• The Journal of the Korean bone and joint tumor society
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• v.3 no.1
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• pp.9-17
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• 1997

Resistance to combination chemotherapy remains challenge in the treatment of osteosarcoma. One of the mechanisms of multiple drug resistance is an increased expression of the multidrug resistance gene(mdr1). Expression of the P-glycoprotein(mdr-1 gene product) was studied immunohistochemically and the mdr-1 gene by in situ hybridization in 33 osteosarcomas relating to various prognostic factors. Thirty cases out of 33 osteosarcomas(90.9%) showed positive cytoplasmic reactions with P-glycoprotein and nineteen instances(57.6%) were strong positive(2+). The older(>20 years) and female patients revealed more intense immunohistochemical reactions rather than those of the younger and male patients. Osteoblastic and chondroblastic osteosarcomas revealed more strong immunohistochemical reactions compared to fibroblastic types. There were no significant staining differences between the type of bony involvement, Broder's grade and the presence of necrosis. On follow-up, the mean survival rate was decreased in the strong positive group, however, this was not statistically significant. In situ hybridization for mdr-1 gene revealed positive signals in 22 cases out of 29 osteosarcomas(75.9%). Chemotherapy was done in 15 cases out of 28 patients(53.6%). The results of immunohistochemistry and in situ hybridization were not correlated with the protocols for chemotherapy. However, this result should be confirmed by a larger scale study about mdr1 mRNA expression.

• The Journal of the Korean bone and joint tumor society
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• v.4 no.2
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• pp.103-106
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• 1998

Giant cell tumor was described by Sir Astley Cooper in 1818. This tumor is considered to be a benign tumor but has problems of recurrence and metastatic change after treatment. Methods of operative treatment of this tumor have included currettage, currettage and bone graft, excision, resection, excision and graft and amputation. We experienced a case of giant cell tumor which involved the distal part of right radius and treated by wide excision and fibular graft. The postoperative courses have been satisfactory because of no recurrence or malignant change. After 6 years and 1 month follow up, the patient was able to return to daily life without any problem.

• The Journal of the Korean bone and joint tumor society
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• v.3 no.2
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• pp.131-136
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• 1997

Although chondrosarcoma is a common primary malignant bone tumor, its occurrence in the spine is very rare. It is also well known that even after complete removal of chondrosarcoma in bone, not a few recurrence is possible. Surgical cure of a spinal chondrosarcoma is even more difficult because total excision of chondrosarcoma is usually impossible in the spine. No patients with spinal chondrosarcoma surviving more than 18 years has been reported in literature. We are reporting one patient(32 year old housewife) with chondrosarcoma at the $12^{th}$ thoracic spine which was treated with complete corpectomy of the $12^{th}$ thoracic vertebral body and rib and cancellous bone graft fixed with plating. She was followed for more than 3 years without local recurrence or distant metastasis.

• The Journal of the Korean bone and joint tumor society
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• v.3 no.2
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• pp.127-130
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• 1997

Tumoral calcinosis is a rare disorder of unknown etiology, which is characterized by the developement of large calcified masses overlying the large joints in otherwise healthy subjects. If histologic tests are not confirmed, the condition may be treated erroneously as bursitis. This report describes the case of a 10-year-old man with tumoral calcinosis of the knee, a joint very rarely affected by this unusual disorder. Microscopically the tumor consists of a stroma of chronic inflammatory tissue surrounding cystic spaces containing calcium-rich material. We made excision alone, and the patient made an uneventful recovery with no evidence of recurrence up to 13 months postoperatively.

• The Journal of the Korean bone and joint tumor society
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• v.18 no.1
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• pp.32-36
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• 2012

A 56 year-old female presented with dysphagia 8 weeks ago and newly developed dysphonia 2 weeks ago. The radiology study and swallowing difficulty evaluation study revealed the esophagus and the posterior wall of the laryngopharynx to be severely compressed by the mass of the anterior $4^{th}$ and $5^{th}$ vertebral body of cervical spine. En bloc excisional biopsy of the bony mass was performed, which completely resolved the clinical symptoms. We report a rare case of osteochondroma occurring at the anterior portion of cervical spine leading to dysphasia and dysphonia with a review of relevant literature.

• The Journal of the Korean bone and joint tumor society
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• v.13 no.2
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• pp.124-129
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• 2007

Synovial sarcomas of the hand are rare. It should be treated with wide resection. In the cases of soft tissue sarcomas of the hand, functional reconstruction must be considered. We report 46-year-old male patient with synovial sarcoma of the right thenar muscle which was treated with unplanned intralesional resection at outside hospital, that has been treated with wide resection including trapezium and first metacarapl bone then, reconstructed with nonvascularized fibular graft and anterolateral thigh free flap.

• The Journal of the Korean bone and joint tumor society
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• v.13 no.2
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• pp.167-172
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• 2007

Malignant transformation of giant cell tumor (GCT) is known to be rare. Most of malignant transformation is reported to occur after radiation and malignant transformation without prior radiation is extremly rare. Both radiographic and pathologic findings are confusing to make a correct diagnosis. Due to the poor prognosis, early aggressive treatment is mandatory. We report this rare case together with the review of the literature.

• The Journal of the Korean bone and joint tumor society
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• v.13 no.2
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• pp.201-206
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• 2007

It is a well-accepted tenet that wide surgical margins are necessary for the treatment of soft-tissue sarcomas, and it is still true that the rate of recurrence depends on the adequacy of the surgical margins. Sarcomas that rest directly against bone pose a dilemma for the surgeon. A wide margin is not possible in the literal sense without excision of the bone. Whereas reconstruction of skeletal defects is possible, it adds to the complexity of the surgery and increases potential complications. We report the experience of treatment in a case of synovial sarcoma which located at popliteal fossa adjacent to proximal tibia.

• The Journal of the Korean bone and joint tumor society
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• v.12 no.2
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• pp.131-135
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• 2006

Chondrosarcoma can be divided into grade I, II and III by histological finding and a relationship between the prognosis and the histological grading has been identified. Although the surgical treatment of grade II and III chondrosarcoma necessitates wide resection margin, there has been controversy about curettage versus wide resection in case of grade I chondrosarcoma. The authors report a case of grade I chondrosarcoma of proximal humerus and grade II chondrosarcoma of distal humerus with good oncological and functional result through curettage and wide resection respectively.

• The Journal of the Korean bone and joint tumor society
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• v.15 no.1
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• pp.87-91
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• 2009

Fibrous dysplasia is a developmental benign disorder in which normal bone is replaced by fibrous tissue. Malignant transformation of fibrous dysplasia is a rare complication and more commonly occur in the polyostotic form than monostotic form. We report a case in which osteosarcoma developed in area of fibrous dysplasia of proximal femur after treating with curettage, wedge osteotomy, internal fixation, and bone graft. A review of the literature is presented.