• 정신신체의학
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• 제16권1호
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• pp.47-51
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• 2008

연구목적 : 최근 세로토닌-노르에피네프린차단제가 공황장애를 비롯한 불안장애에 효과가 있음이 알려지면서 불안증상의 발생에 있어서 노르에피네프린의 역할에 대한 관심이 늘어나고 있다. 본 연구는 노르에피네프린 수송체 T182C유전자 다형성과 불안관련특질의 연관여부를 탐색하고자 하였다. 방법 : 169명의 여고생을 대상으로 노르에피네프린 T182C유전자 다형성을 조사하였다. 불안관련특질과의 연관 여부를 확인하기 위해 불안민감성척도와 스필버그 상태-특성 불안척도의 특성불안척도를 작성하게 하여 유전자형에 따른 점수의 차이여부를 비교하였다. 결과 : 피험자는 전원여성으로 평균연령은 $16.73{\pm}0.7$세였다. 유전자 분석결과 TT형은 106명, TC형은 55명, CC형은 8명이였으며 이는 Hardy-Weinberg평형에 위배되지 않았다. 노르에피네프린 T182C유전자형에 따른 불안민감성의 차이는 관찰되지 않았다. 불안민감성척도의 하위척도와 특성불안척도에 대한 분석에서도 통계적으로 의미있는 차이는 관찰되지 않았다. C 대립유전자 보유여부에 따라 동일한 비교를 수행하였을 때 에도 유의한 차이는 나타나지 않았다. 결론 : 저자들의 연구에서는 노르에피네프린 수송체 T182C유전자 다형성과 불안민감성척도를 사용해 측정한 불안민감성 및 스필버그 상태-특성 불안척도를 사용하여 측정한 특성불안간의 유의한 연관을 관찰할 수 없었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제25권2호
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• pp.82-88
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• 2014

Objectives : The aim of our study was to investigate association of norepinephrine transporter gene (SLC6A2) polymorphism and side effects of osmotic-release oral system methylphenidate (OROS MPH) in children with attention-deficit hyperactivity disorder (ADHD). Methods : We recruited drug naive children with ADHD (N=97). We administered OROS MPH by tolerable dosage. At week 8 of treatment, parents completed the Barkley's side effect rating scale. We analyzed two SLC6A2 single nucleotide polymorphisms (SNPs), rs192303 and rs3785143, with blood of subjects. We compared the frequency and severity of each side effect among SLC6A2 genotypes of 2 SNPs. Results : In the analysis of frequency of each side effect, irritability differed according to rs192303 and rs3785143 genotype. In comparisons of severity, talking less and disinterest differed according to rs192303 genotype. In the case of rs3785143, severities of disinterest and irritability were involved with genotype. Conclusion : Side effects of OROS MPH showed an association with SLC6A2 genotype.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권1호
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• pp.23-30
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• 2010

Objectives ： This study aimed to examine the association between norepinephrine transporter gene (SLC6A2) polymorphisms and attention-deficit hyperactivity disorder (ADHD) and to examine the relationship between the genotypes and allele variants of SLC6A2 and results of the Korean version of the parent ADHD rating scale (K-ARS). Methods ： We examined the association between ADHD and norepinephrine transporter gene polymorphism using DNA from 137 Korean children with ADHD and 120 normal controls. We compared the genotype distributions and allele frequencies of SLC6A2 polymorphism between the control group and the ADHD group. Then, we correlated the children's K-ARS mean totals, inattention scores, and hyperactivity/impulsivity scores with the genotypes and alleles for each SLC6A2 polymorphism. Results ： There were no significant differences in genotype and allele distribution for each SLC6A2 polymorphism, as shown by the Chi-square test (p>.01). There was a trend toward a difference in allele frequency in rs 5568, but it was not statistically significant after adjusting for multiple comparisons (p=.048). Also, there were no significant differences in K-ARS scores according to the genotypes and alleles for the SLC6A2 polymorphisms. Conclusion ： Our study found no significant evidence of an association between SLC6A2 polymorphisms and ADHD.