• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.206-206
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• 1994

1차년도에 F9 EC cell의 분화유도 시스템을 확립한뒤 계속적으로 해양생물로 부터 분리한 여러가지 물질을 처리하여 세포의 형태 변화 및 분화 관련 유전자 즉 laminin Bl, type IV collagen, RAR-$\beta$ 의 발현을 조사하였다. 그 결과 다수의 물질이 F9 세포를 분화시키는데 효과가 있는 것으로 나타났으며, 효과있는 물질들에 대한 구조분석이 계속적으로 실시되고 있다. 뿐만 아니라 분화효과가 있는 물질중에서 그 구조적으로 특이한 성질을 가진 물질에 대하여 이 물질이 암세호의 분화에 미치는 기작에 대해 조사하였다. 구체적인 실험내용을 요약하면 다음과 같다. 1. F9 EC cell에 스크리링할 물질의 처리 후 형태 변화 관찰 2. 분화 maker 유전자의 발현 조사 3, 작용 기작에 대한 조사

• Journal of the Korea Institute of Military Science and Technology
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• v.10 no.4
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• pp.185-194
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• 2007

This paper presents a motor selection technique for a manipulator design that is used in a multipurpose dog-horse robot. Since the dynamics of a manipulator and its servo drives are closely related to each other, it requires a repetitive analysis to determine a suitable motor. In order to simplify this procedure, Straete et al. proposed a simple normalization method to separate the load dependent terms and the motor dependent terms. This technique is adopted in this paper for selecting a motor in designing a manipulator.

• Journal of the KSME
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• v.33 no.6
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• pp.552-570
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• 1993

이 글에서는 마이크로머신 특성을 응용한 제품들과 이에 내포된 기반기술 및 관련 연구분야를 소개하고자 한다. 먼저 세부기술과 연구과제를 언급하기에 앞서, 마이크로머신 기술의 배경과특 성을 소개하고, 기존 기술들과의 비교 . 연계를 통해 기술 공간상에서의 마이크로머신 기술의 좌표를 제시하고자 한다. 그 이후 본론에 들어가서, 마이크로머신 관련기술 및 연구분야를 다음과 같이 크게 두 가지 관점에서 정리하여 소개한다. 먼저 산업분야별 응용제품 및 기술적용 예를 통하여 '제품기술' 관점에서 마이크로머신 기술을 조명한 후, 이러한 제품기술의 근간이 되는 연구 분야별 관련기술의 소개를 통하여 '기반기술' 측면에서 마이크로머신기술을 정리하고자 한다. 특히 후반부 마이크로머신 기반 기술부분에서는 마이크로머신의 설계, 해석, 제작과 관련된 기술과제 중 비교적 기계공학분야와 연관이 있는 부분을 중점적으로 다루었다. 끝으로, 제품 기 술로서의 마이크로머신기술의 현황 기술로서의 당면 과제 등을 조명하고, 관련기술의 성숙요건을 제시해본다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.1063-1066
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• 1995

This paper presents a precition control of an electrostatic microactuator. For the generation of sufficient electrostatic force, a donse comb-type electrostatic microactuator is designed and manufactureed via MEMS (micro-electro-mechanical systems) process. The nonlinear plant and the linear plant of the microactuator are established through the comparison of experimental results and simulation results. A feedforward controller is designed via MATLAB simulation using the inverse function of the nonlinear plant. the experiment for the precise position tracking control is undertaken to show the control efficiency of the proposed controller.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.15-18
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• 2006

Recently, experimental visualization of microscale fluid transport has attacted considerable attention in designing microelectromechanical systems. Fluid-surface interactions on hydrophobic and hydrophilic surfaces can play a key role in passively controlling microfluidics. Here we investigate the slip boundary condition depending on the surface characteristics; hydrophilic, hydrophobic wettabilities. Using the micro-PIV, velocity profiles are measured in the glass (hydrophilic), PDMS (hydrophobic) microchannels.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1321-1325
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• 2003

Nickel thin film is one of the most important materials used in micromachined structure. To measure the mechanical properties of electroplated nickel thin film, two techniques are adopted and compared quantitatively with. One is nano-indentation test to measure the elastic modulus. The other is tensile test to measure not only elastic modulus but also yield strength and plastic deformation, ultimate strength. To perform the tensile test, the test apparatus was constructed with linear guided servo motor for actuation, load cell for force measurement and dual microscope for strain measurement.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.419-422
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• 2002

A three-dimensional inlet flow structure inside a microfluidic element has been investigated using a micro-PIV(particle image velocimetry) measurement as well as a numerical analysis. The present study employs a state-of-art micro-PIV system which consists of epi-fluorescence microscope, 620nm diameter fluorescent seed particles and an 8-bit megapixel CCD camera. For the numerical analysis, a commercial software CFD-ACE+(V6.6) was employed for comparison with experimental data. Fixed pressure boundary condition and a 39900 structured grid system was used for numerical analysis. Velocity vector fields with a resolution of $6.7{\times}6.7{\mu}m$ has been obtained, and the attention has been paid on the effect of varying measurement conditions of particle diameter and particle concentration on the resulting PIV results. In this study, the microfluidic elements were fabricated on plastic chips by means of MEMS processes and a subsequent melding process.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.400-404
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• 2001

A micro-PIV(particle image velocimetry) measurement has been conducted to investigate flow fields in such microfluidic devices as microchannels and micronozzle. The present study employs a state-of-art micro-PIV system which consists of epi-fluorescence microscope, 620nm diameter fluorescent seed particles and an 8-bit megapixel CCD camera. Velocity vector fields with a resolution of $6.7\times6.7{\mu}m$ has been obtained, and the attention has been paid on the effect of varying measurement conditions of particle diameter and particle concentration on the resulting PIV results. In this study, the microfluidic elements were fabricated on plastic chips by means of MEMS processes and a subsequent molding process. Flow fields in a variety of microchannels as well as micronozzle have been investigated.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.9
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• pp.135-141
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• 2003

MEMS structures generally have been fabricated using surface-machining method, but the interface failure between silicon substrate and evaporated thin film frequently takes place due to the residual stress inducing by the applied the various loads. And the very important physical property in the heated environment is the linear coefficient of thermal expansion. Therefore this paper studied the residual stress caused the thermal loads in the thin film and introduced the simple method to measure the trend of the residual stress by the indentation. Specimens were made of materials such as Al, Au and Cu and thermal load was applied repeatedly. The residual stress was measured by nano-indentation using AFM and FEA. The existence of the residual stress due to thermal load was verified by the experimental results. The indentation length of the thermal loaded specimens increased minimum 11.8％ comparing with the virgin thin film caused by tensile residual stress. The finite element analysis results are similar to indentation test.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.63-63
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• 1992

할로페리돌(HP)은 정신분열증 환자에 널리 사용되는 Dopamine D$_2$-receptor의 antagonist인 antipsychotic drug이다. 이 약물의 혈장농도와 임상 반응사이의 'curvilinear'한 상관성 존재여부와 여기에 대한 대사체(reduced haloperidol, RH)의 영향에 대해 논란은 많지만, 본 연구 팀에서도 위의 상관성이 존재하며 또한 여기에 RH가 영향을 미칠 것으로 보고한바 있다. 따라서 본 연구에서는 앞의 결과에 대한 기전을 밝히고, 궁극적으로 효율적인 뇌송달 시스템의 개발가능성을 검토하기위한 1차적 인구로 HP의 약물속도론적 연구를 사람, 랫트 및 가토에서 실시하여 그특성을 비교하였다. 사람경우는 13명의 정신분열증 초기환자를 대상으로 경구(20mg HP, 5명) 및 주사(10mg HP, 8명) 투여한 후, 또한 랫트 및 가토의 경우는 마리당 5mg의 HP 및 RH를 각각 정맥주사한 후 경시적으로 혈장중 HP 및 RH의 농도를 측정하여 체내동태 특성을 검토하였다.