• Title/Summary/Keyword: 교차설계

Search Result 522, Processing Time 0.029 seconds

Individual Bioequivalence Tests under 3 X 2 Design (3 X 2 교차설계법에서 개인 생물학적 동등성 검정)

  • Jung, Gyu-Jin;Lim, Nam-Kyoo;Park, Sang-Gue
    • The Korean Journal of Applied Statistics
    • /
    • v.23 no.1
    • /
    • pp.139-150
    • /
    • 2010
  • In recent years, more generic drug products became available. The current regulation for assessing the bioequivalence of two drug formulations is based on the concept of average bioequivalence. This approach has been indicated to be insufficient for assessing switchability between two drug formulations and US FDA has adopted individual bioequivalence as one of the bioequivalence criterion since 2001. The US FDA recommends that individual bioequivalence be assessed based on $2\;{\times}\;4$ crossover design, while a $2\;{\times}\;3$ crossover design may be used as an alternative design to reduce the length and cost of the study. In this paper, a statistical procedure for assessment of individual bioequivalence under $3\;{\times}\;2$ crossover designs is proposed and some statistical points are discussed with $2\;{\times}\;3$ crossover design and $2\;{\times}\;3$ extra-reference design through simulation studies.

A Study on the Prior Forecast System of Crossroads Traffic Information based on Vehicle-IT for Decision Assistant (차량 IT 기반 의사결정 지원을 위한 교차로 신호 사전예보 시스템에 관한 연구)

  • Lee, Yang Sun
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.19 no.9
    • /
    • pp.2107-2113
    • /
    • 2015
  • This paper proposed a Prior Forecast System of Crossroad Traffic Information that allows vulnerable road users to perceive traffic signal changes beforehand and respond in concentrated traffic areas such as crossroads. Also, it mapped out information linking procedures of the proposed system and it designed a PHY based wireless communication simulator to verify the operational feasibility of wireless communications. Conclusively, by conducting performance analysis according to crossroad channel environments using the simulator designed in this paper, it verified that a Prior Forecast System of Crossroads Traffic Information service for vehicle IT based decision-making support for vulnerable road users is a possibility.

A Comparative Study on Four-Legged Roundabout and Five-Legged Roundabout (4지 회전교차로와 5지 회전교차로의 비교 분석)

  • Kim, Dong Nyong;Choi, Dae Kyu;Park, Soon Yong
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.31 no.2D
    • /
    • pp.209-215
    • /
    • 2011
  • Roundabout has circular traffic island in the intersection center and is kind of intersection where the automobile bypass circular traffic island. In Korea, the provisional Roundabouts Design Guidelines were published in 2004 by MLTM (Ministry of Land, Transport and Maritime Affairs). This guideline did not discussed domestic traffic circumstance. It just only introduced foreign instances and their guidelines. In addition, the recent National Competitiveness roundabouts as part of the green growth has been concentrated on the interest. In this paper, 90 degree of the 4-legged roundabout was compared with 72 degree, 45 degree, and 30 degree 5-legged roundabouts by micro simulation VISSIM. As a result of analysis, average travel time is decreased when the inscribed circle diameter become bigger the roundabout. 5-legged roundabout until 2,000 volume per hour evaluated to be similar effect at 90 degree of 4-legged roundabout.

A Study of Interactions Between Perpendicularly Spaced Tunnels (상하교차터널의 상호거동에 대한 연구)

  • Kim, Sang-Hwan;Lee, Hyung-Joo
    • Journal of the Korean Geotechnical Society
    • /
    • v.19 no.5
    • /
    • pp.273-280
    • /
    • 2003
  • This paper describes a study of the effect of shield tunnel construction on the liners of nearby existing perpendicular tunnels. The research programme investigated the influence of tunnel proximity and alignment, liner stiffness on the nature of the interactions between closely spaced tunnels in clay. A total of two sets of carefully controlled 1g physical model tests, including the same test for repeatability, were performed. A cylindrical test tank was developed and used to produce clay samples of Speswhite kaolin. In each of the tests, three model tunnels were installed in order to conduct two interaction experiments in one clay sample. The tunnel liners were installed using a model tunnelling machine that was designed and developed to simulate the construction of a full scale shield tunnel. The first tunnel liner was instrumented to investigate its behaviour due to the installation of each of the new tunnels. The interaction mechanisms observed from the physical model tests are discussed and interpreted.

A PLC Program for seosor based intersection to reduce trafic congestion (교통혼잡도 해소를 위한 센서기반 교차로 PLC 프로그램)

  • Hur, Joonkyoo;Kim, Woo Je;Kim, Jahee;Lee, Younho
    • Proceedings of the Korean Society of Computer Information Conference
    • /
    • 2015.07a
    • /
    • pp.161-163
    • /
    • 2015
  • 본 논문은 교통 혼잡도가 높은 월계 2교 4거리 교차로에 센서를 이용하기 위한 교차로 PLC 프로그램을 개발하는 것을 목적으로 한다. 이를 위해 교차로에서 발생하는 차량사고와 혼잡을 방지하지 위한 소프트웨어 요구사항 명세서(SRS)를 정의하고, 이를 바탕으로 소프트웨어 설계서를 작성한다. 또한 XP-Builder 시뮬레이터를 사용하여 센서기반 교차로 신호등 PLC 프로그램을 구현한다.

  • PDF

A Comparative Study on Optimization Procedures to Robust Design (로버스트설계에서 최적화방안에 대한 비교 연구)

  • Kwon, Yong-Man;Mun, In-Suk
    • Journal of the Korean Data and Information Science Society
    • /
    • v.11 no.1
    • /
    • pp.65-72
    • /
    • 2000
  • Robust design is an approach to reducing performance variation of quality characteristic values in quality engineering. Taguchi parameter design has a great deal of advantages but it also has some disadvantages. The various research efforts aimed at developing alternative methods. In the Taguchi parameter design, the product-array approach using orthogonal arrays is mainly used. However, it often requires an excessive number of experiments. An alternative approach, which is called the combined-array approach, was suggested by Welch et. al. (1990) and studied by others. In this paper we make a comparative study on optimization procedures to robust design in the two different experimental design(product array, combined array) approaches the Mough the Monte Carlo simulation.

  • PDF

Analysis and Optimization of Cross-Modulation Noise in CDMA Cellular RF System (CDMA 셀룰러 RF 시스템에서 교차변조 잡음 레벨 분석 및 최적화)

  • 곽준호;김학선
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.28 no.6A
    • /
    • pp.397-404
    • /
    • 2003
  • In this paper, we have analyzed the level of cross-modulation noise required for CDMA mobile station and proposed a guideline for optimum design. From the analysis, the level of cross-modulation noise is determined by the system's noise figure(NF) and VCO's phase noise and there is a trade-off relationships between them. In addition, we have determined the value of LNA's IIP3 and duplexer's isolation to satisfy the above level in designing the system. Therefore, this paper will give a guideline for a selection of components in designing cdma2000 mobile station.

A Comparative Study of Statistical Methods for Population Bioequivalence in 2 X 2 Crossover Design (2 X 2 교차설계법에서 모집단 생물학적 동등성 검정 방법 비교)

  • Park Sang-Gue;Lim Nam-Kyoo;Lee Jae-Young;Kim Byung-Chun
    • The Korean Journal of Applied Statistics
    • /
    • v.18 no.1
    • /
    • pp.159-171
    • /
    • 2005
  • The US Food and Drug Administration(FDA) recommends that population bioequivalence and individual bioequivalence would be assessed to address the prescribability and switchability between a brand-name drug and its new formulation or generic copy in its 2001 guidance document. The test for population bioequivalence in the latest FDA guidance is recommended in 2 x 4 crossover design, but it turns out to be very conservative. Recently Lee, Shao & Chow(2002), Chow, Shao & Wang(2003) and McNally, Iyer & Mathew(2002) proposed new statistical methods for assessing population bioequivalence between drugs to correct the biasness of current FDA method. Since 2 x 2 crossover experiment is most welcomed design in bioequivalence testing, we adopt their methods to 2 x 2 crossover designs and compare their methodologies with FDA one through the simulation study.

A Study on Decision of Stop-line Position and Capacity according to the Left-turn Trajectory at Intersection (교차로 좌회전 궤적에 따른 용량 및 정지선 위치결정에 관한 연구)

  • 김기용
    • Proceedings of the KOR-KST Conference
    • /
    • 1999.10a
    • /
    • pp.315-320
    • /
    • 1999
  • 교차로 좌회전 이동류에 대해 곡선반경의 확보여부는 용량 및 안전성측면에 많은 영향을 주게 된다. 죄회전 곡선반경의 결정은 설계기준차량의 회전궤적에 따라 결정되며 곡선반경의 모양은 원곡선의 형태를 유지하는 것이 바람직한 형태로 제시되고 있다. 교차로 설게시 곡선반경의 확보방안으로 정지선을 후퇴시키는 방안을 제시함으로서 좌회전 이동류에 대해 용량 및 안전성을 개선할 수 있도록 하였다.

  • PDF