• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1573-1576
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• 2003

The quality of bundles is closely related with the apparent thickness. Especially the variation of apparent thickness of bundle determines the qualify of the plane structure made or the bundle such as surface evenness, pore size, and the shape of air-gap, etc.,. This study is dealing with the development of a new measuring system of the thickness of bundle or cross-section by determining the size of the shadow of the object covered by a laser slit beam. Also the measured signal is characterized in terms of the correlogram, the irregularity in wavelength. The correlogram for the irregularity of several sample types could be represented by a sinusoidal function with exponentially decaying amplitude. Moreover, influence of the measuring speed on the signal and the characteristic differences according to the different types of bundle are investigated.

• YAKHAK HOEJI
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• v.41 no.2
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• pp.187-194
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• 1997

For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hete ro cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50${\mu}g$/ml). On the other hand, the other compounds had no activity.

• Tuberculosis and Respiratory Diseases
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• v.65 no.5
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• pp.400-404
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• 2008

Aspergillus tracheobronchitis (ATB), a variant of invasive pulmonary aspergillosis, is characterized by extensive tracheobronchitis and pseudomembrane formation. ATB usually occurs in immunocompromised patients with a high fatality rate. We report a case of ATB in a previously healthy patient who responded well to antifungal therapy.

• The Korean Journal of Mycology
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• v.26 no.4 s.87
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• pp.525-530
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• 1998

Antifungal activities of cinnamaldehyde derivatives against various fungi were investigated using paper disc diffusion method. Among the derivatives tested, ${\alpha}-chlorocinnamaldehyde$ was stronger than cinnamaldehyde in antifungal activity and was effective in inhibiting the growth of the representative fungi of dermatomycosis with minimum inhibitory concentration of $9.76{\sim}19.5\;{\mu}g/ml$. A comparison of antifungal activity of cinnamaldehyde derivatives revealed that antifungal action of cinnamaldehyde might be related to a basic structure of acrolein.

• The Journal of the Korean Society for Microbiology
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• v.21 no.1
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• pp.63-71
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• 1986

The antifungal activities of amphotericin B, 5-fluorocytosine, and ketoconazole in combination of amphotericin B/ketoconazole and 5-fluorocytosine/ketoconazole were determined against 42 strains of Candida spp. isolated from oral cavity. Among 42 strains of Candida species, 36 strains of Candida albicans, 2 strains of Candida parapsilosis and Candida tropicalis 1 strain of Candida krusei and Candida stellatoidea were identified. The minimum inhibitory concentrations(MICs) of amphotericin B, 5-fluorocytosine and ketoconazole for these strains were ranged from 0.05-1.56 mcg/ml, 12.5->100.0 mcg/ml and 0.2-50.0 mcg/ml. In all of the experimental strains, amphotericin B had the greatest antifungal activity on a dilution basis. When a microtiter checkerboard technique was used 5-fluorocytosine acted synergistically with ketoconazole against all strains, whereas amphotericin B has a reduced effect. The killing curve experiments with on strain of Candida albicans WMC-85024 demonstrated that the combination of amphotericin B/ketoconazole and 5-fluorocytosine/ketoconazole produced a decrease in number of colony forming unit of >3 logs in 72 hours.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.163-163
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• 1993

대상환자는 모두 23명이였으여, 이중 12명은 fluconazole을, 11명은 nystatin을 투여받았다. 두 군사이에 연령, 남여비, 기저질환, 진균감염의 위험요소는 차이가 없었다. 투약기간은 fluconazole군(F)이 24일, nystatin군(N)이 23일이였다. 중도탈락은 3례로 F중 MRSA ？혈증 1례, N중 오심, 구토 1례외 Stevens-Johnson증후군 1례였다. 평가가능한 20례중, F 11례중 8례와, N 9례중 4례에서 진균감염중의 예방에 성공하였고, F 3례와 N 5례는 실패하였다. 실패한 F 3례는 코의 피부조직에서 aspergillus가 중명된 1례와 경험적으로 amphotericin을 투여한 2례였고, N 5례는 혈액배양에서 Candida tropicalis가 분리된 1례와 경험적 amphotericin을 받은 4례였다. 진균의 colonization은 F중 3균주는 치료중 소실되었으나, 2례는 증가하였다. N은 1균주가 소실된 반면, 3례는 증가하였다. Colonization이 증가한 F 2례는 C. albicans와 Trichosporon beigelli가 대변에서 분리된 경우이고. M 3례는 대변에서 C. albicans가 분리된 1례, 구강에서 aspergillus가 분리된 1례, 혈액배양에서 C. tropicalis가 분해된 1례였다. 부작용은 오심 구토가 F중 1례, N중 2례 였으며, 이중 N의 1례는 증상이 심하여 투약을 중지하였다. 간기능 검사상 SGOT/SGPT의 상승은 F 12중 3례, N 11중 2례에서 관찰되었으나, 두 군사이에 통계학적으로 유의한 차이는 없었다.

• Journal of Life Science
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• v.8 no.2
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• pp.173-180
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• 1998

As a part of the investigation on useful compounds from microalgae, and its recently that marine planktonic algae have been recognized as potial sources of antibacterial and antifungal substances, we searched for antimicrobial active compounds from the extracts of six microalgae-Lyngbya sp., Tetraselmis sp., Microcystis sp., Chlorella sp., Navicula sp. and Rhalassiosira sp.-treated with several solvents. There were two active species-Lyngbya ap., Teraselmis sp.- in the antimicrobial activity test to bacteria, yeast and molds, especially the activity existed in the extracts by ethyl acetate of supernatants to the microalgae incubatio. and there won’t any activity in two diatoms to the test microorganism.

• Journal of Veterinary Clinics
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• v.19 no.4
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• pp.426-428
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• 2002

A seven-year old mare had endometritis after history of abortion and repeated intra-uterine infusion of antibiotics. She showed hyperemia and oedema of the cervical mucosa with grayish white purulent discharge. Candida albicans was determined to be the causative agent of the endometritis. The diagnosis was established by the direct demonstration of the pathogen in the uterine exudate and its isolation in pure, heavy and luxuriant growth. In vitro disc diffusion test showed the organism was sensitive to all the four antifungal drugs tested, which are amphotericin B, clotrimazole, fluconazole and nystatin. The intrauterine nystatin infusion was found very effective as C. albicans could not be recovered 7 days after the last treatment.

• Journal of Environmental Health Sciences
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• v.19 no.1
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• pp.71-76
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• 1993

Nasal carrige of Staphylococcus was studied in relation to its significance as a source of the Staphylococci that caused hospital-acquired infection. Due to the trend of the increasing r esistance of S. aureus to many antimicrobial agents, it is necessary to study the sensitivity to antibiotics of this infectious microorganisms. 50 persons from general hospital and 50 college students were the object of this study. The following results were obtained 3 0 Strains of S. aureus were isolated. The rate of S. aureus nasal carrying were 26% in college students and 34% in hospital personnel. S. aureus which showed resistance to penicillin were 90%, tetracyclin 43%, erythromycin 37% and oxacillin 17%. The number of penicillin resistance of S. aureus were 11 (84%) in college students and 16 (94%) in hospital personnel. The number of strains of penicillin resistant S. aureus which produced 13-1actamase were 9 (82%) in college student and 14 (88%) in hospital personnel. Methicillin-resistant S. aureus (MRSA) which showed resistance to erythromycin and penicillin G were 100%, tetracyline, cephalothin and clindamycin were over 40% respectively, gentamicin 20%, SAM 20% and chloramphenicol 0%.

• Microbiology and Biotechnology Letters
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• v.13 no.3
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• pp.203-207
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• 1985

Bifidobacteria are normal inhabitants of the intestinal tract of humans. Using Bif. longum isolated from feces of Korean adult and Bifidus preparation, we observed the growth inhibitory actions of these organisms toward E. coli $A_2$ causing bacterial diarrhea. Bif. longum SKD-2001 SKD-2004 inhibited the growth of E. coli $A_2$ drastically. It is supposed that the mechanism of the growth inhibitory actions is due to acid conditions created by Bif. longum.