• 한국임상수의학회지
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• 제14권2호
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• pp.208-214
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• 1997

The objective of this study was (a) to examine the change of bloodchemistry and (b) to investigate the secretion trend of endocrinological substance in a dog model after laser-beam radiation at different level of frequency (250 Hz, 2,000 Hz, 5,000 Hz and 8,000 Hz). The experimental groups were divided into four groups were divided into four groups on the basis of the level of frequency radiated and stimulated for five minutes. Before stimulation and after a lapse of time (10-minute, 30-minute and 60-minute) all dogs were checked the following parameters; cortisol, ACTH, RBC, hemoglobin, hematocrit, WBC, Ca, P, ALT, AST and creatinine. The results were as follow: ten minutes after stimulation, cortisol level of 250 Hz group, 2,000 Hz group, 5,000 Hz group and 8,000 Hz group was increased 18.8%, 20.5%, 23.2% and 309%, respectively. Ten minutes after stimulation, ACTH level of 250 Hz group, 2,000 Hz group, 5,000 Hz group and 8,000 Hz group was increased 26.7%, 26.6%, 30.5% and 29.5%, respectively. It began to decrease and at 30-minute after stimulation resturned to pre-stimulation level at 60-minute after stimulation. In blood examination RBC, hemaoglobin, hematocrit and WBC level showed slight increase and decrease and returned to pre-stimulation level at 60-minute after radiation. In bloodchemical examination serum calcium, inorganic phosphorus, ALT, AST and creatinine level were within normal physiological ranges.

• 대한수의학회지
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• 제30권2호
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• pp.129-143
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• 1990

In the present paper, the distribution, relative frequences and cell types of endocrine cells in the gastrointestinal tract of the frog (Rana dybowskii) during the hibernating and the active phase were examined by light and electron microscopy. The results obtained are summarized as follow: The reactive cells for Grimelius were frequently found in the gastrointestinal tract, whereas the reactive cells for Hellman-$Hellerstr{\hat{o}}m$ were found numerous in the fundus and pylorus of stomach, a few in the duodenum and lower small intestine, and very few in the rectum during both phases. No reactive cells for Masson-Fontana were found in the gastrointestinal tract during both phases. Elecron microscopically, 4 types of endocrine cells in the fundus of the stomach, 3 types in the pylorus of the stomach and duodenum, and 1 type in the lower small intestine and rectum, respectively, were identified during the hibernating phase. In the active phase, 3 types of endocrine cell in the fundus of the stomach, 2 types in the pylorus of the stomach and duodenum, and 1 type in the lower small intestine and rectum were observed, respectively. In the hibernating phase, more cytoplasmic granules and various types of endocrine cells were generally found than in the active phase.

• 대한수의학회지
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• 제37권1호
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• pp.9-13
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• 1997

ABC법에 의해 면역조직화학적으로 아프리카발톱두꺼비(Xenopus laevis)의 위장관내분비세포를 관찰하였던 바, neurotensin 면역반응세포는 중등도로 소장에서 약하게 반응하였다. 구형의 gastrin releasing peptide(GRP) 면역반응세포는 위에서 위저부의 상피 세포 바로 아래와 유문부선에서 다수로, 소장에서는 가는 방추형으로 극소수 또는 중등도로 분포하였다. 한편 substance P 면역반응세포는 방추형으로 장상피에서 관찰되었다. 그러나 secretin, motilin, met-enkephalin-8 (M-Enk) 및 polypeptide YY(PYY) 면역반응세포는 전체 소화관에서 관찰할 수 없었다.

• 한국물환경학회지
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• 제28권5호
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• pp.669-675
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• 2012

Recently, there have been active researches regarding endocrine-disrupting chemicals (EDCs). In this study, fifteen small freshwater streams in Cholla-namdo province, South Korea were investigated with respect to the concentration of the endocrine disruptors - Bisphenol A (BPA), styrene monomer (SM), styrene dimer (SD), and styrene trimer (ST) by gas chromatography-mass spectrometry (GC-MS). Measured concentration of the target compounds in the sampled water ranged from

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2006년도 추계학술발표대회
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• pp.117-120
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• 2006

뼈 나이 평가는 소아 뼈의 골화정도, 내분비선 장애 등을 쉽게 알아 볼 수 있어 소아 방사선 의학에서 자주 사용되는 방법이다. 뼈 나이 평가를 위해서는 골단판과 손마디 뼈의 길이 넓이 등 뼈 정보가 필요하기 때문에 골단판 영역의 추출이 선행되어야 한다. 하지만 골단판의 성장이 많이 진행되어 손마디 뼈 부분과 붙어 있는 경우 골단판 추출이 어려운 점이 있다. 본 논문에서는 골단판 성장 여부와 상관없이 다양한 나이의 디지털 X-ray 영상에서 손가락의 골단판을 추출하는 알고리즘을 제안한다. 손가락 경계선의 레이블링 처리를 이용하여 정확한 손가락 영역을 추출하고 골단판 위치의 통계적 특성을 사용하여 골단판의 후보 지역을 생성한다. 그리고 골단판 영역에서는 손가락 영상의 수직 투영 미분값이 크기 때문에 후보 지역 내에서 수직 투영 미분값의 변화량으로 골단판의 위치를 정확하게 추출한다. 다양한 나이에 대해 실험해 본 결과 제안한 방법은 골단판의 성장 여부와 상관없이 골다판과 손가락 뼈가 붙은 곳에서도 골단판의 통계적 특성을 사용해 정확한 골단판 영역을 추출할 수 있었다.

• 상하수도학회지
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• 제20권6호
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• pp.893-904
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• 2006

To improve sensitivity of biosensor as yeast two-hybrid detection system for estrogenic activity of suspected chemicals, we tested effects of several combinations of the bait and fish components in the two-hybrid system on Saccharomyces cerevisiae inducted a chromosome-integrated lacZ reporter gene that was under the control of CYC1 promoter and the upstream Gal4p-binding element $UAS_{GAL}$. The bait components that were fused with the Gal4p DNA binding domain are full-length human estrogen receptor ${\alpha}$ and its ligand-binding domain. The fish components that were fused with the Gal4p transcriptional activation domain were nuclear receptor-binding domains of co-activators SRC1 and TIF2. We found that the combination of the full-length human estrogen receptor ${\alpha}$ with the nuclear receptor-binding domain of co-activator SRC1 was most effective for the estrogen-dependent induction of reporter activity among the two-hybrid systems so far reported. The relative strength of transcriptional activation by representative natural and xenobiotic chemicals was well correlated with their estrogenic potency that had been reported with other assay systems.

• Radiation Oncology Journal
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• 제28권2호
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• pp.111-116
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• 2010

부갑상선암은 매우 드문 내분비악성 종양으로 부갑상선기능 항진증의 0.5~4%를 차지하며 흔히 고칼슘 혈증과 부갑상선호르몬의 증가를 보인다. 비기능성 부갑상선암은 부갑상선기능 항진증으로 나타나는 증상이 없으며 병리조직학적 진단기준이 분명하지 않아 늦게 진단이 되는 질환이다. 근치적 절제술이 가장 표준적인 치료이지만 수술 후 국소재발이 흔하기 때문에 불완전 절제가 시행되었거나 미세 잔류 종양이 있는 경우 외부 방사선치료를 시행하여 국소 조절률 향상을 얻을 수 있다고 보고되고 있다. 저자는 부갑상선에 발생한 비기능성 악성종양으로 근치적 절제술 후 외부 방사선치료를 시행한 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하고자 한다.

• Nuclear Medicine and Molecular Imaging
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• 제40권2호
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• pp.90-95
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• 2006

Neuroendocrine tumors (NETs) consist of a heterogeneous group of tumors that are able to uptake neuroamine and/or specific receptors, such as somatostatin receptors, which can play important roles of the localization and treatment of these tumors. When considering therapy with radionuclides, the best radioligand should be carefully investigated. $^{131}I$-MIBG and beta-particle emitter labeled somatostatin analogs are well established radionuclide therapy modalities for NETs. $^{111}In,\;^{90}Y\;and\;^{177}Lu$ radiolabeled somatostatin analogues have been used for treatment of NETs. Further, radionuclide therapy modalities, for example, radioimmunotherapy, radiolabeled peptides such as minigastrin are currently under development and in different phases of clinical investigation. for all radionuclides used for therapy, long-term and survival statistics are not yet available and only partial tumour responses have been obtained using $^{131}I$-MIBG and $^{111}In$-octreotide. Experimental results using $^{90}Y$-DOTA-lanreotide as well as $^{90}Y-DOTA-D-Phe1-Tyr^3-octreotide$ and/or $^{177}Lu-DOTA-Tyr^3-octreotate$ have indicated the possible clinical potential of radionuclides receptor-targeted radiotherapy it may be hoped that the efficacy of radionuclide therapy will be improved by co-administration of chemotherapeutic drugs whose antitumoral properties may be synergistic with that of irradiation.

• Annals of Pediatric Endocrinology and Metabolism
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• 제22권1호
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• pp.15-26
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• 2017

The prevalence of type 2 diabetes (T2D) is increasing worldwide. Patients with T2D suffer from various diabetes-related complications. Since there are many patients with T2D that cannot be controlled by previously developed drugs, it has been necessary to develop new drugs, one of which is a glucagon-like peptide-1 (GLP-1) based therapy. GLP-1 has been shown to ameliorate diabetes-related conditions by augmenting pancreatic ${\beta}-cell$ insulin secretion and having the low risk of causing hypoglycemia. Because of a very short half-life of GLP-1, many researches have been focused on the development of GLP-1 receptor (GLP-1R) agonists with long half-lives such as exenatide and dulaglutide. Now GLP-1R agonists have a variety of dosing-cycle forms to meet the needs of various patients. In this article, we review the physiological features of GLP-1, the effects of GLP-1 on T2D, the features of several GLP-1R agonists, and the therapeutic effect on T2D.

• Annals of Pediatric Endocrinology and Metabolism
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• 제23권4호
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• pp.176-181
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• 2018

Noonan syndrome (NS) is an autosomal dominant disorder that involves multiple organ systems, with short stature as the most common presentation (>70%). Possible mechanisms of short stature in NS include growth hormone (GH) deficiency, neurosecretory dysfunction, and GH resistance. Accordingly, GH therapy has been carried out for NS patients over the last three decades, and multiple studies have reported acceleration of growth velocity (GV) and increase of height standard deviation score (SDS) in both prepubertal and pubertal NS patients upon GH therapy. One year of GH therapy resulted in almost doubling of GV compared with baseline; afterwards, the increase in GV gradually decreased in the following years, showing that the effect of GH therapy wanes over time. After four years of GH therapy, ~70% of NS patients reached normal height considering their age and sex. Early initiation, long duration of GH therapy, and higher height SDS at the onset of puberty were associated with improved final height, whereas gender, dosage of GH, and the clinical severity did not show significant association with final height. Studies have reported no significant adverse events of GH therapy regarding progression of hypertrophic cardiomyopathy, alteration of metabolism, and tumor development. Therefore, GH therapy is effective for improving height and GV of NS patients; nevertheless, concerns on possible malignancy remains, which necessitates continuous monitoring of NS patients receiving GH therapy.