• Journal of Chest Surgery
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• v.35 no.4
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• pp.325-328
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• 2002

The neuroendocrine tumor is a rare thymic neoplasm, which has been regarded as a distinct tumor from thymoma and originates from Kultschizky cell. The pathologic diagnosis of thymic neuroendocrine tumor has been on findings from light microscopy, immunohistochemical studies, and electron microscopy. About 50% of thymic carcinoids are seen with endocrinopathies. Recurrence and extrathoracic metastasis are characteristics of thymic carcinoids. Surgical removal of the initial and recurred tumor is considered to be the most effective treatment. The role of the adjuvant chemotherapy and radiotherapy is still uncertain. Herein we report a case of thymic neuroendocrine tumor, which was resected surgically.

• The Science & Technology
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• v.33 no.6 s.373
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• pp.76-78
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• 2000

많은 호르몬의 작용중 동ㆍ식물의 생식과 관련된 호르몬의 작용을 규명하고 호르몬의 응용방법을 개발 연구하는 '전남대 호르몬연구센터'는 생식내분비, 분자내분비, 응용내분비 등 3개 연구부를 두고 왕성한 연구활동을 펴오고 있다. 현재 4명의 연구교수와 국내 각 대학교수 25명 그리고 박사후 연구원과 대학원생 등 모두 1백여명의 연구진으로 구성된 이 연구센터는 매년 국제생식내분비학 심포지엄과 2회의 국내 심포지엄을 개최하고 있다.

• Journal of Digestive Cancer Reports
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• v.9 no.1
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• pp.19-24
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• 2021

The incidence of small and asymptomatic pancreatic neuroendocrine neoplasms (PNENs) has been increased due to the widespread use of high-resolution imaging techniques and endoscopic procedures in screening programmes. Most of PNENs are indolent neoplasms with slow-growing. However, sometimes, PNENs show local invasion or metastasis with poor prognosis. The management of small, nonfunctioning PNENs remain under debate. The National Comprehensive Cancer Network guidelines recommend observation in selected cases of small PNENs less than 2 cm. Pancreatic surgeons are divided into two factions: "the hawks," who indicate the high risk of malignancy even in small PNENs and, therefore, the need for an aggressive surgical treatment, and the "the doves," who accepts the risk of malignancy in some ≤ 2 cm PNENs, advocate that the risk of overtreating many benign ≤ 2 cm PNENs would be much higher. As the pancreatic surgery remains a high-risk operation with a 28-30% morbidity and 1% mortality, the decision for small PNENs is challenging.

• Journal of Chest Surgery
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• v.35 no.12
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• pp.909-913
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• 2002

The large cell neuroendocrine carcinoma is uncommon and its diagnostic criteria was recently established as pulmonary neuroendocrine carcinoma. A 74-year-old man who was a heavy smoker without symptoms was presented with a lung mass in right lower lobe. He was diagnosed as having large cell neuroendocrine carcinoma by needle biopsy. He was treated with right lower lobe lobectomy and mediastinal lymph node dissection. We experienced one case of large cell neuroendocrine carcinoma of lung and report it with reference.

• The Monthly Diabetes
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• s.130
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• pp.34-36
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• 2000

내분비과에서 다루는 신체 장기나 조직은 특별히 한정되어 있지 않으며, 우리 몸이 살아 있는 생물체로서 기능하는데 필요한 여러가지 체내 물질의 작용에 관련한 모든 생리현상을 포함한다

• Journal of Chest Surgery
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• v.34 no.11
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• pp.887-890
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• 2001

Neuroendocrine tumor in thymus is rare and has poor prognosis due to frequent recurrence and distant metastasis. Approximately half of thymic carcinoids are hormonally active and Cushing\`s syndrome is seen in 33% of affected patients. Treatment of choice is surgical excision of tumor and role of chemotherapy and radiotherapy is controversal. We report 2 cases of thymic neuroendocrine carcinoma associated with Cushing\`s syndrome.

• Journal of Chest Surgery
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• v.35 no.12
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• pp.906-908
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• 2002

A 60-year-old male was admitted to our hospital complaining of general weakness. Chest radiography showed lung mass on left lower lobe. After left lower lobectomy and mediastinal lymph node dissection, The mass was pathologically diagnosed as large cell neuroendocrine carcinoma. Pulmonary large cell neuroendocrine carcinoma is rare. Herein we report a case of large cell neuroendocrine carcinoma in lung.

• Journal of Food Hygiene and Safety
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• v.14 no.4
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• pp.408-414
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• 1999

A number of chemical released into the environment eliciting their effects by disrupting normal hormonal pathways. Endocrine disrupting compounds are present in the aquatic environment and pose potential health consequences to wildlife and humans. This review are designing fur xenobiotic estrogens based on induction of the egg-yolk precursor protein vitelloge-nin. In fish of aquatic environment, it may result in decrease fertility and egg production in females or lead to reduced gonad size or feminization of genetic male fish. It has been known that male fish exposed to estrogenic compounds show induced production of vitellogenin. Vitello-genin production is normally restricted to adult females, which have elevated estrogen levels during egg production. However, vitellogenin can be induced in males by Pollution of environmental endocrine disruptors. Consequently, the presence of vitellogenin in male fish can serve as an indicator of exposure of environmental endocrine disrupting compounds. In immature fish pol-luted at low levels of environmental endocrine disrupter, vitellogenin can serve as a reliable biomarker for exposure to endocrine disrupter. This review demonstrates the utility of vitellogenin as a biomarker fur exposure to estrogenin agents in auqatic environment.

• Korean Journal of Microbiology
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• v.44 no.1
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• pp.10-13
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• 2008

Endocrine disrupting chemicals (EDCs) are hard to be degraded in nature, and are also accumulated in diverse organisms. They finally give negative effects to human through the food web. White rot fungi which have lignin-degrading enzymes have high potentials for degradation of recalcitrant compounds, and a white rot fungus, Phlebia tremellosa, isolated in Korea show good degrading activity against the endocrine disrupting phthalates. We have isolated a laccase cDNA which was involved in the degradation of EDCs, and constructed a laccase expression vector to use in the genetic transformation of P. tremellosa. The expression vector was stably integrated into the chromosomal DNAs and showed increased laccase activity in transformants. One of transformants showed not only increased degradation of several EDCs but also faster estrogenic decreasing activities generated by the EDCs.

• 건강소식
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• v.35 no.8
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• pp.40-41
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• 2011

2011년 6얼 미국 내분비학회 전문가들은 비타민 D 부족의 진단, 치료 및 예방과 관련된 새로운 가이드라인을 제시하였다. 충분한 양의 비타민 D가 뼈 건강에 매우 중용한 요인이라는 사실은 오래전부터 잘 알려져 왔지만 비타민 D 부족은 아직도 흔한 건강문제로 간주된다. 또한, 뼈의 건강 이외에도 심혈관계의 건강과 유의한 연관성이 있다는 연구결과도 지속적으로 발표되고 있다.