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In Vitro Imaging of MRI and Ultrasound for Gastric Carcinoma (위암 조직의 자기공명영상과 초음파 소견에 대한 비교 연구)

  • Kil, Sung-Won;Jee, Keum-Nahn
    • Investigative Magnetic Resonance Imaging
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    • v.12 no.2
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    • pp.178-187
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    • 2008
  • Purpose : To evaluate and compare the diagnostic accuracy of MRI and ultrasound(US) for estimation of invasion depth of gastric carcinoma by correlation with histopathologic findings in vitro and to find out the best MR pulse sequence for detection and accurate delineation of tumor. Materials and Methods : Resected specimen of total or subtotal gastrectomy from 53 patients with gastric carcinoma were done of imaging studies of MRI and US. And US was examined by using high frequency linear transducer for tumor invasion depth by a radiologist. In each case, both imaging findings of MRI and US were evaluated independently for tumor detection and invasion depth by consensus of two radiologists and were compared the diagnostic accuracy between two imaging modalities according to the histopathologic findings. MR imaging with five MR pulse sequences, spin echo T1 and in- and out-of phase gradient echo T1 weighted images, FSE and SSFSE T2 weighted images, were performed. Five MR pulse sequences were evaluated and compared on the point of detection and accurate distinction of tumor from surrounding normal tissue. Results : In EGC, diagnostic accuracy of US(77%) was superior than that of MRI(59%) but no statistically significant difference was noted between two imaging modalities(p=0.096). In AGC, both imaging modalities of MRI and US showed relatively high diagnostic accuracy as 97% and 84% respectively. Diagnostic accuracy of MRI was statistically better than that of US at the significant level(p<0.001). The best MR pulse sequence among five in each specimen was FSE T2WI(75.5%, 40/53) in both EGC and AGC. In AGC, FSE T2WI showed excellent imaging quality by showing very high ratio (93.5%, 29/31) of accurate delineation of tumor. Conclusion : MRI and US show relatively high diagnostic accuracy in the evaluation of tumor invasion depth of resected specimen in AGC. The most excellent pulse sequence of MRI for the evaluation of tumor invasion depth is FSE T2WI on the point of detection and accurate delineation of tumor in both EGC and AGC.

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Establishment of Reference Range of Proinsulin (Proinsulin 참고치 설정에 관한 연구)

  • Nam, Yee Moon;Shin, Yong Hwan;Kim, Ji Young;Seok, Jae Dong
    • The Korean Journal of Nuclear Medicine Technology
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    • v.17 no.1
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    • pp.76-79
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    • 2013
  • Purpose: It is very important to establish the appropriate reference range in the laboratory for preventing mistakes like false positive or false negative. Because the reference range in the laboratory is standard of patient test results interpretation. Proinsulin is precursor hormone of insulin, and the importance is increasing for diagnosing diabetes or insulinoma. Proinsulin reagent used in our laboratory is produced in the USA, and the reference range provided by manufacturer was adapted to our reference range after the validation test. But, it is generally recommend for the every laboratory to establish the their own reference range. So, we decided to re-evaluate the reference range with our patients' test results. Materials and Methods: Among 737 patients who had been to health promotion center in our hospital between Dec. $8^{th}$ 2011 and Dec. $21^{st}$ 2011, 563 patients are chosen with exception of diabetics patients and patients showing abnormal test results in Fasting Glucose, HbA1c, Insulin, and C-peptide. The 563 test results (275 males and 288 females) were classified with three groups(entire, male, female), and analysis of normal distribution was performed with aid of SPSS(version 19.0). Because Each group didn't show normal distribution, the reference range was set from the lowest limit of 2.5% to the highest limit of 97.5% with Percentile method used in non-normal distribution. Results: When evaluation values are sorted in ascending order, the entire range is 4.5~52.0 pM and 5.3~51.9 pM for male and 4.5~52.0 pM for female. The calculated reference range with percentile method shows 6.7~26.5 pM for entire group, 6.8~26.5 pM for male and 6.7~26.5 pM for female, respectively. Conclusion: The reference range provided by reagent manufacturer is 6.4~9.4 pM and the one established in this study is 6.7~26.5 pM. This difference might be caused by racial characteristics between Western people and Koreans. So an ideal reference range can be gotten with normal population visiting to every hospital. Our hospital has been using the newly re-establishing reference range under consultation with the department of endocrinology since Aug. $1^{st}$ 2012.

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Preferences of Foodservice Types for the Elderly Patients at the Long-term Care Facilities through Conjoint Analysis (컨조인트 분석에 의한 노인의료전문 병원의 급식서비스 선호도 연구)

  • Yoon, Hei-Ryoe;Cho, Mi-Sook
    • The Korean Journal of Food And Nutrition
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    • v.22 no.1
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    • pp.141-149
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    • 2009
  • The elderly population in Korea is growing rapidly and their needs for long-term care has also increased. By the year 2018, our society will be approaching aged society and by 2026 it will be a super-aged society. The purpose of this study was to employ conjoint analysis to establish the relative importance of foodservice encounters in terms of determining the utility values of hospital foodservice for elderly patients. According to the results pearson's R(0.420) and Kendall's tau(0.402) statistics showed that the model fits the data well(p<0.05). The relative importance scores of hospital foodservice encounters were as follows: dietary counseling with dietetics(51.2%), foodservice personnel(48.7%), and food(0.1%). A soft cooking method(0.001) was preferred to a general cooking method(0.001), and kind foodservice personnel(0.086) were preferred to quick service(-0.086). Finally, counseling with a dietitian once a week(-0.138) was preferred to counseling twice a week (-0.276). Based on this conjoint analysis, the most preferable model for foodservice at a long-term care facility would be; soft cooking methods, kind service by foodservice personnel, and dietetic counseling once a week. Overall, a better understanding of the specific needs of our institutionalized elderly is one of the key elements that can help our long-term care system develop improved foodservice programs.

Effect of Animal Organic Soil Amendment on Growth of Korean Lawngrass and Kentucky Bluegrass (동물성 유기질 개량재가 들잔디 및 캔터키 블루그래스 잔디생육에 미치는 효과)

  • Koh, Seuk-Koo;Tae, Hyun-Sook;Ryu, Chang-Hyun
    • Asian Journal of Turfgrass Science
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    • v.20 no.1
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    • pp.33-40
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    • 2006
  • Many soil amendments have been used nowadays to improve physical and chmical condition of turf soil, which might ultimately optimize turfgrass growth in golf courses. This study was carried out to Investigate the effects of new organic soil amendment containing pig excreta 50% and sawdust 50% on growth of zoysiagrass (Zoysia japonica L.) and kentucky bluegrass (Poa pratensis L.) in greenhouse. Three applicable treatments with soil mixtures of 10, 20, and 30% (v/v) animal organic soil amendment (AOSA) with sand, were tested for chemical property, physical property, visual quality and root length of zoysiagrass and Kentucky bluegrass. As results, application of $10{\sim}30%$ AOSA mixtures were proper to grow turfgrass in soil nutrition. Especially, the treatment with 20% AOSA mixtures showed 0.7% in organic matter, which meets to green standard of USGA. Also, 30% AOSA mixtures was 1.1% in organic matter, which might be desirable for zoysiagrass-planted golf courses in Korea. It was turned out that addition of AOSA decreased the hydraulic conductivity in soil physical property Because the sand possess high hydraulic conductivity, it is recommended to combine $10{\sim}30%$ AOSA with sand in order to sustain soil balance. The treatment with $10{\sim}30%$ AOSA noticeably increased visual quality of both zoysiagras and Kentucky bluegrass during 90 days. However, treatments with either 20% or 30% AOSA were effective to develop root length of zoysiagrass but treatments with 20% AOSA were more effective than that of 30% AOSA mixtures to promote root length of Kentucky bluegrass at 60 days. In conclusion, considering all vital factors such as visible quality, root growth, organic matter content, and economical efficiency, was taken, it is recommended that a $20{\sim}30%$ mixture of AOSA with sand is good for the growth of zoysiagrass and 20% mixture for Kentucky bluegrass.

A study on the effect of air velocity through a damper on smoke extraction performance in case of fire in road tunnels (도로터널 화재 시 집중배기방식의 배기포트 통과풍속이 배연성능에 미치는 영향에 관한 연구)

  • Ryu, Ji-Oh;Na, Kwang-Hoon
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.22 no.4
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    • pp.347-365
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    • 2020
  • In order to resolve traffic problems in urban areas and to increase the area of green spaces, tunnels in downtown areas are being increased. Additionally, the application of large port smoke extraction ventilation systems is increasing as a countermeasure to smoke extraction ventilation for tunnels with high potential for traffic congestion. It is known that the smoke extraction performance of the large port smoke extraction system is influenced not only by the amount of the extraction flow rate, but also by various factors such as the shape of the extraction port (damper) and the extraction air velocity through a damper. Therefore, in this study, the design standards and installation status of each country were investigated. When the extraction air flow rate was the same, the smoke extraction performance according to the size of the damper was numerically simulated in terms of smoke propagation distance, compared and evaluated, and the following results were obtained. As the cross-sectional area of the smoke damper increases, the extraction flow rate is concentrated in the damper close to the extraction fan, and the smoke extraction rate of the damper in downstream decreases, thereby increasing the smoke propagation distance on the downstream side. In order to prevent such a phenomenon, it is necessary to reduce the cross-sectional area of the smoke damper and increase the velocity of passing air through the damper so that the pressure loss passing through the damper increases, thereby reducing the non-uniformity of smoke extraction flow rate in the extraction section. In this analysis, it was found that when the interval distance of the extraction damper was 50 m, the air velocity passing through damper was 4.4 m/s or more, and when the interval distance of the extraction dampers was 100 m, the air velocity passing through damper was greater than 4.84 m/s, it was found to be advantageous to ensure smoke extraction performance.

Spawning Behavior and Early Life History of Grass Puffer, Takifugu niphobles (Jordan et Snyder) (Teleostei: Tetraodontidae) (복섬, Takifugu niphobles(Jordan et Snyder)의 산란습성(産卵習性) 및 초기생활사(初期生活史))

  • Oh, Sung-Hyun;Han, Kyeong-Ho;Kim, Yong-Min;Joung, Hyun-Ho;Shin, Sang-Soo;Kim, Yong-Uk
    • Korean Journal of Ichthyology
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    • v.12 no.4
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    • pp.236-243
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    • 2000
  • The purpose of present the study was to describe the spawning behavior and early life history of the grass puffer, Takifugu niphobles. The grass puffer was caught at the spawning ground on the coast Dolsan, Korea from May to the 1998. Artificial fertilization was carried out to get fertilied eggs. Spawning season was from the end of May to the beginning of July on the coast of the Dolsan, Korea. Form 2~6 days before the spring tide the aduct males and females began to aggregate in the shore water, and they spawned in the upper part of intertidal zone exposed to air among pebble stone. The fertilized eggs were demersal, transparent and spherical in shape, and its diameter were 0.87~0.95 mm with several oil globules of 0.0014~0.0540 mm. Hatching began about 146 hours after fertilization under water temperature $21.2{\sim}22.3^{\circ}C$. The newly-hatched larva was 2.02~2.24 mm in total length (TL, mean: 2.14 mm), with 22~24(8~9+14~15) myotomes, and mouth and anus was not yet open. In 3 days after hatching it was measured 2.64~2.93 mm in TL (mean: 2.76 mm), and yolk sac was completely absorbed and transformed to postlarval stage. In 15 days after hatching it was measured 4.43~4.82mm in TL (mean: 4.59mm), and the caudal notochord flexion started. The larvae reached the juvenile stage in 28 days after hatching and attained 7.55~7.65mm in TL (mean: 7.60mm), and all fin-rays were formed.

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Ototoxic Evaluation of Cis-platinum (Cis-Platinum의 이중독증에 관한 임상적 고찰)

  • 홍원표;정명현;오혜경;이경재
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1982.05a
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    • pp.17.1-17
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    • 1982
  • In 1965, Rosenberg reported that platinum compounds not only inhibit growth and cell division of E. coli but also has anti-tumor activity. Since then, through animal and clinical experiments by Welsch(1971), Speer(1972), Rossof(1972), Hill(1974), and Wittes(1975), it was proved that Cis-platinum has excellent supressive effects on malignant tumor, especially on head and neck cancer. Accordingly, Cis-platinum is now widely used, sometimes without any other durg, or sometimes with Bleomycin and Methotrexate etc. Inspite of the strong anticancer effect, the use of Cis-platinum is quite often discouraged because of the reports that Cis-platinum causes auditory impairment at high frequencies above the speech range due to inner ear damage and irreversible change in the renal tubules. Since Kohonen et al(1965), Standnicki et al(1974) reported that Cisplatinum has toxic effects at the basal turn of the cochlea using guinea pig, many studies on ototoxicity after infusion of Cis-platinum have been carried out using animals. But the studies on ototoxicity in human beings can hardly be found except in reports by Piel et al(1974) and Hong et al (1979). So the authors did a study which tried to clarify the ototoxic effect by comparing the hearing level after infusion of Cis-plastinum with the hearing level before infusion of Cis-plastinum in 30 patients who was treated with Cis-platinum and admitted to the dept. of otolaryngology of Yonsei University Hospital during 2 years and a half from July. 1979 to March. 1982 and the following results were obtained. 1) The results of auditory evaluation, using the pure tone average, hearing loss of 4kHz and 8kHz, Speech Reception Threshold, PB score, SISI showed that the difference of dosage does not change the hearing level after infusion of Cis-platinum and before infusion of Cis-platinum. 2) Cis-platinum had no effect on the hearing level of patients with conductive hearing loss, or with sensorineural hearing loss, as well as with normal hearing level. 3) The infusion of Cis-platinum did not cause any change in creatinine clearance, creatinine, uric acid, but only one case showed that Cis-platinum caused severe nephrotoxicity. 4) The infusion of Cis-plastinum did not cause any change in hemoglobin, leukocyte count, platelet count and there was no correlation with the amount of infusion. 5) To see the side effect of hydration practiced with the infusion of Cis-platinum, the electrolytes, particularly the K level in the serum was measured. But the results did not show any change. 6) Judging from the results of this study mentioned above, ototoxicity caused by infusion of Cis-platinum can be prevented by sufficient hydration. Also the results might say that the appropriate method of infusion of Cis-platinum might be effective in the patients with head and neck cancer who had sensorineural hearing loss for whom the infusion of Cis-platinum has been absolutely cotraindicated.

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Effects of Temperature on the Development and Longevity of the Gray Field Slug, Deroceras reticulatum Müller (Stylommatophora: Limacidae) (작은뾰족민달팽이(Deroceras reticulatum)의 발육과 수명에 미치는 온도효과)

  • Kim, Hyun-Ju;Bae, Soon-Do;Lee, Geon-Hwi;Yoon, Young-Nam;Park, Sung-Tae;Choi, Byeong-Ryeol;Park, Chung-Gyoo
    • Korean journal of applied entomology
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    • v.48 no.4
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    • pp.541-546
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    • 2009
  • The egg size and weight of the gray field slug, Deroceras reticulatum Muller, was $1.91{\times}2.19$ mm and 3.3 mg at $24^{\circ}C$, respectively. Its weight increased from newly laid eggs to adults for 17 weeks at four temperature regimes and was heaviest at $20^{\circ}C$, followed by 24, 16 and $28^{\circ}C$. Likewise, hatching rate of the egg batches was highest with 95% at $20^{\circ}C$, followed by 24, 16 and $28^{\circ}C$ with significant differences. The number of eggs in the batches was increased with 20 at $20^{\circ}C$ while it was only 10 at $28^{\circ}C$. The average accumulated egg-laying days was longest with 15 days at $20^{\circ}C$ while shortest with 9 days at $24^{\circ}C$. The range of egg-laying period was shortest with 84-134 days at $16^{\circ}C$ and longest at $20^{\circ}C$. Thus, the total number of eggs laid by adult D. reticulatum was highest with 217 at $20^{\circ}C$ and lowest with 105 at $16^{\circ}C$. The egg period was 12-19 days while the juvenile period and adult longevity were 51-68 days and 85-134 days, respectively. The life span of D. reticulatum from egg to adult was longest with 216 days at $20^{\circ}C$, followed by 193 days at $24^{\circ}C$, 170 days at $16^{\circ}C$ and 151 days at $28^{\circ}C$. Accordingly, the most favorable temperature for the oviposition, development and longevity of D. reticulatum is $20^{\circ}C$.

Locates the Sunken Ship 'Dmitri Donskoi' using Marine Geophysical Survey Techniques in Deep Water (지구물리 탐사기법을 이용한 심해 Dmitri Donskoi호 확인)

  • Yoo, Hai-Soo;Kim, Su-Jeong;Park, Dong-Won
    • 한국지구물리탐사학회:학술대회논문집
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    • 2004.08a
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    • pp.104-117
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    • 2004
  • Dmitri Donskoi, which went down during the Russo-Japanese War occurred 100 years ago, was found by using geophysical exploration techniques at the 400 m water depth of submarine valley off Jeodong of Ulleung Island. In the submarine area with the rugged seabed topography and volcanic seamounts, in particular, the reliable seabed images were acquired by using the mid-to-shallow Multibeam exploration technique The strength of corrosion (causticity) of the sunken Donskoi, measured by the electrochemical method, decreased to 2/5 compared with the original strength.

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Pathogenicity of Two Species of Sclerotium to Nine Cultivars of Garlic Cultivated Widely in Korea (마늘의 흑색썩음균핵병에 대한 품종저항성의 역학적 평가)

  • Kim, Yong-Ki;Kwon, Mi-Kyung;Cho, Weon-Dae;Kim, Tack-Soo;Shim, Hong-Sik;Lee, Yong-Hwon;Lee, Chan-Jung;Lee, Seong-Chan
    • Research in Plant Disease
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    • v.10 no.2
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    • pp.105-111
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    • 2004
  • Mycelial growth and days required for sclerotial formation(DRSF) in vitro, and disease incidence of infected plants in the field were investigated to evaluate disease resistance of nine garlic cultivars against two species of Sclerotium causing garlic white rot. There were differences among mycelial growth and sclerotial formation of two white rot pathogens on different garlic cultivars in vitro. Mycelial growth showed the highest level on the clove of 'Daeseo'. Sclerotia of two white rot pathogen were formed the earliest on the clove of 'Kodang' and the latest on the clove of 'Namdo'. In field trial all of nine garlic cultivars were highly susceptible to Sclerotium cepivorum and cold-type garlics were less susceptible than warm-type garlics. Meanwhile garlic cultivars used showed differences among resistant responses to Sclerotium sp., forming large sclerotia. All of warm-type garlics showed highly susceptible response, but three cold-type garlics, 'Seosan', 'Danyang' and 'Yechon' showed moderate resistant response and 'Euisung' showed resistant response. To evaluate cultivar resistance of garlics quantitatively disease progress curve was transformed as linear regression equation. Among the intercept (early disease incidence) and the slope (disease infection rate) obtained from the transformed equation, final disease incidence, and area under disease progress curve(AUDPC), AUDPC was the most effective to evaluate disease resistance of garlics to both of white rot pathogens. There was little correlation between mycelial growth and sclerotial formation on garlic cloves in vitro, and epidemiological parameters (early disease incidence, final disease incidence, disease infection rate, AUDPC) obtained from the field trial. Mycelial growth of S. cepivorum was positively correlated with final disease incidence and disease infection rate obtained from the field trial, meanwhile DRSF was negatively correlated with the epidemiological parameters.