• Journal of Yeungnam Medical Science
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• v.20 no.2
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• pp.160-168
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• 2003

Background: Confirm the stability of intervertebral disc sustaining each fused lumbar spine cases, comparing vertical compression, A-P shear force and rotational moment on intervertebral disc of instrumented lumbar spine with simple vertical compression load and follower load using finite element analysis. Materials and Methods: We analyze the stability of intervertebral disc L4-5 supporting fused lumbar spine segments. After performing finite element modelling about L1-L5 lumbar vertebral column and L1-L4 each fusion level pedicle screw system for fused lumbar spine fine element model. Intervertebral discs with complex structure and mechanical properties was modeled using spring element that compensate stiffness and tube-to-tube contact element was employed to give follower load. Performing geometrical non-linear analysis. Results: The differences of intervertebral disc L4-5 behavior under the follower compression load in comparision with vertical compression load are as follows. Conclusion: As a result of finite element interpretation of instrumented lumbar spine, the stability of L4-5 sustaining fused lumbar segment, the long level fused lumbar spine observed hing stability under follower load. This research method can be the basis tool of effects prediction for instrumentation, a invention of a more precious finite element interpretation model which consider the role of muscle around the spine is loaded.

• Journal of Biomedical Engineering Research
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• v.20 no.4
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• pp.461-469
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• 1999

In this paper, an ECG-NIBP patient monitor is designed. This is an essential equipment to measure and monitor patient's physical condition - electrocardiogram(ECG) wave, heart rate(HR), and noninvasive blood pressure(NIBP) - in ICU, CCU, and operating room. The ECG is an electrical waveform produced by relaxation and contraction of the cardiac muscle. Most physicians diagnose patient's cardiac states from ECG pattern. A blood pressure is one of the clinical indexes measured in a emergency room or operating room. In this paper, the blood pressure is measured in artery by using the nonivasive oscillometric method. The developed patient monitor was inspected and compared with other instruments in operating rooms. The results were 1bpm of maximum difference in the heart rate, 15mmHg in the systolic pressure, 16mmHg in the diastolic pressure, and 25mmHg in the mean blood pressure. But the total results were 0.15bpm of the mean difference in the heart rate, 5mmHg in the systolic pressure, 10mmHg in the diastolic pressure, and 9mmHg in the mean blood pressure. The designed ECG-NIBP patient monitor can measure the ECG wave, HR, and BP. And the multi-tasking module of pulse oximetry . respiration . temperature monitor will be added in the near future.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.9
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• pp.2105-2112
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• 2010

The noise component of electrocardiogram is not distributed in a certain frequency band. It is expressed in various types of signals by rater's physical and environmental conditions. Particularly, since the baseline wander is occurred by the mixture of the original signal and 0 ~ 2 [Hz] range of the frequency components according to muscle constraction of part attaching to an electrode and respiration rythm, it makes the ECG signal analysis difficult. Several methods have been proposed to eliminate the wandering effectually. However, they have some problems. In some methods, the high processing time is required due to the computational complexity, while in other cases ECG signal morphology can be distorted. This paper suggests a simple and effective algorithm that eliminates baseline wander with low computational complexity and without distorting signal morphology. First, the algorithm detects and segments a baseline wandering interval using slope analysis and curve point detection, second, approximates the wandering in the interval as a sinusoid, and then subtracts the sinusoid from signal. Finally, ecg signals without baseline wander are obtained. In order to evaluate the performance of the algorithm, several ECG signals with baseline wandering in MIT/BIH ECG database 101, 111, 113, 234 record were chosen and applied to the algorithm. It is found that the algorithm removes baseline wanders effectively without significant morphological distortion.

• Korean Journal of Applied Biomechanics
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• v.16 no.3
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• pp.19-31
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• 2006

이 연구의 목적은 각 분절의 마커세트와 무릎관절 중심 정의가 3차원 무릎 관절각을 산출하는데 얼마나 민감하게 영향을 미치는지를 연구하였다. 자료수집은 1명을 실험대상자로 하여 두 가지 형태의 각기 다른 분절의 정의와 무릎관절의 중심을 나타내는 반사마커들을 동시에 오른쪽 하지에 부착시켜 실험을 실시하였다. 실험대상자의 달리기동작 중 좌측으로 45도 방향전환동작의 지지기를 분석하였다. 이를 위해서 8대의 고속카메라들을 이용하였고 달리기속도는 4m/$sec{\pm}(10%)$로 통제하였다. 하지분절의 발분절에는 하나의 마커세트를, 정강이와 대퇴분절에는 두 가지의 다른 마커세트들을 부착시켰다. 발분절에는 3개의 마커를 신발의 뒷부분에 부착하였고 정강이분절을 정의하기 위하여 첫 번째 마커세트는 경골을 중심으로 3개의 마커들을 두 번째 마커세트는 비골을 중심으로 3개의 마커를 부착하였다. 대퇴분절의 마커세트를 정의하기 위하여 첫 번째 마커세트에는 대퇴골을 중심으로 3개의 마커를 두 번째 마커세트에는 대퇴근육을 중심으로 3개의 마커들을 부착하였다. 무릎관절중심을 정의하는데 두 가지 다른 정의가 적용되었다. 첫 번째 무릎중심을 무릎의 내측과 외측의 마커들을 통해 두 마커의 중심을 무릎관절의 중심으로 정의하였다. 두 번째 무릎중심정의는 무릎의 외측부분과 슬개골의 중심에 부착된 마커들로부터의 교차점을 무릎관절중심으로 산출하였다. 무릎관절의 각도를 산출하기 위해서 JCS(Joint Coordinate System)의 정의가 적용되었고 연구의 결과는 다음과 같았다. 두 가지의 다른 분절마커세트 사이에서 무릎의 신전(extension)과 굴곡(flexion)은 유사한 형태를 나타냈으며 최대 무릎굴곡(peak knee flexion)각에서 $4.746^{\circ}$의 차이를 나타냈다. 다른 분절마커세트 사이의 회전(rotation)각과 내전(adduction)/외전(abduction)에서는 서로 다른 형태를 나타내었고, 두 마커세트간 최대무릎외측회전(peak knee external rotation)각도에서는 $15.628^{\circ}$의 차이를 나타냈다. 또한, 각 분절마커세트 내에서 두 가지의 다른 무릎관절 중심의 정의가 얼마나 무릎도 산출에 영향을 미치는지를 비교했을 때 무릎의 최대외측회전(peak external rotation)각에서 차이를 나타내었다. 첫 번째 분절마커세트의 무릎관절중심정의의 형태변화에 따라 최대외측회전각은 $0.549^{\circ}$의 차이를 나타냈고, 두 번째 분절마커 세트에서 무릎관절중심정의의 형태변화에 따라 최대외측회전각은 $0.309^{\circ}$의 차이를 나타냈다. 이와 같이 분절을 나타내는 마커세트와 무릎관절중심정의의 형태변화에 따라 무릎간을 계산하는데 있어서 결과가 다르게 산출되었다. 즉, 관절각의 계산이 분절에 부착되는 마커의 정의 혹은 위치에 매우 민감하게 영향을 받았다. 따라서 연구자가 여러 실험대상자들을 대상으로 실험시 마커세트 혹은 마커들을 동일한 위치에 가깝게 부착하는 것이 마커부착으로부터 발생하는 실험오차를 줄일 수 있을 것이다.

• Journal of fish pathology
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• v.24 no.2
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• pp.161-166
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• 2011

The metacercariae of Clinostomum complanatum (Rudolphi, 1814) were isolated in the whole body muscle of wild freshwater fish, spotted barbel gudgeon (Squalidus multimaculatus Rosoya et Jeon) from the local river in Yeongdeok, Gyeongsangbuk-do, Korea. The infected fish with bumpy body surface by "yellow grub" showed erratic swimming behavior and some fish were died. The isolated excysted metacercariae were tongue shaped and 2.85~5.89 mm ${\times}$ 0.8~1.99 mm in size. 1~98 metacercariae were isolated in individual fish and mean infection intensity was 25. All examined adult spotted barbel gudgeon sizing 7 cm in body length were infected. This is the first report of disease outbreak and mortality caused by C. complanatum infection in wild freshwater fish in Korea.

• Journal of Gastric Cancer
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• v.4 no.4
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• pp.282-285
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• 2004

We report a case of advanced gastric cancer with Virchow's node and lung metastasis that responded remarkably to preoperative chemotherapy. A 47-year-old female patient was diagnosed as having incurable advanced gastric cancer with Virchow's node and multiple lung metastasis. Preoperative chemotherapy with Taxotere, CDDP and 5FU was carried out. After four courses of the regimen, the Virchow's node and the lung metastasis had disappeared, and a marked reduction of the gastric lesion was observed on the CT scan. Consequently, the patient underwent a total gastrectomy with D2 lymph node dissection. On histopathological examination, cancer cells were found to have infiltrated up to the muscle layer of the gastric wall, and 42 out of 60 resected lymph nodes were found to be metastatic. The patient received another two courses of chemotherapy after the operation. (J Korean Gastric Cancer Assoc 2004;4:282-285)

• Tuberculosis and Respiratory Diseases
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• v.57 no.3
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• pp.278-283
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• 2004

The incidence of a pulmonary leiomyosarcoma as a primary lung tumor is quite rare. We report a case of primary leiomyosarcoma with a cardiac invasion in a 76 year old man. He was admitted due to left anterior chest wall pain for one month. Chest computed tomography showed a $9{\times}8{\times}10cm$ sized, large round mass in the left upper and lower lobes, and an amorphous low density lesion within the left atrium. Chest magnetic resonance imaging showed a large round mass in the left upper and lower lobes with growth into the left atrium. A diagnosis of leiomyosarcoma with prominent osteoclast-like giant cells was made based on the microscopic and immunohistochemical findings of a permanent specimen by explothoracotomy. The pathologic features of the tumor showed round mononuclear hyperchromatic cells and multinucleated giant cells that resembled osteoclasts. The immunohistochemical staining showed that the giant cells are positive for CD68 but negative for the muscle markers while the round cells were positive for the muscle marker. The patient refused further treatment and died after two months.

• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.1028-1032
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• 2002

Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical lymphoid cells infiltrating between adipocytes. The optimal treatment for this disease is undefined and prognosis of this disease is poor, even when treated with multiagent chemotherapy regimens considered optimal for agressive lymphoma of other types. Poor prognosis factors include clinical features such as anemia, leukocytopenia, hepatosplenomegaly, lymphadenopathy and coagulopathy, which are suggestive of hemophagocytosis. Much of the mortality of this disease is due not to disseminated lymphoma with organ failure, but rather to complications of the cytopenias associated with the hemophagocytic syndrome. We report a case of subcutaneous panniculitis-like T cell lymphoma in a 12 year-old boy who presented with initial complaints of fever and multiple subcutaneous nodules, and briefly review the related literature.

• Journal of Life Science
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• v.19 no.10
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• pp.1484-1488
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• 2009

Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant muscle disorder characterized by episodic attacks of muscle weakness with concomitant hypokalemia. Mutations in either a calcium channel gene (CACNA1S) or a sodium channel gene (SCN4A) have been shown to be responsible for this disease. The combination of sarcolemmal depolarization and hypokalemia has been attributed to abnormalities of the potassium conductance governing the resting membrane potential. To understand the pathophysiology of this disorder, we examined both mRNA and protein levels of delayed rectifier potassium channel genes, KCNQ3 and KCNQ5, in skeletal muscle fibers biopsied from patients with HOKOur results showed an increase in the cytoplasmic level of KCNQ3 protein in patients' cells exposed to 50 mM external concentration of potassium. However, mRNA levels of both channel genes did not show significant change in the same condition. Our results suggest that long term exposure of skeletal muscle cells in HOKPP patients to high extracellular potassium alters the KCNQ3 localization, which could possibly hinder the normal function of this channel protein. These findings may provide an important clue to understanding the molecular mechanism of familial hypokalemic periodic paralysis.

• Journal of Life Science
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• v.19 no.10
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• pp.1410-1416
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• 2009

The present study aims to examine the effect of turbid water on fishes in streams which branch into a turbid water area (Yeongyang-gun) and a non-turbid water area (Cheongsong-gun), and finally flow into the Imha reservoir. In a comparison of water quality, the chemical status of the water showed higher pH, DO and SS in the turbid water area than in the non-turbid water area. Also, high density of clay minerals such as vermiculite (V) and illite (I), which is from clay mineral leakage during rainfall, was detected in turbid water, resulting in an increase of turbidity. Fishes inhabiting the turbid water showed irregular spaces in gill lamella, cell separation, edema, and clubbing in epithelial tissues. Also, the gill surface showed roughness and plenty of muddy debris substances inside the gills. The Bowman's space was expanded because of contraction of the glomerulus in the Bowman's space of the kidney tissues. Antioxidant enzymes such as SOD, CAT, GPX, and GST showed higher activities in the specific tissues, muscles and kidney, of fishes living in turbid water than in the non-turbid area. We suggested that; first, the antioxidant activities were increased due to removal of harmful radicals generated in fish bodies in the turbid water area, second, long-time exposure of these histological changes in the tissues might have induced secondary lesion accompanying the inaccurate physiological constancy of fishes.