• Title/Summary/Keyword: 구강암

Search Result 306, Processing Time 0.029 seconds

Autophagy and Oral Cancer (자가포식작용과 구강암)

  • Son, Seung Hwa;Kim, Eun-Jung
    • Journal of Life Science
    • /
    • v.27 no.8
    • /
    • pp.958-964
    • /
    • 2017

  • Autophagy plays an important role in cellular homeostasis and survival for cell recycling and various stresses within the cell. Recent studies have shown that autophagy activity modulates the expression of oncogene and tumor suppressor genes, leading to the development or suppression of cancer. Induction of autophagy is involved in preventing cancer development in normal cells and plays an important role in prompting a specific cell death mechanism in cancer cells with damaged cell death function. It is also known that autophagy inhibition increases the therapeutic efficacy by sensitizing cancer cells that are resistant to chemotherapy. However, the role of autophagy has not yet been fully understood in cancer treatment. Oral squamous cell carcinoma accounts for more than 90% of oral cancer and is the sixth most common cancer in the world. The incidence of oral cancer has increased by 50% over the last 20 years and the mortality rate is over 40% within 5 years after the onset. In oral cancers, the role of autophagy are described to look for tumor inhibitory in the early stages of tumor formation, like other cancers, indicating the dual functions involved in tumor cell survival include tumor progression stages. This review summarizes the various roles of autophagy in cancer cells and suggests the possibility of autophagy as a promising target for effective oral cancer therapy.

  • https://doi.org/10.5352/JLS.2017.27.8.958 인용 PDF KSCI

Radiation prosthetic stents applied to oral cancer patients during the radiation therapy: case reports (효율적 방사선요법을 위한 구강 방사선스텐트의 적용: 증례보고)

  • Nam, Ki Young
    • Journal of Dental Rehabilitation and Applied Science
    • /
    • v.36 no.4
    • /
    • pp.282-288
    • /
    • 2020

  • Radiation prosthetic stent is defined as the customized oral devices which serve for an efficient administration of radiation dose to the affected areas or a minimizing the unnecessary irradiation to surrounding normal tissues during maxillofacial cancer radiotherapy. Since the use of stents is individualized, a close collaboration among radiotherapist, surgeon and prosthodontist is essential thereby which helps in limiting the post-therapy morbidity as well as the stable oral rehabilitation. In this report, two customized stents (bolus carrier and tongue depressing) were fabricated and applied to patient undergone irradiation for soft palate and tongue carcinoma selectively. Multidisciplinary approach can be a proper strategy and recommended for control the sequel of post-irradiation.

  • https://doi.org/10.14368/jdras.2020.36.4.282 인용 PDF KSCI