• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.387-396
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• 2022

Skeletal muscle accounts for about 40-50% of body weight and is an important tissue that performs various functions, such as maintaining posture, supporting soft tissues, maintaining body temperature, and respiration. Cancer, which occurs widely around the world, causes cancer cachexia accompanied by muscular atrophy, which reduces the effectiveness of anticancer drugs and greatly reduces the quality of life and survival rate of cancer patients. Therefore, research to improve cancer cachexia is ongoing. However, there are few studies on the link between cancer and muscle atrophy. Cancer cells exhibit distinct microenvironment and metabolism from tumor cells, including tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), and insulin resistance due to the Warburg effect. Therefore, we summarize the microenvironment and metabolic characteristics of cancer cells, and the molecular mechanisms of muscle atrophy that can be affected by cytokine and insulin resistance. In addition, this suggests the possibility of improving cancer cachexia of substances affecting TAM, TAN, and Warburg effect. We also summarize the mechanisms identified so far through single agents and the signaling pathways mediated by them that may ameliorate cancer cachexia.

• Journal of Korean Academy of Nursing
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• v.21 no.3
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• pp.281-294
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• 1991

The purpose of this study was to determine the amount of soleus muscle atrophy in rats due to 28 days of decreased activity induced by hindlimb suspension, to observe the restoration of mass and relative muscle weight of the atrophied soleus muscle at day 28 of recovery to control value, and to compare the effect of run training on the mass and relative muscle weight of the atrophied soleus muscle at day 28 of recovery with that of sedentary rats. Adult female Wistar rats were maintained for 28 days with hindlimb suspension. Rats were then assigned randomly to a cage sedentary or running group. Soleus muscle mass and relative muscle weight following hindlimb suspension were compared with a control value. The soleus muscle mass and relative muscle weight of the running and cage sedentary groups following hindlimb suspension were compared with those of a control group. Soleus muscle mass and relative muscle weight of the run training group were compared with those of cage sedentary group. The results obtained were as follows : 1. Soleus muscle mass and relative muscle weight was reduced to 53.28% and 51.11% respectively by hindlimb suspension. 2. Soleus muscle mass and relative muscle weight of the training group t day 28 of recovery was restored to the control value. 3. Soleus muscle mass of the training group was greater than that of the cage sedentary group by 6.6% without statistical significance at day 28 of recovery. 4. Relative soleus muscle weight of the traning group was significantly greater than that of the cage sedentary group by 15.79% From these results, it may be concluded that run training during the posthypokinetic period facilitates the recovery of the atrophied soleus muscle mass of rats.

• Journal of Sericultural and Entomological Science
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• v.13 no.1
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• pp.17-22
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• 1971

A series of experiments were conducted from 1968 to 1970 to find the transmission effects of the dwarf disease of mulberry tree in connection with inlay grafting and insect vector with the following conclusions: 1. The inlay-grafting of sound scions on diseased roots showed a 30 per cent transmission rate among the successful grafts. The inlay-grafting of diseased scions on sound roots showed a 14 per cent transmission rate among the successful grafts ir the case of scions cut and stored before wintering but no transmission effect in the case of scions prepared after wintering, There were some stocks, among the unsuccesful grasfts of diseased scions upon sound roots, that sprouted out new buds, no transmission effects were found in them, 2. Leafhoppers (Hishimonus disciguttus Walker) collected from areas with no dwarf disease infection were grouped into three plots and let to feed on mulberry tree severely infected by dwarf disease for 7 days, 14 days and 21 days respectively. After these preliminary treatment, the leafhoppers were recollected to be fed on the sound seedling divided into three plots for 10 days, 15 days and 20 days respectively to find the transmission effects. The results are that the 7 day plot showed no transmission effect whereas the 14 day plot showed a 22 per cent disease rate and the 21 day plot 61 per cent rate indicating that the longer the feeding period is the higher the transmission rate.

• The Journal of Korean Physical Therapy
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• v.19 no.3
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• pp.19-30
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• 2007

Purpose: This study was performed to investigate the effects of NMES for recovery of skeletal muscle. Methods: The normal group consisted of healthy rat without cast immobilization. The control group was breeding at standard cage during 7 days after 2 weeks-cast immobilization on hind limb. The experimental group. I. received NMES application during days after 2 weeks-cast immobilization on hind limb. The effects were measured with NT-3 immunoreactivity in neuromuscular junction by light microscope. Results: Immunoreactivity of NT-3 at the neuromuscular junction was higher appeared experimental groups than control group. Then, There was a little detection in the normal and control group. Conclusion: These therapeutic interventions enhance expression of NT-3 at the neuromuscular junction. Also, NMES is considered to effect on a normal structural formation and NT-3 expression at the neuromuscular junction.

• Biomedical Science Letters
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• v.2 no.1
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• pp.91-108
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• 1996

The present study was designed to examine effect of short term treadmill and weight-training on aging arophy in the rat skeletal muscle. Male rats of 24 months old were used. Each groups included control, treadmill and weight-training for 4 weeks by using treadmill apparatus and body press apparatus. The histo and cytochemical, ultrastructural and stereological changes in senile skeletal muscles of the rat were observed in the present study. During the training period the body weight and muscular weight in all groups remained constant. The volume density of muscle fiber type IIC and IIB were increased, that of type IIA was decreased, but type I remained constant in treadmill-training group. In weight-training rat, the density of type IIA and IIB were increased, both those of type IIC was decreased. But, all changes of muscle fiber type is not significant. Senile control group some usual formation of mild contraction band, liposuscin pigment and muscular splitting were observed. After treadmill-training, histological and ultrastructural changes occurred in the muscle fiber, such as irregularity of the sarcolemma, interfibrillar vacuolization, longitudinal splitting, and widened I-bond. After weight-training, the changes occurred in the trained muscle fiber, such as appearances of many lysosomes and autophagic vacuoles, severe contraction band, and breakup of myofibrils. Histo and cytochemical studies showed that the activities of succinic dehydrogenase and acid phosphatase remained constant, activities of $Mg^{++}$-ATPase decrease with training. Stereological changes were not observed in the volume and numerical density of all subject component, but the surface density of mitochondrial inner membrane was increased with treadmill-training. These experimental results suggested that endurance training during short-term may result in the adaptible response in senile skeletal muscles. On the other side, weight-training is bad for senile skeletal muscle.

• Information and Communications Magazine
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• v.29 no.1
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• pp.4-9
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• 2011

IT산업은 우리 경제 성장에 큰 역할을 해왔다. 최근 세계경기가 위축되면서 IT산업에 대한 기대가 다시 커졌다. 그러나 IT 환경 변화로 세계시장 구조, 혁신 원천, 경쟁 양상이 급변하고 있다. 즉, 융합 시장이 커지고 SW기업이 시장을 주도한다. 기업 간 인수합병(M&A)과 특허분쟁도 빈발한다. 우리는 이런 변화에 적극 대응하며 다양한 성과를 냈다. 하지만 융합이 초기단계이고 SW 경쟁력이 여전히 취약하다. 2012년 IT산업은 그간 쌓아온 역량을 토대로 글로벌 입지를 더 넓혀야 한다. 이를 위해 IT산업 정책은 IT융합 확산, SW 경쟁력 확보, 선제적 미래 준비에 초점을 두고 추진할 계획이다.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2009.03a
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• pp.12-13
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• 2009

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2001.05a
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• pp.57-58
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• 2001

최근 우리나라는 연근해 어업에 대한 환경변화가 심화되면서 어로작업의 생력화 및 지역특성에 알맞은 어구어법개발이 필요시 되고 있는데 제주도의 경우 주변국가와의 어업협정 이후 어장축소 등으로 말미암아 종래의 어선어업이 위축되면서 따라 연안 유용수산자원 생산성 향상을 도모하여 어민소득증대에 기여할 새로운 어구어법 개발이 시급히 요구되고 있다. 학공치 표층예망어구는 장래 이러한 문제를 해결 할 수 있는 연안어업의 하나이다. (중략)

• Child Health Nursing Research
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• v.4 no.1
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• pp.17-30
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• 1998

In order to investigate the effects of a decreased activity on skinfold thickness, circumference and muscle strength of the extremities during the recovery period following heart surgery, skinfold thickness, circumference and muscle strength of the extremities were measured on days 0, 3, 6, and 9 following the surgery, and compared with those on the arrival day of intensive care unit. Skinfold thickness was measured using a skinfold caliper(Saehan Cor., Korea), circumference of the limbs were measured with a tape measure, upper extremity strength was determined using the Takei grip dynamometer and lower extremity strength was measured by pressing the flatfoot on an electronic digital health meter while tying on a bed. Results from this study were thus : 1. Skinfold thickness of triceps, quadriceps and gastrocnemius muscle on days 3, 6, 9 following the heart surgery was not significantly different from that of on the day of operation. 2. Circumference of midupperarm and midthigh on days 3, 6, 9 following the heart surgery was not significantly different from that of on the day of operation. Circumference of midcalf on days 3, 6 following the heart surgery was not significantly different from that of on the day of operation, while that of midcalf on day 9 following the surgery decreased significantly compared with that of on the day of operation. 3. Muscle strength of the upper extremity was not significantly different from that of on the day of operation, while that of the lower extremity on day 9 following the surgery decreased significantly compared with that of on the day of operation. From these results, it may be concluded that circumference and muscle strength of lower extremity can be decreased due to the postoperative inactivity following heart surgery in congenital heart disease children.

• Journal of Korean Academy of Nursing
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• v.22 no.3
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• pp.325-336
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• 1992

The purpose of this study was to determine the effect of exercise training on the length and circumference of atrophied muscles to see whether improvement in restoring the atrophied muscle mass, of either length or circumference growth could be induced through exercise training. Adult female Wistar rats were maintained for 14 days with hindlimb suspension. Rats were then assigned randomly to a sedentary group or training group. The length and circumference of both atrophied soleus and plantaris muscle for the training and sedentary groups following hindlimb suspension were compared with those of a control group. Length and circumference of both atrophied soleus and plantaris muscle in trained group was compared with those in the sedentary group. The results can be summarized as follows ; 1) Atrophy of soleus and plantaris muscle was induced with hindlimb suspension. 2) The circumference of both the soleus and plantaris muscle following hindlimb suspension was reduced to 51. 72%, 66.67% respectively compared to the control group. The length of both the soleus and plantaris muscle following hindlimb suspension did not show any difference compared to the control group. 3) There was no difference in length for either the atrophied soleus or plantaris muscle between the trained and the sedentary group during recovery from hindlimb suspension. 4) The circumference of both the atrophied soleus and plantaris muscle did not return to normal in the sedentary group, however, the circumference of both the atrophied soleus and plantaris muscle were significantly greater than of the control in the trained group, 14.22% and 9.38% respectively. 5) The circumference of both the atrophied soleus and plantaris muscle in the trained group was significantly larger than that of both muscles in the sedentary group at day 28 of recovery. From these results, it can be suggested that improvement in restoring the atrophied muscle mass through exercise training might be induced by growth of the muscle circumference.