• Journal of the Korean Orthopaedic Association
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• v.53 no.6
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• pp.540-546
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• 2018

Purpose: The purpose of this study was to suggest a multimodal diagnostic approach to determine the cause of the disease in patients diagnosed with synovitis of the wrist and who underwent synovectomy. Materials and Methods: Twenty-nine patients, who underwent contrast magnetic resonance imaging (MRI) preoperatively and synovectomy from January 2000 to December 2013, were reviewed retrospectively. Among them, 17 patients underwent a $Tc^{99m}$ white blood cell (WBC) scan preoperatively. In patients who met the diagnostic criteria of rheumatoid arthritis (RA), the diagnosis was confirmed as RA if the MRI finding or histology was compatible with RA. If the MRI finding and histology were disparate, the final diagnosis was made based on the histologic finding. Results: Of the nine patients who met the diagnostic criteria of RA, seven patients were finally diagnosed as RA and two patients as tuberculous arthritis. Of the 20 patients who did not meet the diagnostic criteria of RA, the MRI findings and histology were consistent with the same disease in 12 patients. In the remaining eight patients, five were diagnosed with nonspecific chronic synovitis, one with RA, and two with tuberculous arthritis based on the clinical findings, MRI, and histology findings. Conclusion: MRI and a WBC scan are very useful imaging modalities for diagnosing the causative condition of the wrist synovitis. A histology evaluation after synovectomy can also be useful in cases with a difficult diagnosis or are refractory to medications.

• Journal of the Korean Arthroscopy Society
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• v.15 no.1
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• pp.28-31
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• 2011

Pyogenic arthritis of the shoulder is very rare disease in infant. Early diagnosis and proper treatment are very important prognostic factors. We treated a 10-month-old infant who was suffering pyogenic arthritis of the shoulder by arthroscopic irrigation and synovectomy with direct inspection. Finally, satisfactory result was achieved without any major scar or complications.

• 대한근관절건강학회:학술대회논문집
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• 2000.11a
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• pp.341-346
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• 2000

• Journal of the Korean Orthopaedic Association
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• v.52 no.1
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• pp.97-102
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• 2017

The incidence of septic arthritis after knee arthroscopy surgery has rarely been reported in approximately 0.04% to 3.4%. Moreover, septic arthritis after arthroscopic meniscal repair is more rare. There have been some reported cases, but in Korea, it has not been reported thus far. Herein, we report two cases of septic arthritis after arthroscopic meniscal repair with review of literature.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.5
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• pp.631-640
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• 2014

The inhibitory effects of Boswellia serrata (BW) extracts on degenerative osteoarthritis were investigated in primary-cultured rat cartilage cells and a monosodium-iodoacetate (MIA)-induced osteoarthritis rat model. To identify the protective effects of BW extract against $H_2O_2$ ($800{\mu}M$, 2 hr) in vitro, cell survival was measured by MTT assay. Cell survival after $H_2O_2$ treatment was elevated by BW extract at a concentration of $20{\mu}g/mL$. In addition, BW extract treatment significantly reduced and normalized the productions of pro-inflammatory factors, nuclear transcription factor ${\kappa}B$, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interleukin-6 at a concentration of $20{\mu}g/mL$. Treatment of chondrocytes with BW extract significantly reduced 5-lipoxygenase activity and production of prostaglandin E2, especially at a concentration of $10{\sim}20{\mu}g/mL$. For the in vivo animal study, osteoarthritis was induced by intra-articular injection of MIA into knee joints of rats. Consumption of a diet containing BW extract (100 and 200 mg/kg) for 35 days significantly inhibited the development and severity of osteoarthritis in rats. To determine the genetic expression of arthritic factors in articular cartilage, real-time PCR was applied to measure matrix metalloproteinases (MMP-3, MMP-9, and MMP-13), collagen type I, collagen type II, and aggrecan, and BW extract had protective effects at a concentration of 200 mg/kg. In conclusion, BW extract was able to inhibit articular cartilage degeneration by preventing extracellular matrix degradation and chondrocyte injury. One can consider that BW extract may be a potential therapeutic treatment for degenerative osteoarthritis.

• Journal of the Korean Orthopaedic Association
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• v.55 no.6
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• pp.472-486
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• 2020

Rheumatoid arthritis is a systemic disease with chronic progress, but the recent rapid developments of drug treatments have led many patients to gain control of their disease activity. As a result, surgery has been performed less commonly on the wrist or hand than in the past. On the other hand, surgical treatment is still essential to patients who do not respond to those medications. For the successful treatment of symptomatic deformed joints or functional disability, surgeons should understand that the pathology of rheumatoid arthritis proceeds differently in every patient. Furthermore, because rheumatoid arthritis often invades multiple joints in the hand and wrist, the patients often require multiple operations simultaneously. This paper summarizes the current concepts of surgical treatment of rheumatoid arthritis in the hand and wrist based on more than 30 years' experience of our senior surgeon and a literature review.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.94-94
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• 2019

황해쑥(Artemisia argyi H.Lev. & Vaniot)은 우수한 항염증 활성을 지닌 것으로 다양하게 보고 되었다. 그러나, 대표적인 염증 질환 중 하나인 골관절염에 미치는 영향은 현재까지 알려져 있지 않다. 따라서, 본 연구에서는 염증 유발 연골 세포 및 골관절염 유발 동물 모델에 미치는 황해쑥 효과에 대해 조사하였다. 첫째, interleukin 1 beta를 투여한 관절 연골 세포에 황해쑥 물 추출물을 투여한 후 metalloporeinase (MMP) -3 및 MMP-13의 발현을 mRNA 및 단백질 수준에서 분석 하였다. 또한, 내측 반월상 연골의 불안정화에 의해 유도 된 골관절염 마우스 모델을 사용하여 황해쑥 물 추출물의 골관절염 억제 효과를 분석 하였다. 세포 실험에서, 본 황해쑥은 MMP-3와 MMP-13의 mRNA 및 단백질 발현을 유의하게 억제하였다. 또한. 황해쑥 물 추출물을 투여한 실험 동물의 관절 조직을 Safranin O 염색을 실시하여 분석한 결과 연골 하 골판 두께의 감소 및 활막 염증 개선 효과가 관찰 되었다. HPLC를 이용한 성분 분석 결과, 황해쑥 물 추출물은 항염증 및 항관절염 활성을 가진 jaceosidin과 eupatilin을 함유하는 것으로 나타났다. 본 연구결과로부터 황해쑥은 골관절염의 치료 또는 예방에 유망한 소재로 개발될 수 있음을 시사한다.

• Journal of dental hygiene science
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• v.15 no.5
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• pp.612-619
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• 2015

The purpose of this study was to examine the association between oral health status and rheumatoid arthritis (RA). The study used a nationally representative sample of Koreans (2013 Korea National Health and Nutrition Examination Survey) aged 19 years over (n=6,113). Dependent variable was RA, which was assessed with oral health status. Independent variable was oral health status (periodontal status, missing tooth). The chi-square test and logistic regression analysis were performed to identify the association between oral health status and RA. Results of logistic regression analysis for association between periodontal status and RA was no significant. Results of logistic regression analysis for association between missing tooth and RA was statistically significant. The odds ratio (OR) for RA participants was 3.03 (95% confidence interval [CI], 1.47~6.23) in missing tooth 19~28 than missing tooth 0~8. The OR for RA participants was 2.08 (95% CI, 1.06~4.08) in missing tooth 9~18 than missing tooth 0~8. After adjustment for confounders (socio-demographic factors, health behaviors), results of logistic regression analysis was no significant. More missing tooth among adults was greater the risk of RA. By promoting the improvement of oral hygiene and oral health would contribute to reduce the risks associated with systemic diseases. Future study is needed to examine the detailed causal relations between oral health status and RA bidirectionally.

• Journal of Korean Foot and Ankle Society
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• v.15 no.3
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• pp.119-123
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• 2011

This article has reviewed the alignment of the ankle and hindfoot in varus ankle osteoarthritis. The indication and surgical technique of the supramalleolar osteotomy has been reviewed. Alignment of tibial plafond and hindfoot is variable in early stages of ankle osteoarthritis. Supramalleolar osteotomy is indicated for the treatment of ankle osteoarthritis in patients with minimal talar tilt and neutral or varus heel alignment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.9
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• pp.4073-4081
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• 2012

This study was designed to estimate the prevalence of arthritis and to identify subgroups with high prevalence rates of arthritis. Study subjects were 18,406 Korean adults aged 19 and more from the 4th (2007-2009) Korea National Health and Nutrition Examination Surveys data. Annual self-reported prevalence and its rate ratios by demographic and behavioral factors were calculated using SAS 9.2 with survey procedure. The result was as follows. The crude prevalence of arthritis was 11.7% (osteoarthritis 10.2% and rheumatoid arthritis 1.7%). The prevalence was increased by age strata (2.4% in 19-44 aged, 16.4% in 45-64, 38.3% in 65 and more). After adjusting for age, we found the subgroups with high prevalence: older people, women, residents in non-apartment area, separated and divorced people, people with low education, people with several occupations (agricultural and fishery workers, elementary occupations, and unemployed), people with low household incomes, people with medical aid, and people with higher BMI. Those subgroups may be target populations in community health programs to control the disability from arthritis.