• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 1999.11a
• /
• pp.509-515
• /
• 1999

신체를 구성하는 여러 가지 요소 중에서 인간이 일상생활을 하는 데에는 신진대사를 일정하게 유지하기 위한 인체내의 여러 가지 전달물질들이 그 구성에 맞게 역할을 수행하여야 한다. 그러나, 만약 그 구성 비율이 바뀔 때에는 인체 내에 이상이 발생하게 된다. 그 대표적인 예로는 운동을 심하게 하였을 경우 갈증과 근육의 피로감이 몰려오게 되는데 이는 세포내의 이온농도의 변화에 의한 것이며 이때 물, 스포츠 이온 음료 등을 섭취한다. 순간적으로 그 증상이 회복되지는 않지만 신경계 내에서 회복하는데 에는 많은 시간이 소요된다. 생리학, 임상적으로 나트륨과 물은 신진대사에 밀접한 연관이 있다. 인체의 나트륨은 음식물의 섭취량과 나트륨의 생리작용사이의 균형에 좌우된다. 건강한 상태에서 나트륨의 생리적인 손실은 무시할 만 하며 나트륨 생리작용은 음식물의 섭취량과 밀접한 관련이 있다. 칼륨은 단지 전체 신경계 용질의 일부이기 때문에 이것은 세포의 체적과 세포 용질의 삼투현상을 결정하는 주요한 것이다. 더욱더 칼륨은 신진대사 과정의 많은 중요한 변수가 되며, 세포밖의 칼륨은 전체중에 매우 작은 일부이긴 하지만 신경근육 작용에 매우 큰 영향을 준다. 세포안과 밖의 칼륨의 농도 비율은 흥분성 조직내의 막 전위의 주요한 결정요소가 된다. 본연구에서는 세포막 설계 후 시뮬레이션을 통한 정상상태의 세포막 전위의 활동전위 전달 특성과 Na, K의 이온 농도를 변화시킬 경우의 세포막 전위의 활동저위 전달 특성곡선을 비교 관찰하여 운동 생리학적인 신경세포내의 전달특성 메카니즘을 이해, 분석하였다.서의 속도를 최소한으로 줄이면서 스케줄링에 의해 시간 문제를 해결하는 방법을 제시하도록 한다. 이는 기초과학 수준이 높은 북방권 국가들의 과학자들이 주로 활용되고 있다는 점에서도 잘 알 수 있으며 우리의 과학기술 약점을 보완하는 원천으로써 외국인 연구 인력이 대안이 되고 있음을 시사한다. 본 연구에서는 한국 연구 조직에서 일하는 외국인 연구자들의 동기 및 성과에 영향을 미치는 많은 요인들을 확인할 수 있었다. 상관관계, 분산분석, 회귀분석 등을 통해 활용 성과에 미치는 영향 요인들을 도출하였다. 설문 분석을 통하여 동기 및 성과 사이에는 강한 상관관계가 존재하는 것을 확인할 수 있었으며 이는 전통적인 동기 이론들과 부합한다. 대부분의 변수가 동기 및 성과에 동시에 영향을 미치는 것으로 조사되었으며 그중에서도 조직 협력 문화, 외국인 연구자의 의사소통 및 협력성, 외국인 연구자의 연구 능력 관련 변수들 및 연구 프로젝트의 기술수명주기, 외국인 연구자의 기존 기술지식의 흡수 등이 가장 중요한 변수로 나타났다. 이는 우리가 주로 중국 및 러시아 과학자들을 활용하여 상업화하는 외국인 연구인력 활용 패턴과도 일치하는 결과이다. 즉 우호적인 조직문화를 가지고 있는 연구 조직에서, 이미 과학기술 지식을 많이 가지고 있고 연구 능력도 높은 외국인 과학기술자를, 한국에서 기술이 태동 또는 성장하고 있는 연구 분야에서 활용하는 것이 가장 성과가 좋다는 사실을 확인시켜 주고 있다. 국내에서 최초로 수행된 본 연구는 외국인 연구 인력의 활용 성과가 매우 높으며, 우리의 과학기술혁신시스템을 보완하는

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.16 no.2
• /
• pp.93-101
• /
• 2016

Purpose: McArdle disease, glycogen storage disease type V (GSD V), is one of the most common adolescent-onset glycogen storage diseases. It is caused by recessive mutations in PYGM encoding myophosphorylase, which is critical to glycogen metabolism. Since only a few korean patients have been reported, we will observe the clinical and genetic features of three korean patients with McArdle disease. Methods: We retrospectively reviewed the medical records of three patients with genetically confirmed McArdle disease, including the results of forearm ischemic exercise test, electromyogram, nerve conduction velocity, muscle biopsy, and PYGM analysis in peripheral leukocytes. Results: All three cases were males and their age of symptom onset was 12, 5, 14 years old, respectively. A high basal level of serum creatine kinase was noted in all three patients. They experienced the recurrent episodes of rhabdomyolysis, but second wind phenomenon was not definite. In muscle biopsy, subsarcolemmal space vacuoles including periodic acid schiff stained materials were found in two patients, while no evidence of glycogen storage disease was found in the other. A total of five different mutations, $p.Arg50^*$, p.Trp798Arg, $p.Arg50^*$, p.Glu779del, $p.Asp511Thrfs^*28$ and p.Phe710del, were found in three patients. Avoidance of isometric exercise, aerobic exercise and glucose intake before each exercise were recommended for all patients. Conclusion: The three Korean patients with McArdle disease showed the typical manifestations of the condition. The most mutations were private. Therefore, identification of more cases with long-term follow-up will be required to understand the clinical and genetic features of this disease among Korean population.

• Journal of Life Science
• /
• v.26 no.3
• /
• pp.309-317
• /
• 2016

Industrial advancements have resulted in food culture development, followed by increased seafood consumption and large-scale seafood farming, which has been accompanied by an increased prevalence of fish disease. The antibiotic oxytetracycline (OTC) is commonly used to prevent and treat bacterial diseases in fish. However, overuse of OTC had led to negative aspects. In view of this, we conducted a research with regard to aspects of remnants on olive flounder skin, liver, and muscle through dipping treatment and oral feeding of OTC and analyzed the results with bioassay and HPLC quantitative analyses. The dipping treatment was carried out once with 25 g/ton/hr of OTC, and the oral treatment with 62.5 mg/kg body weight/7 days. The results underwent a bioassay analysis. The dipping group reacted only on the skin right after dipping, while the oral feeding group responded on the skin for 77 days after feeding and on the muscle for 14 days. In the dipping group, the HPLC quantitative analysis revealed remnants in the skin on the 37th day and on the 13th day in the liver group. No remnants were found in the muscle, even immediately after dipping. In the oral feeding group, there was a high concentration (1.07 mg/kg) of remnant in the skin, even on the 77th day. 0.56 mg/kg in the liver, even a small amount, and no remnant in the muscle on the 42nd day. To sum up, the results suggest that it will not be harmful to our body to observe the OTC withdrawal period of 40 days with the muscle because OTC will hardly remain on it. When using olive flounder for sashimi, the skin and liver should not be used for broth, as the quantity of OTC residue is several times higher than that found in muscle. As previous studies reported that the concentration of remnants gradually decreased with heating, so it was likely to lessen, depending on the cooking temperature.

• Progress in Medical Physics
• /
• v.9 no.2
• /
• pp.115-121
• /
• 1998

In this paper, basic study of diagnostic device development for early detection of cancer, we present the optical property measurements of 12 histologically classified biological tissue and blood specimens in order to determine whether significant optical contrast exists for detection of disease(cancer). In vitro, optical properties of each 630nm, 660nm, 780n, 880nm and 940nm shows consistent changes in effective absorbtion coefficients, ${\mu}$$\_$${\alpha}$/ with tissue classification of pig an chicken and human blood according to the 27.3%, 35.4%, 45.6% and 59.1% of HCT. We found differences in optical properties at each of specific wavelengths and histologically classified biological tissue.

• Food Science and Preservation
• /
• v.16 no.6
• /
• pp.875-883
• /
• 2009

We investigated the effects of manufacturing method on the quality of beef jerky using electron micrography. Six types of beef jerky were prepared by the addition of sugar (A), licorice (B), one of three kinds of spice extract (clove: C, fennel fruit: D, and Chungyang green pepper extract: E), or a mixture of all spice extracts (F). Microstructural changes in beef jerky during preparation by drying, with respect to drying method and the nature of the added spice extract, were observed by scanning electron micrography (SEM) and transmission electron micrography (TEM). The latter technique showed that the microstructure of fresh meat showed actin and myosin in myofibril lines, and also mitochondria and inner membranes. Beef muscle structure was broken at many myofibril lines and decomposition of inner membrane material was evident after seasoning. SEM of air-blast dried beef jerky with added medicinal herb extracts showed both large spaces and regular myofibrils, whereas hot air-dried beef jerky had no spaces and the muscle myofibrils were still evident. After review of all available micrographs from SEM and TEM, we concluded that use of medicinal herb extracts could be helpful in preserving the muscle myofibril structure during drying, and the air-blast drying method is recommended to optimize the textural quality characteristics of beef jerky.

• Journal of Animal Science and Technology
• /
• v.49 no.3
• /
• pp.387-394
• /
• 2007

To investigate the effects of deboning time and muscle type of ham on quality characteristics of cooked press ham, a total of twelve pigs(barrow, 100±5kg) were slaughtered and split in half. The left side ham of carcasses was deboned immediately after slaughter whereas the right side ham was deboned after chilling for 24 hours at 4℃. Each of two muscles(SM; Semimembranosus, BF; Biceps femoris) was used to make a press ham. The pH of hot-boning muscles was significantly(p＜0.05) higher than that of cold- boning muscles, and the pH of SM samples was significantly(p＜0.05) higher than BF samples. Hot-boning muscles showed significantly(p<0.05) longer sarcomere length compared with cold-boning muscles. There was no significant difference in myoglobin(Mb) percentage between SM and BF muscles, but SM samples of hot-boning showed significantly(p<0.05) lower L* value compared to hot-boning BF samples. The lightness(L*) of hot-boning muscles was significantly(p<0.05) lower than that of cold-boning muscles. These results suggested that the dark color of hot-boning samples might be due to not only the high muscle pH but also the long sarcomere length without difference in Mb percentage. Hardness and gumminess of hot-boning press ham were significantly(p<0.05) lower than those of cold-boning samples. These results implied that color and pH of press ham did not affected by deboning time or muscle type of ham. However data suggested that texture and panel test of press ham might be improved by using hot-boned muscle due to long sarcomere length of raw meat.

• Journal of dental hygiene science
• /
• v.12 no.4
• /
• pp.437-442
• /
• 2012

The current research examines the aching part and the muscle activity that happens during scaling practice subject to 20 dental hygienic students and therefore propose a basic data according to the working attitude of the Dental Hygienist. During the scaling we used the free EMG (BTS Inc., Milan, Italy) to measure the muscle activity, and in order to check the musculoskeletal pain area we used the Nordic-style questionnaire, and the measured research results are as following: At the moment of scaling according to posture the occurrence of the pain showed no difference among the groups elbow, back, leg, knee, ankle/foot but in the neck, shoulder, wrist/hand, waist showed a high difference in the degree of pain according to posture. Results from measuring the muscular activity according to posture, in the group that had a good posture, the trapezius and brachial muscles showed a change according to time, and in the group that had a bad posture a high muscle activity was shown in larynx, trapezius and brachial muscles. In the muscle activity, the changing aspect between the two parts, the group that fulfilled a scaling in a good posture showed a low muscle activity, but in the group that fulfilled the scaling in a bad posture the muscle activity increased excessively. Therefore we examined that when fulfilling a scaling maintaining a bad posture can help in using more effectively the activity of the muscle, in the future I think there is a need to raise the office efficiency by subjecting to dental hyginiest that are in the clinics and performing experiments.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.13 no.9
• /
• pp.3991-3998
• /
• 2012

The aim of this study was to effect of muscle activity on muscle architectural of medial gastrocnemius in chronic stroke patient based on ankle joint degree. The subjects of this study were 10 chronic stroke patients modified Ashworth scale(MAS) 2. Ultrasonographic and dynamometer was measured during resting and maximum voluntary isometric contraction(MVIC) on muscle thickness, pennation angle, fascicle length, MVIC. Result from analysis showed that muscle thickness was thinner in the paretic side than in the non-paretic side(p<.001) and the more plantarflexion increased, the thinner muscle thickness became. And at the time of resting rather than of MVIC significant(p<.001). Result from analysis showed that penneation angle was smaller in the paretic side than in the non-paretic side(p<.001) and the more plantarflexion increased, the larger pennation became. And at the time of resting rather than of MVIC significant(p<.001). Result from analysis showed that fascicle was shorter in the paretic side than in the non-paretic side(p<.001) and the more plantarflexion increased, the shorter fascicle length became. And at the time of resting rather than of MVIC significant(p<.001). The results of this study showed that effect of muscle activity on muscle architectural of medial gastrocnemius in chronic stroke patient based on ankle joint degree. Therefore, Ultrasonographic evaluation of chronic stroke patients according ankle joint degree and muscle activity in the clinical diagnosis and therapy is considered a very useful data.

• Polymer(Korea)
• /
• v.30 no.1
• /
• pp.14-21
• /
• 2006

Tissue engineering techniques require the use of a porous biodegradable/bioresorbable scaffold, which server as a three-dimensional template for initial cell attachment and subsequent tissue formation in both in vitro and in vivo. Small intestinal submucosa (SIS) has been investigated as a source of collagenous tissue with the potential to be used as biomaterials because of its inherent strength and biocompatibility. SIS-loaded poly(L-lactide-co-glicolide)(PLGA) scaffolds were prepared by solvent casting/particle leaching. Characterizations of SIS/PLGA scaffold were carried out by SEM, mercury porosimeter, and so on. Muscle-derived stem cells can be differentiated in culture into osteoblasts, chondrocytes, and even myoblasts by the controlling the culture environment. Cellular viability and proliferation were assayed by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium-bromide(MTT) test. Osteogenic differential cells were analyzed by alkaline phosphatase(ALP) activity. SIS/PLGA scaffolds were implanted into the back of athymic nude mouse to observe the effect of SIS on the osteoinduction compared with controlled PLGA scaffolds. Thin sections were cut from paraffin embedded tissues and histological sections were conducted hematoxylin and eosin (H&E), Trichrome, and von Kossa. We observed that bone formatioin of SIS/PLGA hybrid scaffold as natural/synthetic scaffold was better thean that of only PLGA scaffold. It canb be explained that SIS contains various kinds of bioactive molecules for osteoinduction.

• Korean Journal of Poultry Science
• /
• v.31 no.3
• /
• pp.151-155
• /
• 2004

This experiment was conducted to investigate the influence of dietary supplementation of granite porphyry (GP) on growth performances and meat sensory quality in commercial broiler chicks. A total of four hundred-fifty 5-day-old male broiler chicks were divided into 15 pens and fed one of five experimental diets for 5 weeks; 0% GP with antibiotics (Control), 1% GP with or without antibiotics, and 2% GP with or without antibiotics. Final body weight and daily weight gain of all GP supplemented groups were slightly higher than those of control. Feed conversion rate was improved in GP 1 % supplemented groups, although there was no significant difference. Feeding antibiotics in addition to GP did not influence the growth parameters. Relative weights of liver and abdominal fat tended to be reduced in broiler chickens fed GP supplemented diets. Feeding of 2% GP diet resulted in a significant improvement in meat sensory quality in terms of taste and tenderness(P < 0.05), but the effect of the 1% GP on meat sensory quality was not significant. The results of this study indicate that GP could be used as a favorable feed additive for production of sensory-enhanced broiler meats.