• Title/Summary/Keyword: 농약 독성

Search Result 352, Processing Time 0.026 seconds

Selective Toxicity and Acetylcholinesterase Inhibition of Diazinon and Carbofuran to Killifish(Oryzias latipes) and Loach(Misgurnus anguillicaudatus) (Diazinon과 Carbofuran의 송사리(Oryzias latipes)와 미꾸리(Misqurnus anguillicaudatus)에 대한 선택적 독성과 Acetylcholinesterase저해)

  • Kim, Young-Bae;Lee, Sung-Kyu;Kim, Yong-Hwa;Roh, Jung-Koo
    • Korean Journal of Environmental Agriculture
    • /
    • v.7 no.2
    • /
    • pp.117-123
    • /
    • 1988

  • This study was initiated to understand the mechanism of selective toxicity of diazinon and carbofuran to killifish and loach. Conventional LC50 was calculated from fish test. IC50 with acetylcholinesterase activity was estimated using whole body and wet brain homogenate of the two fish species. Acetylcholinesterase activity of killifish was approximately twice as high as that of loach. The selective toxicity of diazinon to killifish and loach was partly (14 : 4) explained by the IC50 of diazoxon, a toxic metabolite of diazinon. IC50 of carbofuran also partly (14 : 3.4) contributed to the selectivity. These result suggested that the enzymatic method might be utilized as a screening tool for the chemicals affecting fish species of environmental concern with certain limitations which should be overcome in future studies.

  • PDF