• Clinical and Experimental Pediatrics
• /
• v.48 no.4
• /
• pp.387-394
• /
• 2005

Purpose : We performed this study to compare the TSH and free $T_4$ levels according to gestational age and birth weight, and to reevaluate the cut-off values in the neonatal screening test for congenital hypothyroidism. Methods : Total 2,133 neonates(1,749 healthy newborns and 384 sick neonates) were screened in Dankook University Hospital from May 2000 to January 2003. Neonates with abnormal TSH values (higher than $20{\mu}IU/mL$) or abnormal free $T_4$ levels(lower than 1 ng/dL) were recalled to recheck the thyroid function test. At that time, physical examinations and history-taking regarding perinatal problem, medication history, and mother's illness were undertaken. Results : Serum TSH and free $T_4$ values revealed no significant difference according to sex, delivery type, and Apgar score. The free $T_4$ levels showed statistically significant differences, with gestational age or birth weight(P<0.01). The recall rate of neonates due to abnormal screening test was 7.48 percent. Compared with original cut-off values, the recall rate of the new cut-off values setted to TSH higher than $20{\mu}IU/mL$ or free $T_4$ lower than 0.64 ng/dL decreased from 7.48 percent to 4.8 percent in the healthy group. But, it compromised sensitivity when applied to the sick group. Conclusion : In this study, neonatal free $T_4$ levels were significantly different according to birth weight, gestational age, and the presence of compromised condition. Although the recall rate by TSH > $20{\mu}IU/mL$ or free $T_4$ <1 ng/dL was relatively high, it was impossible to set up new cut-off values without compromising sensitivity. We think studies including a larger study population will be required to change the cut-off values.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1972.03a
• /
• pp.16.2-16
• /
• 1972

Persistance of developmental remnants during fetal life may be attributed to congenital cysts and fistulas in the neck, which are experienced rather rarely. Recently authors have experienced three cases of progressive increased tumor mass in the lateral side of the neck and four cases of tumor mass in the suprathyroid region. We have performed surgical removal under the diagnosis of branchial cysts and thyroglossal duct cysts, respectively. The biopsy specimens were confirmed by histopathological study.

• The Korean Journal of Medicine
• /
• v.99 no.3
• /
• pp.127-133
• /
• 2024

Subclinical hypothyroidism (SCH) is characterized by elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine levels. The Korean Thyroid Association recently issued guidelines for managing SCH. Based on the Korea National Health and Nutrition Examination Survey (2013-2015), a serum TSH level of 6.8 mIU/L is the reference value for SCH. SCH is classified as mild (TSH 6.8-10.0 mIU/L) or severe (TSH > 10.0 mIU/L), and patients are categorized as adult (age < 70 years) or elderly (age ≥ 70 years). Levothyroxine treatment (LT4-Tx) is not recommended for mild or even severe SCH in elderly patients. Immediate LT4-Tx can be given to adults in most cases, but not to women who are pregnant, patients with progressive disease, or patients with underlying coronary artery disease, heart failure, or dyslipidemia.

• Proceedings of the KAIS Fall Conference
• /
• 2011.05b
• /
• pp.802-805
• /
• 2011

본 연구는 갑상선암 초음파 수검의도에 영향을 미치는 요인들을 규명하기 위해 시도하였다. 자료는 2010년 12월 13일부터 2011년 1월 31일까지 한 종합병원 건강검진센타에 내원한 검진자 205명을 대상으로 설문 및 면접조사로 도출하였다. 연구결과 첫째, 보건의료에 따른 갑상선암 초음파수검의도는 수검의도가 있는 응답자의 경우 본인의 건강이 양호하다는 85.5%로 건강이 양호하지 못하다의 14.5%보다 유의하게 높았다($X^2$=6.73 p<.01). 둘째 갑상선암 초음파수검의도의 영향요인은 본인이 건강하다는 사람이 그렇지 않은 사람에 비해 2.53배 수검의도가 유의하게 높았다(95% Cl=1.39-12.7) 따라서 홍보를 통한 초음파검진에 대한 국민적 호응을 유도하는 것이 갑상선암의 조기발견을 위한 초음파검진 정책을 효율적으로 운영하는 대안이 될 것이다.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1977.06a
• /
• pp.10.1-10
• /
• 1977

The authors have experienced 8 cases of the thyroglossal duct cysts and fistula which were diagnosed and treated surgically in the Dept. of Otolaryngology, Taegu Presbyterian Hospital during the period of last 2 years. 1. Age distribution showed at age 2∼10 years old (4 cases), and 10∼30 years old (3 cases); The youngest age of 2, and the oldest age of 42. 2. The form of disease revealed as cystic form (7 cases) and fistula form (1 case). 3. Operating procedure were excision of thyroglossal duct cyst with partial removal of hyoid bone. 4. Sex distribution 7 in female and 1 in male. 5. Histologic examination revealed as stratified squamous epithelial lining were 7 cases, its cell composed with plasma cells lymphocytes. No epithelial lining is 1 case. 6. Post-operative complications were not developed in all cases.

• The Journal of the Korea Contents Association
• /
• v.13 no.5
• /
• pp.303-310
• /
• 2013

Thyroid nodular disease is the most frequently appeared in thyroid disease. Thyroid ultrasonography offers location of nodules, size, the number, information of internal echo characteristic. Thus, it makes possible to sort high-risk nodule containing high possibility about thyroid cancer and to induct precisely when take a Fine Needle Biopsy Aspiration. On thyroid nodule, the case which is diagnosed as malignant is less than 5% but screening test is very important on ultrasound and also must be reduced unnecessary procedure. Therefore, in this study an approach for describing a region is to quantity its texture content. We applied TFA algorithm on case which has been pathologically diagnosed as papillary thyroid cancer. we obtained experiment image which set the ROI on ultrasound and cut the $50{\times}50$ pixel size, histogram equalization. Consequently, Disease recognition detection efficiency of GLavg, SKEW, UN, ENT parameter were high as 91~100%. It is suggestion about possibility on CAD which distinguishes thyroid nodule. In addition, it will be helpful to differential diagnosis of thyroid nodule. If the study on additional parameter algorithm is continuously progressed from now on, it is able to arrange practical base on CAD and it is possible to apply various disease in the thyroid US.

• Journal of the Korean Society of Radiology
• /
• v.8 no.5
• /
• pp.241-248
• /
• 2014

The purpose of this study were to analyze the clinical correlation between the thyroid autoimmune antibodies (anti-TPO Ab, anti-TG Ab, and TSH) and the maximum standardized uptake value ($SUV_{max}$) base on the Hashimoto's thyroiditis and the Graves' disease in diffusely $^{18}F-FDG$ uptake of the thyroid gland to the PET/CT image. To achieve this, we was performed the PET/CT examination for the 1,097 subjects from May 2010 to April 2013 in the health screening, and was detected the diffused FDG thyroid uptake, and was additionally performed the thyroid function test (TFT) and the ultrasound (US). As a results, the autoimmune thyroid disease with the diffused FDG thyroid uptake were discovered 39 patients (3.9%), of this, the Hashimoto's thyroiditis was 43.6% and the Graves' disease was 23.1%. Hashimoto's thyroiditis was shown the positive reaction of high titer between the anti-TPO Ab and the anti-TG Ab level, and the correlation coefficient between the $SUV_{max}$ and the anti-TPO Ab was a statistically significant (r>04, p<0.05). Also, Graves' disease was shown the positive reaction of high titer most of the thyroid autoimmune antibodies, and the correlation coefficient between the $SUV_{max}$ and the anti-TPO Ab was a statistically significant (r>05, p<0.01). Therefor, when have a high standard of the $SUV_{max}$ due to the diffusely $^{18}F-FDG$ uptake of the thyroid gland, Hashimoto's thyroiditis and Graves' disease were proportionally increased the anti-TPO Ab and TSH level, respectively. The correlation coefficient between the $SUV_{max}$ and the thyroid autoimmune antibodies will be the most influential criterion that was a standard of judgment for the epihpenomenon of the autoimmune thyroid disease, and it will be available for the clinical application.

• 대한핵의학회:학술대회논문집
• /
• 1990.04a
• /
• pp.185.2-185.2
• /
• 1990

• 대한핵의학회:학술대회논문집
• /
• 1990.04a
• /
• pp.188.2-189
• /
• 1990

• 대한핵의학회:학술대회논문집
• /
• 1989.06a
• /
• pp.122.3-123
• /
• 1989