• The korean journal of orthodontics
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• v.36 no.1 s.114
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• pp.63-73
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• 2006

Numbers of postulations lie on the difference of integumental changes with two major surgical remedies of one jaw vs. two jaw surgery in skeletal Class III malocclusion. Accordingly it was the aim of the study to elucidate the skeletal profile changes with an accompanying disposition of soft tissues, consequently to yield the correlation and ratio of soft tissue changes with two types of surgical procedures, which in turn make it possible to predict the soft tissue outcomes by means of assembled regression equations. Cephalometric headfilms of fifty two adult skeletal Class III comprised of 26 maxillary advancement by Le Fort I osteotomy and mandibular setback by sagittal split ramus osteotomy simultaneously (double jaw surgery, group A), 26 mandibular setback alone (one jaw surgery, group B) were statistically analyzed. Group A manifested 72.4% soft tissue advancement to skeletal changes in the upper lip area, while group B appeared to have no statistically significant changes. The nasolabial angle showed more increment in group A than in group B, whereas the mentolabial angle illustrated more reduction in group B. The backward movement of soft tissue pogonion to skeletal change revealed 98% in group A, and 109% in group B. The double jaw surgery group characteristically revealed remarkable integ umental change in the upper lip area, while the one jaw surgery had major effects in the lower lip and soft tissue pogonion areas.

• Radiation Oncology Journal
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• v.22 no.1
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• pp.25-32
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• 2004

Purpose : Evaluate the efficacies and toxicities of concurrent chemoradiotherapy (CCRT), with or without intraluminal brachytherapy (ILB), using a retrospective analysis in esophageal carcinomas with respect to survival. Materials and Methods : From April 1995 to July 2001, a total of 65 patients, diagnosed with an esophageal carcinoma, were treated by CCRT, with 21 also treated by ILB after CCRT. External radiotherapy was peformed using 6 or 10 MV X-rays, with a dose range of $46.8~\69.6$ Gy (median; 59.4). The ILB was peformed using high-dose-rate brachytherapy with Ir-192. The fractionation of ILB was 3 Gy by 4, or 5 Gy by 2 fractions. Cisplatin $(75\;mg/m^2)$ was given on each first day of weeks 1, 5, 9 and 13, and 5-FU $(1,000\;mg/m^2)$ as a continuous infusion for the first 4 days of each course. Results : The median survival time of all patients was 15 months, and the 1, 2 and 3-year survival rates were 55.4, 29.2 and $20.7\%$, respectively. The 2-year survival rates of the patients with and without ILB were 33.3 and $27.3\%$, respectively (p=0.80). The 2-year survival rates of the patients with a complete, partial and no response were 44.1, 13.8 and $0\%$, respectively (p=0.02). The response to treatment was the only significant factor affecting the overall survival from a multivariate analysis. Conclusion : This study has shown that the survival outcomes of CCRT were much better than previous results with radiotherapy alone. However, the addition of ILB after CCRT showed no advantage over that of CCRT alone.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.443-447
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• 1999

최근들어 제품개발에 앞서 제품으로 인해 유발되는 감성을 측정하기 위한 시도가 늘고 있다. 그러나 제품을 사용하면서 나타나는 행동의 변화는 많은 영향 요소를 포함하고 있어 이를 해석하기가 어렵다. 본 연구는 안정을 유도하는 Herb차를 개발하거나 치약과 같이 사용으로 인한 감성유발 효과를 보고싶어하는 요구에 따라 시행하였다. 우선 실험전 피검자의 불안 척도, 기본 check list에 따라 피검자를 선택하였다. 또한 객관적 감성 지표로는 Fz, Fp1, Cz, Oz에서 뇌파를 측정하였고 EOG를 시행하여 noise를 제거하였다. 자율신경계 반응으로 galvanic skin resistance(GSR), 피부온도, 심박수등을 동시에 측정하였다. 이들 제품 사용으로 인한 객관적 감성 변화의 대조군으로는 행동 시행전에 측정하였다. 제품 사용 후 10분 간격으로 30-60분까지 나타나는 변화를 측정하였으며, 이들 제품들은 안정 효과를 유도하고자 기획되었으므로 대조군으로 00 $\times$ 0의 복잡한 계산문제를 주어 stress로 인한 감성, 걷는 동작, 손 씻는 행위등을 나누어 측정하였다. 본 연구의 결과에 의하면, 제품 사용으로 인한 감성의 변화는 GSR에서 가장 잘 반영되었고 또한 계산 문제로 인한 자극에서도 역시 GSR의 변화가 가장 뚜렷하였다. Herb차인 경우 기호도에 따른 차이가 나타났음을 알 수 있었다.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1173-1180
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• 2018

Purpose: We evaluated the postoperative accuracy of intraocular lens power prediction for patients undergoing phacotrabeculectomy and identified preoperative factors associated with refractive outcome in those with primary open-angle glaucoma (POAG). Methods: We retrospectively reviewed the medical records of 27 patients who underwent phacotrabeculectomy to treat POAG. We recorded all discrepancies between predicted and actual postoperative refractions. We compared the data to those of an age- and sex-matched control group that underwent uncomplicated cataract surgery during the same time period. Preoperative factors associated with the mean absolute error (MAE) were identified via multivariate regression analyses. Results: The mean refractive error of the 27 eyes that underwent phacotrabeculectomy was comparable to that of the 27 eyes treated via phacoemulsification (+0.02 vs. -0.01 D, p = 0.802). The phacotrabeculectomy group exhibited a significantly higher MAE (0.65 vs. 0.35 D, p = 0.035) and more postoperative astigmatism (-1.07 vs. -0.66 D, p = 0.020) than the phacoemulsification group. The preoperative anterior chamber depth (ACD) and the changes in the postoperative intraocular pressure (IOP) were significantly associated with a greater MAE after phacotrabeculectomy. Conclusions: POAG treatment via combined phacoemulsification/trabeculectomy was associated with greater error in terms of final refraction prediction, and more postoperative astigmatism. As both a shallow preoperative ACD and a greater postoperative change in IOP appear to increase the predictive error, these two factors should be considered when planning phacotrabeculectomy.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1996.04a
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• pp.82-82
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• 1996

후두전적출술은 상부 소화관의 연속성을 변형시킴으로써, 식도운동의 장애를 가져올 수 있으며, 술 후에 연하곤란을 호소하는 경우는 10% 가량 된다. 본 연구의 목적은 식도내압검사를 통하여, 후두전적출술이 상부식도괄약근의 휴지기와 최대 압력에 어떠한 변화를 주는가 및 술 후 인두와 상부식도괄약근의 조화성 여부와, 만일 상부식도괄약근의 기능에 변화가 생긴다면, 그 영향이 식도체부 및 하부식도괄약근의 운동성에 어떠한 영향을 주는지를 알아보기 위함이다. 식도내압검사는 8개의 내관을 가진 폴리에틸렌 도관으로, 후두전적출술을 받은 환자군 14명과 정상인 12명을 대상으로, stational pull-through 방법으로 시행하였다. 환자군에서 상부 식도괄약근은, 휴지기 압력, 최대 수축압력, 이완정도, 괄략운동의 조화성 및 괄약근의 길이 등이, 정상 대조군 보다 의미있게 감소되었다. 환자군에 있어서 식도체부의 운동성은 주로 근위부 식도체부에서, 수축력, 수축기간 및 연동파의 전파시간이 대조군에 비하여 의미있게 감소되었고, 연동운동시 동시 수축도 3례에서 관찰되었다. 하부 식도괄약근의 기능은 환자군과 대조군이 의미있는 차이를 보이지 않았다.

• Journal of Acupuncture Research
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• v.27 no.6
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• pp.67-75
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• 2010

목적 : 족삼리($ST_{36}$) 자침이 유방 조직에 미치는 혈역학적 변화를 측정하기 위하여 diffuse optical imaging 기법을 사용하였다. 방법 : 실험에 사용한 쥐는 자침을 하지 않은 대조군 7마리, 자침을 한 실험군 7마리로 총 2개의 군으로 나누었다. 몸무게 170g 정도의 건강한 암컷 쥐는 100% 산소와 1.5% isoflurane을 혼합한 것을 이용하여 마취 시켰다. 자침은 경골 조면에서 2mm 외측에 위치한 지점인 족삼리($ST_{36}$)에 20분간 시행하였다. 자침을 시작할 때와 자침 후 10분에 각각 침을 5회 회전하였다. Diffuse optical imaging system을 이용하여 자침하는 동안 의 산화혈색소(OHb), 탈산소혈색소(RHb), 총 혈색소(THb)와 조직 산소 포화도($StO_2$)의 변화를 측정했다. 결과 : 실험 결과 족삼리($ST_{36}$) 자침을 시행한 실험군에서 대조군에 비하여 유의성이 있는 OHb, RHb, THb의 증가와 유의성이 없는 $StO_2$의 감소가 나타났다. 결론 : 이러한 결과 족삼리($ST_{36}$) 자침이 혈류를 증가시키고 동시에 세포 대사 활동을 증가 시키는 것을 알 수 있었다. 또한 diffuse optical imaging 기법으로 족삼리($ST_{36}$) 자침 시의 유방 조직의 산소공급과 혈류량의 변화를 확인할 수 있었고, 이는 비침습적으로 자침의 효과를 측정하는 데 활용될 수 있을 것으로 생각된다.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1137-1141
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• 2018

Purpose: We explored the mydriatic effects of injected intracameral epinephrine after phacoemulsification (PE) combined with phacovitrectomy to treat proliferative diabetic retinopathy (PDR). Methods: We enrolled 96 patients (96 eyes) who underwent phacovitrectomy to treat PDR; we used ImageJ software to measure pupil sizes and the ratios of pupil to cornea area (PCA) before and after PE and after pars plana vitrectomy (PPV). We compared pupil sizes between those who received intracameral epinephrine (0.001% w/v) after PE but before PPV (study group, 46 eyes) and patients not so treated (control group, 50 eyes). Results: The PCA ratios of the study group were $0.52{\pm}0.11$ before PE, $0.43{\pm}0.12$ after PE, and $0.51{\pm}0.11$ after PPV, respectively. Changes in pupil size were significant (p < 0.001, p < 0.001 respectively). The PCA ratios of the control group were $0.52{\pm}0.10$ before PE, $0.39{\pm}0.15$ after PE, and $0.43{\pm}0.15$ after PPV, respectively. Changes in pupil size after PE were significant (p = 0.011) but the change after PPV was not (p = 0.056). Conclusions: Intracameral epinephrine given after PE but before PPV effectively dilates the pupils during phacovitrectomy to treat PDR.

• Journal of the Korean Arthroscopy Society
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• v.6 no.2
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• pp.150-155
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• 2002

Purpose : The purpose of this study was to evaluate the clinical results of meniscal repair using the bioabsorbable devices. Materials and Methods : From 1998, 21 meniscal repairs were underwent using the bioabsorbable devices and followed more than 1 year. The Meniscus $Arrow^{\circledR}$(Bionx) and the Meniscal $Fastener^{\circledR}$(Mitek) had been applied. The indication for meniscus refixation was an unstable longitudinal tear in the posterior horn of the medial or lateral meniscus. Concurrent ACL reconstruction with meniscal repair was performed on 9 knees. The clinical result was evaluated using Lysholm knee score. Result : The average Lysholm knee scores for all patients improved from 56 preoperatively, to 89 postoperatively. The type of the device were not significantly related to clinical outcome or Lysholm knee score. But the concurrent ACL reconstruction group and the patients treated within 8 weeks had better clinical result than the others. Conclusion : The all-inside meniscal repair technique using bioabsorbable devices can be considered to be an useful method in the well selected patients and concurrent ACL reconstruction surgery.

• The korean journal of orthodontics
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• v.28 no.1 s.66
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• pp.165-174
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• 1998

The turnover of collagen is controlled by the balance between collagen synthesis and degradation. The production of collagenase (matrix metalloproteinase-1) and its inhibitor, tissue inhibitor of matrix metallopmteinase-1 (TIMP-1) are one of the substances which regulate this balance. The periodontal ligament fibroblast plays an important role in collagen metabolism during orthodontic treatment and is believed to be an origin of the osteoblast in the alveolar bone. The collagenase secreted by the periodontal ligament fibroblast and the osteoblast initiates the bone resorption by removing the osteoid layer in the alveloar bone. The interleukin-$1{\beta}$ is secreted by the macrophage during orthodontic treatment. The present study was undertaken to assess the effect of mechanical stress and interleukin-$1{\beta}$ on the expression of collagenase and TIMP-1 in the periodontal ligament fibroblasts using reverse transcription polymerase chain reaction and immunohistochemical staining. The periodontal ligament fibroblasts were stitched by placing the $Petriperm dish^{\circledR}$ dish on the top of spheroidal convex watch glass ($5\%$ surface increase) and tented with interleukin-$1{\beta}$ (1.0 ng/ml), or treated with both of them. Treatment with mechanical stress and/or interleukin-$1{\beta}$ resulted in increased collagenase mRNA expression. The mechanical stress treated group (1.61, 1.62, 1.37 fold increase), the interleukin-$1{\beta}$, tented group (1.68, 1.60, 3.78 fold increase), the mechanical stress and interleukin-$1{\beta}$ treated group (1.89, 1.72, 5.48 fold increase) induced increases in collagenase mRNA compared with the control group after 2, 4, 8 hours respectively. But TIMP-1 mRNA expressions at experimental groups were decreased after 2, 4 hours and increased after 8 hours. The mechanical stress treated group (0.16, 0.49 fold decrease and 3.77 fold increase), the interleukin-$1{\beta}$ treated group (0.15,0.44 fold decrease and 4.46 fold increase), the mechanical stress and interleukin-$1{\beta}$ tented group (0.15, 0.69 fold decrease and 4.81 fold increase) induced changes in TIMP-1 mRNA compared with the control group after 2, 4, 8 hours, respectively. Immunohistochemical stain showed that increased collagenase and TIMP-1 staining of the mechanical stress tented group, the interleukin-$1{\beta}$ treated group, and the mechanical stress and interleukin-$1{\beta}$ treated group compared with that of the control group after 8 hours. These findings suggest that mechanical stress and interleukin-$1{\beta}$ regulate expression of collagenase and TIMP-1.

• Clinical and Experimental Reproductive Medicine
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• v.35 no.4
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• pp.275-283
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• 2008

Objective: This study was conducted to investigate the effects of the artificial shrinkage and assisted hatching (PZD; patial zona dissetion) before vitrification on the development of vitrified mouse expanding blastocyst. Methods: Mouse 2-cell embryos were collected and cultured in G1.1 and G2.2 to expanding blastocyst. For artificial shrinkage (AS) the micro injection pipette was inserted into blastocoele cavity and blastocoele fluid was aspirated. For assisted hatching (AH) PZD method was used. Control group was -AS/-AH and treatment groups were -AS/+AH, +AS/-AH and +AS/+AH. After AS and AH mouse blastocysts were equillibrated in G10 and G10E20 for 3 mins, respectively, and vitrified in G25E25 after loading on capped pulled-straw. Vitrified mouse blastocysts were thawed and cultured for 24 hrs. The survival and hatching rate was compared among one control and three treatment groups. Results: The survival rates were 99%, 92% in +AS/+AH and +AS/-AH groups and 54%, 58% in -AS/-AH and -AS/+AH group, respectively. The survival rate was significantly higher in +AS group than in -AS group (p<0.01). Hatching rates were 34%, 96% in -AS/-AH and -AS/+AH groups and 41%, 100% in +AS/-AH and +AS/+AH, respectively. The hatching rates was higher in +AH group than in -AH group (p<0.01). After thawing recovery rates were 100%. Loading on capped pulled-straw, that is effective and useful method on vitrification. Conclusion: This study showed that artificial shrinkage of blastocoele cavity and assisted hatching (PZD) significantly improved the development of the vitrified mouse expanding blastocysts.