• ETRI Journal
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• v.11 no.1
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• pp.41-58
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• 1989

Neural network연구는 뇌로부터 얻은 아이디어를 공학적으로 응용하려는 생각을 바탕으로 뇌의 구조와 유사한 mechanism에 의한 정보처리장치의 기초가 되는 정보처리의 양식 확립과 함께 그 정보처리 양식을 구체적으로 각각의 정보처리 문제에 응용하기 위한 응용기술을 연구하는 것이다. Neural network의 계산 기능적 특성은 병렬처리, 학습 및 noisy한 정보의 효율적처리 등으로써 특히 pattern인식 문제에 효율적으로 응용될 수 있다. 본 논문에서는 neural network의 역사적 고찰과 기존의 model들을 살펴보고 새로운 계산 구조와 계산 방식을 가진 neural network의 응용분야를 살펴 봄으로써 기존의 AI 기법으로 해결하기 어려운 pattern recognition(image,문자,speech등), robot vision 및 control 등 여러가지 문제에 효율적으로 적용가능함과 neural network의 앞으로의 전망에 대하여 기술한다.

• Journal of Biomedical Engineering Research
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• v.20 no.3
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• pp.283-290
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• 1999

Because MR(Magnetic Resonance) slice images have much information of functions about body organs, it is very effeclive for diagnoses lo analyze and visualize MR slice images. A visuahzation process is composed of medical image acquisition, preprocessmg, segmentation, inlerpolation, rendering. Segmentation and interpolation among thenl ,1re currenl hot topics because of MR slice image imperfections. This paper proposes a method for segmentalion, mlerpolation respectively and addresses 3 D-visualizmg of a head. We segmented head tissues uomg otructural knowledge of head studied by clinical experiments sequentially. We improved the dynamic elastic inlerpolation to Utilize in concave conlour. We compared the proposed segmentation method and the interpolation method with other methods.

• Investigative Magnetic Resonance Imaging
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• v.14 no.2
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• pp.103-114
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• 2010

Purpose : To generate a Korean specific brain template, especially in patients with Alzheimer's disease (AD) by optimizing the voxel-based analysis. Materials and Methods : Three-dimensional T1-weighted images were obtained from 123 subjects who were 43 cognitively normal subjects and patients with 44 mild cognitive impairment (MCI) and 36 AD. The template and the corresponding aprior maps were created by using the matched pairs approach with considering differences of age, gender and differential diagnosis (DDX). We measured several characteristics in both our and the MNI templates, including in the ventricle size. Also, the fractions of gray matter and white matter voxels normalized by the total intracranial were evaluated. Results : The high resolution template and the corresponding aprior maps of gray matter, white matter (WM) and CSF were created with the voxel-size of $1{\times}1{\times}1\;mm$. Mean distance measures and the ventricle sizes differed between two templates. Our brain template had less gray matter and white matter areas than the MNI template. There were volume differences more in gray matter than in white matter. Conclusion : Gray matter and/or white matter integrity studies in populations of Korean elderly and patients with AD are needed to investigate with this template.

• 건강소식
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• v.11 no.4 s.101
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• pp.44-47
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• 1987

두통이 매우 흔한 이유로는 아마도 두개골내의 귀중한 뇌조직을 보호하기 위해서 말단 통각수용기가 안면과 두피에 신체의 다른 부위에서 보다 더 풍부하게 분포되어 있고, 눈, 코, 입같은 고도로 민감한 조직들이 두부에 있어 보호의 필요가 있고, 또 지적인 사람의 두부는 뇌가 있는 곳이므로 신체의 다른 어느 부위에서 보다 더 관심이 대상이 되는 구조이기 때문이다.

• Journal of KIISE
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• v.43 no.1
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• pp.54-60
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• 2016

Brain gene expression information is closely related to the structural and functional characteristics of the brain. Thus, extensive research has been carried out on the relationship between gene expression patterns and the brain's structural organization. In this study, Principal Component Analysis was used to extract features of gene expression patterns, and genes were automatically classified by spatial distribution. Voxels were then clustered with classified specific region expressed genes. Finally, we visualized the clustering results for mouse hippocampal region gene expression with the Allen Brain Atlas. This experiment allowed us to classify the region-specific gene expression of the mouse hippocampal region and provided visualization of clustering results and a brain atlas in an integrated manner. This study has the potential to allow neuroscientists to search for experimental groups of genes more quickly and design an effective test according to the new form of data. It is also expected that it will enable the discovery of a more specific sub-region beyond the current known anatomical regions of the brain.

• Science of Emotion and Sensibility
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• v.15 no.4
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• pp.585-592
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• 2012

Food is crucial for the nutrition and survival of humans. Taste system is one of the fundamental senses. Taste cells detect and respond to five basic taste modalities (sweet, bitter, salty, sour, and umami). However, the cortical processing of taste sensation is much less understood. Recently, there were many efforts to observe the brain activation in response to taste stimulation using functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and optical imaging. These different techniques do not provide directly comparable data each other, but the complementary investigations with those techniques allowed the description and understanding of the sequence of events with the dynamics of the spatiotemporal pattern of activation in the brain in response to taste stimulation. The purpose of this study is the understanding of the brain activities to taste stimuli in sensory and affective aspects and the reviewing of the recent research of the gustotopic map by functional brain mapping.

• Sleep Medicine and Psychophysiology
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• v.5 no.1
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• pp.54-70
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• 1998

Objectives : The purpose of this study is to evaluate the role of structural and functional changes of the brain in the pathophysiology of schizophrenia. Methods : The authors measured the regions of interest on the magnetic resonance imaging of the brain in 20 patients with paranoid schizophrenia(15 men and 5 women) and 23 control subjects(15 men and 8 women). We also assessed the neurocognitive functions with the Wisconsin Card Sorting Test, the Benton Neuropsychological Assessment, and the Weschler IQ test-Korean version, soft neurologic signs, and psychiatric symptoms in the patient group. Results : In the patient group, all ventricles and basal ganglia including caudate nucleus and globus pallidus were significantly enlarged. Although there were no significant differences between the two groups in the values of right frontal lobe and left temporal lobe, there was a tendency of decrease in the values of right frontal lobe and left temporal lobe. There were significant positive correlations between the values of ventricles and the frequency of previous hospitalization. However, there were no significant correlations between other values of regions of interest and clinical data. The value of the right frontal lobe was significantly correlated with the score of soft neurologic signs, which is suggestive of the neurodevelopmental abnormalities. There were significant correlations between the value of frontal lobe and the scores of the various subscales of Benton Neuropsychiatric Inventory. In contrast, the value of left amygdala and putamen showed significant correlation with the score of verbal IQ on the Weschler IQ test. Structural changes of the temporal lobe areas were related with the positive and general symptom scores on PANSS, while those of the basal ganglia were related with the negative symptom scores. Conclusions : These results suggest that the structural changes of the brain in the patients with schizophrenia show the dual process, which is suggestive that the enlarged ventricle show the neurodegenerative process, while enlarged basal ganglia, and shrinked right frontal and left temporal lobe show the neurodevelopmental abnormalities. Among these changes, structural changes of the frontal lobe related with various neuropsychological deficits, while those of left temporal lobe related with language abnormality. Relative to the relation between structural changes and psychiatric symptoms, structural changes of the temporal lobe areas were related with the positive and general symptoms, while those of the basal ganglia were related with the negative symptoms.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.208-210
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• 2002

신경과 의사들은 실제 임상에서 환자들에게 대뇌피질감각의 이상 여부를 알기 위해 손바닥에 숫자나 문자를 쓰게 하여 알아 맞추게 하는 검사를 시행한다. 손바닥에 쓰여진 문자나 숫자를 인식하기 위해서는 몇 가지 단계의 인지과정이 필요할 것으로 생각된다. 첫번째로 손바닥에 닿는 감각을 인지해야 하고, 다음 단계로 이 감각들을 시공간적으로 통합하는 과정이 필요할 것이고, 이러한 정보들을 유지하면서 마지막 단계로 우리 머리 속에 있는 문자와 일치시키는 과정이 필요할 것이다. 본 연구에서는 위와 같은 가설 아래 각각에 해당할 수 있는 뇌영역을 밝히기 위해 기능적 뇌자기공명영상을 이용하였다. 손바닥의 일차적 감각을 인지하는 데는 일차감각영역이 활성화 되었고, 이차감각영역의 활성은 감각들의 시공간적 통합과 관련될 것으로 생각되었으며, 이것들을 유지하는 것은 작업기억의 하부구조인 시공간 그림판과 관련되는 영역이며, 문자를 일치시키는 과정은 브로카영역 부근의 활성과 관련되는 것으로 생각되었다. 위의 가설에 대한 추가검증 및 실제로 일어나는 인지과정에 대한 추가적인 연구가 필요할 것이다.

• Proceedings of the KIPE Conference
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• 2013.07a
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• pp.153-154
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• 2013

고전압, 대전류를 갖는 뇌서지는 전원회로에 유입되었을 때 소자 파손 및 회로 오동작 등의 문제를 일으킨다. 이에 대한 보호대책으로 SPD(Surge Protection Device)소자와 스파크-갭(Spark-gap)을 주로 사용한다. 이 때, 기존의 스파크-갭은 뇌서지 유입 시 방전현상 이후에 발생된 스파크-갭의 패턴 마모로 패턴의 복구가 불가능하고, 불규칙하고 변칙적인 방전으로 인하여 발생되는 서지주요 예측경로의 소자 및 패턴 파괴와 같이 2차적인 문제를 발생시킨다. 이를 해결하기 위해 본 논문에서는 초기 유입 시부터 스파크-갭의 방전을 통해 에너지를 우회시킴으로서 전원회로의 뇌서지 부담을 줄여 전원회로의 안전성 및 안정적인 정상동작을 확보하는 대책을 제안하고, 스파크-갭의 구조에 따른 효과를 실험을 통해 검증한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.173-182
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• 2005

This review is a clinical and research update of recent literature related to childhood onset schizophrenia (with an onset of psychosis by age 12). Childhood onset schizophrenia(COS) is a rare disorder, but that may represent a more homogeneous patient population in which to search for risk or etiologic factors of schizophrenia. These overview data show that COS shares the same clinical and neurobiological features as later onset forms of the disorder. Compared with later onset schizophrenia, however, this subgroup of patients appear to have more severe premorbid neurodevelopmental abnormalities, more cytogenic abnormalies, poor outcome, and potentially greater family histories of schizophrenia and associated spectrum disorders. Future studies of this subgroup may provide important clues as to the genetic basis for schizophrenia and how gene products influence certain feature of the disease, such as age of onset and mode of inheritance.