• Archives of Reconstructive Microsurgery
• /
• 제15권2호
• /
• pp.107-110
• /
• 2006

Malignancy in a chronic pressure sore is rare among Marjolin's ulcers. Carcinomas arising in pressure sores are highly aggressive and usually fatal. Although carcinomas in pressure sores are generally well-differentiated squamous carcinomas, they can show quite an aggressive course and do not respond either to chemotherapy or radiotherapy. The mortality rate is high despite wide surgical resection. Extensive surgical excisions with wide surgical margins are necessary and elective lymph node dissection should be considered for optimal therapy. We report a squamous carcinoma arising in a pressure sore. The related literature was reviewed.

• 대한한방내과학회지
• /
• 제26권3호
• /
• pp.685-691
• /
• 2005

A 33 year-old male who had been diagnosed with severe ulcerative and ankylosing spondylitis was treated and observed. Even though he had been treated with western medicine, he still complained of severe diarrhia, hemafecia, abdominal pain, general weakness, mild fever($37.8^{\circ}C$) and lower back pain. On radiologic examination, the lumbar view revealed the sacroliac joint space are irregular with adjacent bony sclerosis on both sides. He was treated with Chengsim Yeunja-Tang. Having been treated for 99 days, severity of ulcerative colitis changed from severe to mild ade, lower back pain reduced from nine to three, and all other symptoms improved.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1997년도 춘계학술대회
• /
• pp.96-96
• /
• 1997

YJA 20379-1(YJA-1)은 영진약품(주)에서 합성한 Thiazole유도체로서 급만성 위궤양 및 십이지장 궤양에 유효한 proton pump 억제 작용물질이다. 이 실험은 신약개발을 지향한 한 단계로서 YJA-1의 일반약리작용에 관한 것이다. 실험은 YJA-1에 대하여 중추신경계작용, 진통작용, 정상체온에 대한 작용, 항경련작용 및 장수송능시험을 실시하였고, 용량은 50, 100 및 200$\mu\textrm{g}$/$m\ell$를 경구투여하였고, 혈압 및 호흡에의 작용은 토끼에 10, 20 및 40mg/kg을 정맥주사하여 실시하였으며, 적출장기 실험에서는 100 및 200$\mu\textrm{g}$/$m\ell$를 적용시켰다.

• Pediatric Infection and Vaccine
• /
• 제10권1호
• /
• pp.127-131
• /
• 2003

Hyperimmunoglobulin E syndrome(HIES) is a primary immunodeficiency characterized by severe recurrent soft-tissue infections, pneumonias, pruritic dermatitis and markedly elevated serum IgE levels. Pneumatocele and empyema develop as result of recurrent pneumonias. It is inherited in an autosomal dominant fashion, with variable expressivity. We experienced the case of a 10 month old girl with hyper IgE syndrome. Patient was admitted for local ulceration and muscle soreness at the site of BCG inoculation. The diagnosis of hyper IgE syndrome was made because she had a coarse facial appearance, pruritic dermatitis, pneumatocele and markedly elevated serum IgE level with a past history of frequent skin abscess and pneumonia.

• Journal of Pharmaceutical Investigation
• /
• 제14권3호
• /
• pp.131-135
• /
• 1984

염산디싸이클로민은 항(抗)콜린성(性) 약물로 소화성궤양(消化性潰瘍) 치료제로서 제산제(制酸劑)와 함께 널리 사용되고 있다. 전보(前報) 에서 이 약물의 수용액(水溶液)에서의 가수분해반응기구연구(加水分解反應機構硏究)를 통하여 반응차수(反應次數) 및 속도(速度) 등을 보고(報告)한 바 있으며 본(本) 연구(硏究)에서는 수용액(水溶液)에서의 가수분해(加水分解)에 미치는 pH의 영향을 검토하였고 또한 제산제성분(制酸劑成分)인 magnesium ion이 가수분해(加水分解)에 미치는 영향 등을 검토하였다.

• 한국병원경영학회지
• /
• 제5권1호
• /
• pp.24-39
• /
• 2000

This paper aims to analyze the effects that marketing mix variables have on the marketing performance of pharmaceutical manufacturers. It examines how product characteristics, price, marketing channel and promotion effort influence the sales and market share of anti-ulcer drugs in the markets for clinics and hospitals separately. Empirical results from 29 products of anti-ulcer drugs show that sales in hospitals are affected by the profit per prescription to the physician, brand name drugs relative to generics, and the age of ingredients since its introduction to the markets. Profit per prescription to the hospital, relative price, age of ingredients and promotion effort have positive effects on the market share.

• Advances in pediatric surgery
• /
• 제5권2호
• /
• pp.141-145
• /
• 1999

Idiopathic small bowel ulceration distal to the duodenum is rare. Less than 5 % of the reported cases were in children. In the majority of the patients, a single ulcer of unknown cause is found in the jejunum or ileum. The diagnosis is difficult and usually made at the time of surgical exploration for complications, such as perforation, hemorrhage or obstruction. We treated a pediatric patient with perforation of an idiopathic ileal ulceration. The child was an 11-year-old boy who sustained blunt abdominal trauma. The involved ileal segment was resected. Pathologic findings were compatible with idiopathic small bowel ulceration. The clinical and pathological aspects of idiopathic ulcerations are discussed, and the literature reviewed.

• 대한치과의사협회지
• /
• 제50권12호
• /
• pp.727-731
• /
• 2012

An ulcer is defined as loss of epithelium. Although many oral ulcers have similar clinical appearances, their etiologies encompass many disorders, including trauma, infection, immunologic disease, and malignant oral cancer. Oral squamous cell carcinoma(SCC) occupying about 90% of oral cancer, usually manifests as unhealed ulcer over 2 weeks. Oral SCC can metastasize to the cervical neck lymph node, and therefore the surgical therapeutic modality for oral SCC could encompass the neck node dissection as well as wide excision for primary lesions, which should leave the post-operative complication of functional damage like dysphagia and facial deformity. Therefore, it is important to discriminate oral SCC from other ulcerative conditions to make a prompt management. The knowledge for the pathogenesis of the ulcerative lesions could help the clinicians to understand the differences of clinical features and to practice an appropriate therapeutics.

• 대한기관식도과학회:학술대회논문집
• /
• 대한기관식도과학회 1982년도 제16차 학술대회연제순서 및 초록
• /
• pp.7.3-7
• /
• 1982

기관지내의 삽관은 전신마취나 인위적인 기도확보를 위해 흔히 시행되며, 그것의 유용성은 재론의 여지가 없다. 그러나 기관내 삽관후에 후두종창 궤양 그리고 육아종이 합병증으로 가끔 생기며 또한 성대마비도 드물게 온다. 최근에 저자들은 충수절제술을 위한 기관삽관마취후에 애성을 동반한 좌측 성대마비를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한두경부종양학회지
• /
• 제23권2호
• /
• pp.199-201
• /
• 2007

피지선종(sebaceous adenoma)은 피지선 분화를 보이는 신생물 중 가장 흔한 종양으로 피지선이 정상적으로 많이 분포하는 안면부, 두피부, 안검부 등에 주로 발생하나 안검에서는 비교적 드물게 발생한다. 피지선종은 피부부속기 종양 중 발생빈도가 아주 낮으며 안면부 중에도 피지선이 많이 분포하는 비부와 협부에 주로 발생하며 종괴 형성으로 인한 이물감이나 소양감, 출혈, 궤양형성등의 증상을 동반한다. Shields 등의 보고에 의하면 내안누구에 발생한 신생물 57예중에서 피지선종은 2예만이 존재할 정도로 극히 드물다고 하였다. Font와 Rishi도 피지선종의 안검 발생에 대하여 상안검과 하안검은 각각 같은 빈도로 발생한다고 하였으며 내안각 피지선종은 단 1예만을 보고하였다. 이에 저자들은 내안누구의 피지선에서 발생한 피지선종을 경험하고 문헌고찰과 함께 그 1예를 보고하고자 한다.