• Title/Summary/Keyword: 김만성

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IL-1 gene polymorphisms in Korean periodontitis patients (한국인 치주염 환자에서의 IL-1 유전자 다변성 연구)

  • Nam, Seung-Ji;Chung, Hyun-Ju;Kim, Ok-Su;Kim, Young-Joon;Koh, Jung-Tae
    • Journal of Periodontal and Implant Science
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    • v.34 no.3
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    • pp.623-637
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    • 2004
  • 중증 만성 치주염과 1L-1B+3954 및 1L-1A+4845 유전자의 대립유전자 2 보유 유전자 다변성이 관련된다고 보고되었다. 그러나 이러한 1L-1 복합유전자 다변성과 만성 치주염 및 급진성 치주염과의 관련성에 대해서는 상반되게 보고되고 있는데 이는 인종적 배경과 질환특성의 차이에 기인한 것으로 보인다. 이 연구는 한국인에서 경도, 중등도와 중증의 만성 치주염 그리고 급진성 치주염 환자를 대상으로 하여 1L-1A+4845, 1L-1B+3954, 1L1B-511, 1L-1 RN intron 2 (VNTR) 유전자 다변성의 분포를 평가하고, 치주질환의 심도와 유형에 관련되는지 알아보고자 시행되었다. 전남대학교 병원 치주과에서 검진과 치료를 받은 100명의 치주질환자를 대상으로 하였고 질환군은 치주낭 깊이, 부착 소실, 골 소실을 기준으로 하여 경도, 중등도, 중증의 만성 치주염, 급진성 치주염군으로 분류하였다. 대조군으로는 전남대학교 병원 소아치과에 내원한 전신적으로 건강한 92명의 아동을 포함하였다. 각 대상 환자에서 채취된 협점막상피에서 genomic DNA를 얻어 1L-1A+4845, 1L-1B+3954, 1L-1B-511 genotype은 중합효소 연쇄반응을 시행한 후 제한 효소분해과정을 거쳐 전기영동 후 분리한 결과를 해석하였으며 1L-1 RN(VNTR) 유전형은 중합효소연쇄반응 후 분리한 결과를 해석하여 다음의 결과를 얻었다. 대립유전자 2 보유자 비율은 치주질환자에서 1L-1A+4845, 1L-1B+3954, 1L-1B-511, 1L-1 RN이 각각 61%, 13%, 76.6%, 34%였으며 대조군에서는 76.9%, 7.7%, 62.2%, 19.1%였다. 1L-1B+3954과 1L-1A+4845 대립유전자 2 보유자인 양성유전자형 비율은 경도, 중등도, 중증의 만성치주염, 급진성 치주염환자에서 각각 10%, 7.9%, 22.2%, 12% 였으며 치주질환자의 13%, 대조군의 7.7%에서 양성 복합유전자형(positive genotype)을 보였다. IL-1B-511 유전자 다변성은 치주질환자에서 대조군에 비하여 높았으며 급진성 치주염환자에서 대립유전자 2 보유자율이 유의하게 높았다(p<0.01). IL-1 RN intron 2 유전자 다변성은 중등도 및 중증 만성 치주염환자에서 대립유전자 2 보유자율이 유의하게 증가하였다. 이러한 결과는 IL-1 gene cluster의 유전형이 한국인에서도 치주염의 유형과 질환 심도에 관련될 수 있음을 시사하였다.

Development of medication adherence scale for the elderly with chronic disease (만성질환 노인의 약물이행 측정도구 개발)

  • Kang, Sook;Kim, Jeong sun
    • 한국노년학
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    • v.41 no.1
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    • pp.149-168
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    • 2021
  • This study was to develop the Medication Adherence Scale in Elderly (MAS-E) with chronic disease and verify its reliability and validity. The MAS-E was developed in 5 steps: Configuration of conceptual frame by content analysis, preliminary items, pilot study, reliability and validity test, and development of final MAS-E with chronic disease. The questionnaires were collected from 345 adults with one-to-one interviews. Verification of its reliability and validity was divided into two phases. Reliability was tested using Cronbach's alpha, split-halves reliability, and test-retest. For validity tests, item analysis, factor analysis, total score-factor score correlation analysis, and criterion related validity were used. The developed scale consisted of 18 items and 4 factors - remember of taking medication (2 items), expectations for drug effects (5 items), practice taking medication according to instructions (8 items), communicating with health professionals (3 items), and explained 69.7% of total variance. The scale had significantly positive correlation (r = .72, p <.001) with the Morisky Medication Adherence Scale (MMAS-8). Cronbach's alpha was .91, Guttman split half coefficient was .80, and test-retest reliability was .912. Finding suggest that the MAS-E is a suitable scale to assess the status of medication adherence in elderly with chronic disease.

Concept Analysis of Health Equilibrium in the Community-dwelling Elderly With Chronic Diseases (만성질환 노인의 건강 평형감에 대한 개념분석)

  • Kim, Jeong Soo
    • Journal of Korean Public Health Nursing
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    • v.26 no.3
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    • pp.428-439
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    • 2012
  • Purpose: The purpose of this study was to define and clarify the concept of 'equilibrium' in community-dwelling elderly persons with chronic diseases. Methods: A hybrid model was used for development of the concept of equilibrium. The model included a field study conducted in Seoul, Korea. Participants in this study included 12 elderly persons with chronic diseases who were taking medicine regularly. Results: The concept of equilibrium was found to be a complex phenomenon having meaning in two dimensions: the family-friendly and social relation-oriented dimensions. Four attributes and nine indicators were defined. Conclusion: Equilibrium was defined as the state of having health recognition, will power, and motive power (family-friendly dimension) and having a feeling of participation (social relation-oriented). Therefore, nurses who work with elderly persons with chronic disease in the community should be aware of the attributes and indicators of equilibrium in order to enhance the equilibrium of their elderly clients with chronic diseases.

Granulocytic Sarcoma Involving the Pectoralis Muscle in a Patient with Chronic Myelogenous Leukemia (만성골수성백혈병 환자에서 대흉근에 발생한 과립백혈구육종)

  • Baek, Jong-Hyun;Lee, Jung-Cheul;Lee, Jang-Hoon;Kim, Jung-Hee;Kim, Mi-Jin
    • Journal of Chest Surgery
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    • v.43 no.4
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    • pp.466-469
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    • 2010
  • We report here on a very rare case of granulocytic sarcoma of the pectoralis muscle on the left chest wall of a patient with chronic myelogenous leukemia, and this malady presented as a very rapidly growing hematoma-like mass.