• 대한두경부종양학회지
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• 제15권2호
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• pp.149-155
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• 1999

Objectives: To study the clinical features of the primary nasal/nasopharyngeal non-Hodgkin's lymphomas and to evaluate the implication of immunophenotyping as a prognostic factor. Patients and Methods: From January 1990 to December 1997,41 patients(median age, 41 years) of primary nasal/nasopharyngeal non-Hodgkin's lymphoma were studied. The clinical records and paraffin-embedded tissue blocks were reviewed retrospectively. The histologic features, immunophenotypic findings(pan-T, pan-B, CD3, CD56) and Epstein-Barr virus in situ hybridizatios were examined. The prognostic factors for clinical outcome were evaluated in these patients. According to Ann-Arbor system, there were 30 patiets(73%) with stage IE, 4(10%) with stage IIE, 3(7%) with stage IIIE, 4(10%) with stage IVE lymphoma. Among the patients with stage IE/IIE, 4 patients received local radiation alone, 4 received chemotherapy alone, 25 received combination chemotherapy and radiotherapy and 1 refused treatment. The patients with stage IIIE/IVE were given combination chemotherapy and radiotherapy. Results: Immunophenotyping were performed in 40 patients and staining results were as follows: 3(7%) patients with B cell, 17(42%) with T cell, 18(44%) with NK/T cell(CD56 positive), and two patients with unclassifiable result. Epstein-Barr(EB) virus in situ hybridization were performed in 28 patients and 23(82%) patients had positive EBV-encoded RNAs(EBERs). 21(55%) patients achieved a complete remission. There was no difference in complete remission between radiation alone and combination therapy. With median follow-up of 30 months, 5-years disease free survival of complete responders was 60% and 5-years overall survival rate was 36%. Multivariate analysis showed that better overall survival was related with absence of B symptoms, ECOG performance${\leq}1$ and non-NK cells. Conclusion: Most of all cases were positive for EBER. Since NK/T phenotype carried the worst prognosis, analysis for CD56 expression should be done. Further prospective studies were warranted to evaluate the role of chemotherapy in stage IE/IIE.

• 한국수자원학회논문집
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• 제52권spc2호
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• pp.811-822
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• 2019

본 연구에서는 용담댐 하류, 원주천댐, 홍천강을 대상으로 환경생태유량을 산정하였으며, 멸종위기종 및 국내고유종을 고려한 대상어종으로 용담댐 하류는 감돌고기, 원주천댐은 쉬리, 홍천강은 묵납자루를 선정하여 각 하천에서 환경생태유량을 산정하였다. 환경생태유량을 산정을 위한 물리서식처 분석은 수리모형과 서식처 모형이 결합된 Physical Habitat Simulation (PHABSIM)과 RIVER2D를 적용하여 수행하였다. 생태 환경 모니터링을 통해 연구 대상지별 대상종의 서식처 적합도 지수를 Instream Flow and Aquatic Systems Group (IFASG) 방법을 적용하여 성장단계별 서식처 작합도 지수를 산정하였다. 특히 어류 모니터링 성과를 바탕으로 대상종의 성장단계별 서식처 적합도 지수를 산정하였다. PHABSIM을 활용한 분석 결과, 조절 하천인 용담댐하류에서 산란기에는 $4.9m^3/s$, 치어기 $5.8m^3/s$, 성어기에는 $8.9m^3/s$에서 가중가용면적이 최대인 최적 환경생태유량이었다. 원주천댐에서는 쉬리의 산란기에는 $0.4m^3/s$, 치어기에는 $1.0m^3/s$, 그리고 성어기에는 $1.5m^3/s$의 최적 환경생태유량을 나타내었다. 또한 비조절하천인 홍천강에서는 묵납자루의 산란기 $5m^3/s$, 치어기 $4m^3/s$, 그리고 성어기에는 $6m^3/s$의 최적 환경생태유량이 산정되었다.