosis (ALS) who can not move free. Face and pupil are tracked using OpenCV, and eye movements are detected using DE1-SoC board. We use the webcam, track the pupil, identify the pupil's movement according to the pupil coordinate value, and select the character according to the user's intention. We propose a system that can use relatively low development cost and FPGA can be reusable, and can select a text easily to mobile phone by using Bluetooth.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.700-702
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• 2018

In this abstract, introduces a system that enables communication by tracking the pupils of Lou Gehrig's disease patients who are unable to move their bodies. Face and eye pupil tracking perform using OpenCV, and eye movement recognition and character selection by eye movement is obtained using Python. In this paper, you will use the webcams, track your eyes, determine eye movements based on the coordinates of your pupils, and print characters that meet your preferences. It can easily output text messages using Bluetooth.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.703-704
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• 2018

An artificial neural network design that traces the pupil for the disables suffering from Lou Gehrig disease is introduced. It grasps the position of the pupil required for the communication system. Tensorflow is used for generating and learning the neural network, and the pupil position is determined through the learned neural network. Convolution neural network(CNN) which consists of 2 stages of convolution layer and 2 layers of complete connection layer is implemented for the system.

• Journal of Korean Medical Ki-Gong Academy
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• v.19 no.1
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• pp.25-42
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• 2019

Objective : This study is a report on treatment effect of Korean medical treatment to ALS(Amyotrophic Lateral Sclerosis) patient. The purpose of this case study is to improvement of Korean medical treatment and evaluate prognosis and clinical course of ALS patients. Methods : The patient was treated by acupuncture, Su-Gi therapy, herbal medication, physical treatment. To determine the effects of Korean medical treatment, we evaluated every four days used by Korean version of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (KALSFRS-R), Amyotrophic Lateral Sclerosis Severity Scale(ALSSS). Results : Before mental contraction caused by everyday life nursing management, symptoms such as lumbar pain, getting hoarse, lower limb powerless & spasticity, upper limbs powerless, neckache, tongue-tied etc. were improved after above treatment. K-ALSFRS-R and ALSSS scores were also increased till patient's mental contraction Conclusions : The Korean medical treatment is effective on local symptoms of ALS, and there is also functional improvement of ALS diagnosed by external examination. It is necessary to have more examination about ALS.

• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.193-198
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• 2019

This study analyzed the changes of vowel formant, voice intensity, and fundamental frequency of vowels for 11 months using acoustochemical spectrogram analysis of women diagnosed with amyotrophic lateral sclerosis (ALS). The test word was a vowel /a, i, u/ and a diphthong /h + ja + da/, /h + wi + da/, and /h +ɰi+ da/. Speech data were collected through the word reading task presented on the monitor using 'Alvin' program, and the recording environment was set to 5,500 Hz for the nyquist frequency and 11,000 Hz for the sampling rate. The records were analyzed by using spectrograms to vowel formants, voice intensity, and fundamental frequency. As a result of analysis, the fundamental frequency and intensity of the ALS process were decreased and the formant slope of the diphthong was decreased rather than the formant change in the vowel. This result suggests that the vowel distortion of ALS due to disease progression is due to the decrease of tongue and jaw co morbidity.

• Journal of Korea Entertainment Industry Association
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• v.14 no.3
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• pp.443-454
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• 2020

This study aims to develop one-stop support service for the ALS. To achieve the purpose, the cases of Korea and Japan were researched. The data used in the multiple-case study mainly referred to diaries, blogs, social networking sites, Youtube, and interviews of the disabled with ALS disease in Korea and Japan, and analyzed support services of both countries. The result of the study showed that, in the onset stage of ALS disease, a fellow counselor should be assigned by family member or person who experienced the disease from KALSA or other organizations to which a patient belongs. Also, it need a counseling by fellow counselor in the stage of softening disability. And after the gastrointestinal procedure, the number of home visits by visiting nurses should increase, and other services by OT and PT are required. In the stage of wearing a respirator, it needs to train and dispatch volunteers for ALS exclusive activities. And it is necessary to set up a family rest area or a respite service for the mentally and physically exhausted primary caregiver by long-term care. Most of all, these services should be one-stop support with linking step by step, not fragmentary support.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.07a
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• pp.259-260
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• 2020

기존의 전동휠체어를 사용하는 약자 또는 중증 장애인 등 지체(肢體)가 불편한 사람들이 휠체어 사용 시 생기는 문제점을 해소할 목적으로 시작되었다. 이는 전동휠체어가 보행 기구임에도 자동차에 준하는 교통사고에 대해 무방비하게 노출되고, 중증 장애인에 대한 이동권 보장이 아직 미흡하여 생기는 문제이다. 따라서 본 연구에서는 이러한 문제로 인한 불편함을 해소하고자 아이트래킹을 이용한 스마트 전동휠체어 기술을 적용하고자 한다. 루게릭병 등으로 인해 지체(肢體)의 움직임에 제한이 있는 사람들에게 보호자가 밀어주는 휠체어에 의존하는 것이 아닌 Eye-Tracker를 이용한 시선 추적(Eye-Tracking) 기술로 휠체어 동작이 가능하다. Web-Cam과 라즈베리 파이를 통해 얻은 전·후·좌·우의 영상정보를 디스플레이 화면에 송출한다. 그 후 Eye-Tracking 기술을 이용해 디스플레이 화면에 표시된 전·후·좌·우 이동에 관한 UI(User Interface)룰 사용자가 송출된 영상을 보면서 눈의 움직임만으로 선택해 휠체어의 방향을 제어한다. 또한 전동휠체어의 조작 실수로 다른 행인 또는 장애물과 충돌하는 문제점을 초음파 센서를 이용하여 일정 거리 내에 사물이나 사람이 있을 경우 디스플레이 화면에 경고표시 및 경고음, 각 초음파 센서 위치에 맞는 LED작동으로 사용자들에게 추돌 위험경고와 함께 장애물의 위치파악이 가능하도록 한다. 따라서 스마트 전동휠체어를 통하여 수동적인 움직임이 아닌 능동적이고, 초음파 센서로 인해 안전한 이동이 가능하게 한다.